Compounds > excisanin a
Page last updated: 2024-11-08

excisanin a

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Description

excisanin A: isolated from leaves and stems of Radbosia serra (Maxim) Hara; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID11772488
CHEMBL ID480677
MeSH IDM0136869

Synonyms (6)

Synonym
excisanin a
CHEMBL480677
(1r,2r,4r,8s,9r,10s,12s,13r,16r)-2,8,12,16-tetrahydroxy-5,5,9-trimethyl-14-methylidenetetracyclo[11.2.1.01,10.04,9]hexadecan-15-one
AKOS040761723
HY-136699
CS-0133355
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (6)

Assay IDTitleYearJournalArticle
AID422509Cytotoxicity against human PC3 cells after 48 hrs by WST-8 assay2009Journal of natural products, Jan, Volume: 72, Issue:1
ent-Kaurane diterpenoids from Isodon scoparius.
AID400230Cytotoxicity against mouse P388 cells2004Journal of natural products, Mar, Volume: 67, Issue:3
Excisanin H, a novel cytotoxic 14,20-epoxy-ent-kaurene diterpenoid, and three new ent-kaurene diterpenoids from Rabdosia excisa.
AID422506Cytotoxicity against human NB4 cells after 48 hrs by WST-8 assay2009Journal of natural products, Jan, Volume: 72, Issue:1
ent-Kaurane diterpenoids from Isodon scoparius.
AID422508Cytotoxicity against human SH-SY5Y cells after 48 hrs by WST-8 assay2009Journal of natural products, Jan, Volume: 72, Issue:1
ent-Kaurane diterpenoids from Isodon scoparius.
AID422507Cytotoxicity against human A549 cells after 48 hrs by WST-8 assay2009Journal of natural products, Jan, Volume: 72, Issue:1
ent-Kaurane diterpenoids from Isodon scoparius.
AID422510Cytotoxicity against human MCF7 cells after 48 hrs by WST-8 assay2009Journal of natural products, Jan, Volume: 72, Issue:1
ent-Kaurane diterpenoids from Isodon scoparius.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (7)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (14.29)18.7374
1990's0 (0.00)18.2507
2000's4 (57.14)29.6817
2010's2 (28.57)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other7 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
pyrazolanthrone
pyrazolanthrone: JNK (c-Jun N-terminal kinase) inhibitor; structure in first source. anthra[1,9-cd]pyrazol-6(2H)-one : A member of the class of anthrapyrazoles that is anthra[1,9-cd]pyrazole substituted at position 6 by an oxo group. An inhibitor of c-Jun N-terminal kinase.		2.0310anthrapyrazole;
aromatic ketone;
cyclic ketone		antineoplastic agent;
c-Jun N-terminal kinase inhibitor;
geroprotector
paclitaxel
Taxus: Genus of coniferous yew trees or shrubs, several species of which have medicinal uses. Notable is the Pacific yew, Taxus brevifolia, which is used to make the anti-neoplastic drug taxol (PACLITAXEL).		2.0510taxane diterpenoid;
tetracyclic diterpenoid		antineoplastic agent;
human metabolite;
metabolite;
microtubule-stabilising agent
etoposide
[no description available]		2.4420beta-D-glucoside;
furonaphthodioxole;
organic heterotetracyclic compound		antineoplastic agent;
DNA synthesis inhibitor
kamebakaurin
kamebakaurin: isolated from leaves and stems of Radbosia serra (Maxim) Hara; structure given in first source		2.3920
ConditionIndicatedRelationship StrengthStudiesTrials
Leukemia P388
An experimental lymphocytic leukemia originally induced in DBA/2 mice by painting with methylcholanthrene.		02.0210
Breast Cancer
[description not available]		07.4720
Invasiveness, Neoplasm
[description not available]		02.0810
Breast Neoplasms
Tumors or cancer of the human BREAST.		02.4720
Hepatocellular Carcinoma
[description not available]		02.0510
Cancer of Liver
[description not available]		02.0510
Carcinoma, Hepatocellular
A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.		02.0510
Liver Neoplasms
Tumors or cancer of the LIVER.		02.0510