| Protein | Synonyms | Taxonomy |
|---|
| Coronin-1A | Coronin-like protein A; Clipin-A; Coronin-like protein p57; Tryptophan aspartate-containing coat protein; TACO | Homo sapiens (human) |
| N-acetyltransferase Eis | EC 2.3.1.-; Aminoglycoside N-acetyltransferase; Enhanced intracellular survival protein; Protein-lysine N-acetyltransferase | Mycobacterium tuberculosis H37Rv |
| DNA-directed RNA polymerase subunit alpha | RNAP subunit alpha; EC 2.7.7.6; RNA polymerase subunit alpha; Transcriptase subunit alpha | Mycobacterium tuberculosis H37Rv |
| Dihydrolipoyl dehydrogenase | LPD; EC 1.8.1.4; Component of peroxynitrite reductase/peroxidase complex; Component of PNR/P; Dihydrolipoamide dehydrogenase; E3 component of alpha-ketoacid dehydrogenase complexes | Mycobacterium tuberculosis H37Rv |
| Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex | EC 2.3.1.12; Component of peroxynitrite reductase/peroxidase complex; Component of PNR/P; Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; Pyruvate dehydrogenase complex component E2; PDH component E2 | Mycobacterium tuberculosis H37Rv |
| Cathepsin G | CG; EC 3.4.21.20 | Homo sapiens (human) |
| Mitogen-activated protein kinase 3 | MAP kinase 3; MAPK 3; EC 2.7.11.24; ERT2; Extracellular signal-regulated kinase 1; ERK-1; Insulin-stimulated MAP2 kinase; MAP kinase isoform p44; p44-MAPK; Microtubule-associated protein 2 kinase; p44-ERK1 | Homo sapiens (human) |
| Mitogen-activated protein kinase 1 | MAP kinase 1; MAPK 1; EC 2.7.11.24; ERT1; Extracellular signal-regulated kinase 2; ERK-2; MAP kinase isoform p42; p42-MAPK; Mitogen-activated protein kinase 2; MAP kinase 2; MAPK 2 | Homo sapiens (human) |
| Nitric oxide synthase, inducible | EC 1.14.13.39; Hepatocyte NOS; HEP-NOS; Inducible NO synthase; Inducible NOS; iNOS; NOS type II; Peptidyl-cysteine S-nitrosylase NOS2 | Homo sapiens (human) |
| Phosphoglycerate kinase 1 | EC 2.7.2.3; Cell migration-inducing gene 10 protein; Primer recognition protein 2; PRP 2 | Homo sapiens (human) |
| Beta-2-microglobulin | | Homo sapiens (human) |
| Glycogen synthase kinase-3 alpha | GSK-3 alpha; EC 2.7.11.26; Serine/threonine-protein kinase GSK3A; 2.7.11.1 | Homo sapiens (human) |
| Low molecular weight protein-tyrosine phosphatase A | LMW-PTP; PTPase; EC 3.1.3.48; Low molecular weight tyrosine phosphatase PtpA; MPtpA | Mycobacterium tuberculosis H37Rv |
| Ras-related protein Rab-7a | EC 3.6.5.2 | Homo sapiens (human) |
| Superoxide dismutase [Cu-Zn] | EC 1.15.1.1 | Mycobacterium tuberculosis H37Rv |
| Hepatocyte growth factor-regulated tyrosine kinase substrate | Hrs; Protein pp110 | Homo sapiens (human) |
| Macrophage mannose receptor 1 | MMR; C-type lectin domain family 13 member D; C-type lectin domain family 13 member D-like; Human mannose receptor; hMR; Macrophage mannose receptor 1-like protein 1 | Homo sapiens (human) |
| DNA-directed RNA polymerase subunit beta | RNAP subunit beta; EC 2.7.7.6; RNA polymerase subunit beta; Transcriptase subunit beta | Mycobacterium tuberculosis H37Rv |
| Alpha-enolase | EC 4.2.1.11; 2-phospho-D-glycerate hydro-lyase; C-myc promoter-binding protein; Enolase 1; MBP-1; MPB-1; Non-neural enolase; NNE; Phosphopyruvate hydratase; Plasminogen-binding protein | Homo sapiens (human) |
| Lactotransferrin | Lactoferrin; EC 3.4.21.-; Growth-inhibiting protein 12; Talalactoferrin | Homo sapiens (human) |
| Toll-like receptor 2 | EC 3.2.2.6; Toll/interleukin-1 receptor-like protein 4 | Homo sapiens (human) |
| Thioredoxin reductase | TR; TRXR; EC 1.8.1.9 | Mycobacterium tuberculosis H37Rv |
| Importin subunit beta-1 | Importin-90; Karyopherin subunit beta-1; Nuclear factor p97; Pore targeting complex 97 kDa subunit; PTAC97 | Homo sapiens (human) |
| Catalase-peroxidase | CP; EC 1.11.1.21; Peroxidase/catalase | Mycobacterium tuberculosis H37Rv |
| Bacterioferritin | BFR; EC 1.16.3.1 | Mycobacterium tuberculosis H37Rv |
| Ferritin BfrB | EC 1.16.3.1; Non-heme ferritin Ftn; Nox19 | Mycobacterium tuberculosis H37Rv |
| Thioredoxin | Trx; MPT46 | Mycobacterium tuberculosis H37Rv |
| Protein translocase subunit SecY | | Mycobacterium tuberculosis H37Rv |
| F420-dependent glucose-6-phosphate dehydrogenase | FGD; FGD1; G6PD; EC 1.1.98.2 | Mycobacterium tuberculosis H37Rv |
| Thiol peroxidase | Tpx; EC 1.11.1.24; Peroxiredoxin tpx; Prx; Thioredoxin peroxidase; Thioredoxin-dependent peroxiredoxin | Mycobacterium tuberculosis H37Rv |
| Alkyl hydroperoxide reductase E | EC 1.11.1.29; Mycoredoxin-dependent peroxiredoxin; Peroxiredoxin AhpE; Prx; Thioredoxin peroxidase; TPx | Mycobacterium tuberculosis H37Rv |
| DNA-directed RNA polymerase subunit omega | RNAP omega subunit; EC 2.7.7.6; RNA polymerase omega subunit; Transcriptase subunit omega | Mycobacterium tuberculosis H37Rv |
| Importin subunit alpha-5 | Karyopherin subunit alpha-1; Nucleoprotein interactor 1; NPI-1; RAG cohort protein 2; SRP1-beta | Homo sapiens (human) |
| Zinc finger protein RFP | EC 2.3.2.27; RING finger protein 76; RING-type E3 ubiquitin transferase TRIM27; Ret finger protein; Tripartite motif-containing protein 27 | Homo sapiens (human) |
| Protein translocase subunit SecD | | Mycobacterium tuberculosis H37Rv |
| Phosphate-binding protein PstS 1 | PBP 1; PhoS1; PstS-1; 38-kDa glycolipoprotein; 38-kDa lipoprotein; P38; Antigen Ag78; Protein antigen B; Pab | Mycobacterium tuberculosis H37Rv |
| Probable protein-export membrane protein SecG | | Mycobacterium tuberculosis H37Rv |
| Protein translocase subunit SecF | | Mycobacterium tuberculosis H37Rv |
| Probable triacylglyceride transporter Rv1410c | MFS-type drug efflux transporter P55 | Mycobacterium tuberculosis H37Rv |
| Uncharacterized protein Rv2895c | | Mycobacterium tuberculosis H37Rv |
| Splicing factor, proline- and glutamine-rich | 100 kDa DNA-pairing protein; hPOMp100; DNA-binding p52/p100 complex, 100 kDa subunit; Polypyrimidine tract-binding protein-associated-splicing factor; PSF; PTB-associated-splicing factor | Homo sapiens (human) |
| E3 ubiquitin-protein ligase RNF213 | EC 2.3.2.27; EC 3.6.4.-; ALK lymphoma oligomerization partner on chromosome 17; Mysterin; RING finger protein 213; RING-type E3 ubiquitin transferase RNF213 | Homo sapiens (human) |
| Dual specificity protein phosphatase 16 | EC 3.1.3.16; EC 3.1.3.48; Mitogen-activated protein kinase phosphatase 7; MAP kinase phosphatase 7; MKP-7 | Homo sapiens (human) |
| Vacuolar protein sorting-associated protein 33B | hVPS33B | Homo sapiens (human) |
| V-type proton ATPase subunit H | V-ATPase subunit H; Nef-binding protein 1; NBP1; Protein VMA13 homolog; V-ATPase 50/57 kDa subunits; Vacuolar proton pump subunit H; Vacuolar proton pump subunit SFD | Homo sapiens (human) |
| Outer membrane channel protein CpnT | Channel protein with necrosis-inducing toxin | Mycobacterium tuberculosis H37Rv |
| Phosphatidylinositol-3-phosphatase | PI3P phosphatase; EC 3.1.3.64; Acid phosphatase SapM; 3.1.3.2; Secreted acid phosphatase | Mycobacterium tuberculosis H37Rv |
| Superoxide dismutase [Fe] | EC 1.15.1.1 | Mycobacterium tuberculosis H37Rv |
| Protein translocase subunit SecA 2 | | Mycobacterium tuberculosis H37Rv |
| Protein translocase subunit SecA 1 | tbSecA | Mycobacterium tuberculosis H37Rv |
| Nucleoside diphosphate kinase | NDK; NDKA; NDP kinase; EC 2.7.4.6; Nucleoside-2-P kinase | Mycobacterium tuberculosis H37Rv |
| Mycobactin import ATP-binding/permease protein IrtB | EC 7.2.2.-; Iron-regulated transporter B | Mycobacterium tuberculosis H37Rv |
| Mycobactin import ATP-binding/permease protein IrtA | EC 7.2.2.-; Iron-regulated transporter A | Mycobacterium tuberculosis H37Rv |
| Gamma-glutamyltransferase | | Mycobacterium tuberculosis CDC1551 |
| S-nitrosomycothiol reductase MscR | | Mycobacterium tuberculosis H37Rv |
| Possible Mce-family lipoprotein LprM | | Mycobacterium tuberculosis H37Rv |
| Possible transcriptional regulatory protein | | Mycobacterium tuberculosis H37Rv |
| Apoptosis inhibitor Rv3654c | | Mycobacterium tuberculosis H37Rv |
| Apoptosis inhibitor Rv3655c | | Mycobacterium tuberculosis H37Rv |
| DNA-directed RNA polymerase subunit beta' | RNAP subunit beta'; EC 2.7.7.6; RNA polymerase subunit beta'; Transcriptase subunit beta' | Mycobacterium tuberculosis H37Rv |
| Group 1 truncated hemoglobin GlbN | Truncated hemoglobin; trHbN; Hemoglobin-like protein HbN | Mycobacterium tuberculosis H37Rv |
| Putative peptide transport permease protein Rv1283c | | Mycobacterium tuberculosis H37Rv |
| Putative peptide transport permease protein Rv1282c | | Mycobacterium tuberculosis H37Rv |
| Protein translocase subunit SecE | | Mycobacterium tuberculosis H37Rv |
| Uncharacterized protein Rv1280c | | Mycobacterium tuberculosis H37Rv |
| PPE family protein PPE2 | | Mycobacterium tuberculosis H37Rv |
| Uncharacterized ABC transporter ATP-binding protein Rv1281c | | Mycobacterium tuberculosis H37Rv |
| ESAT-6-like protein EsxG | Conserved protein TB9.8 | Mycobacterium tuberculosis H37Rv |
| ESAT-6-like protein EsxH | 10 kDa antigen CFP7; CFP-7; Low molecular weight protein antigen 7; Protein TB10.4 | Mycobacterium tuberculosis H37Rv |
| 6 kDa early secretory antigenic target | ESAT-6 | Mycobacterium tuberculosis H37Rv |
| Alkyl hydroperoxide reductase AhpD | EC 1.11.1.28; Alkylhydroperoxidase AhpD | Mycobacterium tuberculosis H37Rv |
| Alkyl hydroperoxide reductase C | MtAhpC; EC 1.11.1.28; Peroxiredoxin; Thioredoxin peroxidase | Mycobacterium tuberculosis H37Rv |
| Lipoarabinomannan carrier protein LprG | 27 kDa lipoprotein; Antigen P27; Lipoprotein LprG; Triacylated glycolipid carrier LprG; Triacylglyceride transfer protein LprG | Mycobacterium tuberculosis H37Rv |
| Serine protease inhibitor Rv3364c | | Mycobacterium tuberculosis H37Rv |
| Compound | Description |
|---|
| hydronium ion | |
| Glutathione | A tripeptide with many roles in cells. It conjugates to drugs to make them more soluble for excretion, is a cofactor for some enzymes, is involved in protein disulfide bond rearrangement and reduces peroxides. |
| rifampin | A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation of RNA synthesis. Rifampin is bactericidal, and acts on both intracellular and extracellular organisms. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1160) |
| Nitric Oxide | A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP. |
| carbonates | Salts or ions of the theoretical carbonic acid, containing the radical CO2(3-). Carbonates are readily decomposed by acids. The carbonates of the alkali metals are water-soluble; all others are insoluble. (From Grant & Hackh's Chemical Dictionary, 5th ed) |
| NADH | |
| ammonium hydroxide | The hydroxy salt of ammonium ion. It is formed when AMMONIA reacts with water molecules in solution. |
| Copper | A heavy metal trace element with the atomic symbol Cu, atomic number 29, and atomic weight 63.55. |
| iron | A metallic element with atomic symbol Fe, atomic number 26, and atomic weight 55.85. It is an essential constituent of HEMOGLOBINS; CYTOCHROMES; and IRON-BINDING PROTEINS. It plays a role in cellular redox reactions and in the transport of OXYGEN. |
| Iron | A metallic element with atomic symbol Fe, atomic number 26, and atomic weight 55.85. It is an essential constituent of HEMOGLOBINS; CYTOCHROMES; and IRON-BINDING PROTEINS. It plays a role in cellular redox reactions and in the transport of OXYGEN. |
| Zinc | A metallic element of atomic number 30 and atomic weight 65.38. It is a necessary trace element in the diet, forming an essential part of many enzymes, and playing an important role in protein synthesis and in cell division. Zinc deficiency is associated with ANEMIA, short stature, HYPOGONADISM, impaired WOUND HEALING, and geophagia. It is known by the symbol Zn. |
| Orthophosphate | |
| Superoxides | Highly reactive compounds produced when oxygen is reduced by a single electron. In biological systems, they may be generated during the normal catalytic function of a number of enzymes and during the oxidation of hemoglobin to METHEMOGLOBIN. In living organisms, SUPEROXIDE DISMUTASE protects the cell from the deleterious effects of superoxides. |
| Hydrogen Peroxide | A strong oxidizing agent used in aqueous solution as a ripening agent, bleach, and topical anti-infective. It is relatively unstable and solutions deteriorate over time unless stabilized by the addition of acetanilide or similar organic materials. |
| nitrosonium ion | a nitric oxide congener |
| niacinamide | An important compound functioning as a component of the coenzyme NAD. Its primary significance is in the prevention and/or cure of blacktongue and PELLAGRA. Most animals cannot manufacture this compound in amounts sufficient to prevent nutritional deficiency and it therefore must be supplemented through dietary intake. |
| nitrates | Inorganic or organic salts and esters of nitric acid. These compounds contain the NO3- radical. |
| nitrites | Salts of nitrous acid or compounds containing the group NO2-. The inorganic nitrites of the type MNO2 (where M=metal) are all insoluble, except the alkali nitrites. The organic nitrites may be isomeric, but not identical with the corresponding nitro compounds. (Grant & Hackh's Chemical Dictionary, 5th ed) |
| Water | A clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed) |
| Oxygen | An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration. |
| Guanosine Monophosphate | A guanine nucleotide containing one phosphate group esterified to the sugar moiety and found widely in nature. |
| Guanosine Diphosphate | A guanine nucleotide containing two phosphate groups esterified to the sugar moiety. |
| s-nitrosoglutathione | A sulfur-containing alkyl thionitrite that is one of the NITRIC OXIDE DONORS. |
| nad | A coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed) |
| NADP | Nicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed) |
| NADP | Nicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed) |
| 6-phosphonoglucono-delta-lactone | |
| mycothiol | a glyco-inositol-cysteine found in MYCOBACTERIUM BOVIS which conjugates exogenous compounds for detoxication; it is a microbe counterpart to eucaryotic GLUTATHIONE; acted on by mycothiol disulfide reductase and mycothiol S-conjugate amidase and MDF dehydrogenase; |
| s-nitrosocysteinylglycine | nitric oxide adduct; found in the rat brain |
| Peroxynitrite | |
| Coenzyme A | |
| Acetyl Coenzyme A | Acetyl CoA participates in the biosynthesis of fatty acids and sterols, in the oxidation of fatty acids and in the metabolism of many amino acids. It also acts as a biological acetylating agent. |
| Flavin-Adenine Dinucleotide | A condensation product of riboflavin and adenosine diphosphate. The coenzyme of various aerobic dehydrogenases, e.g., D-amino acid oxidase and L-amino acid oxidase. (Lehninger, Principles of Biochemistry, 1982, p972) |
| heme | The color-furnishing portion of hemoglobin. It is found free in tissues and as the prosthetic group in many hemeproteins. |