Page last updated: 2024-10-24

hydrolase activity, hydrolyzing O-glycosyl compounds

Definition

Target type: molecularfunction

Catalysis of the hydrolysis of any O-glycosyl bond. [GOC:mah]

Hydrolase activity, hydrolyzing O-glycosyl compounds, refers to the enzymatic ability to break down O-glycosidic bonds, which link a sugar moiety to a hydroxyl group of another molecule. These enzymes are critical in a wide range of biological processes, including:

* **Carbohydrate metabolism:** Hydrolyzing O-glycosyl compounds allows for the breakdown of complex carbohydrates into simpler sugars, which can be utilized as energy sources or building blocks for other biomolecules.

* **Signal transduction:** Some O-glycosyl compounds are involved in cell signaling pathways. Hydrolyzing these molecules can activate or deactivate signaling cascades, impacting cellular processes like growth, differentiation, and response to environmental stimuli.

* **Glycoprotein processing:** Many proteins are glycosylated, meaning they have sugar moieties attached to them. Hydrolyzing O-glycosyl compounds can modify these glycoproteins, influencing their structure, function, and interactions with other molecules.

* **Biomaterial degradation:** O-glycosyl compounds are found in various biomaterials, including plant cell walls and extracellular matrices. Hydrolyzing these molecules is essential for the breakdown and recycling of these materials.

* **Pathogen defense:** Some O-glycosyl compounds are associated with pathogens, such as bacteria and viruses. Hydrolyzing these molecules can disrupt pathogen attachment, invasion, and survival.

The specific mechanism of O-glycosyl compound hydrolysis varies depending on the enzyme and substrate. However, all these enzymes utilize a catalytic mechanism that involves the formation of an enzyme-substrate complex and the subsequent cleavage of the O-glycosidic bond, often through nucleophilic attack by a catalytic residue in the enzyme active site. This process results in the release of the individual sugar and aglycone (non-sugar) components of the O-glycosyl compound.'
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Proteins (4)

ProteinDefinitionTaxonomy
Beta-glucuronidaseA beta-glucuronidase that is encoded in the genome of Escherichia coli K-12. [OMA:P05804, PRO:DNx]Escherichia coli K-12
Chitotriosidase-1A chitotriosidase-1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q13231]Homo sapiens (human)
Cytosolic endo-beta-N-acetylglucosaminidaseA cytosolic endo-beta-N-acetylglucosaminidase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NFI3]Homo sapiens (human)
Chitotriosidase-1A chitotriosidase-1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q13231]Homo sapiens (human)

Compounds (16)

CompoundDefinitionClassesRoles
theophyllinedimethylxanthineadenosine receptor antagonist;
anti-asthmatic drug;
anti-inflammatory agent;
bronchodilator agent;
drug metabolite;
EC 3.1.4.* (phosphoric diester hydrolase) inhibitor;
fungal metabolite;
human blood serum metabolite;
immunomodulator;
muscle relaxant;
vasodilator agent
caffeinepurine alkaloid;
trimethylxanthine
adenosine A2A receptor antagonist;
adenosine receptor antagonist;
adjuvant;
central nervous system stimulant;
diuretic;
EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor;
EC 3.1.4.* (phosphoric diester hydrolase) inhibitor;
environmental contaminant;
food additive;
fungal metabolite;
geroprotector;
human blood serum metabolite;
mouse metabolite;
mutagen;
plant metabolite;
psychotropic drug;
ryanodine receptor agonist;
xenobiotic
lansoprazoleLansoprazole: A 2,2,2-trifluoroethoxypyridyl derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits H(+)-K(+)-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS. Lansoprazole is a racemic mixture of (R)- and (S)-isomers.benzimidazoles;
pyridines;
sulfoxide
anti-ulcer drug;
EC 3.6.3.10 (H(+)/K(+)-exchanging ATPase) inhibitor
omeprazole5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole : A member of the class of benzimidazoles that is 1H-benzimidazole which is substituted by a [4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl group at position 2 and a methoxy group at position 5.

omeprazole : A racemate comprising equimolar amounts of (R)- and (S)-omeprazole.

Omeprazole: A 4-methoxy-3,5-dimethylpyridyl, 5-methoxybenzimidazole derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits an H(+)-K(+)-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS.
aromatic ether;
benzimidazoles;
pyridines;
sulfoxide
pentoxifyllineoxopurine
rabeprazoleRabeprazole: A 4-(3-methoxypropoxy)-3-methylpyridinyl derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits H(+)-K(+)-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS.benzimidazoles;
pyridines;
sulfoxide
anti-ulcer drug;
EC 3.6.3.10 (H(+)/K(+)-exchanging ATPase) inhibitor
dehydroepiandrosteronedehydroepiandrosterone : An androstanoid that is androst-5-ene substituted by a beta-hydroxy group at position 3 and an oxo group at position 17. It is a naturally occurring steroid hormone produced by the adrenal glands.

Dehydroepiandrosterone: A major C19 steroid produced by the ADRENAL CORTEX. It is also produced in small quantities in the TESTIS and the OVARY. Dehydroepiandrosterone (DHEA) can be converted to TESTOSTERONE; ANDROSTENEDIONE; ESTRADIOL; and ESTRONE. Most of DHEA is sulfated (DEHYDROEPIANDROSTERONE SULFATE) before secretion.
17-oxo steroid;
3beta-hydroxy-Delta(5)-steroid;
androstanoid
androgen;
human metabolite;
mouse metabolite
androstenedioneandrost-4-ene-3,17-dione : A 3-oxo Delta(4)-steroid that is androst-4-ene substituted by oxo groups at positions 3 and 17. It is a steroid hormone synthesized in the adrenal glands and gonads.

Androstenedione: A delta-4 C19 steroid that is produced not only in the TESTIS, but also in the OVARY and the ADRENAL CORTEX. Depending on the tissue type, androstenedione can serve as a precursor to TESTOSTERONE as well as ESTRONE and ESTRADIOL.
17-oxo steroid;
3-oxo-Delta(4) steroid;
androstanoid
androgen;
Daphnia magna metabolite;
human metabolite;
mouse metabolite
glycyrrhetinic acidcyclic terpene ketone;
hydroxy monocarboxylic acid;
pentacyclic triterpenoid
immunomodulator;
plant metabolite
glycyrrhizic acidglycyrrhizinic acid : A triterpenoid saponin that is the glucosiduronide derivative of 3beta-hydroxy-11-oxoolean-12-en-30-oic acid.enone;
glucosiduronic acid;
pentacyclic triterpenoid;
tricarboxylic acid;
triterpenoid saponin
EC 3.4.21.5 (thrombin) inhibitor;
plant metabolite
methyl methanethiosulfinatemethyl methanethiosulfinate: structure in first source; a metabolite of S-methyl cysteine sulfoxidesulfur oxoacid derivative
argadinargadin: a chitinase inhibitor, produced by Clonostachys sp. FO-7314; structure in first source
argifinargifin: possible lead insecticide; isolated from Gliocladium; structure in first source
tenatoprazoleTenatoprazole: structure in first sourceimidazopyridine
kuwanon gkuwanon G: a non-peptide bombesin receptor antagonist; RN refers to (1S-(1alpha,5alpha,6beta))-isomer; structure given in first source

kuwanone G : A tetrahydroxyflavone isolated from the root barks of Morus alba and has been shown to exhibit anti-inflammatory activity.
resorcinols;
tetrahydroxyflavone
anti-inflammatory agent;
plant metabolite
dexlansoprazoleDexlansoprazole: The R-isomer of lansoprazole that is used to treat severe GASTROESOPHAGEAL REFLUX DISEASE.benzimidazoles;
sulfoxide