lophotoxin: belongs to the cembrene class of diterpenoids; neuromuscular toxin isolated from several pacific gorgonians of the genus Lophogorgia; RN given refers to (1R-(1R*,2S*,4S*,10R*,12R*,14R*,15R*))-isomer; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 108179 |
| MeSH ID | M0095953 |
| Synonym |
|---|
| lophotoxin |
| 78697-56-0 |
| 11,16,18,19-tetraoxapentacyclo(12.2.2.1(sup 6,9).0(sup 1,15).0(10,12))nonadeca-6,8-diene-7-carboxaldehyde, 2-(acetyloxy)-12-methyl-4-(1-methylethenyl)-17-oxo-, (1r-(1r*,2s*,4s*,10r*,12r*,14r*,15r*))- |
| 11,16,18,19-tetraoxapentacyclo(12.2.2.16,9.01,15.010,12)nonadeca-6,8-diene-7-carboxaldehyde, 2-(acetyloxy)-12-methyl-4-(1-methylethenyl)-17-oxo-, (1r-(1r*,2s*,4s*,10r*,12r*,14r*,15r*))- |
| brn 4339458 |
| 11,16,18,19-tetraoxapentacyclo(12.2.2.16,9.01,15.010,12)nonadeca-6,8-diene-7-carboxaldehyde, 2-(acetyloxy)-12-methyl-4-(1-methylethenyl)-17-oxo-, (1r,2s,4s,10r,12r,14r,15r)- |
| 6ll2iet058 , |
| unii-6ll2iet058 |
| lophotoxin [mi] |
| (22r,23r,41r,44r,45r,5s,7s)-14-formyl-23-methyl-42-oxo-7-(prop-1-en-2-yl)-43,46-dioxa-1(2,5)-furana-2(2,3)-oxirana-4(4,1)-bicyclo[3.1.0]hexanacyclooctaphane-5-yl acetate |
| [(1r,2s,4s,10r,12r,14r,15r)-7-formyl-12-methyl-17-oxo-4-prop-1-en-2-yl-11,16,18,19-tetraoxapentacyclo[12.2.2.16,9.01,15.010,12]nonadeca-6,8-dien-2-yl] acetate |
| AKOS040752671 |
Lophotoxin is a diterpene lactone isolated from gorgonian corals. It inhibits agonist binding to nicotinic acetylcholine receptors by reacting covalently with Tyr190.
| Excerpt | Reference | Relevance |
|---|---|---|
| "Lophotoxin is a small cyclic diterpene that irreversibly inhibits agonist binding to nicotinic acetylcholine receptors by reacting covalently with Tyr190 in the alpha-subunits of the receptor. " | ( Structure/activity and molecular modeling studies of the lophotoxin family of irreversible nicotinic receptor antagonists. Abramson, SN; Fenical, W; Harold, EE; Tapiolas, DM; Taylor, P; Trischman, JA, 1991) | 1.97 |
| "Lophotoxin is a diterpene lactone isolated from gorgonian corals. " | ( Lophotoxin: selective blockade of nicotinic transmission in autonomic ganglia by a coral neurotoxin. Chiappinelli, VA; Culver, P; Sorenson, EM, 1987) | 3.16 |
| Excerpt | Reference | Relevance |
|---|---|---|
| "Lophotoxin has also been shown to block nicotinic transmission in autonomic ganglia of the frog and in ileal strips of guinea pig and rabbit." | ( Lophotoxin: selective blockade of nicotinic transmission in autonomic ganglia by a coral neurotoxin. Chiappinelli, VA; Culver, P; Sorenson, EM, 1987) | 2.44 |
| Excerpt | Relevance | Reference |
|---|---|---|
| " ACh dose-response curves suggested that his inhibition was noncompetitive." | ( Diterpenoids from Caribbean gorgonians act as noncompetitive inhibitors of the nicotinic acetylcholine receptor. Eterović, VA; Ferchmin, PA; Hann, RM; Lee, YH; Li, L; McNamee, MG; Rodriguez, AD, 1993) | 0.29 |
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 11 (47.83) | 18.7374 |
| 1990's | 10 (43.48) | 18.2507 |
| 2000's | 2 (8.70) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| This Compound (21.57) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 3 (13.04%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 20 (86.96%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||