Compounds > cyc 202
Page last updated: 2024-09-04

cyc 202 and vx680

cyc 202 has been researched along with vx680 in 8 studies

Compound Research Comparison

Studies
(cyc 202)		Trials
(cyc 202)		Recent Studies (post-2010)
(cyc 202)		Studies
(vx680)		Trials
(vx680)		Recent Studies (post-2010) (vx680)
97973932273143

Protein Interaction Comparison

ProteinTaxonomycyc 202 (IC50)vx680 (IC50)
Aurora kinase AHomo sapiens (human)0.1805
Tyrosine-protein kinase ABL1Homo sapiens (human)0.4538
Tyrosine-protein kinase ABL1Mus musculus (house mouse)5
Proto-oncogene tyrosine-protein kinase SrcGallus gallus (chicken)0.34
Cyclin-dependent kinase 1Homo sapiens (human)0.4432
Insulin-like growth factor 1 receptorHomo sapiens (human)0.5
Beta-1 adrenergic receptorHomo sapiens (human)0.055
Breakpoint cluster region proteinHomo sapiens (human)0.0501
Cyclin-dependent kinase 4Homo sapiens (human)0.0006
G2/mitotic-specific cyclin-B1Homo sapiens (human)0.0092
G1/S-specific cyclin-D1Homo sapiens (human)0.0006
Cyclin-dependent kinase 2Homo sapiens (human)0.4974
Receptor-type tyrosine-protein kinase FLT3Homo sapiens (human)0.03
Serine/threonine-protein kinase PLK1Homo sapiens (human)0.4974
Aurora kinase AMus musculus (house mouse)0.0006
Receptor-interacting serine/threonine-protein kinase 1Homo sapiens (human)0.208
Maternal embryonic leucine zipper kinaseHomo sapiens (human)0.42
Discoidin domain-containing receptor 2Homo sapiens (human)0.1295
Receptor-interacting serine/threonine-protein kinase 1 Mus musculus (house mouse)1
Aurora kinase B-AXenopus laevis (African clawed frog)0.019
Aurora kinase BHomo sapiens (human)0.2175
Serine/threonine-protein kinase TBK1Homo sapiens (human)3.1131
Aurora kinase CHomo sapiens (human)0.3516

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (37.50)29.6817
2010's5 (62.50)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Alessi, DR; Arthur, JS; Bain, J; Cohen, P; Elliott, M; Hastie, CJ; Klevernic, I; McLauchlan, H; Plater, L; Shpiro, N1
Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Gallant, P; Herrgard, S; Hunt, JP; Karaman, MW; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Treiber, DK; Wodicka, LM; Zarrinkar, PP1
Russu, WA; Shallal, HM1
Davis, MI; Khan, J; Li, SQ; Patel, PR; Shen, M; Sun, H; Thomas, CJ1
Aiche, S; Bassermann, F; Becker, W; Canevari, G; Casale, E; Depaolini, SR; Ehrlich, HC; Felder, ER; Feuchtinger, A; Garz, AK; Gohlke, BO; Götze, K; Greif, PA; Hahne, H; Heinzlmeir, S; Helm, D; Huenges, J; Jeremias, I; Kayser, G; Klaeger, S; Koch, H; Koenig, PA; Kramer, K; Kuster, B; Médard, G; Meng, C; Petzoldt, S; Polzer, H; Preissner, R; Qiao, H; Reinecke, M; Reiter, K; Rueckert, L; Ruland, J; Ruprecht, B; Schlegl, J; Schmidt, T; Schneider, S; Schoof, M; Spiekermann, K; Tõnisson, N; Vick, B; Vooder, T; Walch, A; Wilhelm, M; Wu, Z; Zecha, J; Zolg, DP1
Arlot-Bonnemains, Y; Dalbiès-Tran, R; Dupont, J; Mermillod, P; Papillier, P; Pennetier, S; Perreau, C; Prigent, C; Thélie, A; Uzbekov, R; Uzbekova, S1
Hirotsune, S; Kumamoto, K; Sato, M; Takitoh, T; Toba, S; Wang, CC; Wynshaw-Boris, A1
Arang, N; Bello, T; Dudgeon, DR; Glennon, EK; Gujral, TS; Kain, HS; Kaushansky, A; Walter, ENF1

Other Studies

8 other study(ies) available for cyc 202 and vx680

ArticleYear
The selectivity of protein kinase inhibitors: a further update.
    The Biochemical journal, 2007, Dec-15, Volume: 408, Issue:3

    Topics: Amino Acid Sequence; Animals; Cell Line; Drug Design; Enzyme Activation; Humans; Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Recombinant Proteins; Spodoptera

2007
A quantitative analysis of kinase inhibitor selectivity.
    Nature biotechnology, 2008, Volume: 26, Issue:1

    Topics: Binding Sites; Enzyme Activation; Humans; Phosphotransferases; Protein Binding; Protein Interaction Mapping; Protein Kinase Inhibitors; Proteome; Quantitative Structure-Activity Relationship

2008
Discovery, synthesis, and investigation of the antitumor activity of novel piperazinylpyrimidine derivatives.
    European journal of medicinal chemistry, 2011, Volume: 46, Issue:6

    Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Molecular Structure; Piperazines; Protein Kinase Inhibitors; Protein Kinases; Pyrimidines; Stereoisomerism; Structure-Activity Relationship

2011
Identification of potent Yes1 kinase inhibitors using a library screening approach.
    Bioorganic & medicinal chemistry letters, 2013, Aug-01, Volume: 23, Issue:15

    Topics: Binding Sites; Cell Line; Cell Survival; Drug Design; Humans; Hydrogen Bonding; Molecular Docking Simulation; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-yes; Small Molecule Libraries; Structure-Activity Relationship

2013
The target landscape of clinical kinase drugs.
    Science (New York, N.Y.), 2017, 12-01, Volume: 358, Issue:6367

    Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cytokines; Drug Discovery; fms-Like Tyrosine Kinase 3; Humans; Leukemia, Myeloid, Acute; Lung Neoplasms; Mice; Molecular Targeted Therapy; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Proteomics; Xenograft Model Antitumor Assays

2017
Spatio-temporal expression patterns of aurora kinases a, B, and C and cytoplasmic polyadenylation-element-binding protein in bovine oocytes during meiotic maturation.
    Biology of reproduction, 2008, Volume: 78, Issue:2

    Topics: Animals; Aurora Kinase A; Aurora Kinase B; Aurora Kinase C; Aurora Kinases; Butadienes; Cattle; CDC2 Protein Kinase; Cyclin B; Cyclin B1; Cytoplasm; Embryo, Mammalian; Female; Fertilization; Meiosis; Metformin; mRNA Cleavage and Polyadenylation Factors; Nitriles; Oocytes; Piperazines; Polyadenylation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-mos; Purines; RNA, Messenger; Roscovitine

2008
Activation of Aurora-A is essential for neuronal migration via modulation of microtubule organization.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012, Aug-08, Volume: 32, Issue:32

    Topics: Amiodarone; Analysis of Variance; Animals; Animals, Newborn; Aurora Kinase A; Aurora Kinases; Bromodeoxyuridine; Calcium-Binding Proteins; Carrier Proteins; Cell Cycle Proteins; Cell Movement; Cells, Cultured; Cerebellum; Cyclin-Dependent Kinase 5; Enzyme Inhibitors; Female; Gene Expression Regulation, Developmental; Green Fluorescent Proteins; Male; Mice; Mice, Transgenic; Microscopy, Confocal; Microtubule-Associated Proteins; Microtubules; Mutation; Neurons; Phosphorylation; Piperazines; Pregnancy; Protein Serine-Threonine Kinases; Purines; RNA, Small Interfering; Roscovitine; Sex Factors; Signal Transduction

2012
Identifying host regulators and inhibitors of liver stage malaria infection using kinase activity profiles.
    Nature communications, 2017, 11-01, Volume: 8, Issue:1

    Topics: Animals; Cell Line, Tumor; HEK293 Cells; Hepatocytes; Host-Parasite Interactions; Humans; Indoles; Liver; Malaria; Mice; Piperazines; Plasmodium yoelii; Protein Kinase Inhibitors; Protein Kinases; Purines; Pyrroles; RNA Interference; Roscovitine; Sporozoites; Sunitinib

2017