GSK2245035: a Toll-like receptor 7 agonist [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
ID Source | ID |
---|---|
PubMed CID | 44623937 |
CHEMBL ID | 4297492 |
SCHEMBL ID | 565847 |
MeSH ID | M000612681 |
Synonym |
---|
SCHEMBL565847 |
6-amino-2-{[(1s)-1-methylbutyl]oxy}-9[5-(1-piperidinyl) pentyl]-7,9-dihydro-8h-purin-8-one |
6-amino-2-{[(1s)-1-methylbutyl]oxy}-9-[5-(1-piperidinyl)pentyl]-7,9-dihydro-8h-purin-8-one |
LFMPVTVPXHNXOT-HNNXBMFYSA-N |
6-amino-2-{[(1s)-1-methylbutyl]oxy}-9-[5-(1-piperidinyl) pentyl]-7,9-dihydro-8h-purin-8-one |
6-amino-2-[(2s)-pentan-2-yloxy]-9-[5-(piperidin-1-yl)pentyl]-8,9-dihydro-7h-purin-8-one |
gtpl9254 |
gsk2245035 |
compound 32 [pmid: 26861551] |
gsk-2245035 |
unii-5l3sx16qbq |
5L3SX16QBQ , |
8h-purin-8-one, 6-amino-7,9-dihydro-2-((1s)-1-methylbutoxy)-9-(5-(1-piperidinyl)pentyl)- |
1207629-49-9 |
AKOS032954203 |
CS-0065520 |
HY-118250 |
6-amino-2-[(2s)-pentan-2-yl]oxy-9-(5-piperidin-1-ylpentyl)-7h-purin-8-one |
F3409-0744 |
(s)-6-amino-2-(pentan-2-yloxy)-9-(5-(piperidin-1-yl)pentyl)-7,9-dihydro-8h-purin-8-one |
CHEMBL4297492 |
MS-26512 |
6-amino-7,9-dihydro-2-[(1s)-1-methylbutoxy]-9-[5-(1-piperidinyl)pentyl]-8h-purin-8-one |
GSK2245035 is a novel selective TLR7 agonist in pharmaceutical development.
Excerpt | Reference | Relevance |
---|---|---|
"GSK2245035 is a novel selective TLR7 agonist in pharmaceutical development." | ( Safety and pharmacodynamics of intranasal GSK2245035, a TLR7 agonist for allergic rhinitis: A randomized trial. Ellis, AK; Lee, LA; Powley, W; Quint, D; Tsitoura, DC, 2017) | 1.44 |
Excerpt | Reference | Relevance |
---|---|---|
" Adverse events (AEs) including cytokine release syndrome AEs (CytoRS-AEs) and nasal symptoms were assessed." | ( Safety and pharmacodynamics of intranasal GSK2245035, a TLR7 agonist for allergic rhinitis: A randomized trial. Ellis, AK; Lee, LA; Powley, W; Quint, D; Tsitoura, DC, 2017) | 0.72 |
Assay ID | Title | Year | Journal | Article |
---|---|---|---|---|
AID1345471 | Human TLR7 (Toll-like receptor family) | 2016 | Journal of medicinal chemistry, Mar-10, Volume: 59, Issue:5 | Discovery of 6-Amino-2-{[(1S)-1-methylbutyl]oxy}-9-[5-(1-piperidinyl)pentyl]-7,9-dihydro-8H-purin-8-one (GSK2245035), a Highly Potent and Selective Intranasal Toll-Like Receptor 7 Agonist for the Treatment of Asthma. |
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Timeframe | Studies, This Drug (%) | All Drugs % |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 3 (60.00) | 24.3611 |
2020's | 2 (40.00) | 2.80 |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| This Compound (17.57) All Compounds (24.57) |
Publication Type | This drug (%) | All Drugs (%) |
---|---|---|
Trials | 3 (60.00%) | 5.53% |
Reviews | 0 (0.00%) | 6.00% |
Case Studies | 0 (0.00%) | 4.05% |
Observational | 0 (0.00%) | 0.25% |
Other | 2 (40.00%) | 84.16% |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |