Compounds > vx-745
Page last updated: 2024-09-05

vx-745 and gdc 0941

vx-745 has been researched along with gdc 0941 in 3 studies

Compound Research Comparison

Studies
(vx-745)		Trials
(vx-745)		Recent Studies (post-2010)
(vx-745)		Studies
(gdc 0941)		Trials
(gdc 0941)		Recent Studies (post-2010) (gdc 0941)
5813561056

Protein Interaction Comparison

ProteinTaxonomyvx-745 (IC50)gdc 0941 (IC50)
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoformRattus norvegicus (Norway rat)0.052
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoformHomo sapiens (human)0.0553
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alphaHomo sapiens (human)6.039
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit betaHomo sapiens (human)0.3219
High affinity nerve growth factor receptorHomo sapiens (human)2.85
Cytochrome P450 3A4Homo sapiens (human)0.0033
Cholesteryl ester transfer proteinHomo sapiens (human)0.032
Phosphatidylinositol 3-kinase regulatory subunit alphaHomo sapiens (human)0.0737
RAC-alpha serine/threonine-protein kinaseHomo sapiens (human)0.037
AcetylcholinesteraseRattus norvegicus (Norway rat)0.003
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoformHomo sapiens (human)0.0415
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoformHomo sapiens (human)0.1086
Serine/threonine-protein kinase mTORHomo sapiens (human)0.7449
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform Homo sapiens (human)0.1626
DNA-dependent protein kinase catalytic subunitHomo sapiens (human)1.23
Phosphatidylinositol 3-kinase catalytic subunit type 3Homo sapiens (human)0.4534
Phosphoinositide 3-kinase regulatory subunit 5Homo sapiens (human)0.117
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoformRattus norvegicus (Norway rat)0.146

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's3 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Hajduk, PJ; Johnson, EF; Kifle, L; Merta, PJ; Metz, JT; Soni, NB1
Ciceri, P; Davis, MI; Herrgard, S; Hocker, M; Hunt, JP; Pallares, G; Treiber, DK; Wodicka, LM; Zarrinkar, PP1
Davis, MI; Khan, J; Li, SQ; Patel, PR; Shen, M; Sun, H; Thomas, CJ1

Other Studies

3 other study(ies) available for vx-745 and gdc 0941

ArticleYear
Navigating the kinome.
    Nature chemical biology, 2011, Volume: 7, Issue:4

    Topics: Drug Design; Pharmacogenetics; Protein Kinases; Proteome; Systems Biology

2011
Comprehensive analysis of kinase inhibitor selectivity.
    Nature biotechnology, 2011, Oct-30, Volume: 29, Issue:11

    Topics: Catalysis; Drug Design; Enzyme Stability; High-Throughput Screening Assays; Humans; Protein Binding; Protein Kinase Inhibitors; Protein Kinases; Proteomics; Signal Transduction; Substrate Specificity

2011
Identification of potent Yes1 kinase inhibitors using a library screening approach.
    Bioorganic & medicinal chemistry letters, 2013, Aug-01, Volume: 23, Issue:15

    Topics: Binding Sites; Cell Line; Cell Survival; Drug Design; Humans; Hydrogen Bonding; Molecular Docking Simulation; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-yes; Small Molecule Libraries; Structure-Activity Relationship

2013