The chemical name (3-(n-hydroxy)carboxamido-2-benzylpropanoyl)glycine is a bit unwieldy and doesn't readily reveal its structure or function. Let's break it down and see if we can understand its significance:
**Understanding the Structure:**
* **(3-(n-hydroxy)carboxamido-2-benzylpropanoyl)**: This part describes a specific organic molecule with a few key features:
* **Benzyl:** This refers to a phenyl group (a six-membered ring of carbon atoms) attached to a CH2 group.
* **Propanoyl:** This indicates a three-carbon chain with a carbonyl group (C=O) at one end.
* **Carboxamido:** This means the propanoyl group is linked to a nitrogen atom (amide) and also has a hydroxyl group (-OH) attached to the nitrogen.
* **Glycine:** This is the simplest amino acid, with a single hydrogen atom as its side chain.
**Putting it Together:**
This compound is likely a **modified peptide**. It consists of a glycine amino acid linked to a modified propanoyl group. The modified propanoyl group carries a benzyl group and a hydroxyl group attached to the nitrogen.
**Importance in Research:**
Without more context, it's difficult to definitively state the importance of this specific compound in research. However, based on its structure, we can make some educated guesses:
* **Peptidomimetics:** Modified peptides like this are often used as **peptidomimetics** in drug discovery. Peptidomimetics are molecules designed to mimic the structure and function of natural peptides, but with improved properties like stability, bioavailability, or selectivity.
* **Biological Activity:** The presence of the benzyl group and the hydroxyl group suggests that this compound could interact with biological targets like proteins or enzymes. It might have potential applications in areas such as:
* **Pharmacology:** Targeting specific receptors or pathways related to disease processes.
* **Materials Science:** Developing materials with novel properties, potentially through self-assembly or interaction with biological systems.
**To Learn More:**
To understand the specific importance of this compound, you would need to know its context:
* **What research area is it related to?** (e.g., cancer, neurobiology, etc.)
* **What specific biological activity is it known or suspected to have?**
* **What is its purpose in the research study?** (e.g., drug candidate, probe molecule, etc.)
**Finding More Information:**
You could try searching for this compound online using its full chemical name or a more concise description (e.g., benzyl-modified propanoyl glycine). You can also search scientific databases like PubMed or Google Scholar for publications that might mention it.
ID Source | ID |
---|---|
PubMed CID | 124786 |
CHEMBL ID | 16779 |
SCHEMBL ID | 7325845 |
MeSH ID | M0132237 |
Synonym |
---|
hcbp-gly |
CHEMBL16779 , |
(2-benzyl-3-hydroxycarbamoyl-propionylamino)-acetic acid |
(r,s)(2-benzyl-3-hydroxycarbamoyl-propionylamino)-acetic acid |
bdbm50002022 |
(3-(n-hydroxy)carboxamido-2-benzylpropanoyl)glycine |
SCHEMBL7325845 |
DTXSID80919328 |
n-[2-benzyl-1,4-dihydroxy-4-(hydroxyimino)butylidene]glycine |
Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
---|---|---|---|---|---|---|---|
Neprilysin | Rattus norvegicus (Norway rat) | IC50 (µMol) | 0.0014 | 0.0010 | 0.1702 | 2.3000 | AID67348 |
Neprilysin | Oryctolagus cuniculus (rabbit) | IC50 (µMol) | 0.0014 | 0.0004 | 0.6611 | 8.2000 | AID147214; AID147516 |
Neprilysin | Homo sapiens (human) | IC50 (µMol) | 0.0014 | 0.0002 | 0.5422 | 6.7000 | AID147393 |
Aminopeptidase N | Sus scrofa (pig) | IC50 (µMol) | 0.0020 | 0.0005 | 3.5354 | 8.9000 | AID35686 |
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] |
Process | via Protein(s) | Taxonomy |
---|---|---|
phosphatidylserine binding | Neprilysin | Homo sapiens (human) |
endopeptidase activity | Neprilysin | Homo sapiens (human) |
metalloendopeptidase activity | Neprilysin | Homo sapiens (human) |
protein binding | Neprilysin | Homo sapiens (human) |
exopeptidase activity | Neprilysin | Homo sapiens (human) |
zinc ion binding | Neprilysin | Homo sapiens (human) |
peptide binding | Neprilysin | Homo sapiens (human) |
protein homodimerization activity | Neprilysin | Homo sapiens (human) |
oligopeptidase activity | Neprilysin | Homo sapiens (human) |
cardiolipin binding | Neprilysin | Homo sapiens (human) |
[Information is prepared from geneontology information from the June-17-2024 release] |
Process | via Protein(s) | Taxonomy |
---|---|---|
cytoplasm | Neprilysin | Homo sapiens (human) |
early endosome | Neprilysin | Homo sapiens (human) |
trans-Golgi network | Neprilysin | Homo sapiens (human) |
plasma membrane | Neprilysin | Homo sapiens (human) |
brush border | Neprilysin | Homo sapiens (human) |
focal adhesion | Neprilysin | Homo sapiens (human) |
synaptic vesicle | Neprilysin | Homo sapiens (human) |
cell surface | Neprilysin | Homo sapiens (human) |
membrane | Neprilysin | Homo sapiens (human) |
axon | Neprilysin | Homo sapiens (human) |
dendrite | Neprilysin | Homo sapiens (human) |
secretory granule membrane | Neprilysin | Homo sapiens (human) |
cytoplasmic vesicle | Neprilysin | Homo sapiens (human) |
neuronal cell body | Neprilysin | Homo sapiens (human) |
neuron projection terminus | Neprilysin | Homo sapiens (human) |
membrane raft | Neprilysin | Homo sapiens (human) |
synapse | Neprilysin | Homo sapiens (human) |
extracellular exosome | Neprilysin | Homo sapiens (human) |
presynapse | Neprilysin | Homo sapiens (human) |
plasma membrane | Neprilysin | Homo sapiens (human) |
[Information is prepared from geneontology information from the June-17-2024 release] |
Assay ID | Title | Year | Journal | Article |
---|---|---|---|---|
AID147393 | Inhibitory potency against neutral endopeptidase | 1992 | Journal of medicinal chemistry, Apr-03, Volume: 35, Issue:7 | Potent and systemically active aminopeptidase N inhibitors designed from active-site investigation. |
AID35688 | Inhibition of dipeptidyl amino peptidase activity in rat brain with 10 nM [3H]Leu-enkephalin as substrate | 1989 | Journal of medicinal chemistry, Jul, Volume: 32, Issue:7 | New kelatorphan-related inhibitors of enkephalin metabolism: improved antinociceptive properties. |
AID56053 | Inhibition of [3H]Leu-enkephalin binding to Dipeptidyl aminopeptidase (DAP) | 1988 | Journal of medicinal chemistry, Sep, Volume: 31, Issue:9 | Retro-inverso concept applied to the complete inhibitors of enkephalin-degrading enzymes. |
AID67348 | In vitro inhibition of enkephalinase purified from rat kidney. | 1985 | Journal of medicinal chemistry, Sep, Volume: 28, Issue:9 | New bidentates as full inhibitors of enkephalin-degrading enzymes: synthesis and analgesic properties. |
AID38366 | Inhibition of Aminopeptidase N activity in pig kidney with 10 nM [3H]Leu-enkephalin as substrate | 1989 | Journal of medicinal chemistry, Jul, Volume: 32, Issue:7 | New kelatorphan-related inhibitors of enkephalin metabolism: improved antinociceptive properties. |
AID35684 | Inhibition of [3H]Leu-enkephalin binding to aminopeptidase | 1988 | Journal of medicinal chemistry, Sep, Volume: 31, Issue:9 | Retro-inverso concept applied to the complete inhibitors of enkephalin-degrading enzymes. |
AID35686 | Inhibitory activity against rabbit kidney aminopeptidase using 10 nM of [3H]Leu-enkephalin as substrate | 1985 | Journal of medicinal chemistry, Sep, Volume: 28, Issue:9 | New bidentates as full inhibitors of enkephalin-degrading enzymes: synthesis and analgesic properties. |
AID147516 | Inhibition of [3H]Ala2-Leu-enkephalin binding to Neutral endopeptidase (NEP) | 1988 | Journal of medicinal chemistry, Sep, Volume: 31, Issue:9 | Retro-inverso concept applied to the complete inhibitors of enkephalin-degrading enzymes. |
AID147214 | Inhibition of neutral endopeptidase activity in rabbit kidney with 20 nM [3H]D-Ala2-Leu-enkephalin as substrate | 1989 | Journal of medicinal chemistry, Jul, Volume: 32, Issue:7 | New kelatorphan-related inhibitors of enkephalin metabolism: improved antinociceptive properties. |
AID56051 | Inhibitory activity against rat brain Dipeptidyl aminopeptidase using 10 nM of [3H]Leu-enkephalin as substrate | 1985 | Journal of medicinal chemistry, Sep, Volume: 28, Issue:9 | New bidentates as full inhibitors of enkephalin-degrading enzymes: synthesis and analgesic properties. |
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Timeframe | Studies, This Drug (%) | All Drugs % |
---|---|---|
pre-1990 | 4 (80.00) | 18.7374 |
1990's | 1 (20.00) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 0 (0.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Publication Type | This drug (%) | All Drugs (%) |
---|---|---|
Trials | 0 (0.00%) | 5.53% |
Reviews | 0 (0.00%) | 6.00% |
Case Studies | 0 (0.00%) | 4.05% |
Observational | 0 (0.00%) | 0.25% |
Other | 5 (100.00%) | 84.16% |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |