zln005 and Dyslipidemias

zln005 has been researched along with Dyslipidemias* in 1 studies

Other Studies

1 other study(ies) available for zln005 and Dyslipidemias

ArticleYear
Novel small-molecule PGC-1α transcriptional regulator with beneficial effects on diabetic db/db mice.
    Diabetes, 2013, Volume: 62, Issue:4

    Peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) has been shown to influence energy metabolism. Hence, we explored a strategy to target PGC-1α expression to treat metabolic syndromes. We developed a high-throughput screening assay that uses the human PGC-1α promoter to drive expression of luciferase. The effects of lead compound stimulation on PGC-1α expression in muscle cells and hepatocytes were investigated in vitro and in vivo. A novel small molecule, ZLN005, led to changes in PGC-1α mRNA levels, glucose uptake, and fatty acid oxidation in L6 myotubes. Activation of AMP-activated protein kinase was involved in the induction of PGC-1α expression. In diabetic db/db mice, chronic administration of ZLN005 increased PGC-1α and downstream gene transcription in skeletal muscle, whereas hepatic PGC-1α and gluconeogenesis genes were reduced. ZLN005 increased fat oxidation and improved the glucose tolerance, pyruvate tolerance, and insulin sensitivity of diabetic db/db mice. Hyperglycemia and dyslipidemia also were ameliorated after treatment with ZLN005. Our results demonstrated that a novel small molecule selectively elevated the expression of PGC-1α in myotubes and skeletal muscle and exerted promising therapeutic effects for treating type 2 diabetes.

    Topics: Adipose Tissue; Animals; Benzimidazoles; Dyslipidemias; Gene Expression Regulation; Gluconeogenesis; Glucose Intolerance; HEK293 Cells; Humans; Hyperglycemia; Hypoglycemic Agents; Liver; Male; Mice; Mice, Inbred NOD; Molecular Structure; Muscle Fibers, Skeletal; Muscle, Skeletal; Oxidation-Reduction; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Random Allocation; Trans-Activators; Transcription Factors

2013