marineosin-a and roseophilin

Covering: up to the end of 2017 The roles played by Rieske non-heme iron-dependent oxygenases in natural product biosynthesis are reviewed, with particular focus on experimentally characterised examples. Enzymes belonging to this class are known to catalyse a range of transformations, including oxidative carbocyclisation, N-oxygenation, C-hydroxylation and C-C desaturation. Examples of such enzymes that have yet to be experimentally investigated are also briefly described and their likely functions are discussed.

Topics: Biological Products; Cyclization; Electron Transport Complex III; Heme; Heterocyclic Compounds, 3-Ring; Hydroxylation; Oxygenases; Prodigiosin; Pyrroles; Pyrrolnitrin; Spiro Compounds