Page last updated: 2024-09-04

bh 3 and abt-737

bh 3 has been researched along with abt-737 in 4 studies

Compound Research Comparison

Studies
(bh 3)
Trials
(bh 3)
Recent Studies (post-2010)
(bh 3)
Studies
(abt-737)
Trials
(abt-737)
Recent Studies (post-2010) (abt-737)
9036320484

Protein Interaction Comparison

ProteinTaxonomybh 3 (IC50)abt-737 (IC50)
Bcl-2-like protein 11Homo sapiens (human)0.002
Apoptosis regulator Bcl-2Homo sapiens (human)0.0206
Alpha-1B adrenergic receptorRattus norvegicus (Norway rat)0.0003
Alpha-2B adrenergic receptorRattus norvegicus (Norway rat)0.0003
Alpha-2C adrenergic receptorRattus norvegicus (Norway rat)0.0003
Alpha-2A adrenergic receptorRattus norvegicus (Norway rat)0.0003
Adenosine receptor A2aRattus norvegicus (Norway rat)0.02
BH3-interacting domain death agonistHomo sapiens (human)0.0485
Apoptosis regulator BAX Homo sapiens (human)0.023
Bcl-2-like protein 1Homo sapiens (human)0.0207
Induced myeloid leukemia cell differentiation protein Mcl-1Homo sapiens (human)0.0248
Aspartyl/asparaginyl beta-hydroxylaseHomo sapiens (human)3.44
Bcl-2 homologous antagonist/killerHomo sapiens (human)0.0335
Bcl-2-like protein 2Homo sapiens (human)0.0335
Bcl-2-binding component 3, isoforms 1/2Homo sapiens (human)0.0003

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (50.00)29.6817
2010's2 (50.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Biesterfeld, S; Hoffarth, S; Huber, C; Kröll, M; Schuler, M; Wesarg, E; Wiewrodt, R1
Cummings, J; Dive, C; Elmore, S; Foster, K; Greaves, M; Micha, D; Rosenberg, S; Shoemaker, A; Simpson, K; Ward, T1
Antonietti, P; Bartsch, G; Blaheta, R; Haferkamp, A; Kögel, D; Mani, J; Rakel, S1
Auer, F; Bis, AM; Borkhardt, A; Dujovny, T; Fischer, U; Ginzel, S; Gombert, M; Harlev, D; Keller, B; Koren, A; Levin, C; Miskin, H; Nabhani, S; Postovsky, S; Schipp, C; Stepensky, P; Warnatz, K1

Other Studies

4 other study(ies) available for bh 3 and abt-737

ArticleYear
Targeting BCL-2 family proteins to overcome drug resistance in non-small cell lung cancer.
    International journal of cancer, 2007, Dec-01, Volume: 121, Issue:11

    Topics: Antineoplastic Agents; Apoptosis; bcl-2 Homologous Antagonist-Killer Protein; Biphenyl Compounds; Butylated Hydroxytoluene; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Doxorubicin; Drug Resistance, Neoplasm; Electrophoresis; Etoposide; Flow Cytometry; Gene Expression Regulation, Neoplastic; Humans; Immunoblotting; Immunohistochemistry; Lung Neoplasms; Mitochondria; Myeloid Cell Leukemia Sequence 1 Protein; Neoplasm Proteins; Nitrophenols; Paclitaxel; Permeability; Piperazines; Proto-Oncogene Proteins c-bcl-2; Signal Transduction; Sulfonamides

2007
Circulating biomarkers of cell death after treatment with the BH-3 mimetic ABT-737 in a preclinical model of small-cell lung cancer.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2008, Nov-15, Volume: 14, Issue:22

    Topics: Animals; Antineoplastic Agents; Apoptosis; Biomarkers, Tumor; Biomimetic Materials; Biphenyl Compounds; Butylated Hydroxytoluene; Caspase 3; Cell Line, Tumor; Enzyme-Linked Immunosorbent Assay; Humans; Immunohistochemistry; Keratin-18; Lung Neoplasms; Mice; Nitrophenols; Piperazines; Small Cell Lung Carcinoma; Sulfonamides; Xenograft Model Antitumor Assays

2008
Knockdown of BAG3 sensitizes bladder cancer cells to treatment with the BH3 mimetic ABT-737.
    World journal of urology, 2016, Volume: 34, Issue:2

    Topics: Adaptor Proteins, Signal Transducing; Apoptosis; Apoptosis Regulatory Proteins; Biphenyl Compounds; Blotting, Western; Butylated Hydroxytoluene; Carcinoma, Transitional Cell; Cell Line, Tumor; DNA, Neoplasm; Flow Cytometry; Gene Expression Regulation, Neoplastic; Humans; Nitrophenols; Piperazines; Proto-Oncogene Proteins c-bcl-2; Sulfonamides; Urinary Bladder Neoplasms

2016
STAT3 gain-of-function mutations associated with autoimmune lymphoproliferative syndrome like disease deregulate lymphocyte apoptosis and can be targeted by BH3 mimetic compounds.
    Clinical immunology (Orlando, Fla.), 2017, Volume: 181

    Topics: Apoptosis; Autoimmune Lymphoproliferative Syndrome; Biphenyl Compounds; Butylated Hydroxytoluene; Case-Control Studies; Child, Preschool; Enzyme-Linked Immunosorbent Assay; Family; Fas Ligand Protein; fas Receptor; Female; Gene Expression Profiling; Germ-Line Mutation; Humans; Immunoblotting; Immunophenotyping; Leukocytes, Mononuclear; Lymphocytes; Nitrophenols; Piperazines; Proto-Oncogene Proteins c-bcl-2; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; Sequence Analysis, DNA; STAT3 Transcription Factor; Sulfonamides; T-Lymphocytes

2017