Compounds > leupyrrin a1
Page last updated: 2024-11-12

leupyrrin a1

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

leupyrrin A1: from myxobacterium Sorangium cellulosum; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID10908784
CHEMBL ID510851
MeSH IDM0460933

Synonyms (2)

Synonym
leupyrrin a1
CHEMBL510851
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (9)

Assay IDTitleYearJournalArticle
AID356418Antifungal activity against Rhodotorula glutinis2003Journal of natural products, Sep, Volume: 66, Issue:9
The leupyrrins: a structurally unique family of secondary metabolites from the myxobacterium Sorangium cellulosum.
AID356423Inhibition of DNA synthesis in Rhodotorula glutinis assessed as inhibition of [methyl-3H]thymine incorporation at 2.5 ug/mL after 30 mins2003Journal of natural products, Sep, Volume: 66, Issue:9
The leupyrrins: a structurally unique family of secondary metabolites from the myxobacterium Sorangium cellulosum.
AID356417Antifungal activity against Candida albicans2003Journal of natural products, Sep, Volume: 66, Issue:9
The leupyrrins: a structurally unique family of secondary metabolites from the myxobacterium Sorangium cellulosum.
AID356420Antifungal activity against Botrytis cinerea2003Journal of natural products, Sep, Volume: 66, Issue:9
The leupyrrins: a structurally unique family of secondary metabolites from the myxobacterium Sorangium cellulosum.
AID356424Inhibition of RNA synthesis in Rhodotorula glutinis assessed as inhibition of [2-14C]uracil incorporation at 2.5 ug/mL after 30 mins2003Journal of natural products, Sep, Volume: 66, Issue:9
The leupyrrins: a structurally unique family of secondary metabolites from the myxobacterium Sorangium cellulosum.
AID356419Antifungal activity against Aspergillus niger2003Journal of natural products, Sep, Volume: 66, Issue:9
The leupyrrins: a structurally unique family of secondary metabolites from the myxobacterium Sorangium cellulosum.
AID356422Cytotoxicity against mouse L929 cells2003Journal of natural products, Sep, Volume: 66, Issue:9
The leupyrrins: a structurally unique family of secondary metabolites from the myxobacterium Sorangium cellulosum.
AID356425Inhibition of protein synthesis in Rhodotorula glutinis assessed as inhibition of [U-14C]protein hydrolysate incorporation at 2.5 ug/mL after 30 mins2003Journal of natural products, Sep, Volume: 66, Issue:9
The leupyrrins: a structurally unique family of secondary metabolites from the myxobacterium Sorangium cellulosum.
AID356421Antifungal activity against Mucor hiemalis2003Journal of natural products, Sep, Volume: 66, Issue:9
The leupyrrins: a structurally unique family of secondary metabolites from the myxobacterium Sorangium cellulosum.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (7)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (28.57)29.6817
2010's5 (71.43)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.75

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.75 (24.57)
Research Supply Index2.08 (2.92)
Research Growth Index4.83 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.75)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (14.29%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (85.71%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
4-butyrolactone
4-Butyrolactone: One of the FURANS with a carbonyl thereby forming a cyclic lactone. It is an endogenous compound made from gamma-aminobutyrate and is the precursor of gamma-hydroxybutyrate. It is also used as a pharmacological agent and solvent.. tetrahydrofuranone : Any oxolane having an oxo- substituent at any position on the tetrahydrofuran ring.. gamma-butyrolactone : A butan-4-olide that is tetrahydrofuran substituted by an oxo group at position 2.		4.5570butan-4-olidemetabolite;
neurotoxin
pyrroles
1H-pyrrole : A tautomer of pyrrole that has the double bonds at positions 2 and 4.. pyrrole : A five-membered monocyclic heteroarene comprising one NH and four CH units which forms the parent compound of the pyrrole group of compounds. Its five-membered ring structure has three tautomers. A 'closed class'.. azole : Any monocyclic heteroarene consisting of a five-membered ring containing nitrogen. Azoles can also contain one or more other non-carbon atoms, such as nitrogen, sulfur or oxygen.		2.0110pyrrole;
secondary amine
furan
furan : A monocyclic heteroarene with a structure consisting of a 5-membered ring containing four carbons and one oxygen, with formula C4H4O. It is a toxic, flammable, low-boiling (31degreeC) colourless liquid.		2.0810furans;
mancude organic heteromonocyclic parent;
monocyclic heteroarene		carcinogenic agent;
hepatotoxic agent;
Maillard reaction product
oxazoles
Oxazoles: Five-membered heterocyclic ring structures containing an oxygen in the 1-position and a nitrogen in the 3-position, in distinction from ISOXAZOLES where they are at the 1,2 positions.. 1,3-oxazole : A five-membered monocyclic heteroarene that is an analogue of cyclopentadiene with O in place of CH2 at position 1 and N in place of CH at position 3.. oxazole : An azole based on a five-membered heterocyclic aromatic skeleton containing one N and one O atom.		2.44201,3-oxazoles;
mancude organic heteromonocyclic parent;
monocyclic heteroarene
zirconium
Zirconium: A rather rare metallic element with atomic number 40, atomic weight 91.224, and symbol Zr.		3.6320titanium group element atom
ConditionIndicatedRelationship StrengthStudiesTrials