N,N-dimethylaminoisopropanol: RN given refers to parent cpd without isomeric designation [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 37511 |
| CHEMBL ID | 3186209 |
| SCHEMBL ID | 8389 |
| MeSH ID | M0099734 |
| Synonym |
|---|
| 108-16-7 |
| nsc-3163 |
| n,n-(dimethylamino)-2-propanol |
| dimethylisopropanolamine |
| 2-propanol,1-(dimethylamino)- |
| wln: qy1 & 1n1 & 1 |
| nsc3163 |
| n,n-dimethyl-2-hydroxypropylamine |
| dimethyl(2-hydroxypropyl)amine |
| 1,1-(dimethylamino)propanol-2 |
| 1-(dimethylamino)-2-propanol |
| n,n-dimethylisopropanolamine |
| 2-propanol, 1-(dimethylamino)- |
| dimepranol [inn] |
| einecs 203-556-4 |
| ai3-18202 |
| 2-propanol, 1,1-(dimethylamino)- |
| nsc 3163 |
| brn 1209244 |
| n,n-dimethylaminoisopropanol |
| 1,1-dimethylaminopropanol-2 |
| dimepranolum [inn-latin] |
| 1-(dimethylamino)propan-2-ol |
| 1-dimethylamino-2-propanol, >=99% |
| NCGC00166041-01 |
| dimepranol |
| 1-dimethylamino-2-propanol |
| D0660 |
| dtxsid5031210 , |
| tox21_112297 |
| dtxcid3011210 |
| cas-108-16-7 |
| AKOS005206825 |
| 4-04-00-01666 (beilstein handbook reference) |
| unii-ox17195h4t |
| ec 203-556-4 |
| ox17195h4t , |
| dimepranolum |
| FT-0640183 |
| FT-0605825 |
| 1-dimethylamino-propan-2-ol |
| 1-dimethylaminopropan-2-ol |
| 1-(n,n-dimethylamino)-2-propanol |
| 1-dimethyamino-2-propanol |
| racemic 1-dimethylamino-2-propanol |
| SCHEMBL8389 |
| dimethyl isopropanolamine |
| (+/-)-1-(n,n-dimethylamino)-2-propanol |
| n,n-dimethylamino-2-propanol |
| 1-methyl-2-(dimethylamino)ethanol |
| n,n-dimethyl-2-hydroxy-1-propanamine |
| dimethyl isopropanolamine [inci] |
| 2-(dimethylamino)-1-methylethanol |
| dl-1-(dimethylamino)-2-propanol |
| 3-(dimethylamino)-2-propanol |
| dma-2p |
| 2-propanol, 1-(dimethylamino)-, (+/-)- |
| extendex 50 |
| 2-(dimethylamino)-1-methyl-1-ethanol |
| (+/-)-1-(dimethylamino)-2-propanol |
| 3-dimethylamino-2-propanol |
| 1,1-dimethylaminopropan-2-ol |
| W-108726 |
| CHEMBL3186209 |
| mfcd00004532 |
| SR-01000944920-1 |
| sr-01000944920 |
| 1-dimethylamino-2-propanol, 99% |
| Q26841310 |
| AMY13331 |
| SB74230 |
| SB46768 |
| BS-22423 |
| 1-dimethylamino-2-propanol(dimepranol) |
| 2-propanol, 1-[di(methyl-d3)amino]- |
| mfcd00065951 |
| (r)-1-(dimethylamino)-2-propanol |
| SY164931 |
| Excerpt | Reference | Relevance |
|---|---|---|
| "The ATP-binding cassette transporter P-glycoprotein (P-gp) is known to limit both brain penetration and oral bioavailability of many chemotherapy drugs." | ( A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Ambudkar, SV; Brimacombe, KR; Chen, L; Gottesman, MM; Guha, R; Hall, MD; Klumpp-Thomas, C; Lee, OW; Lee, TD; Lusvarghi, S; Robey, RW; Shen, M; Tebase, BG, 2019) | 0.51 |
| Excerpt | Relevance | Reference |
|---|---|---|
| " This metabolite accounted for 50% of the administered dose in orally dosed animals and 31% in iv dosed animals." | ( Inosiplex: metabolism and excretion of the dimethylaminoisopropanol and p-acetamidobenzoic acid components in rhesus monkeys. Pfadenhauer, EH; Streeter, DG, ) | 0.13 |
| Protein | Taxonomy | Measurement | Average (µ) | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 16.5880 | 0.0002 | 29.3054 | 16,493.5996 | AID743075; AID743079 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID504749 | qHTS profiling for inhibitors of Plasmodium falciparum proliferation | 2011 | Science (New York, N.Y.), Aug-05, Volume: 333, Issue:6043 | Chemical genomic profiling for antimalarial therapies, response signatures, and molecular targets. |
| AID1296008 | Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening | 2020 | SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1 | Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening. |
| AID1346986 | P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5 | A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1346987 | P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5 | A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 1 (14.29) | 18.7374 |
| 1990's | 1 (14.29) | 18.2507 |
| 2000's | 2 (28.57) | 29.6817 |
| 2010's | 2 (28.57) | 24.3611 |
| 2020's | 1 (14.29) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.57) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 8 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||