| ID Source | ID |
|---|---|
| PubMed CID | 9890375 |
| CHEMBL ID | 558802 |
| CHEMBL ID | 274599 |
| SCHEMBL ID | 2578898 |
| MeSH ID | M0299688 |
| Synonym |
|---|
| CHEMBL558802 , |
| CHEMBL274599 , |
| l-162752 |
| 1n-[1-(1h-3-indolylmethyl)-2-oxo-2-spiro[2,3-dihydro-1h-indene-1,4''-(hexahydropyridine)]-1-yl-(1r)-ethyl]-2-amino-2-methylpropanamide |
| 1-{[(2r)-1-{2,3-dihydrospiro[indene-1,4''-piperidine]-1''-yl}-3-(1h-indol-3-yl)-1-oxopropan-2-yl]carbamoyl}-1-methylethan-1-aminium |
| 1n-[1-(1h-3-indolylmethyl)-2-oxo-2-spiro[2,3-dihydro-1h-indene-1,4''-(hexahydropyridine)]-1-ylethyl]-2-amino-2-methylpropanamide |
| bdbm50069108 |
| bdbm50403630 |
| SCHEMBL2578898 |
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Growth hormone secretagogue receptor type 1 | Rattus norvegicus (Norway rat) | EC50 (µMol) | 0.0140 | 0.0013 | 0.0154 | 0.0600 | AID175853 |
| Growth hormone secretagogue receptor type 1 | Homo sapiens (human) | EC50 (µMol) | 0.0141 | 0.0002 | 0.0087 | 0.0660 | AID265201; AID306735 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Process | via Protein(s) | Taxonomy |
|---|---|---|
| growth hormone secretagogue receptor activity | Growth hormone secretagogue receptor type 1 | Homo sapiens (human) |
| G protein-coupled receptor activity | Growth hormone secretagogue receptor type 1 | Homo sapiens (human) |
| growth hormone-releasing hormone receptor activity | Growth hormone secretagogue receptor type 1 | Homo sapiens (human) |
| peptide hormone binding | Growth hormone secretagogue receptor type 1 | Homo sapiens (human) |
| [Information is prepared from geneontology information from the June-17-2024 release] | ||
| Process | via Protein(s) | Taxonomy |
|---|---|---|
| plasma membrane | Growth hormone secretagogue receptor type 1 | Rattus norvegicus (Norway rat) |
| plasma membrane | Growth hormone secretagogue receptor type 1 | Homo sapiens (human) |
| cell surface | Growth hormone secretagogue receptor type 1 | Homo sapiens (human) |
| neuron projection | Growth hormone secretagogue receptor type 1 | Homo sapiens (human) |
| membrane raft | Growth hormone secretagogue receptor type 1 | Homo sapiens (human) |
| synaptic membrane | Growth hormone secretagogue receptor type 1 | Homo sapiens (human) |
| Schaffer collateral - CA1 synapse | Growth hormone secretagogue receptor type 1 | Homo sapiens (human) |
| postsynapse | Growth hormone secretagogue receptor type 1 | Homo sapiens (human) |
| glutamatergic synapse | Growth hormone secretagogue receptor type 1 | Homo sapiens (human) |
| plasma membrane | Growth hormone secretagogue receptor type 1 | Homo sapiens (human) |
| [Information is prepared from geneontology information from the June-17-2024 release] | ||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID175496 | Tested in vitro for growth hormone release from rat pituitary cells | 1998 | Bioorganic & medicinal chemistry letters, Apr-07, Volume: 8, Issue:7 | Tripeptide growth hormone secretagogues. |
| AID175512 | Concentration required for GH-releasing activity in the rat pituitary cell assay was determined in vitro | 1998 | Bioorganic & medicinal chemistry letters, Jun-02, Volume: 8, Issue:11 | Synthesis and biological activities of phenyl piperazine-based peptidomimetic growth hormone secretagogues. |
| AID265201 | Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH release | 2006 | Journal of medicinal chemistry, Jun-01, Volume: 49, Issue:11 | Construction of human ghrelin receptor (hGHS-R1a) model using a fragmental prediction approach and validation through docking analysis. |
| AID175853 | In vitro growth hormone release was determined in rat pituitary cell assay | 1998 | Bioorganic & medicinal chemistry letters, Jan-06, Volume: 8, Issue:1 | Potent 3-spiropiperidine growth hormone secretagogues. |
| AID306735 | Agonist activity at human GHS-R1 | 2007 | Bioorganic & medicinal chemistry, Apr-15, Volume: 15, Issue:8 | Modeling of human ghrelin receptor (hGHS-R1a) in its close state and validation by molecular docking. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (60.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.50) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 5 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||