Page last updated: 2024-12-08
isocolchicine
Description
Research Excerpts
Clinical Trials
Roles
Classes
Pathways
Study Profile
Bioassays
Related Drugs
Related Conditions
Protein Interactions
Research Growth
Description
isocolchicine: structure given in first source; RN given refers to cpd without isomeric designation [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
| ID Source | ID |
|---|---|
| PubMed CID | 352796 |
| CHEMBL ID | 111809 |
| SCHEMBL ID | 1899270 |
| MeSH ID | M0165153 |
Synonyms (15)
| Synonym |
|---|
| acetamide, n-(5,6,7,10-tetrahydro-1,2,3,9-tetramethoxy-10-oxobenzo(a)heptalen-7-yl)- |
| 30771-10-9 |
| nsc-527981 |
| nsc628992 |
| 518-12-7 |
| isocolchicine |
| nsc-628992 |
| nsc527981 |
| n-(1,2,3,9-tetramethoxy-10-oxo-6,7-dihydro-5h-benzo[a]heptalen-7-yl)acetamide |
| n-(1,2,3,9-tetramethoxy-10-oxo-5,6,7,10-tetrahydrobenzo[a]heptalen-7-yl)acetamide |
| CHEMBL111809 |
| SCHEMBL1899270 |
| n-(1,2,3,9-tetramethoxy-10-oxo-5,6,7,10-tetrahydrobenzo[a]heptalen-7-yl)acetamide # |
| MDYALASTPGGXQH-UHFFFAOYSA-N |
| DTXSID60875377 |
Research Excerpts
Overview
Isocolchicine is a structurally related isomer of colchicines altered in the methoxytropone C ring.
| Excerpt | Reference | Relevance |
|---|---|---|
| "Isocolchicine is a structurally related isomer of colchicine altered in the methoxytropone C ring. " | ( The binding of isocolchicine to tubulin. Mechanisms of ligand association with tubulin. Hastie, SB; Macdonald, TL; Puett, D; Williams, RC, 1989) | 2.07 |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Bioassays (11)
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID23476 | Partition coefficient (logP) | 1991 | Journal of medicinal chemistry, Nov, Volume: 34, Issue:11 | Fluorinated colchicinoids: antitubulin and cytotoxic properties. |
| AID228466 | Inhibition of tubulin polymerization, induced by 1 mM GTP at a concentration of 2 uM. | 1991 | Journal of medicinal chemistry, Nov, Volume: 34, Issue:11 | Fluorinated colchicinoids: antitubulin and cytotoxic properties. |
| AID150343 | Cytotoxic activity against P388 mouse lymphocytic leukemia cell line | 1991 | Journal of medicinal chemistry, Nov, Volume: 34, Issue:11 | Fluorinated colchicinoids: antitubulin and cytotoxic properties. |
| AID228463 | Inhibition of tubulin polymerization, induced by 10 mM taxol at a concentration of 2 uM; NT-Not Tested | 1991 | Journal of medicinal chemistry, Nov, Volume: 34, Issue:11 | Fluorinated colchicinoids: antitubulin and cytotoxic properties. |
| AID150344 | Cytotoxic activity against P388 mouse lymphocytic leukemia cell line (doxorubicin resistant). | 1991 | Journal of medicinal chemistry, Nov, Volume: 34, Issue:11 | Fluorinated colchicinoids: antitubulin and cytotoxic properties. |
| AID228465 | Inhibition of tubulin polymerization, induced by 10 mM taxol at a concentration of 5 uM; NT-Not Tested | 1991 | Journal of medicinal chemistry, Nov, Volume: 34, Issue:11 | Fluorinated colchicinoids: antitubulin and cytotoxic properties. |
| AID221849 | Cytotoxic activity against mouse macrophage cell line J774.2 | 1991 | Journal of medicinal chemistry, Nov, Volume: 34, Issue:11 | Fluorinated colchicinoids: antitubulin and cytotoxic properties. |
| AID221846 | Cytotoxic activity against mouse macrophage cell line J7.COL-100; NT-Not Tested | 1991 | Journal of medicinal chemistry, Nov, Volume: 34, Issue:11 | Fluorinated colchicinoids: antitubulin and cytotoxic properties. |
| AID24567 | Retention time of the compound; NT-Not Tested | 1991 | Journal of medicinal chemistry, Nov, Volume: 34, Issue:11 | Fluorinated colchicinoids: antitubulin and cytotoxic properties. |
| AID228615 | Inhibition of tubulin polymerization, induced by 1 mM GTP at a concentration of 5 uM. | 1991 | Journal of medicinal chemistry, Nov, Volume: 34, Issue:11 | Fluorinated colchicinoids: antitubulin and cytotoxic properties. |
| AID221848 | Cytotoxic activity against mouse macrophage cell line J7.VBL-1 | 1991 | Journal of medicinal chemistry, Nov, Volume: 34, Issue:11 | Fluorinated colchicinoids: antitubulin and cytotoxic properties. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
Research
Studies (12)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 5 (41.67) | 18.7374 |
| 1990's | 4 (33.33) | 18.2507 |
| 2000's | 2 (16.67) | 29.6817 |
| 2010's | 1 (8.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 12 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||