Page last updated: 2024-09-05

allocolchicine and colchicine

allocolchicine has been researched along with colchicine in 31 studies

Compound Research Comparison

Studies
(allocolchicine)
Trials
(allocolchicine)
Recent Studies (post-2010)
(allocolchicine)
Studies
(colchicine)
Trials
(colchicine)
Recent Studies (post-2010) (colchicine)
360715,4724042,974

Protein Interaction Comparison

ProteinTaxonomyallocolchicine (IC50)colchicine (IC50)
Tubulin alpha-1A chainSus scrofa (pig)3.7639
Tubulin beta chainSus scrofa (pig)3.8663
Tubulin beta-4A chainHomo sapiens (human)2.4334
Tubulin beta chainHomo sapiens (human)2.7244
Tubulin alpha-3C chainHomo sapiens (human)2.4334
Serine/threonine-protein kinase pim-1Homo sapiens (human)4.3
Tubulin alpha-1B chainHomo sapiens (human)2.4334
Tubulin alpha-4A chainHomo sapiens (human)2.4334
Tubulin beta-4B chainHomo sapiens (human)2.4334
Vesicular acetylcholine transporterTetronarce californica (Pacific electric ray)2.62
Tubulin beta-3 chainHomo sapiens (human)2.4334
Tubulin beta-2A chainHomo sapiens (human)2.4334
Tubulin beta-8 chainHomo sapiens (human)2.4334
Tubulin beta-2B chainBos taurus (cattle)2.8255
Tubulin alpha-3E chainHomo sapiens (human)2.4334
Tubulin alpha-1A chainHomo sapiens (human)2.4334
Similar to alpha-tubulin isoform 1 Bos taurus (cattle)3.0611
Similar to alpha-tubulin isoform 1 Bos taurus (cattle)3.1553
Tubulin alpha-1C chainHomo sapiens (human)2.4334
Tubulin beta-6 chainHomo sapiens (human)2.4334
Tubulin beta-2B chainHomo sapiens (human)2.4334
Tubulin beta-1 chainHomo sapiens (human)2.4334

Research

Studies (31)

TimeframeStudies, this research(%)All Research%
pre-19904 (12.90)18.7374
1990's7 (22.58)18.2507
2000's12 (38.71)29.6817
2010's8 (25.81)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Brossi, A; Feng, J; Hamel, E; Kuo, SC; Lee, KH; Tropsha, A; Zhang, SX1
Prakash, V; Timasheff, SN1
Hastie, SB; Pyles, EA1
Burden, P; Lacey, E; Mackay, MF1
Hastie, SB1
Deinum, J; Lincoln, P1
Deinum, J; Erkell, LJ; Lagercrantz, C; Larsson, T; Lincoln, P1
Seckler, R; Timasheff, SN; Ward, LD1
Perez-Ramirez, B; Shearwin, KE; Timasheff, SN1
Perez-Ramirez, B; Timasheff, SN1
Andreu, JM; Dumortier, C; Engelborghs, Y; Gorbunoff, MJ1
Gorbunoff, MJ; Pérez-Ramírez, B; Timasheff, SN1
Brecht, R; Guénard, D; Seitz, G; Thoret, S1
Baudoin, O; Cesario, M; Guénard, D; Guéritte, F1
Hansen, HJ; Vorogushin, AV; Wulff, WD2
Estes, LA; Kelner, MJ; McMorris, TC; Rojas, RJ; Suthipinijtham, P; Trani, NA; Velasco, TR1
Bastow, KF; Brossi, A; Hamel, E; Han, S; Lee, KH; McPhail, AT1
Hansen, HJ; Predeus, AV; Vorogushin, AV; Wulff, WD1
Fagnou, K; Leblanc, M1
DeShong, P; Seganish, WM1
Boyer, FD; Hanna, I1
Neudörfl, JM; Nicolaus, N; Prokop, A; Schmalz, HG; Strauss, S1
Boyer, FD; Dau, ME; Dubois, J; Hanna, I; Thoret, S1
Djurdjevic, S; Green, JR; Yang, F1
Jain, N; Kalivendi, SV; Reddy, PS; Shaik, TB; Sreedhar, B; Vasantha, G; Yada, D1
Besson, T; Chosson, E; Cresteil, T; Dallemagne, P; Legay, R; Rochais, C; Santoro, F; Santos, JS; Sinicropi, MS; Thoret, S1
Batra, S; Bhowmik, S; Hasanain, M; Khanna, S; Sarkar, J; Srivastava, K; Verma, S1
Djurdjevic, S; Green, J; Larocque, K; Mehdi, M; Ovadje, P; Pandey, S1
Allegro, D; Barbier, P; Beletskaya, IP; Combes, S; Faerman, VI; Fedorov, AY; Fokin, VV; Schmalz, HG; Shegravina, ES; Sitnikov, NS; Svirshchevskaya, EV; Voitovich, YV1
Fedorov, AY; Gavryushin, AE; Gracheva, IA; Ignatov, SK; Maleev, AA; Schmalz, HG; Shchegravina, ES; Stein, A; Svirshchevskaya, EV; Zubareva, AA1

Other Studies

31 other study(ies) available for allocolchicine and colchicine

ArticleYear
Antitumor agents. 199. Three-dimensional quantitative structure-activity relationship study of the colchicine binding site ligands using comparative molecular field analysis.
    Journal of medicinal chemistry, 2000, Jan-27, Volume: 43, Issue:2

    Topics: Antineoplastic Agents; Colchicine; Molecular Structure; Static Electricity; Structure-Activity Relationship

2000
Aging of tubulin at neutral pH: stabilization by colchicine and its analogues.
    Archives of biochemistry and biophysics, 1992, May-15, Volume: 295, Issue:1

    Topics: Animals; Brain Chemistry; Cattle; Circular Dichroism; Colchicine; Hydrogen-Ion Concentration; Protein Conformation; Spectrophotometry, Ultraviolet; Tropolone; Tubulin; Ultracentrifugation; Vincristine

1992
Role of the B-ring substituent in the fluorescence of colchicinoid-tubulin and allocolchicinoid-tubulin complexes.
    Biochemistry, 1992, Aug-11, Volume: 31, Issue:31

    Topics: Colchicine; Fluorescence Polarization; Ligands; Tubulin

1992
Structures of colchicine analogues. I. Allocolchicine.
    Acta crystallographica. Section C, Crystal structure communications, 1989, May-15, Volume: 45 ( Pt 5)

    Topics: Chemical Phenomena; Chemistry, Physical; Colchicine; Crystallization; Crystallography; Molecular Structure

1989
Spectroscopic and kinetic features of allocolchicine binding to tubulin.
    Biochemistry, 1989, Sep-19, Volume: 28, Issue:19

    Topics: Animals; Cattle; Colchicine; Energy Transfer; Molecular Structure; Protein Conformation; Solvents; Spectrometry, Fluorescence; Spectrophotometry, Atomic; Tubulin

1989
Binding to tubulin of an allocolchicine spin probe: interaction with the essential SH groups and other active sites.
    Biochimica et biophysica acta, 1986, Mar-28, Volume: 870, Issue:2

    Topics: Animals; Binding Sites; Brain; Cattle; Colchicine; Cyclic N-Oxides; Electron Spin Resonance Spectroscopy; Kinetics; Microtubules; Protein Binding; Sulfhydryl Compounds; Tubulin

1986
Synthesis and binding to tubulin of an allocolchicine spin probe.
    Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry, 1981, Volume: 35, Issue:10

    Topics: Animals; Binding Sites; Cattle; Cell Division; Colchicine; Kinetics; Protein Binding; Spin Labels; Tubulin

1981
Energy transfer studies of the distances between the colchicine, ruthenium red, and bisANS binding sites on calf brain tubulin.
    Biochemistry, 1994, Oct-04, Volume: 33, Issue:39

    Topics: Anilino Naphthalenesulfonates; Animals; Binding Sites; Brain; Cattle; Colchicine; Energy Transfer; Models, Chemical; Ruthenium Red; Spectrometry, Fluorescence; Spectrophotometry; Spin Labels; Tubulin

1994
The colchicine-induced GTPase activity of tubulin: state of the product. Activation by microtubule-promoting cosolvents.
    Biochemistry, 1994, May-24, Volume: 33, Issue:20

    Topics: Animals; Biphenyl Compounds; Brain Chemistry; Cattle; Colchicine; Enzyme Activation; GTP Phosphohydrolases; Guanosine Diphosphate; Guanosine Triphosphate; Hydrogen-Ion Concentration; Kinetics; Magnesium; Microtubules; Polyethylene Glycols; Solvents; Tubulin

1994
Cosolvent modulation of the tubulin-colchicine GTPase-activating conformational change: strength of the enzymatic activity.
    Biochemistry, 1994, May-24, Volume: 33, Issue:20

    Topics: Animals; Cattle; Colchicine; Glycerol; Glycols; GTP Phosphohydrolases; Guanosine Diphosphate; Guanosine Triphosphate; Hydrolysis; Polyethylene Glycols; Protein Conformation; Solvents; Spectrometry, Fluorescence; Thermodynamics; Tubulin

1994
Alterations of rings B and C of colchicine are cumulative in overall binding to tubulin but modify each kinetic step.
    Biochemistry, 1996, Dec-10, Volume: 35, Issue:49

    Topics: Biphenyl Compounds; Colchicine; Dimerization; Fluorescence; Kinetics; Models, Chemical; Molecular Structure; Podophyllotoxin; Protein Binding; Thermodynamics; Tropolone; Tubulin

1996
Linkages in tubulin-colchicine functions: the role of the ring C (C') oxygens and ring B in the controls.
    Biochemistry, 1998, Feb-10, Volume: 37, Issue:6

    Topics: Acetamides; Binding, Competitive; Colchicine; Enzyme Induction; GTP Phosphohydrolases; Ligands; Methyl Ethers; Microtubules; Oxygen; Polymers; Protein Binding; Protein Synthesis Inhibitors; Structure-Activity Relationship; Tubulin

1998
Novel allocolchicinoids with an eight membered B-ring: design, synthesis and inhibition of tubulin assembly.
    Bioorganic & medicinal chemistry, 2000, Volume: 8, Issue:3

    Topics: Animals; Antineoplastic Agents; Cattle; Colchicine; Lactams; Magnetic Resonance Spectroscopy; Structure-Activity Relationship; Tubulin; Tubulin Modulators

2000
Application of the palladium-catalyzed borylation/Suzuki coupling (BSC) reaction to the synthesis of biologically active biaryl lactams.
    The Journal of organic chemistry, 2002, Feb-22, Volume: 67, Issue:4

    Topics: Alkaloids; Antineoplastic Agents; Biphenyl Compounds; Boron Compounds; Catalysis; Colchicine; Cyclin-Dependent Kinases; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Humans; Indolizines; Inhibitory Concentration 50; KB Cells; Lactams; Magnetic Resonance Spectroscopy; Molecular Structure; Palladium; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry, Infrared; Spectroscopy, Fourier Transform Infrared; Structure-Activity Relationship; X-Ray Diffraction

2002
Stereoselectivity of the benzannulation reaction: efficient central-to-axial chirality transfer.
    Journal of the American Chemical Society, 2002, Jun-12, Volume: 124, Issue:23

    Topics: Colchicine; Stereoisomerism; Substrate Specificity

2002
Enhanced antitumor activity of irofulven in combination with antimitotic agents.
    Investigational new drugs, 2002, Volume: 20, Issue:3

    Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Bridged-Ring Compounds; Cell Survival; Colchicine; Cysteine; Drug Synergism; Female; Lactones; Macrolides; Mice; Mice, Inbred BALB C; Neoplasm Transplantation; Sesquiterpenes; Taxoids; Tubulin; Tumor Cells, Cultured; Vinca Alkaloids

2002
Antitumor agents. Part 215: antitubulin effects of cytotoxic B-ring modified allocolchicinoids.
    Bioorganic & medicinal chemistry letters, 2002, Oct-21, Volume: 12, Issue:20

    Topics: Antineoplastic Agents; Colchicine; Drug Screening Assays, Antitumor; Humans; Indicators and Reagents; Models, Molecular; Molecular Conformation; Tubulin; Tumor Cells, Cultured

2002
Diels-Alder reaction-aromatization approach toward functionalized ring C allocolchicinoids. Enantioselective total synthesis of (-)-7S-allocolchicine.
    The Journal of organic chemistry, 2003, Jul-25, Volume: 68, Issue:15

    Topics: Colchicine; Indicators and Reagents; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Conformation; Stereoisomerism

2003
Steric vs hydrogen-bonding control of atropisomerization: preparation of either diastereomer of configurationally stable allocolchicinoids.
    The Journal of organic chemistry, 2003, Dec-12, Volume: 68, Issue:25

    Topics: Acetylation; Antineoplastic Agents; Colchicine; Hydrogen Bonding; Hydroquinones; Phenols; Stereoisomerism; Structure-Activity Relationship; Thermodynamics

2003
Allocolchicinoid synthesis via direct arylation.
    Organic letters, 2005, Jul-07, Volume: 7, Issue:14

    Topics: Catalysis; Colchicine; Cyclization; Hydrocarbons, Halogenated; Molecular Structure; Palladium; Stereoisomerism

2005
Application of aryl siloxane cross-coupling to the synthesis of allocolchicinoids.
    Organic letters, 2006, Aug-31, Volume: 8, Issue:18

    Topics: Colchicine; Molecular Structure

2006
Synthesis of allocolchicines using sequential ring-closing enyne metathesis-Diels-Alder reactions.
    Organic letters, 2007, Feb-15, Volume: 9, Issue:4

    Topics: Colchicine; Colchicum; Indicators and Reagents; Magnetic Resonance Spectroscopy

2007
A [2 + 2 + 2]-cycloaddition approach toward 6-oxa-allocolchicinoids with apoptosis-inducing activity.
    Organic letters, 2009, Jan-15, Volume: 11, Issue:2

    Topics: Apoptosis; Catalysis; Cell Line, Tumor; Colchicine; Humans

2009
Synthesis and tubulin-binding properties of new allocolchicinoids.
    Bioorganic chemistry, 2010, Volume: 38, Issue:4

    Topics: Animals; Antimitotic Agents; Colchicine; Protein Binding; Sheep; Tubulin

2010
Intramolecular Nicholas reactions in the synthesis of dibenzocycloheptanes. Synthesis of allocolchicine NSC 51046 and analogues and the formal synthesis of (-)-allocolchicine.
    The Journal of organic chemistry, 2010, Dec-03, Volume: 75, Issue:23

    Topics: Alkynes; Colchicine; Dibenzocycloheptenes; Magnetic Resonance Spectroscopy; Molecular Structure; Propanols; Stereoisomerism

2010
Synthesis and antitumor evaluation of nitrovinyl biphenyls: anticancer agents based on allocolchicines.
    ChemMedChem, 2011, May-02, Volume: 6, Issue:5

    Topics: Antineoplastic Agents; Aurora Kinase B; Aurora Kinases; Biphenyl Compounds; Cell Division; Cell Line, Tumor; Colchicine; Cyclin B1; Drug Screening Assays, Antitumor; G2 Phase; Humans; Neoplasms; Protein Serine-Threonine Kinases; Tubulin; Tubulin Modulators

2011
Synthesis of novel 7-oxo and 7-hydroxy trifluoroallocolchicinoids with cytotoxic effect.
    Bioorganic & medicinal chemistry, 2012, Apr-15, Volume: 20, Issue:8

    Topics: Animals; Cell Proliferation; Colchicine; Crystallography, X-Ray; Cyclization; Dose-Response Relationship, Drug; Humans; KB Cells; Models, Molecular; Molecular Structure; Sheep; Structure-Activity Relationship; Tubulin

2012
An efficient combinatorial synthesis of allocolchicine analogues via a triple cascade reaction and their evaluation as inhibitors of insulin aggregation.
    ChemMedChem, 2013, Volume: 8, Issue:11

    Topics: Animals; Cattle; Circular Dichroism; Colchicine; Combinatorial Chemistry Techniques; Insulin Antagonists; Microscopy, Atomic Force; Molecular Structure; Protein Binding; Stereoisomerism

2013
Novel analogue of colchicine induces selective pro-death autophagy and necrosis in human cancer cells.
    PloS one, 2014, Volume: 9, Issue:1

    Topics: Animals; Antineoplastic Agents; Autophagy; Blotting, Western; Cell Proliferation; Cells, Cultured; Colchicine; Fibroblasts; Humans; Leukemia, T-Cell; Male; Mice; Mice, Nude; Microtubules; Mitochondria; Necrosis; Pancreatic Neoplasms; Reactive Oxygen Species; Tubulin

2014
Synthesis and biological evaluation of furanoallocolchicinoids.
    Journal of medicinal chemistry, 2015, Jan-22, Volume: 58, Issue:2

    Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Colchicine; Furans; Humans; Mice; Mice, Inbred C57BL; Microtubules; Models, Molecular; Structure-Activity Relationship; Tubulin Modulators

2015
Synthesis and biological evaluation of novel non-racemic indole-containing allocolchicinoids.
    European journal of medicinal chemistry, 2017, Dec-01, Volume: 141

    Topics: Antineoplastic Agents; Apoptosis; Cell Cycle Checkpoints; Cell Proliferation; Colchicine; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Indoles; Molecular Docking Simulation; Molecular Structure; Structure-Activity Relationship; Tumor Cells, Cultured

2017
chemdatabank.com