lu 135252 and losartan
lu 135252 has been researched along with losartan in 4 studies
Compound Research Comparison
| Studies (lu 135252) | Trials (lu 135252) | Recent Studies (post-2010) (lu 135252) | Studies (losartan) | Trials (losartan) | Recent Studies (post-2010) (losartan) |
|---|---|---|---|---|---|
| 196 | 13 | 14 | 7,231 | 1,245 | 2,118 |
Protein Interaction Comparison
| Protein | Taxonomy | lu 135252 (IC50) | losartan (IC50) |
|---|---|---|---|
| Bile salt export pump | Homo sapiens (human) | 9.01 | |
| Cytochrome P450 2C9 | Homo sapiens (human) | 2.882 | |
| Angiotensin-converting enzyme | Homo sapiens (human) | 0.019 | |
| Atrial natriuretic peptide receptor 3 | Homo sapiens (human) | 0.0018 | |
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | 0.019 | |
| Type-1A angiotensin II receptor | Rattus norvegicus (Norway rat) | 0.0247 | |
| Type-1B angiotensin II receptor | Rattus norvegicus (Norway rat) | 0.0234 | |
| Adenosine receptor A2a | Rattus norvegicus (Norway rat) | 0.0032 | |
| Type-1 angiotensin II receptor | Homo sapiens (human) | 0.047 | |
| Type-1 angiotensin II receptor | Oryctolagus cuniculus (rabbit) | 0.025 | |
| Type-2 angiotensin II receptor | Rattus norvegicus (Norway rat) | 0.0118 | |
| Type-2 angiotensin II receptor | Homo sapiens (human) | 0.019 | |
| Platelet glycoprotein VI | Homo sapiens (human) | 4 | |
| Solute carrier organic anion transporter family member 1B3 | Homo sapiens (human) | 1.1481 | |
| Type-1 angiotensin II receptor | Cavia porcellus (domestic guinea pig) | 0.018 | |
| Solute carrier organic anion transporter family member 1B1 | Homo sapiens (human) | 0.2884 |
Research
Studies (4)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 3 (75.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Ehmke, H; Kirchengast, M; Münter, K | 1 |
| Bohlender, J; Dietz, R; Gerbaulet, S; Gross, M; Kirchengast, M; Krämer, J | 1 |
| Henrion, D; Lévy, BI; Matrougui, K | 1 |
| Epelde, F; Heras, M; Pérez-Villa, F; Rigol, M; Roig, E; Roqué, M; Sanz, G; Solanes, N | 1 |
Other Studies
4 other study(ies) available for lu 135252 and losartan
| Article | Year |
|---|---|
Maintenance of blood pressure in normotensive dogs by endothelin.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Blood Pressure; Dogs; Drug Synergism; Endothelin Receptor Antagonists; Endothelins; Indoles; Losartan; Male; Nitric Oxide; Phenylpropionates; Pyrimidines; Receptor, Endothelin A; Reference Values | 1999 |
Synergistic effects of AT(1) and ET(A) receptor blockade in a transgenic, angiotensin II-dependent, rat model.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Animals, Genetically Modified; Antihypertensive Agents; Blood Pressure; Drug Synergism; Endothelin Receptor Antagonists; Endothelin-1; Humans; Hypertension; Losartan; Phenylpropionates; Pyrimidines; Rats; Renin | 2000 |
Tissue angiotensin II and endothelin-1 modulate differently the response to flow in mesenteric resistance arteries of normotensive and spontaneously hypertensive rats.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Blood Viscosity; Endothelin Receptor Antagonists; Endothelin-1; Hypertension; Imidazoles; Losartan; Mesenteric Arteries; Muscle Tonus; Perindopril; Phenylpropionates; Pyridines; Pyrimidines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Angiotensin; Splanchnic Circulation; Vascular Resistance; Vasodilation | 2000 |
Enalaprilat, losartan and LU 135252 in coronary blood flow regulation.
Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Bradykinin; Coronary Circulation; Enalaprilat; Female; Losartan; Male; Phenylpropionates; Pyrimidines; Swine | 2003 |