allocolchicine and colchicine
allocolchicine has been researched along with colchicine in 31 studies
Compound Research Comparison
Studies (allocolchicine) | Trials (allocolchicine) | Recent Studies (post-2010) (allocolchicine) | Studies (colchicine) | Trials (colchicine) | Recent Studies (post-2010) (colchicine) |
---|---|---|---|---|---|
36 | 0 | 7 | 15,472 | 404 | 2,974 |
Protein Interaction Comparison
Protein | Taxonomy | allocolchicine (IC50) | colchicine (IC50) |
---|---|---|---|
Tubulin alpha-1A chain | Sus scrofa (pig) | 3.7639 | |
Tubulin beta chain | Sus scrofa (pig) | 3.8663 | |
Tubulin beta-4A chain | Homo sapiens (human) | 2.4334 | |
Tubulin beta chain | Homo sapiens (human) | 2.7244 | |
Tubulin alpha-3C chain | Homo sapiens (human) | 2.4334 | |
Serine/threonine-protein kinase pim-1 | Homo sapiens (human) | 4.3 | |
Tubulin alpha-1B chain | Homo sapiens (human) | 2.4334 | |
Tubulin alpha-4A chain | Homo sapiens (human) | 2.4334 | |
Tubulin beta-4B chain | Homo sapiens (human) | 2.4334 | |
Vesicular acetylcholine transporter | Tetronarce californica (Pacific electric ray) | 2.62 | |
Tubulin beta-3 chain | Homo sapiens (human) | 2.4334 | |
Tubulin beta-2A chain | Homo sapiens (human) | 2.4334 | |
Tubulin beta-8 chain | Homo sapiens (human) | 2.4334 | |
Tubulin beta-2B chain | Bos taurus (cattle) | 2.8255 | |
Tubulin alpha-3E chain | Homo sapiens (human) | 2.4334 | |
Tubulin alpha-1A chain | Homo sapiens (human) | 2.4334 | |
Similar to alpha-tubulin isoform 1 | Bos taurus (cattle) | 3.0611 | |
Similar to alpha-tubulin isoform 1 | Bos taurus (cattle) | 3.1553 | |
Tubulin alpha-1C chain | Homo sapiens (human) | 2.4334 | |
Tubulin beta-6 chain | Homo sapiens (human) | 2.4334 | |
Tubulin beta-2B chain | Homo sapiens (human) | 2.4334 | |
Tubulin beta-1 chain | Homo sapiens (human) | 2.4334 |
Research
Studies (31)
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 4 (12.90) | 18.7374 |
1990's | 7 (22.58) | 18.2507 |
2000's | 12 (38.71) | 29.6817 |
2010's | 8 (25.81) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors
Authors | Studies |
---|---|
Brossi, A; Feng, J; Hamel, E; Kuo, SC; Lee, KH; Tropsha, A; Zhang, SX | 1 |
Prakash, V; Timasheff, SN | 1 |
Hastie, SB; Pyles, EA | 1 |
Burden, P; Lacey, E; Mackay, MF | 1 |
Hastie, SB | 1 |
Deinum, J; Lincoln, P | 1 |
Deinum, J; Erkell, LJ; Lagercrantz, C; Larsson, T; Lincoln, P | 1 |
Seckler, R; Timasheff, SN; Ward, LD | 1 |
Perez-Ramirez, B; Shearwin, KE; Timasheff, SN | 1 |
Perez-Ramirez, B; Timasheff, SN | 1 |
Andreu, JM; Dumortier, C; Engelborghs, Y; Gorbunoff, MJ | 1 |
Gorbunoff, MJ; Pérez-Ramírez, B; Timasheff, SN | 1 |
Brecht, R; Guénard, D; Seitz, G; Thoret, S | 1 |
Baudoin, O; Cesario, M; Guénard, D; Guéritte, F | 1 |
Hansen, HJ; Vorogushin, AV; Wulff, WD | 2 |
Estes, LA; Kelner, MJ; McMorris, TC; Rojas, RJ; Suthipinijtham, P; Trani, NA; Velasco, TR | 1 |
Bastow, KF; Brossi, A; Hamel, E; Han, S; Lee, KH; McPhail, AT | 1 |
Hansen, HJ; Predeus, AV; Vorogushin, AV; Wulff, WD | 1 |
Fagnou, K; Leblanc, M | 1 |
DeShong, P; Seganish, WM | 1 |
Boyer, FD; Hanna, I | 1 |
Neudörfl, JM; Nicolaus, N; Prokop, A; Schmalz, HG; Strauss, S | 1 |
Boyer, FD; Dau, ME; Dubois, J; Hanna, I; Thoret, S | 1 |
Djurdjevic, S; Green, JR; Yang, F | 1 |
Jain, N; Kalivendi, SV; Reddy, PS; Shaik, TB; Sreedhar, B; Vasantha, G; Yada, D | 1 |
Besson, T; Chosson, E; Cresteil, T; Dallemagne, P; Legay, R; Rochais, C; Santoro, F; Santos, JS; Sinicropi, MS; Thoret, S | 1 |
Batra, S; Bhowmik, S; Hasanain, M; Khanna, S; Sarkar, J; Srivastava, K; Verma, S | 1 |
Djurdjevic, S; Green, J; Larocque, K; Mehdi, M; Ovadje, P; Pandey, S | 1 |
Allegro, D; Barbier, P; Beletskaya, IP; Combes, S; Faerman, VI; Fedorov, AY; Fokin, VV; Schmalz, HG; Shegravina, ES; Sitnikov, NS; Svirshchevskaya, EV; Voitovich, YV | 1 |
Fedorov, AY; Gavryushin, AE; Gracheva, IA; Ignatov, SK; Maleev, AA; Schmalz, HG; Shchegravina, ES; Stein, A; Svirshchevskaya, EV; Zubareva, AA | 1 |
Other Studies
31 other study(ies) available for allocolchicine and colchicine
Article | Year |
---|---|
Antitumor agents. 199. Three-dimensional quantitative structure-activity relationship study of the colchicine binding site ligands using comparative molecular field analysis.
Topics: Antineoplastic Agents; Colchicine; Molecular Structure; Static Electricity; Structure-Activity Relationship | 2000 |
Aging of tubulin at neutral pH: stabilization by colchicine and its analogues.
Topics: Animals; Brain Chemistry; Cattle; Circular Dichroism; Colchicine; Hydrogen-Ion Concentration; Protein Conformation; Spectrophotometry, Ultraviolet; Tropolone; Tubulin; Ultracentrifugation; Vincristine | 1992 |
Role of the B-ring substituent in the fluorescence of colchicinoid-tubulin and allocolchicinoid-tubulin complexes.
Topics: Colchicine; Fluorescence Polarization; Ligands; Tubulin | 1992 |
Structures of colchicine analogues. I. Allocolchicine.
Topics: Chemical Phenomena; Chemistry, Physical; Colchicine; Crystallization; Crystallography; Molecular Structure | 1989 |
Spectroscopic and kinetic features of allocolchicine binding to tubulin.
Topics: Animals; Cattle; Colchicine; Energy Transfer; Molecular Structure; Protein Conformation; Solvents; Spectrometry, Fluorescence; Spectrophotometry, Atomic; Tubulin | 1989 |
Binding to tubulin of an allocolchicine spin probe: interaction with the essential SH groups and other active sites.
Topics: Animals; Binding Sites; Brain; Cattle; Colchicine; Cyclic N-Oxides; Electron Spin Resonance Spectroscopy; Kinetics; Microtubules; Protein Binding; Sulfhydryl Compounds; Tubulin | 1986 |
Synthesis and binding to tubulin of an allocolchicine spin probe.
Topics: Animals; Binding Sites; Cattle; Cell Division; Colchicine; Kinetics; Protein Binding; Spin Labels; Tubulin | 1981 |
Energy transfer studies of the distances between the colchicine, ruthenium red, and bisANS binding sites on calf brain tubulin.
Topics: Anilino Naphthalenesulfonates; Animals; Binding Sites; Brain; Cattle; Colchicine; Energy Transfer; Models, Chemical; Ruthenium Red; Spectrometry, Fluorescence; Spectrophotometry; Spin Labels; Tubulin | 1994 |
The colchicine-induced GTPase activity of tubulin: state of the product. Activation by microtubule-promoting cosolvents.
Topics: Animals; Biphenyl Compounds; Brain Chemistry; Cattle; Colchicine; Enzyme Activation; GTP Phosphohydrolases; Guanosine Diphosphate; Guanosine Triphosphate; Hydrogen-Ion Concentration; Kinetics; Magnesium; Microtubules; Polyethylene Glycols; Solvents; Tubulin | 1994 |
Cosolvent modulation of the tubulin-colchicine GTPase-activating conformational change: strength of the enzymatic activity.
Topics: Animals; Cattle; Colchicine; Glycerol; Glycols; GTP Phosphohydrolases; Guanosine Diphosphate; Guanosine Triphosphate; Hydrolysis; Polyethylene Glycols; Protein Conformation; Solvents; Spectrometry, Fluorescence; Thermodynamics; Tubulin | 1994 |
Alterations of rings B and C of colchicine are cumulative in overall binding to tubulin but modify each kinetic step.
Topics: Biphenyl Compounds; Colchicine; Dimerization; Fluorescence; Kinetics; Models, Chemical; Molecular Structure; Podophyllotoxin; Protein Binding; Thermodynamics; Tropolone; Tubulin | 1996 |
Linkages in tubulin-colchicine functions: the role of the ring C (C') oxygens and ring B in the controls.
Topics: Acetamides; Binding, Competitive; Colchicine; Enzyme Induction; GTP Phosphohydrolases; Ligands; Methyl Ethers; Microtubules; Oxygen; Polymers; Protein Binding; Protein Synthesis Inhibitors; Structure-Activity Relationship; Tubulin | 1998 |
Novel allocolchicinoids with an eight membered B-ring: design, synthesis and inhibition of tubulin assembly.
Topics: Animals; Antineoplastic Agents; Cattle; Colchicine; Lactams; Magnetic Resonance Spectroscopy; Structure-Activity Relationship; Tubulin; Tubulin Modulators | 2000 |
Application of the palladium-catalyzed borylation/Suzuki coupling (BSC) reaction to the synthesis of biologically active biaryl lactams.
Topics: Alkaloids; Antineoplastic Agents; Biphenyl Compounds; Boron Compounds; Catalysis; Colchicine; Cyclin-Dependent Kinases; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Humans; Indolizines; Inhibitory Concentration 50; KB Cells; Lactams; Magnetic Resonance Spectroscopy; Molecular Structure; Palladium; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry, Infrared; Spectroscopy, Fourier Transform Infrared; Structure-Activity Relationship; X-Ray Diffraction | 2002 |
Stereoselectivity of the benzannulation reaction: efficient central-to-axial chirality transfer.
Topics: Colchicine; Stereoisomerism; Substrate Specificity | 2002 |
Enhanced antitumor activity of irofulven in combination with antimitotic agents.
Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Bridged-Ring Compounds; Cell Survival; Colchicine; Cysteine; Drug Synergism; Female; Lactones; Macrolides; Mice; Mice, Inbred BALB C; Neoplasm Transplantation; Sesquiterpenes; Taxoids; Tubulin; Tumor Cells, Cultured; Vinca Alkaloids | 2002 |
Antitumor agents. Part 215: antitubulin effects of cytotoxic B-ring modified allocolchicinoids.
Topics: Antineoplastic Agents; Colchicine; Drug Screening Assays, Antitumor; Humans; Indicators and Reagents; Models, Molecular; Molecular Conformation; Tubulin; Tumor Cells, Cultured | 2002 |
Diels-Alder reaction-aromatization approach toward functionalized ring C allocolchicinoids. Enantioselective total synthesis of (-)-7S-allocolchicine.
Topics: Colchicine; Indicators and Reagents; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Conformation; Stereoisomerism | 2003 |
Steric vs hydrogen-bonding control of atropisomerization: preparation of either diastereomer of configurationally stable allocolchicinoids.
Topics: Acetylation; Antineoplastic Agents; Colchicine; Hydrogen Bonding; Hydroquinones; Phenols; Stereoisomerism; Structure-Activity Relationship; Thermodynamics | 2003 |
Allocolchicinoid synthesis via direct arylation.
Topics: Catalysis; Colchicine; Cyclization; Hydrocarbons, Halogenated; Molecular Structure; Palladium; Stereoisomerism | 2005 |
Application of aryl siloxane cross-coupling to the synthesis of allocolchicinoids.
Topics: Colchicine; Molecular Structure | 2006 |
Synthesis of allocolchicines using sequential ring-closing enyne metathesis-Diels-Alder reactions.
Topics: Colchicine; Colchicum; Indicators and Reagents; Magnetic Resonance Spectroscopy | 2007 |
A [2 + 2 + 2]-cycloaddition approach toward 6-oxa-allocolchicinoids with apoptosis-inducing activity.
Topics: Apoptosis; Catalysis; Cell Line, Tumor; Colchicine; Humans | 2009 |
Synthesis and tubulin-binding properties of new allocolchicinoids.
Topics: Animals; Antimitotic Agents; Colchicine; Protein Binding; Sheep; Tubulin | 2010 |
Intramolecular Nicholas reactions in the synthesis of dibenzocycloheptanes. Synthesis of allocolchicine NSC 51046 and analogues and the formal synthesis of (-)-allocolchicine.
Topics: Alkynes; Colchicine; Dibenzocycloheptenes; Magnetic Resonance Spectroscopy; Molecular Structure; Propanols; Stereoisomerism | 2010 |
Synthesis and antitumor evaluation of nitrovinyl biphenyls: anticancer agents based on allocolchicines.
Topics: Antineoplastic Agents; Aurora Kinase B; Aurora Kinases; Biphenyl Compounds; Cell Division; Cell Line, Tumor; Colchicine; Cyclin B1; Drug Screening Assays, Antitumor; G2 Phase; Humans; Neoplasms; Protein Serine-Threonine Kinases; Tubulin; Tubulin Modulators | 2011 |
Synthesis of novel 7-oxo and 7-hydroxy trifluoroallocolchicinoids with cytotoxic effect.
Topics: Animals; Cell Proliferation; Colchicine; Crystallography, X-Ray; Cyclization; Dose-Response Relationship, Drug; Humans; KB Cells; Models, Molecular; Molecular Structure; Sheep; Structure-Activity Relationship; Tubulin | 2012 |
An efficient combinatorial synthesis of allocolchicine analogues via a triple cascade reaction and their evaluation as inhibitors of insulin aggregation.
Topics: Animals; Cattle; Circular Dichroism; Colchicine; Combinatorial Chemistry Techniques; Insulin Antagonists; Microscopy, Atomic Force; Molecular Structure; Protein Binding; Stereoisomerism | 2013 |
Novel analogue of colchicine induces selective pro-death autophagy and necrosis in human cancer cells.
Topics: Animals; Antineoplastic Agents; Autophagy; Blotting, Western; Cell Proliferation; Cells, Cultured; Colchicine; Fibroblasts; Humans; Leukemia, T-Cell; Male; Mice; Mice, Nude; Microtubules; Mitochondria; Necrosis; Pancreatic Neoplasms; Reactive Oxygen Species; Tubulin | 2014 |
Synthesis and biological evaluation of furanoallocolchicinoids.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Colchicine; Furans; Humans; Mice; Mice, Inbred C57BL; Microtubules; Models, Molecular; Structure-Activity Relationship; Tubulin Modulators | 2015 |
Synthesis and biological evaluation of novel non-racemic indole-containing allocolchicinoids.
Topics: Antineoplastic Agents; Apoptosis; Cell Cycle Checkpoints; Cell Proliferation; Colchicine; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Indoles; Molecular Docking Simulation; Molecular Structure; Structure-Activity Relationship; Tumor Cells, Cultured | 2017 |