Page last updated: 2024-12-06
khellinone
Description
Khellinone is a naturally occurring coumarin derivative found in the fruit of Ammi visnaga, an herb native to the Mediterranean region. It exhibits a variety of pharmacological activities, including antispasmodic, bronchodilator, and anti-inflammatory effects. Khellinone is particularly known for its ability to relax smooth muscle, making it a potential therapeutic agent for conditions such as asthma and angina. Its mechanism of action involves inhibiting the activity of phosphodiesterase enzymes, which regulate the levels of cyclic adenosine monophosphate (cAMP) in cells. Increased cAMP levels lead to smooth muscle relaxation. Khellinone has been studied for its potential to treat other conditions, including cancer and Alzheimer's disease, but further research is needed to confirm its efficacy and safety.'
khellinone: a Kv1.3 potassium channel blocker [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
| ID Source | ID |
|---|
| PubMed CID | 68086 |
| CHEMBL ID | 78293 |
| SCHEMBL ID | 3189671 |
| MeSH ID | M0496749 |
Synonyms (37)
| Synonym |
|---|
| CHEMBL78293 , |
| EU-0040671 |
| MAYBRIDGE1_002164 |
| SR-01000455056-2 |
| bdbm50145066 |
| 1-(6-hydroxy-4,7-dimethoxy-benzofuran-5-yl)-ethanone |
| 1-(6-hydroxy-4,7-dimethoxybenzofuran-5-yl)ethanone |
| HMS547K08 |
| 1-(6-hydroxy-4,7-dimethoxy-1-benzofuran-5-yl)ethanone |
| 484-51-5 |
| AKOS001631881 |
| 6-hydroxy-4,7-dimethoxybenzofuran-5-yl methyl ketone |
| unii-vj1360ywr9 |
| vj1360ywr9 , |
| khellinone |
| einecs 207-607-1 |
| CCG-46379 |
| FT-0619935 |
| STL377843 |
| 5-acetyl-6-hydroxy-4,7-dimethoxybenzofuran |
| 4,7-dimethoxy-5-acetyl-6-hydroxybenzofuran |
| 6-hydroxy-4,7-dimethoxy-5-benzofuranyl methyl ketone |
| SCHEMBL3189671 |
| BBL028032 |
| 5-acetyl-4,7-dimethoxy-6-benzofuranol |
| ethanone, 1-(6-hydroxy-4,7-dimethoxy-5-benzofuranyl)- |
| DTXSID70197512 |
| SR-01000455056-1 |
| sr-01000455056 |
| 5-acetyl-6-hydroxybenzofuran-4.7-dione |
| 3-bromobutyricacid |
| 1-(6-hydroxy-4,7-dimethoxy-1-benzofuran-5-yl)ethan-1-one |
| VS-08650 |
| 5-acetyl-6-hydroxy-4,7-dimethoxybenzo[b]furan |
| BRD-K35673046-001-01-2 |
| 1-(6-hydroxy-4,7-dimethoxybenzofuran-5-yl)ethan-1-one |
| CS-0317734 |
Protein Targets (2)
Activation Measurements
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] |
Biological Processes (6)
Molecular Functions (4)
Ceullar Components (9)
Bioassays (5)
| Assay ID | Title | Year | Journal | Article |
|---|
| AID1794808 | Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL). | 2014 | Journal of biomolecular screening, Jul, Volume: 19, Issue:6
| A High-Throughput Assay to Identify Inhibitors of the Apicoplast DNA Polymerase from Plasmodium falciparum. |
| AID1794808 | Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL). | | | |
| AID261016 | Effect on blockade of mouse Kv1.3 channel expressed in L929 cells | 2006 | Journal of medicinal chemistry, Feb-23, Volume: 49, Issue:4
| A new class of blockers of the voltage-gated potassium channel Kv1.3 via modification of the 4- or 7-position of khellinone. |
| AID217629 | Dissociation constant for the blockage of voltage-gated potassium channel subunit Kv1.3 in human lymphocytes | 2004 | Journal of medicinal chemistry, Apr-22, Volume: 47, Issue:9
| Khellinone derivatives as blockers of the voltage-gated potassium channel Kv1.3: synthesis and immunosuppressive activity. |
| AID1159607 | Screen for inhibitors of RMI FANCM (MM2) intereaction | 2016 | Journal of biomolecular screening, Jul, Volume: 21, Issue:6
| A High-Throughput Screening Strategy to Identify Protein-Protein Interaction Inhibitors That Block the Fanconi Anemia DNA Repair Pathway. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Research
Studies (9)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (44.44) | 29.6817 |
| 2010's | 3 (33.33) | 24.3611 |
| 2020's | 2 (22.22) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Market Indicators
Research Demand Index: 12.16
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| Metric | This Compound (vs All) |
|---|
| Research Demand Index | 12.16 (24.57) | | Research Supply Index | 2.40 (2.92) | | Research Growth Index | 4.56 (4.65) | | Search Engine Demand Index | 0.00 (26.88) | | Search Engine Supply Index | 0.00 (0.95) |
| |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 10 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |