necic-acid and senecionine

necic-acid has been researched along with senecionine* in 1 studies

Other Studies

1 other study(ies) available for necic-acid and senecionine

Article	Year
Transfer of [3H]pyrrolizidine alkaloids from Senecio vulgaris L. and metabolites into rat milk and tissues. Toxicology letters, 1983, Volume: 17, Issue:3-4 [3H]Retronecine and [3H]necic acid-labelled senecionine and seneciphylline were prepared biosynthetically with seedlings of Senecio vulgaris L. using [2,3-3H]putrescine and [4,5-3H]isoleucine, respectively, as precursors. Lactating rats dosed with these differently labelled pyrrolizidine alkaloids (PAs) excreted within 3 h approx. 0.08% of the applied radioactivity in the milk mainly as yet not identified water-soluble retronecine-derived metabolites and with approx. 0.02% as unchanged PAs. Highest tissue levels of PAs and metabolites, 6 h after administration, were found in liver and lungs. Topics: Animals; Dicarboxylic Acids; Female; Kinetics; Milk; Plants, Toxic; Pregnancy; Pyrrolizidine Alkaloids; Rats; Senecio; Tissue Distribution; Tritium	1983

Article

Year

Transfer of [3H]pyrrolizidine alkaloids from Senecio vulgaris L. and metabolites into rat milk and tissues.

Toxicology letters, 1983, Volume: 17, Issue:3-4

[3H]Retronecine and [3H]necic acid-labelled senecionine and seneciphylline were prepared biosynthetically with seedlings of Senecio vulgaris L. using [2,3-3H]putrescine and [4,5-3H]isoleucine, respectively, as precursors. Lactating rats dosed with these differently labelled pyrrolizidine alkaloids (PAs) excreted within 3 h approx. 0.08% of the applied radioactivity in the milk mainly as yet not identified water-soluble retronecine-derived metabolites and with approx. 0.02% as unchanged PAs. Highest tissue levels of PAs and metabolites, 6 h after administration, were found in liver and lungs.

Topics: Animals; Dicarboxylic Acids; Female; Kinetics; Milk; Plants, Toxic; Pregnancy; Pyrrolizidine Alkaloids; Rats; Senecio; Tissue Distribution; Tritium

1983