n-methyldiethanolamine profile

N-methyldiethanolamine (MDEA) is a tertiary amine used as a solvent in gas purification processes, particularly for removing carbon dioxide (CO2) and hydrogen sulfide (H2S) from natural gas and other industrial gas streams. It is synthesized through the reaction of diethanolamine (DEA) with formaldehyde and hydrogen. MDEA exhibits a high selectivity for acidic gases like CO2 and H2S, making it an efficient absorbent. The amine's high basicity facilitates the absorption of these gases, while its relatively low vapor pressure ensures minimal losses during regeneration. MDEA's chemical properties, including its ability to form stable carbamates with CO2, contribute to its effectiveness in gas purification. The use of MDEA in gas processing plays a crucial role in enhancing the quality of natural gas, reducing greenhouse gas emissions, and improving the efficiency of various industrial processes. Extensive research focuses on optimizing MDEA-based absorption processes, studying its reaction kinetics, and exploring novel applications. These studies aim to enhance the efficiency, selectivity, and sustainability of gas purification technologies, with a focus on reducing environmental impact and minimizing energy consumption.'

ID Source	ID
PubMed CID	7767
CHEMBL ID	3185149
SCHEMBL ID	17605
MeSH ID	M0052273

Synonym
AKOS009031354
LS-13102
nsc-49131
nsc51500
nsc49131
nsc-51500
ethanol,2'-(methylimino)bis-
methylbis(2-hydroxyethyl)amine
n-methylimino-2,2'-diethanol
n-methyl-2,2'-iminodiethanol
methyldiethanolamine
diethanolmethylamine
n,n-bis(2-hydroxyethyl)methylamine
nsc-11690
bis(2-hydroxyethyl) methyl amine
wln: q2n1 & 2q
nsc11690
n-methyliminodiethanol
2,2'-(methylimino)diethanol
105-59-9
usaf do-52
methyliminodiethanol
n-methyldiethanolamine
ethanol,2'-(methylimino)di-
ethanol, 2,2'-(methylimino)bis-
bis(2-hydroxyethyl)methylamine
brn 1734441
n-methyldiethanolimine
methyl diethanolamine
einecs 203-312-7
2-(n-2-hydroxyethyl-n-methylamino)ethanol
ethanol, 2,2'-(methylimino)di-
n-methylaminodiglycol
n,n-di(2-hydroxyethyl)-n-methylamine
2,2'-methyliminodiethanol
nsc 11690
ccris 4843
inchi=1/c5h13no2/c1-6(2-4-7)3-5-8/h7-8h,2-5h2,1h
n-methyldiethanolamine, >=99%
591248-66-7
2-[2-hydroxyethyl(methyl)amino]ethanol
FT-0663293
NCGC00248955-01
NCGC00258751-01
cas-105-59-9
dtxcid605591
dtxsid8025591 ,
tox21_201199
M0505
n-methyl-diethanolamine
STL281951
unii-3ig3k131qj
hsdb 6804
3ig3k131qj ,
4-04-00-01517 (beilstein handbook reference)
ec 203-312-7
bis(hydroxyethyl)methylamine
methyldiethanolamine, n-
amino alcohol mda
n-methyl-n,n-bis(2-hydroxyethyl)amine
n-methyldiethanolamine [hsdb]
methyl diethanolamine [inci]
2,2'-(methylimino)bis(ethanol)
SCHEMBL17605
2-[(2-hydroxyethyl)(methyl)amino]ethan-1-ol
n-methyl diethanolamine
2-[(2-hydroxy-ethyl)methyl-amino]-ethanol
di(hydroxyethyl)methylamine
methyl diethanol amine
n-methyl diethanol-amine
mdea (diol)
n-methyl-diethanol amine
n-(2-hydroxyethyl)-n-methylethanolam
n-methyl-2,2-iminodiethanol
CHEMBL3185149
bis-(hydroxyethyl)methylamine
mfcd00002848
J-523676
n-methyldethanolamne
n-methyldiethanolamine, 99%
n-methyldiethanolamine 1000 microg/ml in ammonium hydroxide
2,2'-(methylazanediyl)diethanol
n,n-bis-(2-hydroxyethyl)-methylamine
Q252344
2-hydroxy-1-[(2-hydroxyethyl)methylamino]-ethyl
AT34020
2,2'-(methylazanediyl)bis(ethan-1-ol)

Excerpt	Reference	Relevance
" The effect of contact time, temperature, and amine concentration on the rate of absorption and the selectivity were studied by absorption experiments in a wetted wall column at atmospheric pressure and constant feed gas ratio."	( Simultaneous absorption of CO2 and H2S into aqueous blends of N-methyldiethanolamine and diethanolamine. Bandyopadhyay, SS; Mandald, B, 2006)	0.57
"Three kinds of blended absorbents were investigated on bench-scale experimental bench according to absorption rate and regeneration grade to select a reasonable additive concentration."	( [Study of new blended chemical absorbents to absorb CO2]. Cen, KF; Fang, MX; Luo, ZY; Wang, JL; Yan, SP, 2007)	0.34

Protein	Taxonomy	Measurement	Average (µ)	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
retinoic acid nuclear receptor alpha variant 1	Homo sapiens (human)	Potency	54.7624	0.0030	41.6115	22,387.1992	AID1159552; AID1159555
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	3 (13.04)	18.2507
2000's	7 (30.43)	29.6817
2010's	9 (39.13)	24.3611
2020's	4 (17.39)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	23 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
carbamates [no description available]	2.1	1	amino-acid anion
hydrogen sulfide Hydrogen Sulfide: A flammable, poisonous gas with a characteristic odor of rotten eggs. It is used in the manufacture of chemicals, in metallurgy, and as an analytical reagent. (From Merck Index, 11th ed). hydrogen sulfide : A sulfur hydride consisting of a single sulfur atom bonded to two hydrogen atoms. A highly poisonous, flammable gas with a characteristic odour of rotten eggs, it is often produced by bacterial decomposition of organic matter in the absence of oxygen.. thiol : An organosulfur compound in which a thiol group, -SH, is attached to a carbon atom of any aliphatic or aromatic moiety.	2.03	1	gas molecular entity; hydracid; mononuclear parent hydride; sulfur hydride	Escherichia coli metabolite; genotoxin; metabolite; signalling molecule; toxin; vasodilator agent
ethanolamine [no description available]	2.73	3	ethanolamines; primary alcohol; primary amine	Escherichia coli metabolite; human metabolite; mouse metabolite
glycine [no description available]	2.02	1	alpha-amino acid; amino acid zwitterion; proteinogenic amino acid; serine family amino acid	EC 2.1.2.1 (glycine hydroxymethyltransferase) inhibitor; fundamental metabolite; hepatoprotective agent; micronutrient; neurotransmitter; NMDA receptor agonist; nutraceutical
nitrites Nitrites: Salts of nitrous acid or compounds containing the group NO2-. The inorganic nitrites of the type MNO2 (where M=metal) are all insoluble, except the alkali nitrites. The organic nitrites may be isomeric, but not identical with the corresponding nitro compounds. (Grant & Hackh's Chemical Dictionary, 5th ed)	2.1	1	monovalent inorganic anion; nitrogen oxoanion; reactive nitrogen species	human metabolite
1-anilino-8-naphthalenesulfonate 1-anilino-8-naphthalenesulfonate: RN given refers to parent cpd. 8-anilinonaphthalene-1-sulfonic acid : A naphthalenesulfonic acid that is naphthalene-1-sulfonic acid substituted by a phenylamino group at position 8.	2.1	1	aminonaphthalene; naphthalenesulfonic acid	fluorescent probe
3,4-methylenedioxyamphetamine 3,4-Methylenedioxyamphetamine: An amphetamine derivative that inhibits uptake of catecholamine neurotransmitters. It is a hallucinogen. It is less toxic than its methylated derivative but in sufficient doses may still destroy serotonergic neurons and has been used for that purpose experimentally.	2.47	2	benzodioxoles
ethylenediamine ethylenediamine: RN given refers to parent cpd; edamine is the recommended contraction for the ethylenediamine radical. ethylenediamine : An alkane-alpha,omega-diamine in which the alkane is ethane.	2.1	1	alkane-alpha,omega-diamine	GABA agonist
mechlorethamine nitrogen mustard : Compounds having two beta-haloalkyl groups bound to a nitrogen atom, as in (X-CH2-CH2)2NR.	2.73	3	nitrogen mustard; organochlorine compound	alkylating agent
piperazine [no description available]	2.45	2	azacycloalkane; piperazines; saturated organic heteromonocyclic parent	anthelminthic drug
2,2',2''-trichlorotriethylamine 2,2',2''-trichlorotriethylamine: RN given refers to parent cpd; structure	2	1
trifluoroacetic acid Trifluoroacetic Acid: A very strong halogenated derivative of acetic acid. It is used in acid catalyzed reactions, especially those where an ester is cleaved in peptide synthesis.. trifluoroacetic acid : A monocarboxylic acid that is the trifluoro derivative of acetic acid.	2.03	1	fluoroalkanoic acid	human xenobiotic metabolite; NMR chemical shift reference compound; reagent
isoprene isoprene: used in manufacture of ''synthetic'' rubber, butyl rubber; copolymer in production of elastomers; structure. isoprene : A hemiterpene with the formula CH2=C(CH3)CH=CH2; the monomer of natural rubber and a common structure motif to the isoprenoids, a large class of other naturally occurring compounds.	2.1	1	alkadiene; hemiterpene; volatile organic compound	plant metabolite
2-diethylaminoethanol 2-diethylaminoethanol: RN given refers to unlabeled parent cpd. 2-diethylaminoethanol : A member of the class of ethanolamines that is aminoethanol in which the hydrogens of the amino group are replaced by ethyl groups.	1.99	1	ethanolamines; primary alcohol; tertiary amino compound
triethanolamine triethanolamine: RN given refers to parent cpd. triethanolamine : A tertiary amino compound that is ammonia in which each of the hydrogens is substituted by a 2-hydroxyethyl group.	2.73	3	amino alcohol; tertiary amino compound; triol	buffer; surfactant
deanol Deanol: An antidepressive agent that has also been used in the treatment of movement disorders. The mechanism of action is not well understood.. N,N-dimethylethanolamine : A tertiary amine that is ethanolamine having two N-methyl substituents.	2.4	2	ethanolamines; tertiary amine	curing agent; radical scavenger
n-methylaminoethanol N-methylaminoethanol: structure. N-methylethanolamine : An ethanolamine compound having an N-methyl substituent.	2.4	2	ethanolamines
thiophenes Thiophenes: A monocyclic heteroarene furan in which the oxygen atom is replaced by a sulfur.. thiophenes : Compounds containing at least one thiophene ring.	2.41	1	mancude organic heteromonocyclic parent; monocyclic heteroarene; thiophenes; volatile organic compound	non-polar solvent
ethyl sebacate ethyl sebacate: causes contact dermatitis	2.13	1	fatty acid ester
diethanolamine diethanolamine: RN given refers to parent cpd. diethanolamine : A member of the class of ethanolamines that is ethanolamine having a N-hydroxyethyl substituent.	2.98	4	ethanolamines	human xenobiotic metabolite
eosine yellowish-(ys) Eosine Yellowish-(YS): A versatile red dye used in cosmetics, pharmaceuticals, textiles, etc., and as tissue stain, vital stain, and counterstain with HEMATOXYLIN. It is also used in special culture media.. eosin YS dye : An organic sodium salt that is 2',4',5',7'-tetrabromofluorescein in which the carboxy group and the phenolic hydroxy group have been deprotonated and the resulting charge is neutralised by two sodium ions.	2.05	1	organic sodium salt; organobromine compound	fluorochrome; histological dye
n,n-dimethylethylamine [no description available]	1.99	1
2-amino-2-methyl-1-propanol 2-amino-2-methyl-1-propanol: RN given refers to parent cpd	2.06	1
fluorescein-5-isothiocyanate Fluorescein-5-isothiocyanate: Fluorescent probe capable of being conjugated to tissue and proteins. It is used as a label in fluorescent antibody staining procedures as well as protein- and amino acid-binding techniques.. fluorescein 5-isothiocyanate : The 5-isomer of fluorescein isothiocyanate. Acts as a fluorescent probe capable of being conjugated to tissue and proteins; used as a label in fluorescent antibody staining procedures as well as protein- and amino acid-binding techniques.	2.05	1	fluorescein isothiocyanate
sulfolane sulfolane : A member of the class of tetrahydrothiophenes that is tetrahydrothiophene in which the sulfur has been oxidised to give the corresponding sulfone. A colourless, high-boiling (285degreeC) liquid that is miscible with both water and hydrocarbons, it is used as an industrial solvent, particularly for the purification of hydrocarbon mixtures by liquid-vapour extraction.	2.41	1	sulfone; tetrahydrothiophenes	polar aprotic solvent
paclitaxel Taxus: Genus of coniferous yew trees or shrubs, several species of which have medicinal uses. Notable is the Pacific yew, Taxus brevifolia, which is used to make the anti-neoplastic drug taxol (PACLITAXEL).	2.13	1	taxane diterpenoid; tetracyclic diterpenoid	antineoplastic agent; human metabolite; metabolite; microtubule-stabilising agent
n,n-dimethylaminoisopropanol N,N-dimethylaminoisopropanol: RN given refers to parent cpd without isomeric designation	1.99	1
glucuronic acid Glucuronic Acid: A sugar acid formed by the oxidation of the C-6 carbon of GLUCOSE. In addition to being a key intermediate metabolite of the uronic acid pathway, glucuronic acid also plays a role in the detoxification of certain drugs and toxins by conjugating with them to form GLUCURONIDES.. D-glucuronic acid : The D-enantiomer of glucuronic acid.. D-glucopyranuronic acid : A D-glucuronic acid in cyclic pyranose form.	2.1	1	D-glucuronic acid	algal metabolite
3,4-methylenedioxyethamphetamine 3,4-methylenedioxyethamphetamine: legal replacement for MDMA; RN given for (+-)-isomer; structure given in first source. 1-(1,3-benzodioxol-5-yl)-N-ethylpropan-2-amine : A secondary amino compound that is N-ethylisopropylamine in which a hydrogen of one of the isopropyl methyl groups has been replaced by a 3,4-methylenedioxyphenyl group.	2.47	2	benzodioxoles; secondary amino compound
docetaxel anhydrous Docetaxel: A semisynthetic analog of PACLITAXEL used in the treatment of locally advanced or metastatic BREAST NEOPLASMS and NON-SMALL CELL LUNG CANCER.. docetaxel anhydrous : A tetracyclic diterpenoid that is paclitaxel with the N-benzyloxycarbonyl group replaced by N-tert-butoxycarbonyl, and the acetoxy group at position 10 replaced by a hydroxy group.	2.1	1	secondary alpha-hydroxy ketone; tetracyclic diterpenoid	antimalarial; antineoplastic agent; photosensitizing agent
biotin vitamin B7 : Any member of a group of vitamers that belong to the chemical structural class called biotins that exhibit biological activity against vitamin B7 deficiency. Vitamin B7 deficiency is very rare in individuals who take a normal balanced diet. Foods rich in biotin are egg yolk, liver, cereals, vegetables (spinach, mushrooms) and rice. Symptoms associated with vitamin B7 deficiency include thinning hair, scaly skin rashes around eyes, nose and mouth, and brittle nails. The vitamers include biotin and its ionized and salt forms.	2.05	1	biotins; vitamin B7	coenzyme; cofactor; Escherichia coli metabolite; fundamental metabolite; human metabolite; mouse metabolite; nutraceutical; prosthetic group; Saccharomyces cerevisiae metabolite
regadenoson [no description available]	2.13	1	purine nucleoside
exaltolide exaltolide: synthetic musk odor; structure	2.1	1	macrolide
n-methyl-n-(tert-butyldimethylsilyl)trifluoroacetamide N-(tert-butyldimethylsilyl)-N-methyltrifluoroacetamide : An N-silyl compound that is N-methyltrifluoroacetamide in which the amide nitrogen is replaced by a tert-butyldimethylsilyl group.	2.03	1	monocarboxylic acid amide; N-silyl compound; trifluoroacetamide	chromatographic reagent
antimony Antimony: A metallic element that has the atomic symbol Sb, atomic number 51, and atomic weight 121.75. It is used as a metal alloy and as medicinal and poisonous salts. It is toxic and an irritant to the skin and the mucous membranes.	2.6	1	metalloid atom; pnictogen
chlorotoxin [no description available]	2.13	1

Condition	Relationship Strength	Studies
Benign Neoplasms, Brain [description not available]	2.13	1
Brain Neoplasms Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.	2.13	1
Electrolytes Substances that dissociate into two or more ions, to some extent, in water. Solutions of electrolytes thus conduct an electric current and can be decomposed by it (ELECTROLYSIS). (Grant & Hackh's Chemical Dictionary, 5th ed)	2.02	1
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	1.99	1
Eye Disorders [description not available]	1.99	1
Eye Diseases Diseases affecting the eye.	1.99	1
Poisoning Used with drugs, chemicals, and industrial materials for human or animal poisoning, acute or chronic, whether the poisoning is accidental, occupational, suicidal, by medication error, or by environmental exposure.	1.99	1
Allergic Contact Dermatitis [description not available]	1.99	1
Dermatitis, Allergic Contact A contact dermatitis due to allergic sensitization to various substances. These substances subsequently produce inflammatory reactions in the skin of those who have acquired hypersensitivity to them as a result of prior exposure.	1.99	1

n-methyldiethanolamine

Cross-References

Synonyms (87)

Research Excerpts

Bioavailability

Protein Targets (1)

Potency Measurements

Research

Studies (23)

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Research Demand Index: 50.01

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