Compounds > remikiren
Page last updated: 2024-12-06

remikiren

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID SourceID
PubMed CID73611
CHEMBL ID443114
CHEBI ID9185
MeSH IDM0180288

Synonyms (26)

Synonym
solamargine
AC1L2K61 ,
CHEMBL443114
chebi:9185 ,
unii-8kg991e7bn
beta-d-glucopyranoside, (3beta,22alpha,25r)-spirosol-5-en-3-yl o-6-deoxy-alpha-l-mannopyranosyl-(1-2)-o-(6-deoxy-alpha-l-mannopyranosyl-(1-4))-
nsc 407810
8kg991e7bn ,
S9145
solamargin
|a-solanigrine
solamargine, (-)-
beta.-d-glucopyranoside, (3.beta.,22.alpha.,25r)-spirosol-5-en-3-yl o-6-deoxy-.alpha.-l-mannopyranosyl-(1->2)-o-(6-deoxy-.alpha.-l-mannopyranosyl-(1->4))-
.delta.-solanigrine
(-)-solamargine
.alpha.-solamargine
HY-N0069
AKOS030526705
AS-75093
mfcd30207844
DB12700
Q3489126
DTXSID00942456
o-solanigrine
(2s,3r,4r,5r,6s)-2-[(2r,3s,4s,5r,6r)-4-hydroxy-2-(hydroxymethyl)-6-[(1s,2s,4s,5'r,6r,7s,8r,9s,12s,13r,16s)-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.02,9.04,8.013,18]icos-18-ene-6,2'-piperidine]-16-yl]oxy-5-[(2s,3r,4r,5r,6s)-3,4,5-trihydroxy-6-met
CCG-270542
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (3)

ClassDescription
azaspiro compoundAn azaspiro compound is a spiro compound in which at least one of the cyclic components is a nitrogen heterocyle.
steroidAny of naturally occurring compounds and synthetic analogues, based on the cyclopenta[a]phenanthrene carbon skeleton, partially or completely hydrogenated; there are usually methyl groups at C-10 and C-13, and often an alkyl group at C-17. By extension, one or more bond scissions, ring expansions and/or ring contractions of the skeleton may have occurred. Natural steroids are derived biogenetically from squalene which is a triterpene.
oxaspiro compoundA spiro compound in which at least one of the cyclic components is an oxygen heterocyle.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (27)

Assay IDTitleYearJournalArticle
AID277388Suppression of gastric emptying in CMC-Na-loaded mouse at 25 mg/kg, po after 30 mins2007Journal of natural products, Feb, Volume: 70, Issue:2
Structures of steroidal alkaloid oligoglycosides, robeneosides A and B, and antidiabetogenic constituents from the Brazilian medicinal plant Solanum lycocarpum.
AID1076273Cytotoxicity against human HL-7702 cells assessed as cell viability after 24 hrs by MTT assay2014Bioorganic & medicinal chemistry letters, Mar-15, Volume: 24, Issue:6
Synthesis and cytotoxic effect of pseudodiosgenyl saponins with thio-ring F.
AID277372Inhibition of increase in serum glucose level in sucrose-loaded Wistar rat at 100 mg/kg, po after 1 hr2007Journal of natural products, Feb, Volume: 70, Issue:2
Structures of steroidal alkaloid oligoglycosides, robeneosides A and B, and antidiabetogenic constituents from the Brazilian medicinal plant Solanum lycocarpum.
AID277371Inhibition of increase in serum glucose level in sucrose-loaded Wistar rat at 50 mg/kg, po after 1 hr2007Journal of natural products, Feb, Volume: 70, Issue:2
Structures of steroidal alkaloid oligoglycosides, robeneosides A and B, and antidiabetogenic constituents from the Brazilian medicinal plant Solanum lycocarpum.
AID1331821Antimigratory activity in human HepG2 cells at 4.5 uM after 24 hrs by wound healing assay2016European journal of medicinal chemistry, Nov-29, Volume: 124Synthesis and anti-metastatic effects of pregn-17(20)-en-3-amine derivatives.
AID1076274Cytotoxicity against human A549 cells assessed as cell viability after 24 hrs by MTT assay2014Bioorganic & medicinal chemistry letters, Mar-15, Volume: 24, Issue:6
Synthesis and cytotoxic effect of pseudodiosgenyl saponins with thio-ring F.
AID277370Inhibition of increase in serum glucose level in sucrose-loaded Wistar rat at 25 mg/kg, po after 1 hr2007Journal of natural products, Feb, Volume: 70, Issue:2
Structures of steroidal alkaloid oligoglycosides, robeneosides A and B, and antidiabetogenic constituents from the Brazilian medicinal plant Solanum lycocarpum.
AID594549Cytotoxicity against human HL-7702 by MTT assay2011Bioorganic & medicinal chemistry letters, May-15, Volume: 21, Issue:10
Total synthesis of solamargine.
AID277374Inhibition of increase in serum glucose level in sucrose-loaded Wistar rat at 50 mg/kg, po after 2 hrs2007Journal of natural products, Feb, Volume: 70, Issue:2
Structures of steroidal alkaloid oligoglycosides, robeneosides A and B, and antidiabetogenic constituents from the Brazilian medicinal plant Solanum lycocarpum.
AID594494Cytotoxicity against human A549 cells by MTT assay2011Bioorganic & medicinal chemistry letters, May-15, Volume: 21, Issue:10
Total synthesis of solamargine.
AID1331822Anti-invasive activity in human HepG2 cells at 4.5 uM after 24 hrs by MTT dye based boyden chamber assay2016European journal of medicinal chemistry, Nov-29, Volume: 124Synthesis and anti-metastatic effects of pregn-17(20)-en-3-amine derivatives.
AID1076275Cytotoxicity against human HepG2 cells assessed as cell viability after 24 hrs by MTT assay2014Bioorganic & medicinal chemistry letters, Mar-15, Volume: 24, Issue:6
Synthesis and cytotoxic effect of pseudodiosgenyl saponins with thio-ring F.
AID1076276Cytotoxicity against human MCF7 cells assessed as cell viability after 24 hrs by MTT assay2014Bioorganic & medicinal chemistry letters, Mar-15, Volume: 24, Issue:6
Synthesis and cytotoxic effect of pseudodiosgenyl saponins with thio-ring F.
AID277369Inhibition of increase in serum glucose level in sucrose-loaded Wistar rat at 100 mg/kg, po after 0.5 hrs2007Journal of natural products, Feb, Volume: 70, Issue:2
Structures of steroidal alkaloid oligoglycosides, robeneosides A and B, and antidiabetogenic constituents from the Brazilian medicinal plant Solanum lycocarpum.
AID594546Cytotoxicity against human HCT116 cells by MTT assay2011Bioorganic & medicinal chemistry letters, May-15, Volume: 21, Issue:10
Total synthesis of solamargine.
AID277368Inhibition of increase in serum glucose level in sucrose-loaded Wistar rat at 50 mg/kg, po after 0.5 hrs2007Journal of natural products, Feb, Volume: 70, Issue:2
Structures of steroidal alkaloid oligoglycosides, robeneosides A and B, and antidiabetogenic constituents from the Brazilian medicinal plant Solanum lycocarpum.
AID594550Cytotoxicity against rat H9c2 cells by MTT assay2011Bioorganic & medicinal chemistry letters, May-15, Volume: 21, Issue:10
Total synthesis of solamargine.
AID594544Cytotoxicity against human MCF7 cells by MTT assay2011Bioorganic & medicinal chemistry letters, May-15, Volume: 21, Issue:10
Total synthesis of solamargine.
AID277373Inhibition of increase in serum glucose level in sucrose-loaded Wistar rat at 25 mg/kg, po after 2 hrs2007Journal of natural products, Feb, Volume: 70, Issue:2
Structures of steroidal alkaloid oligoglycosides, robeneosides A and B, and antidiabetogenic constituents from the Brazilian medicinal plant Solanum lycocarpum.
AID277389Suppression of gastric emptying in CMC-Na-loaded mouse at 50 mg/kg, po after 30 mins2007Journal of natural products, Feb, Volume: 70, Issue:2
Structures of steroidal alkaloid oligoglycosides, robeneosides A and B, and antidiabetogenic constituents from the Brazilian medicinal plant Solanum lycocarpum.
AID594545Cytotoxicity against human K562 cells by MTT assay2011Bioorganic & medicinal chemistry letters, May-15, Volume: 21, Issue:10
Total synthesis of solamargine.
AID594547Cytotoxicity against human U87 cells by MTT assay2011Bioorganic & medicinal chemistry letters, May-15, Volume: 21, Issue:10
Total synthesis of solamargine.
AID277367Inhibition of increase in serum glucose level in sucrose-loaded Wistar rat at 25 mg/kg, po after 0.5 hrs2007Journal of natural products, Feb, Volume: 70, Issue:2
Structures of steroidal alkaloid oligoglycosides, robeneosides A and B, and antidiabetogenic constituents from the Brazilian medicinal plant Solanum lycocarpum.
AID277375Inhibition of increase in serum glucose level in sucrose-loaded Wistar rat at 100 mg/kg, po after 2 hrs2007Journal of natural products, Feb, Volume: 70, Issue:2
Structures of steroidal alkaloid oligoglycosides, robeneosides A and B, and antidiabetogenic constituents from the Brazilian medicinal plant Solanum lycocarpum.
AID594548Cytotoxicity against human HepG2 cells by MTT assay2011Bioorganic & medicinal chemistry letters, May-15, Volume: 21, Issue:10
Total synthesis of solamargine.
AID357519Cytotoxicity against human PLC/PRF/5 cells by microassay
AID594493Cytotoxicity against human HeLa cells by MTT assay2011Bioorganic & medicinal chemistry letters, May-15, Volume: 21, Issue:10
Total synthesis of solamargine.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (4)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (25.00)29.6817
2010's3 (75.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 32.80

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index32.80 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.92 (4.65)
Search Engine Demand Index39.34 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (32.80)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one: specific inhibitor of phosphatidylinositol 3-kinase; structure in first source		2.1310chromones;
morpholines;
organochlorine compound		autophagy inhibitor;
EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor;
geroprotector
metformin
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289). metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.		2.0310guanidinesenvironmental contaminant;
geroprotector;
hypoglycemic agent;
xenobiotic
tolbutamide
Tolbutamide: A sulphonylurea hypoglycemic agent with actions and uses similar to those of CHLORPROPAMIDE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p290). tolbutamide : An N-sulfonylurea that consists of 1-butylurea having a tosyl group attached at the 3-position.		2.0310N-sulfonylureahuman metabolite;
hypoglycemic agent;
insulin secretagogue;
potassium channel blocker
zstk474
ZSTK-474 : A triamino-1,3,5-triazine that is 1,3,5-triazine in which two of the hydrogens have been replaced by morpholin-4-yl groups while the third hydrogen has been replaced by a 2-(difluoromethyl)benzimidazol-1-yl group. It is an inhibitor of phosphatidylinositol 3-kinase.		2.1310benzimidazoles;
morpholines;
organofluorine compound;
triamino-1,3,5-triazine		antineoplastic agent;
EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor
ConditionIndicatedRelationship StrengthStudiesTrials
Metastase
[description not available]		02.1310
Neoplasm Metastasis
The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.		02.1310