Page last updated: 2024-12-08

isocolchicine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Description

isocolchicine: structure given in first source; RN given refers to cpd without isomeric designation [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID352796
CHEMBL ID111809
SCHEMBL ID1899270
MeSH IDM0165153

Synonyms (15)

Synonym
acetamide, n-(5,6,7,10-tetrahydro-1,2,3,9-tetramethoxy-10-oxobenzo(a)heptalen-7-yl)-
30771-10-9
nsc-527981
nsc628992
518-12-7
isocolchicine
nsc-628992
nsc527981
n-(1,2,3,9-tetramethoxy-10-oxo-6,7-dihydro-5h-benzo[a]heptalen-7-yl)acetamide
n-(1,2,3,9-tetramethoxy-10-oxo-5,6,7,10-tetrahydrobenzo[a]heptalen-7-yl)acetamide
CHEMBL111809
SCHEMBL1899270
n-(1,2,3,9-tetramethoxy-10-oxo-5,6,7,10-tetrahydrobenzo[a]heptalen-7-yl)acetamide #
MDYALASTPGGXQH-UHFFFAOYSA-N
DTXSID60875377

Research Excerpts

Overview

Isocolchicine is a structurally related isomer of colchicines altered in the methoxytropone C ring.

ExcerptReferenceRelevance
"Isocolchicine is a structurally related isomer of colchicine altered in the methoxytropone C ring. "( The binding of isocolchicine to tubulin. Mechanisms of ligand association with tubulin.
Hastie, SB; Macdonald, TL; Puett, D; Williams, RC, 1989
)
2.07
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (11)

Assay IDTitleYearJournalArticle
AID23476Partition coefficient (logP)1991Journal of medicinal chemistry, Nov, Volume: 34, Issue:11
Fluorinated colchicinoids: antitubulin and cytotoxic properties.
AID228466Inhibition of tubulin polymerization, induced by 1 mM GTP at a concentration of 2 uM.1991Journal of medicinal chemistry, Nov, Volume: 34, Issue:11
Fluorinated colchicinoids: antitubulin and cytotoxic properties.
AID150343Cytotoxic activity against P388 mouse lymphocytic leukemia cell line1991Journal of medicinal chemistry, Nov, Volume: 34, Issue:11
Fluorinated colchicinoids: antitubulin and cytotoxic properties.
AID228463Inhibition of tubulin polymerization, induced by 10 mM taxol at a concentration of 2 uM; NT-Not Tested1991Journal of medicinal chemistry, Nov, Volume: 34, Issue:11
Fluorinated colchicinoids: antitubulin and cytotoxic properties.
AID150344Cytotoxic activity against P388 mouse lymphocytic leukemia cell line (doxorubicin resistant).1991Journal of medicinal chemistry, Nov, Volume: 34, Issue:11
Fluorinated colchicinoids: antitubulin and cytotoxic properties.
AID228465Inhibition of tubulin polymerization, induced by 10 mM taxol at a concentration of 5 uM; NT-Not Tested1991Journal of medicinal chemistry, Nov, Volume: 34, Issue:11
Fluorinated colchicinoids: antitubulin and cytotoxic properties.
AID221849Cytotoxic activity against mouse macrophage cell line J774.21991Journal of medicinal chemistry, Nov, Volume: 34, Issue:11
Fluorinated colchicinoids: antitubulin and cytotoxic properties.
AID221846Cytotoxic activity against mouse macrophage cell line J7.COL-100; NT-Not Tested1991Journal of medicinal chemistry, Nov, Volume: 34, Issue:11
Fluorinated colchicinoids: antitubulin and cytotoxic properties.
AID24567Retention time of the compound; NT-Not Tested1991Journal of medicinal chemistry, Nov, Volume: 34, Issue:11
Fluorinated colchicinoids: antitubulin and cytotoxic properties.
AID228615Inhibition of tubulin polymerization, induced by 1 mM GTP at a concentration of 5 uM.1991Journal of medicinal chemistry, Nov, Volume: 34, Issue:11
Fluorinated colchicinoids: antitubulin and cytotoxic properties.
AID221848Cytotoxic activity against mouse macrophage cell line J7.VBL-11991Journal of medicinal chemistry, Nov, Volume: 34, Issue:11
Fluorinated colchicinoids: antitubulin and cytotoxic properties.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (12)

TimeframeStudies, This Drug (%)All Drugs %
pre-19905 (41.67)18.7374
1990's4 (33.33)18.2507
2000's2 (16.67)29.6817
2010's1 (8.33)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other12 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]