Page last updated: 2024-11-13

pukalide

Description

pukalide: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Synonym
pukalide
CHEMBL300390
SCHEMBL1760554
methyl (2r,4s,6r,12s)-4-methyl-8-oxo-12-prop-1-en-2-yl-3,7,17-trioxatetracyclo[12.2.1.16,9.02,4]octadeca-1(16),9(18),14-triene-15-carboxylate

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Assay ID	Title	Year	Journal	Article
AID145335	In vitro ability to inhibit the binding of [125I]alpha-bungarotoxin to nicotinic acetylcholine receptor on membranes prepared from the electric organs of Torpedo californica; Not active	1991	Journal of medicinal chemistry, Jun, Volume: 34, Issue:6	Structure/activity and molecular modeling studies of the lophotoxin family of irreversible nicotinic receptor antagonists.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	1 (16.67)	18.2507
2000's	4 (66.67)	29.6817
2010's	1 (16.67)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	6 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
homarine homarine: structure	2.03	1	non-proteinogenic alpha-amino acid
furan furan : A monocyclic heteroarene with a structure consisting of a 5-membered ring containing four carbons and one oxygen, with formula C4H4O. It is a toxic, flammable, low-boiling (31degreeC) colourless liquid.	7.45	2	furans; mancude organic heteromonocyclic parent; monocyclic heteroarene	carcinogenic agent; hepatotoxic agent; Maillard reaction product
perillyl alcohol perillyl alcohol: inhibits geranylgeranyl transferase; structure in first source. perillyl alcohol : A limonene monoterpenoid consists of a cyclohexene ring substituted by a hydroxymethyl and a prop-1-en-2-yl group at positions 1 and 4 respectively. It is a constituent of a variety of essential oils including lavender.	2.15	1	limonene monoterpenoid	plant metabolite; volatile oil component
lophotoxin lophotoxin: belongs to the cembrene class of diterpenoids; neuromuscular toxin isolated from several pacific gorgonians of the genus Lophogorgia; RN given refers to (1R-(1R,2S,4S,10R,12R,14R,15R*))-isomer; structure given in first source	7.01	1