Compounds > murisolin
Page last updated: 2024-11-12

murisolin

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Description

murisolin: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID11399084
CHEMBL ID81089
CHEBI ID176139
SCHEMBL ID13144123
MeSH IDM0494590

Synonyms (9)

Synonym
CHEMBL81089
(2s)-4-[(2r,13r)-2,13-dihydroxy-13-[(2r,5r)-5-[(1r)-1-hydroxytridecyl]oxolan-2-yl]tridecyl]-2-methyl-2h-uran-5-one
CHEBI:176139
murisolin
129683-96-1
SCHEMBL13144123
(2s)-4-[(2r,13r)-2,13-dihydroxy-13-[(2r,5r)-5-[(1r)-1-hydroxytridecyl]oxolan-2-yl]tridecyl]-2-methyl-2h-furan-5-one
DTXSID401317589
(+)-murisolin
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
polyketideNatural and synthetic compounds containing alternating carbonyl and methylene groups ('beta-polyketones'), biogenetically derived from repeated condensation of acetyl coenzyme A (via malonyl coenzyme A), and usually the compounds derived from them by further condensations, etc. Considered by many to be synonymous with the less frequently used terms acetogenins and ketides.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (50)

Assay IDTitleYearJournalArticle
AID411159Growth inhibition of human MDA-MB-231 cells by sulforhodamine B assay2008Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24
Synthesis of C4-fluorinated solamins and their growth inhibitory activity against human cancer cell lines.
AID411350Growth inhibition of human DU145 cells by sulforhodamine B assay2008Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24
Synthesis of C4-fluorinated solamins and their growth inhibitory activity against human cancer cell lines.
AID411173Growth inhibition of human NCI-H522 cells by sulforhodamine B assay2008Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24
Synthesis of C4-fluorinated solamins and their growth inhibitory activity against human cancer cell lines.
AID411177Growth inhibition of human DMS114 cells by sulforhodamine B assay2008Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24
Synthesis of C4-fluorinated solamins and their growth inhibitory activity against human cancer cell lines.
AID411167Growth inhibition of human KM12 cells by sulforhodamine B assay2008Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24
Synthesis of C4-fluorinated solamins and their growth inhibitory activity against human cancer cell lines.
AID411166Growth inhibition of human HCC2998 cells by sulforhodamine B assay2008Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24
Synthesis of C4-fluorinated solamins and their growth inhibitory activity against human cancer cell lines.
AID78999Effective dose required for inhibitory activity against HCT-8 human tumor cell line.2003Journal of medicinal chemistry, Jul-17, Volume: 46, Issue:15
Acetogenins as selective inhibitors of the human ovarian 1A9 tumor cell line.
AID411346Growth inhibition of human MKN7 cells by sulforhodamine B assay2008Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24
Synthesis of C4-fluorinated solamins and their growth inhibitory activity against human cancer cell lines.
AID411169Growth inhibition of human HCT15 cells by sulforhodamine B assay2008Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24
Synthesis of C4-fluorinated solamins and their growth inhibitory activity against human cancer cell lines.
AID411162Growth inhibition of human SF295 cells by sulforhodamine B assay2008Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24
Synthesis of C4-fluorinated solamins and their growth inhibitory activity against human cancer cell lines.
AID411165Growth inhibition of human SNB-78 cells by sulforhodamine B assay2008Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24
Synthesis of C4-fluorinated solamins and their growth inhibitory activity against human cancer cell lines.
AID411176Growth inhibition of human DMS273 cells by sulforhodamine B assay2008Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24
Synthesis of C4-fluorinated solamins and their growth inhibitory activity against human cancer cell lines.
AID411160Growth inhibition of human U251 cells by sulforhodamine B assay2008Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24
Synthesis of C4-fluorinated solamins and their growth inhibitory activity against human cancer cell lines.
AID411174Growth inhibition of human NCI-H460 cells by sulforhodamine B assay2008Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24
Synthesis of C4-fluorinated solamins and their growth inhibitory activity against human cancer cell lines.
AID9255Effective dose required for inhibitory activity against A549 human tumor cell line; Not active2003Journal of medicinal chemistry, Jul-17, Volume: 46, Issue:15
Acetogenins as selective inhibitors of the human ovarian 1A9 tumor cell line.
AID201954Effective dose required for inhibitory activity against SK-MEL-2 human tumor cell line.2003Journal of medicinal chemistry, Jul-17, Volume: 46, Issue:15
Acetogenins as selective inhibitors of the human ovarian 1A9 tumor cell line.
AID411158Growth inhibition of human MCF7 cells by sulforhodamine B assay2008Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24
Synthesis of C4-fluorinated solamins and their growth inhibitory activity against human cancer cell lines.
AID411343Growth inhibition of human ACHN cells by sulforhodamine B assay2008Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24
Synthesis of C4-fluorinated solamins and their growth inhibitory activity against human cancer cell lines.
AID94319Effective dose required for inhibitory activity against KB-VIN human tumor cell line.2003Journal of medicinal chemistry, Jul-17, Volume: 46, Issue:15
Acetogenins as selective inhibitors of the human ovarian 1A9 tumor cell line.
AID411155Growth inhibition of human HBC4 cells by sulforhodamine B assay2008Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24
Synthesis of C4-fluorinated solamins and their growth inhibitory activity against human cancer cell lines.
AID411157Growth inhibition of human HBC5 cells by sulforhodamine B assay2008Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24
Synthesis of C4-fluorinated solamins and their growth inhibitory activity against human cancer cell lines.
AID411171Growth inhibition of human NCI-H23 cells by sulforhodamine B assay2008Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24
Synthesis of C4-fluorinated solamins and their growth inhibitory activity against human cancer cell lines.
AID411348Growth inhibition of human MKN45 cells by sulforhodamine B assay2008Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24
Synthesis of C4-fluorinated solamins and their growth inhibitory activity against human cancer cell lines.
AID411170Growth inhibition of human HCT116 cells by sulforhodamine B assay2008Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24
Synthesis of C4-fluorinated solamins and their growth inhibitory activity against human cancer cell lines.
AID411345Growth inhibition of human MKN1 cells by sulforhodamine B assay2008Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24
Synthesis of C4-fluorinated solamins and their growth inhibitory activity against human cancer cell lines.
AID103064Effective dose required for inhibitory activity against MCF-7 human tumor cell line.2003Journal of medicinal chemistry, Jul-17, Volume: 46, Issue:15
Acetogenins as selective inhibitors of the human ovarian 1A9 tumor cell line.
AID411340Growth inhibition of human OVCAR8 cells by sulforhodamine B assay2008Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24
Synthesis of C4-fluorinated solamins and their growth inhibitory activity against human cancer cell lines.
AID411338Growth inhibition of human OVCAR4 cells by sulforhodamine B assay2008Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24
Synthesis of C4-fluorinated solamins and their growth inhibitory activity against human cancer cell lines.
AID411156Growth inhibition of human BSY1 cells by sulforhodamine B assay2008Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24
Synthesis of C4-fluorinated solamins and their growth inhibitory activity against human cancer cell lines.
AID411175Growth inhibition of human A549 cells by sulforhodamine B assay2008Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24
Synthesis of C4-fluorinated solamins and their growth inhibitory activity against human cancer cell lines.
AID84381Effective dose required for inhibitory activity against HOS human tumor cell line; Not active2003Journal of medicinal chemistry, Jul-17, Volume: 46, Issue:15
Acetogenins as selective inhibitors of the human ovarian 1A9 tumor cell line.
AID411337Growth inhibition of human OVCAR-3 cells by sulforhodamine B assay2008Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24
Synthesis of C4-fluorinated solamins and their growth inhibitory activity against human cancer cell lines.
AID411339Growth inhibition of human OVCAR5 cells by sulforhodamine B assay2008Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24
Synthesis of C4-fluorinated solamins and their growth inhibitory activity against human cancer cell lines.
AID411336Growth inhibition of human LOXIMVI cells by sulforhodamine B assay2008Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24
Synthesis of C4-fluorinated solamins and their growth inhibitory activity against human cancer cell lines.
AID411344Growth inhibition of human St-4 cells by sulforhodamine B assay2008Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24
Synthesis of C4-fluorinated solamins and their growth inhibitory activity against human cancer cell lines.
AID411351Growth inhibition of human PC3 cells by sulforhodamine B assay2008Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24
Synthesis of C4-fluorinated solamins and their growth inhibitory activity against human cancer cell lines.
AID411163Growth inhibition of human SF539 cells by sulforhodamine B assay2008Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24
Synthesis of C4-fluorinated solamins and their growth inhibitory activity against human cancer cell lines.
AID93852Effective dose required for inhibitory activity against KB human tumor cell line.2003Journal of medicinal chemistry, Jul-17, Volume: 46, Issue:15
Acetogenins as selective inhibitors of the human ovarian 1A9 tumor cell line.
AID156344Effective dose required for inhibitory activity against PC-3 human tumor cell line.2003Journal of medicinal chemistry, Jul-17, Volume: 46, Issue:15
Acetogenins as selective inhibitors of the human ovarian 1A9 tumor cell line.
AID411341Growth inhibition of human SKOV3 cells by sulforhodamine B assay2008Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24
Synthesis of C4-fluorinated solamins and their growth inhibitory activity against human cancer cell lines.
AID42561Effective dose required for inhibitory activity against CAK1 human tumor cell line2003Journal of medicinal chemistry, Jul-17, Volume: 46, Issue:15
Acetogenins as selective inhibitors of the human ovarian 1A9 tumor cell line.
AID411172Growth inhibition of human NCI-H226 cells by sulforhodamine B assay2008Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24
Synthesis of C4-fluorinated solamins and their growth inhibitory activity against human cancer cell lines.
AID2971Effective dose required for inhibitory activity against 1A9 human tumor cell line.2003Journal of medicinal chemistry, Jul-17, Volume: 46, Issue:15
Acetogenins as selective inhibitors of the human ovarian 1A9 tumor cell line.
AID411161Growth inhibition of human SF268 cells by sulforhodamine B assay2008Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24
Synthesis of C4-fluorinated solamins and their growth inhibitory activity against human cancer cell lines.
AID411349Growth inhibition of human MKN74 cells by sulforhodamine B assay2008Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24
Synthesis of C4-fluorinated solamins and their growth inhibitory activity against human cancer cell lines.
AID411342Growth inhibition of human RXF631L cells by sulforhodamine B assay2008Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24
Synthesis of C4-fluorinated solamins and their growth inhibitory activity against human cancer cell lines.
AID411347Growth inhibition of human MKN28 cells by sulforhodamine B assay2008Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24
Synthesis of C4-fluorinated solamins and their growth inhibitory activity against human cancer cell lines.
AID411164Growth inhibition of human SNB75 cells by sulforhodamine B assay2008Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24
Synthesis of C4-fluorinated solamins and their growth inhibitory activity against human cancer cell lines.
AID411168Growth inhibition of human HT-29 cells by sulforhodamine B assay2008Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24
Synthesis of C4-fluorinated solamins and their growth inhibitory activity against human cancer cell lines.
AID157343Percent inhibition against PTX10 human tumor cell line at >10 ug/mL2003Journal of medicinal chemistry, Jul-17, Volume: 46, Issue:15
Acetogenins as selective inhibitors of the human ovarian 1A9 tumor cell line.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (9)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's8 (88.89)29.6817
2010's1 (11.11)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.95

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index11.95 (24.57)
Research Supply Index2.30 (2.92)
Research Growth Index4.26 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (11.95)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other9 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
1-anilino-8-naphthalenesulfonate
1-anilino-8-naphthalenesulfonate: RN given refers to parent cpd. 8-anilinonaphthalene-1-sulfonic acid : A naphthalenesulfonic acid that is naphthalene-1-sulfonic acid substituted by a phenylamino group at position 8.		2.0710aminonaphthalene;
naphthalenesulfonic acid		fluorescent probe
4-butyrolactone
4-Butyrolactone: One of the FURANS with a carbonyl thereby forming a cyclic lactone. It is an endogenous compound made from gamma-aminobutyrate and is the precursor of gamma-hydroxybutyrate. It is also used as a pharmacological agent and solvent.. tetrahydrofuranone : Any oxolane having an oxo- substituent at any position on the tetrahydrofuran ring.. gamma-butyrolactone : A butan-4-olide that is tetrahydrofuran substituted by an oxo group at position 2.		2.0310butan-4-olidemetabolite;
neurotoxin
vanillic acid
Vanillic Acid: A flavoring agent. It is the intermediate product in the two-step bioconversion of ferulic acid to vanillin. (J Biotechnol 1996;50(2-3):107-13).. vanillic acid : A monohydroxybenzoic acid that is 4-hydroxybenzoic acid substituted by a methoxy group at position 3.		2.0210methoxybenzoic acid;
monohydroxybenzoic acid		plant metabolite
butenolide
butenolide: inhibits experimental allergic encephalomyelitis in rats. butenolide : A gamma-lactone that consists of a 2-furanone skeleton and its substituted derivatives.		7.0310butenolide
paclitaxel
Taxus: Genus of coniferous yew trees or shrubs, several species of which have medicinal uses. Notable is the Pacific yew, Taxus brevifolia, which is used to make the anti-neoplastic drug taxol (PACLITAXEL).		2.0110taxane diterpenoid;
tetracyclic diterpenoid		antineoplastic agent;
human metabolite;
metabolite;
microtubule-stabilising agent
acetogenins
Acetogenins: Polyketides of up to a few dozen carbons in length, formed by chain extension of multiple PROPIONATES and oxygenated to form tetrahydrofuran and lactone rings along the length of the chain. They are found in ANNONACEAE and other PLANTS. Related compounds cyclize to MACROLIDES.		7.7330
squamocin
squamocin: from seeds of Annona squamosa; a trihydroxy-bis-tetrahydrofuran fatty acid lactone; inhibits E. coli NADH:quinone oxidoreductase (NDH-1); structure given in first source		2.0110polyketide
ConditionIndicatedRelationship StrengthStudiesTrials
Cancer of Ovary
[description not available]		02.0110
Ovarian Neoplasms
Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.		02.0110