Pathways > Infection with Mycobacterium tuberculosis
Page last updated: 2024-10-06

Infection with Mycobacterium tuberculosis

Proteins (74)

ProteinSynonymsTaxonomy
Coronin-1ACoronin-like protein A; Clipin-A; Coronin-like protein p57; Tryptophan aspartate-containing coat protein; TACOHomo sapiens (human)
N-acetyltransferase EisEC 2.3.1.-; Aminoglycoside N-acetyltransferase; Enhanced intracellular survival protein; Protein-lysine N-acetyltransferaseMycobacterium tuberculosis H37Rv
DNA-directed RNA polymerase subunit alphaRNAP subunit alpha; EC 2.7.7.6; RNA polymerase subunit alpha; Transcriptase subunit alphaMycobacterium tuberculosis H37Rv
Dihydrolipoyl dehydrogenaseLPD; EC 1.8.1.4; Component of peroxynitrite reductase/peroxidase complex; Component of PNR/P; Dihydrolipoamide dehydrogenase; E3 component of alpha-ketoacid dehydrogenase complexesMycobacterium tuberculosis H37Rv
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complexEC 2.3.1.12; Component of peroxynitrite reductase/peroxidase complex; Component of PNR/P; Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; Pyruvate dehydrogenase complex component E2; PDH component E2Mycobacterium tuberculosis H37Rv
Cathepsin GCG; EC 3.4.21.20Homo sapiens (human)
Mitogen-activated protein kinase 3 MAP kinase 3; MAPK 3; EC 2.7.11.24; ERT2; Extracellular signal-regulated kinase 1; ERK-1; Insulin-stimulated MAP2 kinase; MAP kinase isoform p44; p44-MAPK; Microtubule-associated protein 2 kinase; p44-ERK1Homo sapiens (human)
Mitogen-activated protein kinase 1MAP kinase 1; MAPK 1; EC 2.7.11.24; ERT1; Extracellular signal-regulated kinase 2; ERK-2; MAP kinase isoform p42; p42-MAPK; Mitogen-activated protein kinase 2; MAP kinase 2; MAPK 2Homo sapiens (human)
Nitric oxide synthase, inducibleEC 1.14.13.39; Hepatocyte NOS; HEP-NOS; Inducible NO synthase; Inducible NOS; iNOS; NOS type II; Peptidyl-cysteine S-nitrosylase NOS2Homo sapiens (human)
Phosphoglycerate kinase 1 EC 2.7.2.3; Cell migration-inducing gene 10 protein; Primer recognition protein 2; PRP 2Homo sapiens (human)
Beta-2-microglobulinHomo sapiens (human)
Glycogen synthase kinase-3 alphaGSK-3 alpha; EC 2.7.11.26; Serine/threonine-protein kinase GSK3A; 2.7.11.1Homo sapiens (human)
Low molecular weight protein-tyrosine phosphatase ALMW-PTP; PTPase; EC 3.1.3.48; Low molecular weight tyrosine phosphatase PtpA; MPtpAMycobacterium tuberculosis H37Rv
Ras-related protein Rab-7aEC 3.6.5.2Homo sapiens (human)
Superoxide dismutase [Cu-Zn]EC 1.15.1.1Mycobacterium tuberculosis H37Rv
Hepatocyte growth factor-regulated tyrosine kinase substrateHrs; Protein pp110Homo sapiens (human)
Macrophage mannose receptor 1MMR; C-type lectin domain family 13 member D; C-type lectin domain family 13 member D-like; Human mannose receptor; hMR; Macrophage mannose receptor 1-like protein 1Homo sapiens (human)
DNA-directed RNA polymerase subunit betaRNAP subunit beta; EC 2.7.7.6; RNA polymerase subunit beta; Transcriptase subunit betaMycobacterium tuberculosis H37Rv
Alpha-enolaseEC 4.2.1.11; 2-phospho-D-glycerate hydro-lyase; C-myc promoter-binding protein; Enolase 1; MBP-1; MPB-1; Non-neural enolase; NNE; Phosphopyruvate hydratase; Plasminogen-binding proteinHomo sapiens (human)
LactotransferrinLactoferrin; EC 3.4.21.-; Growth-inhibiting protein 12; TalalactoferrinHomo sapiens (human)
Toll-like receptor 2EC 3.2.2.6; Toll/interleukin-1 receptor-like protein 4Homo sapiens (human)
Thioredoxin reductaseTR; TRXR; EC 1.8.1.9Mycobacterium tuberculosis H37Rv
Importin subunit beta-1Importin-90; Karyopherin subunit beta-1; Nuclear factor p97; Pore targeting complex 97 kDa subunit; PTAC97Homo sapiens (human)
Catalase-peroxidaseCP; EC 1.11.1.21; Peroxidase/catalaseMycobacterium tuberculosis H37Rv
BacterioferritinBFR; EC 1.16.3.1Mycobacterium tuberculosis H37Rv
Ferritin BfrBEC 1.16.3.1; Non-heme ferritin Ftn; Nox19Mycobacterium tuberculosis H37Rv
ThioredoxinTrx; MPT46Mycobacterium tuberculosis H37Rv
Protein translocase subunit SecYMycobacterium tuberculosis H37Rv
F420-dependent glucose-6-phosphate dehydrogenaseFGD; FGD1; G6PD; EC 1.1.98.2Mycobacterium tuberculosis H37Rv
Thiol peroxidaseTpx; EC 1.11.1.24; Peroxiredoxin tpx; Prx; Thioredoxin peroxidase; Thioredoxin-dependent peroxiredoxinMycobacterium tuberculosis H37Rv
Alkyl hydroperoxide reductase EEC 1.11.1.29; Mycoredoxin-dependent peroxiredoxin; Peroxiredoxin AhpE; Prx; Thioredoxin peroxidase; TPxMycobacterium tuberculosis H37Rv
DNA-directed RNA polymerase subunit omegaRNAP omega subunit; EC 2.7.7.6; RNA polymerase omega subunit; Transcriptase subunit omegaMycobacterium tuberculosis H37Rv
Importin subunit alpha-5Karyopherin subunit alpha-1; Nucleoprotein interactor 1; NPI-1; RAG cohort protein 2; SRP1-betaHomo sapiens (human)
Zinc finger protein RFPEC 2.3.2.27; RING finger protein 76; RING-type E3 ubiquitin transferase TRIM27; Ret finger protein; Tripartite motif-containing protein 27Homo sapiens (human)
Protein translocase subunit SecDMycobacterium tuberculosis H37Rv
Phosphate-binding protein PstS 1PBP 1; PhoS1; PstS-1; 38-kDa glycolipoprotein; 38-kDa lipoprotein; P38; Antigen Ag78; Protein antigen B; PabMycobacterium tuberculosis H37Rv
Probable protein-export membrane protein SecGMycobacterium tuberculosis H37Rv
Protein translocase subunit SecFMycobacterium tuberculosis H37Rv
Probable triacylglyceride transporter Rv1410cMFS-type drug efflux transporter P55Mycobacterium tuberculosis H37Rv
Uncharacterized protein Rv2895cMycobacterium tuberculosis H37Rv
Splicing factor, proline- and glutamine-rich100 kDa DNA-pairing protein; hPOMp100; DNA-binding p52/p100 complex, 100 kDa subunit; Polypyrimidine tract-binding protein-associated-splicing factor; PSF; PTB-associated-splicing factorHomo sapiens (human)
E3 ubiquitin-protein ligase RNF213EC 2.3.2.27; EC 3.6.4.-; ALK lymphoma oligomerization partner on chromosome 17; Mysterin; RING finger protein 213; RING-type E3 ubiquitin transferase RNF213Homo sapiens (human)
Dual specificity protein phosphatase 16EC 3.1.3.16; EC 3.1.3.48; Mitogen-activated protein kinase phosphatase 7; MAP kinase phosphatase 7; MKP-7Homo sapiens (human)
Vacuolar protein sorting-associated protein 33BhVPS33BHomo sapiens (human)
V-type proton ATPase subunit HV-ATPase subunit H; Nef-binding protein 1; NBP1; Protein VMA13 homolog; V-ATPase 50/57 kDa subunits; Vacuolar proton pump subunit H; Vacuolar proton pump subunit SFDHomo sapiens (human)
Outer membrane channel protein CpnTChannel protein with necrosis-inducing toxinMycobacterium tuberculosis H37Rv
Phosphatidylinositol-3-phosphatasePI3P phosphatase; EC 3.1.3.64; Acid phosphatase SapM; 3.1.3.2; Secreted acid phosphataseMycobacterium tuberculosis H37Rv
Superoxide dismutase [Fe]EC 1.15.1.1Mycobacterium tuberculosis H37Rv
Protein translocase subunit SecA 2Mycobacterium tuberculosis H37Rv
Protein translocase subunit SecA 1tbSecAMycobacterium tuberculosis H37Rv
Nucleoside diphosphate kinaseNDK; NDKA; NDP kinase; EC 2.7.4.6; Nucleoside-2-P kinaseMycobacterium tuberculosis H37Rv
Mycobactin import ATP-binding/permease protein IrtBEC 7.2.2.-; Iron-regulated transporter BMycobacterium tuberculosis H37Rv
Mycobactin import ATP-binding/permease protein IrtAEC 7.2.2.-; Iron-regulated transporter AMycobacterium tuberculosis H37Rv
Gamma-glutamyltransferase Mycobacterium tuberculosis CDC1551
S-nitrosomycothiol reductase MscRMycobacterium tuberculosis H37Rv
Possible Mce-family lipoprotein LprM Mycobacterium tuberculosis H37Rv
Possible transcriptional regulatory protein Mycobacterium tuberculosis H37Rv
Apoptosis inhibitor Rv3654cMycobacterium tuberculosis H37Rv
Apoptosis inhibitor Rv3655cMycobacterium tuberculosis H37Rv
DNA-directed RNA polymerase subunit beta'RNAP subunit beta'; EC 2.7.7.6; RNA polymerase subunit beta'; Transcriptase subunit beta'Mycobacterium tuberculosis H37Rv
Group 1 truncated hemoglobin GlbNTruncated hemoglobin; trHbN; Hemoglobin-like protein HbNMycobacterium tuberculosis H37Rv
Putative peptide transport permease protein Rv1283cMycobacterium tuberculosis H37Rv
Putative peptide transport permease protein Rv1282cMycobacterium tuberculosis H37Rv
Protein translocase subunit SecEMycobacterium tuberculosis H37Rv
Uncharacterized protein Rv1280cMycobacterium tuberculosis H37Rv
PPE family protein PPE2Mycobacterium tuberculosis H37Rv
Uncharacterized ABC transporter ATP-binding protein Rv1281cMycobacterium tuberculosis H37Rv
ESAT-6-like protein EsxGConserved protein TB9.8Mycobacterium tuberculosis H37Rv
ESAT-6-like protein EsxH10 kDa antigen CFP7; CFP-7; Low molecular weight protein antigen 7; Protein TB10.4Mycobacterium tuberculosis H37Rv
6 kDa early secretory antigenic targetESAT-6Mycobacterium tuberculosis H37Rv
Alkyl hydroperoxide reductase AhpDEC 1.11.1.28; Alkylhydroperoxidase AhpDMycobacterium tuberculosis H37Rv
Alkyl hydroperoxide reductase CMtAhpC; EC 1.11.1.28; Peroxiredoxin; Thioredoxin peroxidaseMycobacterium tuberculosis H37Rv
Lipoarabinomannan carrier protein LprG27 kDa lipoprotein; Antigen P27; Lipoprotein LprG; Triacylated glycolipid carrier LprG; Triacylglyceride transfer protein LprGMycobacterium tuberculosis H37Rv
Serine protease inhibitor Rv3364cMycobacterium tuberculosis H37Rv

Compounds (34)

CompoundDescription
hydronium ion
GlutathioneA tripeptide with many roles in cells. It conjugates to drugs to make them more soluble for excretion, is a cofactor for some enzymes, is involved in protein disulfide bond rearrangement and reduces peroxides.
rifampinA semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation of RNA synthesis. Rifampin is bactericidal, and acts on both intracellular and extracellular organisms. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1160)
Nitric OxideA free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP.
carbonatesSalts or ions of the theoretical carbonic acid, containing the radical CO2(3-). Carbonates are readily decomposed by acids. The carbonates of the alkali metals are water-soluble; all others are insoluble. (From Grant & Hackh's Chemical Dictionary, 5th ed)
NADH
ammonium hydroxideThe hydroxy salt of ammonium ion. It is formed when AMMONIA reacts with water molecules in solution.
CopperA heavy metal trace element with the atomic symbol Cu, atomic number 29, and atomic weight 63.55.
ironA metallic element with atomic symbol Fe, atomic number 26, and atomic weight 55.85. It is an essential constituent of HEMOGLOBINS; CYTOCHROMES; and IRON-BINDING PROTEINS. It plays a role in cellular redox reactions and in the transport of OXYGEN.
IronA metallic element with atomic symbol Fe, atomic number 26, and atomic weight 55.85. It is an essential constituent of HEMOGLOBINS; CYTOCHROMES; and IRON-BINDING PROTEINS. It plays a role in cellular redox reactions and in the transport of OXYGEN.
ZincA metallic element of atomic number 30 and atomic weight 65.38. It is a necessary trace element in the diet, forming an essential part of many enzymes, and playing an important role in protein synthesis and in cell division. Zinc deficiency is associated with ANEMIA, short stature, HYPOGONADISM, impaired WOUND HEALING, and geophagia. It is known by the symbol Zn.
Orthophosphate
SuperoxidesHighly reactive compounds produced when oxygen is reduced by a single electron. In biological systems, they may be generated during the normal catalytic function of a number of enzymes and during the oxidation of hemoglobin to METHEMOGLOBIN. In living organisms, SUPEROXIDE DISMUTASE protects the cell from the deleterious effects of superoxides.
Hydrogen PeroxideA strong oxidizing agent used in aqueous solution as a ripening agent, bleach, and topical anti-infective. It is relatively unstable and solutions deteriorate over time unless stabilized by the addition of acetanilide or similar organic materials.
nitrosonium iona nitric oxide congener
niacinamideAn important compound functioning as a component of the coenzyme NAD. Its primary significance is in the prevention and/or cure of blacktongue and PELLAGRA. Most animals cannot manufacture this compound in amounts sufficient to prevent nutritional deficiency and it therefore must be supplemented through dietary intake.
nitratesInorganic or organic salts and esters of nitric acid. These compounds contain the NO3- radical.
nitritesSalts of nitrous acid or compounds containing the group NO2-. The inorganic nitrites of the type MNO2 (where M=metal) are all insoluble, except the alkali nitrites. The organic nitrites may be isomeric, but not identical with the corresponding nitro compounds. (Grant & Hackh's Chemical Dictionary, 5th ed)
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
OxygenAn element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.
Guanosine MonophosphateA guanine nucleotide containing one phosphate group esterified to the sugar moiety and found widely in nature.
Guanosine DiphosphateA guanine nucleotide containing two phosphate groups esterified to the sugar moiety.
s-nitrosoglutathioneA sulfur-containing alkyl thionitrite that is one of the NITRIC OXIDE DONORS.
nadA coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed)
NADPNicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
NADPNicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
6-phosphonoglucono-delta-lactone
mycothiola glyco-inositol-cysteine found in MYCOBACTERIUM BOVIS which conjugates exogenous compounds for detoxication; it is a microbe counterpart to eucaryotic GLUTATHIONE; acted on by mycothiol disulfide reductase and mycothiol S-conjugate amidase and MDF dehydrogenase;
s-nitrosocysteinylglycinenitric oxide adduct; found in the rat brain
Peroxynitrite
Coenzyme A
Acetyl Coenzyme AAcetyl CoA participates in the biosynthesis of fatty acids and sterols, in the oxidation of fatty acids and in the metabolism of many amino acids. It also acts as a biological acetylating agent.
Flavin-Adenine DinucleotideA condensation product of riboflavin and adenosine diphosphate. The coenzyme of various aerobic dehydrogenases, e.g., D-amino acid oxidase and L-amino acid oxidase. (Lehninger, Principles of Biochemistry, 1982, p972)
hemeThe color-furnishing portion of hemoglobin. It is found free in tissues and as the prosthetic group in many hemeproteins.
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