Page last updated: 2024-09-20

leucinthiol

Description

leucinthiol: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID139311
CHEMBL ID448735
SCHEMBL ID2002339
MeSH IDM0118522

Synonyms (14)

Synonym
(s)-2-amino-4-methyl-pentane-1-thiol
bdbm50078133
1-pentanethiol, 2-amino-4-methyl-, (s)-
CHEMBL448735 ,
leucinthiol
2-amino-4-methylpentane-1-thiol
2-amino-4-methyl-pentane-1-thiol
(2s)-2-amino-4-methylpentane-1-thiol
AKOS006342069
SCHEMBL2002339
GXEDNWSUKCJLLB-LURJTMIESA-N
(s)-2-amino-4-methyl-1-pentanethiol
l-leucinethiol
DTXSID901008046

Protein Targets (1)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Aminopeptidase NSus scrofa (pig)Ki0.02200.00052.29697.8000AID38370
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (4)

Assay IDTitleYearJournalArticle
AID1581820Inhibition of ERAP1 in human HeLa cells stably expressing H-2 Kb infected with vaccinia virus containing ss-LEQLE-SIINFEKL epitope assessed as suppression of ss-LEQLE-SIINFEKL binding to MHC1 H-2 Kb at cell surface by measuring reduction in 25D1 staining 2020Journal of medicinal chemistry, 01-09, Volume: 63, Issue:1
Discovery of Selective Inhibitors of Endoplasmic Reticulum Aminopeptidase 1.
AID1581821Inhibition of TAP1/2 in human HeLa cells stably expressing H-2 Kb infected with vaccinia virus containing Ub-SIINFEKL epitope assessed as suppression of Ub-SIINFEKL binding to MHC1 H-2 Kb at cell surface by measuring reduction in 25D1 staining at 50 uM me2020Journal of medicinal chemistry, 01-09, Volume: 63, Issue:1
Discovery of Selective Inhibitors of Endoplasmic Reticulum Aminopeptidase 1.
AID35689Inhibition of partially purified soluble aminopeptidase from rat brain1988Journal of medicinal chemistry, Nov, Volume: 31, Issue:11
Design of novel inhibitors of aminopeptidases. Synthesis of peptide-derived diamino thiols and sulfur replacement analogues of bestatin.
AID38370Inhibition of pig kidney Aminopeptidase N1999Bioorganic & medicinal chemistry letters, Jun-07, Volume: 9, Issue:11
Design of the first highly potent and selective aminopeptidase N (EC 3.4.11.2) inhibitor.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19903 (60.00)18.7374
1990's1 (20.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's1 (20.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]