Page last updated: 2024-09-04

lidorestat and tolrestat

lidorestat has been researched along with tolrestat in 1 studies

Compound Research Comparison

Studies
(lidorestat)
Trials
(lidorestat)
Recent Studies (post-2010)
(lidorestat)
Studies
(tolrestat)
Trials
(tolrestat)
Recent Studies (post-2010) (tolrestat)
6021982514

Protein Interaction Comparison

ProteinTaxonomylidorestat (IC50)tolrestat (IC50)
Aldo-keto reductase family 1 member B10Homo sapiens (human)0.0244
Aldo-keto reductase family 1 member B1Rattus norvegicus (Norway rat)0.2689
Aldo-keto reductase family 1 member A1Homo sapiens (human)1.1533
Aldo-keto reductase family 1 member B1Homo sapiens (human)0.2303
Alpha-1B adrenergic receptorRattus norvegicus (Norway rat)0.096
Aldo-keto reductase family 1 member B1Bos taurus (cattle)0.043
Aldo-keto reductase family 1 member A1Sus scrofa (pig)1.365
Aldo-keto reductase family 1 member A1Rattus norvegicus (Norway rat)1.21
Aldo-keto reductase family 1 member B1Sus scrofa (pig)0.0225
Mu-type opioid receptorCavia porcellus (domestic guinea pig)0.03

Research

Studies (1)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (100.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Dicioccio, AT; Geraci, LS; Gunn, DE; Jacot, JL; Jones, JH; Jones, ML; Mitschler, A; Petrova, T; Podjarny, AD; Sawicki, DR; Sredy, J; Van Zandt, MC1

Other Studies

1 other study(ies) available for lidorestat and tolrestat

ArticleYear
Discovery of 3-[(4,5,7-trifluorobenzothiazol-2-yl)methyl]indole-N-acetic acid (lidorestat) and congeners as highly potent and selective inhibitors of aldose reductase for treatment of chronic diabetic complications.
    Journal of medicinal chemistry, 2005, May-05, Volume: 48, Issue:9

    Topics: Aldehyde Reductase; Animals; Cataract; Chronic Disease; Crystallography, X-Ray; Diabetes Complications; Diabetes Mellitus, Experimental; Humans; Indoleacetic Acids; Lens, Crystalline; Male; Models, Molecular; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Structure-Activity Relationship; Thiazoles; Tissue Distribution

2005