Compounds > glucagon (1-6)
Page last updated: 2024-12-08

glucagon (1-6)

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

glucagon (1-6): has lipolytic & adenyl cyclase stimulating activity [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID194323
CHEMBL ID749
SCHEMBL ID18642431
MeSH IDM0110686

Synonyms (13)

Synonym
69658-84-0
gtpl1147
glucagon 1-6
glucagon-(1-6)
(2s)-2-[[(2s,3r)-2-[[2-[[(2s)-5-amino-2-[[(2s)-2-[[(2s)-2-amino-3-(3h-imidazol-4-yl)propanoyl]amino]-3-hydroxypropanoyl]amino]-5-oxopentanoyl]amino]acetyl]amino]-3-hydroxybutanoyl]amino]-3-phenylpropanoic acid
glucagon (1-6)
CHEMBL749
l-phenylalanine, n-(n-(n-(n2-(n-l-histidyl-l-seryl)-l-glutaminyl)glycyl)-l-threonyl)-
SCHEMBL18642431
his-ser-gln-gly-thr-phe
n-[14-amino-1,4,7,10,13-pentahydroxy-2-(1-hydroxyethyl)-8-(3-hydroxy-3-iminopropyl)-11-(hydroxymethyl)-15-(1h-imidazol-5-yl)-3,6,9,12-tetraazapentadeca-3,6,9,12-tetraen-1-ylidene]phenylalanine
DTXSID80989783
Q27077816
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (3)

Assay IDTitleYearJournalArticle
AID1346014Rat glucagon receptor (Glucagon receptor family)1979The Journal of biological chemistry, Jan-25, Volume: 254, Issue:2
Glucagon1-6 binds to the glucagon receptor and activates hepatic adenylate cyclase.
AID73752Relative binding was evaluated by measuring competition for glucagon receptor between [1-6]glucagon and the compound.2001Journal of medicinal chemistry, Apr-26, Volume: 44, Issue:9
Development of potent truncated glucagon antagonists.
AID34457Relative potency was evaluated by measuring potency for conversion of [alpha-32P]ATP to cyclic 3',5'-AMP relative to glucagon2001Journal of medicinal chemistry, Apr-26, Volume: 44, Issue:9
Development of potent truncated glucagon antagonists.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19903 (60.00)18.7374
1990's1 (20.00)18.2507
2000's1 (20.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.42

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.42 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.21 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.42)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
tryptophan
Tryptophan: An essential amino acid that is necessary for normal growth in infants and for NITROGEN balance in adults. It is a precursor of INDOLE ALKALOIDS in plants. It is a precursor of SEROTONIN (hence its use as an antidepressant and sleep aid). It can be a precursor to NIACIN, albeit inefficiently, in mammals.. tryptophan : An alpha-amino acid that is alanine bearing an indol-3-yl substituent at position 3.		1.9810erythrose 4-phosphate/phosphoenolpyruvate family amino acid;
L-alpha-amino acid zwitterion;
L-alpha-amino acid;
proteinogenic amino acid;
tryptophan zwitterion;
tryptophan		antidepressant;
Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
plant metabolite;
Saccharomyces cerevisiae metabolite
cyanogen bromide
Cyanogen Bromide: Cyanogen bromide (CNBr). A compound used in molecular biology to digest some proteins and as a coupling reagent for phosphoroamidate or pyrophosphate internucleotide bonds in DNA duplexes.		1.9610
glucagon (19-29)
[no description available]		1.9810
glucagon
Glucagon: A 29-amino acid pancreatic peptide derived from proglucagon which is also the precursor of intestinal GLUCAGON-LIKE PEPTIDES. Glucagon is secreted by PANCREATIC ALPHA CELLS and plays an important role in regulation of BLOOD GLUCOSE concentration, ketone metabolism, and several other biochemical and physiological processes. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1511). glucagon : A 29-amino acid peptide hormone consisting of His, Ser, Gln, Gly, Thr, Phe, Thr, Ser, Asp, Tyr, Ser, Lys, Tyr, Leu, Asp, Ser, Arg, Arg, Ala, Gln, Asp, Phe, Val, Gln, Trp, Leu, Met, Asn and Thr residues joined in sequence.		2.6630peptide hormone
ConditionIndicatedRelationship StrengthStudiesTrials