Compounds > orantinib
Page last updated: 2024-09-05

orantinib and vx680

orantinib has been researched along with vx680 in 4 studies

Compound Research Comparison

Studies
(orantinib)		Trials
(orantinib)		Recent Studies (post-2010)
(orantinib)		Studies
(vx680)		Trials
(vx680)		Recent Studies (post-2010) (vx680)
11019362273143
8072273143

Protein Interaction Comparison

ProteinTaxonomyorantinib (IC50)vx680 (IC50)
Aurora kinase AHomo sapiens (human)0.1805
Tyrosine-protein kinase ABL1Homo sapiens (human)0.4538
Tyrosine-protein kinase ABL1Mus musculus (house mouse)5
Proto-oncogene tyrosine-protein kinase SrcGallus gallus (chicken)0.34
Cyclin-dependent kinase 1Homo sapiens (human)0.4432
Insulin-like growth factor 1 receptorHomo sapiens (human)0.5
Beta-1 adrenergic receptorHomo sapiens (human)0.055
Breakpoint cluster region proteinHomo sapiens (human)0.0501
Cyclin-dependent kinase 4Homo sapiens (human)0.0006
G2/mitotic-specific cyclin-B1Homo sapiens (human)0.0092
G1/S-specific cyclin-D1Homo sapiens (human)0.0006
Cyclin-dependent kinase 2Homo sapiens (human)0.4974
Receptor-type tyrosine-protein kinase FLT3Homo sapiens (human)0.03
Serine/threonine-protein kinase PLK1Homo sapiens (human)0.4974
Aurora kinase AMus musculus (house mouse)0.0006
Receptor-interacting serine/threonine-protein kinase 1Homo sapiens (human)0.208
Maternal embryonic leucine zipper kinaseHomo sapiens (human)0.42
Discoidin domain-containing receptor 2Homo sapiens (human)0.1295
Receptor-interacting serine/threonine-protein kinase 1 Mus musculus (house mouse)1
Aurora kinase B-AXenopus laevis (African clawed frog)0.019
Aurora kinase BHomo sapiens (human)0.2175
Serine/threonine-protein kinase TBK1Homo sapiens (human)3.1131
Aurora kinase CHomo sapiens (human)0.3516

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (25.00)29.6817
2010's3 (75.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Alessi, DR; Arthur, JS; Bain, J; Cohen, P; Elliott, M; Hastie, CJ; Klevernic, I; McLauchlan, H; Plater, L; Shpiro, N1
Bhatt, HG; Borisa, AC1
Aiche, S; Bassermann, F; Becker, W; Canevari, G; Casale, E; Depaolini, SR; Ehrlich, HC; Felder, ER; Feuchtinger, A; Garz, AK; Gohlke, BO; Götze, K; Greif, PA; Hahne, H; Heinzlmeir, S; Helm, D; Huenges, J; Jeremias, I; Kayser, G; Klaeger, S; Koch, H; Koenig, PA; Kramer, K; Kuster, B; Médard, G; Meng, C; Petzoldt, S; Polzer, H; Preissner, R; Qiao, H; Reinecke, M; Reiter, K; Rueckert, L; Ruland, J; Ruprecht, B; Schlegl, J; Schmidt, T; Schneider, S; Schoof, M; Spiekermann, K; Tõnisson, N; Vick, B; Vooder, T; Walch, A; Wilhelm, M; Wu, Z; Zecha, J; Zolg, DP1
Hajduk, PJ; Johnson, EF; Kifle, L; Merta, PJ; Metz, JT; Soni, NB1

Reviews

1 review(s) available for orantinib and vx680

ArticleYear
A comprehensive review on Aurora kinase: Small molecule inhibitors and clinical trial studies.
    European journal of medicinal chemistry, 2017, Nov-10, Volume: 140

    Topics: Animals; Antineoplastic Agents; Aurora Kinases; Cell Proliferation; Clinical Trials as Topic; Humans; Molecular Structure; Protein Kinase Inhibitors; Small Molecule Libraries

2017

Other Studies

3 other study(ies) available for orantinib and vx680

ArticleYear
The selectivity of protein kinase inhibitors: a further update.
    The Biochemical journal, 2007, Dec-15, Volume: 408, Issue:3

    Topics: Amino Acid Sequence; Animals; Cell Line; Drug Design; Enzyme Activation; Humans; Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Recombinant Proteins; Spodoptera

2007
The target landscape of clinical kinase drugs.
    Science (New York, N.Y.), 2017, 12-01, Volume: 358, Issue:6367

    Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cytokines; Drug Discovery; fms-Like Tyrosine Kinase 3; Humans; Leukemia, Myeloid, Acute; Lung Neoplasms; Mice; Molecular Targeted Therapy; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Proteomics; Xenograft Model Antitumor Assays

2017
Navigating the kinome.
    Nature chemical biology, 2011, Volume: 7, Issue:4

    Topics: Drug Design; Pharmacogenetics; Protein Kinases; Proteome; Systems Biology

2011