saucerneol d

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

saucerneol D: has antioxidant, anti-infllammatory, and antiasthmatic activities; a sesquilignan isolated from Saururus chinensis; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Flora	Rank	Flora Definition	Family	Family Definition
Saururus	genus	[no description available]	Saururaceae	A plant family of the order Piperales, subclass Magnoliidae class Magnoliopsida. Members contain sauristolactam, and aristololactam BII.[MeSH]

Cross-References

ID Source	ID
PubMed CID	44580018
CHEMBL ID	520077
MeSH ID	M0561489

Synonyms (2)

Synonym
CHEMBL520077
saucerneol d

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (6)

Assay ID	Title	Year	Journal	Article
AID391880	Cytotoxicity against human HT29 cells by MTT assay	2008	Journal of natural products, Oct, Volume: 71, Issue:10	Lignans from the roots of Saururus chinensis.
AID1063358	Cytotoxicity against human P3HR1 cells assessed as cell viability after 2 days by trypan blue staining-based light microscopy	2014	Journal of natural products, Jan-24, Volume: 77, Issue:1	Potential antiviral lignans from the roots of Saururus chinensis with activity against Epstein-Barr virus lytic replication.
AID1063359	Antiviral activity against EBV infected in human P3HR1 cells assessed as inhibition of lytic viral DNA replication after 48 hrs by RT-PCR analysis	2014	Journal of natural products, Jan-24, Volume: 77, Issue:1	Potential antiviral lignans from the roots of Saururus chinensis with activity against Epstein-Barr virus lytic replication.
AID1063357	Selectivity index, ratio of CC50 for human P3HR1 cells to EC50 for EBV infected in human P3HR1 cells	2014	Journal of natural products, Jan-24, Volume: 77, Issue:1	Potential antiviral lignans from the roots of Saururus chinensis with activity against Epstein-Barr virus lytic replication.
AID391881	Cytotoxicity against human HEPG2 cells by MTT assay	2008	Journal of natural products, Oct, Volume: 71, Issue:10	Lignans from the roots of Saururus chinensis.
AID391882	Cytotoxicity against human MCF7 cells by MTT assay	2008	Journal of natural products, Oct, Volume: 71, Issue:10	Lignans from the roots of Saururus chinensis.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (16.67)	29.6817
2010's	5 (83.33)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 13.26

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	13.26 (24.57)
Research Supply Index	1.95 (2.92)
Research Growth Index	5.21 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (13.26)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	6 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
camptothecin NSC 100880: carboxylate (opened lactone) form of camptothecin; RN refers to (S)-isomer; structure given in first source	2.04	1	delta-lactone; pyranoindolizinoquinoline; quinoline alkaloid; tertiary alcohol	antineoplastic agent; EC 5.99.1.2 (DNA topoisomerase) inhibitor; genotoxin; plant metabolite
lignans Lignans: A class of dibenzylbutane derivatives which occurs in higher plants and in fluids (bile, serum, urine, etc.) in man and other animals. These compounds, which have a potential anti-cancer role, can be synthesized in vitro by human fecal flora. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)	2.99	4
leukotriene c4 Leukotriene C4: The conjugation product of LEUKOTRIENE A4 and glutathione. It is the major arachidonic acid metabolite in macrophages and human mast cells as well as in antigen-sensitized lung tissue. It stimulates mucus secretion in the lung, and produces contractions of nonvascular and some VASCULAR SMOOTH MUSCLE. (From Dictionary of Prostaglandins and Related Compounds, 1990). leukotriene C4 : A leukotriene that is (5S,7E,9E,11Z,14Z)-5-hydroxyicosa-7,9,11,14-tetraenoic acid in which a glutathionyl group is attached at position 6 via a sulfide linkage.	2.07	1	leukotriene	bronchoconstrictor agent; human metabolite; mouse metabolite
manassantin b manassantin B: isolated from the roots of Saururus chinensis; structure in first source. manassantin B : A lignan isolated from Saururus cernuus and Saururus chinensis and has been shown to exhibit antineoplastic activity.	2.1	1	benzodioxoles; dimethoxybenzene; lignan; oxolanes; secondary alcohol	antineoplastic agent; metabolite

Condition	Relationship Strength	Studies
Asthma, Bronchial [description not available]	2.06	1
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	2.06	1
Experimental Lung Inflammation Inflammation of any part, segment or lobe, of the lung parenchyma.	2.06	1
Asthma A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).	7.06	1
Pneumonia Infection of the lung often accompanied by inflammation.	2.06	1
Hypermelanosis [description not available]	2.06	1
Malignant Melanoma [description not available]	2.06	1
B16 Melanoma [description not available]	2.06	1
Melanoma A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)	2.06	1
Hyperpigmentation Excessive pigmentation of the skin, usually as a result of increased epidermal or dermal melanin pigmentation, hypermelanosis. Hyperpigmentation can be localized or generalized. The condition may arise from exposure to light, chemicals or other substances, or from a primary metabolic imbalance.	2.06	1

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