leupyrrin a1

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

leupyrrin A1: from myxobacterium Sorangium cellulosum; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	10908784
CHEMBL ID	510851
MeSH ID	M0460933

Synonyms (2)

Synonym
leupyrrin a1
CHEMBL510851

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (9)

Assay ID	Title	Year	Journal	Article
AID356418	Antifungal activity against Rhodotorula glutinis	2003	Journal of natural products, Sep, Volume: 66, Issue:9	The leupyrrins: a structurally unique family of secondary metabolites from the myxobacterium Sorangium cellulosum.
AID356423	Inhibition of DNA synthesis in Rhodotorula glutinis assessed as inhibition of [methyl-3H]thymine incorporation at 2.5 ug/mL after 30 mins	2003	Journal of natural products, Sep, Volume: 66, Issue:9	The leupyrrins: a structurally unique family of secondary metabolites from the myxobacterium Sorangium cellulosum.
AID356417	Antifungal activity against Candida albicans	2003	Journal of natural products, Sep, Volume: 66, Issue:9	The leupyrrins: a structurally unique family of secondary metabolites from the myxobacterium Sorangium cellulosum.
AID356420	Antifungal activity against Botrytis cinerea	2003	Journal of natural products, Sep, Volume: 66, Issue:9	The leupyrrins: a structurally unique family of secondary metabolites from the myxobacterium Sorangium cellulosum.
AID356424	Inhibition of RNA synthesis in Rhodotorula glutinis assessed as inhibition of [2-14C]uracil incorporation at 2.5 ug/mL after 30 mins	2003	Journal of natural products, Sep, Volume: 66, Issue:9	The leupyrrins: a structurally unique family of secondary metabolites from the myxobacterium Sorangium cellulosum.
AID356419	Antifungal activity against Aspergillus niger	2003	Journal of natural products, Sep, Volume: 66, Issue:9	The leupyrrins: a structurally unique family of secondary metabolites from the myxobacterium Sorangium cellulosum.
AID356422	Cytotoxicity against mouse L929 cells	2003	Journal of natural products, Sep, Volume: 66, Issue:9	The leupyrrins: a structurally unique family of secondary metabolites from the myxobacterium Sorangium cellulosum.
AID356425	Inhibition of protein synthesis in Rhodotorula glutinis assessed as inhibition of [U-14C]protein hydrolysate incorporation at 2.5 ug/mL after 30 mins	2003	Journal of natural products, Sep, Volume: 66, Issue:9	The leupyrrins: a structurally unique family of secondary metabolites from the myxobacterium Sorangium cellulosum.
AID356421	Antifungal activity against Mucor hiemalis	2003	Journal of natural products, Sep, Volume: 66, Issue:9	The leupyrrins: a structurally unique family of secondary metabolites from the myxobacterium Sorangium cellulosum.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (7)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	2 (28.57)	29.6817
2010's	5 (71.43)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.75

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	12.75 (24.57)
Research Supply Index	2.08 (2.92)
Research Growth Index	4.83 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (12.75)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	1 (14.29%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	6 (85.71%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
4-butyrolactone 4-Butyrolactone: One of the FURANS with a carbonyl thereby forming a cyclic lactone. It is an endogenous compound made from gamma-aminobutyrate and is the precursor of gamma-hydroxybutyrate. It is also used as a pharmacological agent and solvent.. tetrahydrofuranone : Any oxolane having an oxo- substituent at any position on the tetrahydrofuran ring.. gamma-butyrolactone : A butan-4-olide that is tetrahydrofuran substituted by an oxo group at position 2.	4.55	7	butan-4-olide	metabolite; neurotoxin
pyrroles 1H-pyrrole : A tautomer of pyrrole that has the double bonds at positions 2 and 4.. pyrrole : A five-membered monocyclic heteroarene comprising one NH and four CH units which forms the parent compound of the pyrrole group of compounds. Its five-membered ring structure has three tautomers. A 'closed class'.. azole : Any monocyclic heteroarene consisting of a five-membered ring containing nitrogen. Azoles can also contain one or more other non-carbon atoms, such as nitrogen, sulfur or oxygen.	2.01	1	pyrrole; secondary amine
furan furan : A monocyclic heteroarene with a structure consisting of a 5-membered ring containing four carbons and one oxygen, with formula C4H4O. It is a toxic, flammable, low-boiling (31degreeC) colourless liquid.	2.08	1	furans; mancude organic heteromonocyclic parent; monocyclic heteroarene	carcinogenic agent; hepatotoxic agent; Maillard reaction product
oxazoles Oxazoles: Five-membered heterocyclic ring structures containing an oxygen in the 1-position and a nitrogen in the 3-position, in distinction from ISOXAZOLES where they are at the 1,2 positions.. 1,3-oxazole : A five-membered monocyclic heteroarene that is an analogue of cyclopentadiene with O in place of CH2 at position 1 and N in place of CH at position 3.. oxazole : An azole based on a five-membered heterocyclic aromatic skeleton containing one N and one O atom.	2.44	2	1,3-oxazoles; mancude organic heteromonocyclic parent; monocyclic heteroarene
zirconium Zirconium: A rather rare metallic element with atomic number 40, atomic weight 91.224, and symbol Zr.	3.63	2	titanium group element atom

chemdatabank.com