Page last updated: 2024-10-24
initiator methionyl aminopeptidase activity
Definition
Target type: molecularfunction
Catalysis of the release of N-terminal initiator methionine from peptides. [EC:3.4.11.18]
Initiator methionyl aminopeptidase activity refers to the enzymatic ability to specifically remove the N-terminal methionine residue from newly synthesized proteins. This activity is crucial for protein maturation and function, as it often removes the initiator methionine, which can hinder proper folding or interfere with the protein's interaction with other molecules. The enzyme responsible for this activity, methionine aminopeptidase (MetAP), exhibits high specificity for the N-terminal methionine residue, recognizing it based on its unique chemical structure. This specificity is crucial for ensuring that only the appropriate methionine residues are removed, leaving the rest of the protein intact. The removal of the initiator methionine can expose a new N-terminal residue, which can then be modified or interact with other molecules, influencing the protein's function. The activity of methionine aminopeptidases plays a vital role in a wide range of cellular processes, including protein folding, translation initiation, and signal transduction. Defects in MetAP activity can lead to various diseases, highlighting its importance in cellular function.'
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Proteins (3)
| Protein | Definition | Taxonomy |
|---|---|---|
| Methionine aminopeptidase | A methionine aminopeptidase that is encoded in the genome of Escherichia coli K-12. [PRO:DNx, UniProtKB:P0AE18] | Escherichia coli K-12 |
| Methionine aminopeptidase 1 | A methionine aminopeptidase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P53582] | Homo sapiens (human) |
| Methionine aminopeptidase 2 | A methionine aminopeptidase 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P50579] | Homo sapiens (human) |
Compounds (24)
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| 2,2'-dipyridyl | 2,2'-bipyridine : A bipyridine in which the two pyridine moieties are linked by a bond between positions C-2 and C-2'. 2,2'-Dipyridyl: A reagent used for the determination of iron. | bipyridine | chelator; ferroptosis inhibitor |
| oxyquinoline | Oxyquinoline: An antiseptic with mild fungistatic, bacteriostatic, anthelmintic, and amebicidal action. It is also used as a reagent and metal chelator, as a carrier for radio-indium for diagnostic purposes, and its halogenated derivatives are used in addition as topical anti-infective agents and oral antiamebics. quinolin-8-ol : A monohydroxyquinoline that is quinoline substituted by a hydroxy group at position 8. Its fungicidal properties are used for the control of grey mould on vines and tomatoes. | monohydroxyquinoline | antibacterial agent; antifungal agrochemical; antiseptic drug; iron chelator |
| albendazole | aryl sulfide; benzimidazoles; benzimidazolylcarbamate fungicide; carbamate ester | anthelminthic drug; microtubule-destabilising agent; tubulin modulator | |
| cloxyquin | cloxyquin: has antitubercular activity; structure in first source | organochlorine compound; quinolines | |
| ebselen | ebselen : A benzoselenazole that is 1,2-benzoselenazol-3-one carrying an additional phenyl substituent at position 2. Acts as a mimic of glutathione peroxidase. | benzoselenazole | anti-inflammatory drug; antibacterial agent; anticoronaviral agent; antifungal agent; antineoplastic agent; antioxidant; apoptosis inducer; EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor; EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor; EC 1.3.1.8 [acyl-CoA dehydrogenase (NADP(+))] inhibitor; EC 1.8.1.12 (trypanothione-disulfide reductase) inhibitor; EC 2.5.1.7 (UDP-N-acetylglucosamine 1-carboxyvinyltransferase) inhibitor; EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor; EC 3.1.3.25 (inositol-phosphate phosphatase) inhibitor; EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor; EC 3.5.4.1 (cytosine deaminase) inhibitor; EC 5.1.3.2 (UDP-glucose 4-epimerase) inhibitor; enzyme mimic; ferroptosis inhibitor; genotoxin; hepatoprotective agent; neuroprotective agent; radical scavenger |
| fenbendazole | fenbendazole : A member of the class of benzimidazoles that is 1H-benzimidazole which is substituted at positons 2 and 5 by (methoxycarbonyl)amino and phenylsulfanediyl groups, respectively. A broad-spectrum anthelmintic, it is used, particularly in veterinary medicine, for the treatment of nematodal infections. Fenbendazole: Antinematodal benzimidazole used in veterinary medicine. | aryl sulfide; benzimidazoles; carbamate ester | antinematodal drug |
| mebendazole | mebendazole : A carbamate ester that is methyl 1H-benzimidazol-2-ylcarbamate substituted by a benzoyl group at position 5. Mebendazole: A benzimidazole that acts by interfering with CARBOHYDRATE METABOLISM and inhibiting polymerization of MICROTUBULES. | aromatic ketone; benzimidazoles; carbamate ester | antinematodal drug; microtubule-destabilising agent; tubulin modulator |
| thiabendazole | Tresaderm: dermatologic soln containing dexamethasone, thiabendazole & neomycin sulfate | 1,3-thiazoles; benzimidazole fungicide; benzimidazoles | antifungal agrochemical; antinematodal drug |
| 8-hydroxyquinoline-5-sulfonic acid | 8-hydroxyquinoline-5-sulfonic acid: RN given refers to parent cpd | ||
| dimoxyline | quinolines | ||
| 8-hydroxy-2-methylquinoline | 8-hydroxy-2-methylquinoline: structure in first source | hydroxyquinoline | |
| 2-(2'-hydroxyphenyl)benzimidazole | 2-(2'-hydroxyphenyl)benzimidazole: structure in first source | ||
| fuberidazole | fuberidazole : A ring assembly consisting of benzimidazole substituted at position 2 by a 2-furyl group. A fungicide used as a seed treatment to control Fusarium spp. in cereals. fuberidazole: fumigant; structure | benzimidazole fungicide; benzimidazoles; furans | antifungal agrochemical |
| nitroxoline | nitroxoline : A monohydroxyquinoline in which the hydroxy group is positioned at C-8 with a nitro group trans to it at C-5. nitroxoline: structure in Merck Index, 9th ed, #6475; RN given refers to parent cpd | C-nitro compound; monohydroxyquinoline | antifungal agent; antiinfective agent; antimicrobial agent; renal agent |
| carbendazim | carbendazim : A member of the class of benzimidazoles that is 2-aminobenzimidazole in which the primary amino group is substituted by a methoxycarbonyl group. A fungicide, carbendazim controls Ascomycetes, Fungi Imperfecti, and Basidiomycetes on a wide variety of crops, including bananas, cereals, cotton, fruits, grapes, mushrooms, ornamentals, peanuts, sugarbeet, soybeans, tobacco, and vegetables. carbendazim: carcinogen when combined with sodium nitrite; principle metabolite of thiophanate methyl & benomyl; structure | benzimidazole fungicide; benzimidazoles; benzimidazolylcarbamate fungicide; carbamate ester | antifungal agrochemical; antinematodal drug; metabolite; microtubule-destabilising agent |
| 2-(2'-pyridyl)benzimidazole | 2-(2'-pyridyl)benzimidazole: structure in first source | ||
| 1-amino-1-phenylmethyl phosphonic acid | 1-amino-1-phenylmethyl phosphonic acid : A member of the class of phosphonic acids that is phosphonic acid having a amino(phenyl)methyl group attached to the phosphorus. | benzenes; phosphonic acids; primary amino compound | |
| bis(2-(n-phenylcarboxamido)phenyl)diselenide | bis(2-(N-phenylcarboxamido)phenyl)diselenide: selenoorganic cpd which has mitogenic activity in human peripheral leukocytes | ||
| 8-(4-benzenesulfonylamino)quinoline | 8-(4-benzenesulfonylamino)quinoline: has diabetogenic properties; structure given in first source | ||
| o-(chloroacetylcarbamoyl)fumagillol | O-(chloroacetylcarbamoyl)fumagillol : A carbamate ester that is fumagillol in which the hydroxy group has been converted to the corresponding N-(chloroacetyl)carbamate derivative. O-(Chloroacetylcarbamoyl)fumagillol: Semisynthetic analog of fumagillin (a cyclohexane-sesquiterpene antibiotic isolated from ASPERGILLUS FUMIGATUS) that inhibits angiogenesis. | carbamate ester; organochlorine compound; semisynthetic derivative; sesquiterpenoid; spiro-epoxide | angiogenesis inhibitor; antineoplastic agent; EC 1.5.1.3 (dihydrofolate reductase) inhibitor; methionine aminopeptidase 2 inhibitor; retinoic acid receptor alpha antagonist |
| 4,5-dimethylaminobenzylidene-2-thiobarbituric acid | |||
| pyridine-2-carboxylic acid thiazol-2-ylamide | pyridine-2-carboxylic acid thiazol-2-ylamide: structure in first source | ||
| fumagillin | antibiotic antifungal drug; carboxylic ester; dicarboxylic acid monoester; meroterpenoid; organooxygen heterocyclic antibiotic; spiro-epoxide | angiogenesis inhibitor; antibacterial drug; antimicrobial agent; antiprotozoal drug; fungal metabolite; methionine aminopeptidase 2 inhibitor | |
| ppi 2458 | PPI 2458: a methionine aminopeptidase-2 inhibitor with antirheumatic activity; structure in first source |