Page last updated: 2024-09-04

cyc 202 and abt-737

cyc 202 has been researched along with abt-737 in 2 studies

Compound Research Comparison

Studies
(cyc 202)
Trials
(cyc 202)
Recent Studies (post-2010)
(cyc 202)
Studies
(abt-737)
Trials
(abt-737)
Recent Studies (post-2010) (abt-737)
97973936320484

Protein Interaction Comparison

ProteinTaxonomycyc 202 (IC50)abt-737 (IC50)
Bcl-2-like protein 11Homo sapiens (human)0.002
Apoptosis regulator Bcl-2Homo sapiens (human)0.0206
Alpha-1B adrenergic receptorRattus norvegicus (Norway rat)0.0003
Alpha-2B adrenergic receptorRattus norvegicus (Norway rat)0.0003
Alpha-2C adrenergic receptorRattus norvegicus (Norway rat)0.0003
Alpha-2A adrenergic receptorRattus norvegicus (Norway rat)0.0003
Adenosine receptor A2aRattus norvegicus (Norway rat)0.02
BH3-interacting domain death agonistHomo sapiens (human)0.0485
Apoptosis regulator BAX Homo sapiens (human)0.023
Bcl-2-like protein 1Homo sapiens (human)0.0207
Induced myeloid leukemia cell differentiation protein Mcl-1Homo sapiens (human)0.0248
Aspartyl/asparaginyl beta-hydroxylaseHomo sapiens (human)3.44
Bcl-2 homologous antagonist/killerHomo sapiens (human)0.0335
Bcl-2-like protein 2Homo sapiens (human)0.0335
Bcl-2-binding component 3, isoforms 1/2Homo sapiens (human)0.0003

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (100.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Fesik, SW; Huang, X; Li, L; Lin, X; Morgan-Lappe, S; Shen, Y; Vernetti, LA; Zakula, DM1
Chen, S; Dai, Y; Dent, P; Grant, S; Harada, H1

Other Studies

2 other study(ies) available for cyc 202 and abt-737

ArticleYear
'Seed' analysis of off-target siRNAs reveals an essential role of Mcl-1 in resistance to the small-molecule Bcl-2/Bcl-XL inhibitor ABT-737.
    Oncogene, 2007, Jun-07, Volume: 26, Issue:27

    Topics: 3' Untranslated Regions; Antineoplastic Agents; Base Sequence; bcl-X Protein; Benzenesulfonates; Biphenyl Compounds; Blotting, Western; Carcinoma, Small Cell; Cell Line, Tumor; Cell Survival; DNA-Binding Proteins; Drug Resistance, Neoplasm; Humans; Lung Neoplasms; Myeloid Cell Leukemia Sequence 1 Protein; Neoplasm Proteins; Niacinamide; Nitrophenols; Phenylurea Compounds; Piperazines; Proto-Oncogene Proteins c-bcl-2; Purines; Pyridines; Receptor, Fibroblast Growth Factor, Type 2; RNA Interference; RNA, Small Interfering; Roscovitine; Sorafenib; Sulfonamides; Transmembrane Activator and CAML Interactor Protein; Zinc Fingers

2007
Mcl-1 down-regulation potentiates ABT-737 lethality by cooperatively inducing Bak activation and Bax translocation.
    Cancer research, 2007, Jan-15, Volume: 67, Issue:2

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; bcl-2 Homologous Antagonist-Killer Protein; bcl-2-Associated X Protein; bcl-X Protein; Biphenyl Compounds; Cyclin-Dependent Kinases; Down-Regulation; Drug Synergism; HL-60 Cells; Humans; Jurkat Cells; Leukemia; Mice; Mice, Knockout; Myeloid Cell Leukemia Sequence 1 Protein; Neoplasm Proteins; Nitrophenols; Piperazines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-bcl-2; Purines; RNA Interference; Roscovitine; Sulfonamides; U937 Cells

2007