excisanin a

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Description

excisanin A: isolated from leaves and stems of Radbosia serra (Maxim) Hara; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	11772488
CHEMBL ID	480677
MeSH ID	M0136869

Synonyms (6)

Synonym
excisanin a
CHEMBL480677
(1r,2r,4r,8s,9r,10s,12s,13r,16r)-2,8,12,16-tetrahydroxy-5,5,9-trimethyl-14-methylidenetetracyclo[11.2.1.01,10.04,9]hexadecan-15-one
AKOS040761723
HY-136699
CS-0133355

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (6)

Assay ID	Title	Year	Journal	Article
AID422509	Cytotoxicity against human PC3 cells after 48 hrs by WST-8 assay	2009	Journal of natural products, Jan, Volume: 72, Issue:1	ent-Kaurane diterpenoids from Isodon scoparius.
AID400230	Cytotoxicity against mouse P388 cells	2004	Journal of natural products, Mar, Volume: 67, Issue:3	Excisanin H, a novel cytotoxic 14,20-epoxy-ent-kaurene diterpenoid, and three new ent-kaurene diterpenoids from Rabdosia excisa.
AID422506	Cytotoxicity against human NB4 cells after 48 hrs by WST-8 assay	2009	Journal of natural products, Jan, Volume: 72, Issue:1	ent-Kaurane diterpenoids from Isodon scoparius.
AID422508	Cytotoxicity against human SH-SY5Y cells after 48 hrs by WST-8 assay	2009	Journal of natural products, Jan, Volume: 72, Issue:1	ent-Kaurane diterpenoids from Isodon scoparius.
AID422507	Cytotoxicity against human A549 cells after 48 hrs by WST-8 assay	2009	Journal of natural products, Jan, Volume: 72, Issue:1	ent-Kaurane diterpenoids from Isodon scoparius.
AID422510	Cytotoxicity against human MCF7 cells after 48 hrs by WST-8 assay	2009	Journal of natural products, Jan, Volume: 72, Issue:1	ent-Kaurane diterpenoids from Isodon scoparius.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (7)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	1 (14.29)	18.7374
1990's	0 (0.00)	18.2507
2000's	4 (57.14)	29.6817
2010's	2 (28.57)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	7 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
pyrazolanthrone pyrazolanthrone: JNK (c-Jun N-terminal kinase) inhibitor; structure in first source. anthra[1,9-cd]pyrazol-6(2H)-one : A member of the class of anthrapyrazoles that is anthra[1,9-cd]pyrazole substituted at position 6 by an oxo group. An inhibitor of c-Jun N-terminal kinase.	2.03	1	anthrapyrazole; aromatic ketone; cyclic ketone	antineoplastic agent; c-Jun N-terminal kinase inhibitor; geroprotector
paclitaxel Taxus: Genus of coniferous yew trees or shrubs, several species of which have medicinal uses. Notable is the Pacific yew, Taxus brevifolia, which is used to make the anti-neoplastic drug taxol (PACLITAXEL).	2.05	1	taxane diterpenoid; tetracyclic diterpenoid	antineoplastic agent; human metabolite; metabolite; microtubule-stabilising agent
etoposide [no description available]	2.44	2	beta-D-glucoside; furonaphthodioxole; organic heterotetracyclic compound	antineoplastic agent; DNA synthesis inhibitor
kamebakaurin kamebakaurin: isolated from leaves and stems of Radbosia serra (Maxim) Hara; structure given in first source	2.39	2

Condition	Relationship Strength	Studies
Leukemia P388 An experimental lymphocytic leukemia originally induced in DBA/2 mice by painting with methylcholanthrene.	2.02	1
Breast Cancer [description not available]	7.47	2
Invasiveness, Neoplasm [description not available]	2.08	1
Breast Neoplasms Tumors or cancer of the human BREAST.	2.47	2
Hepatocellular Carcinoma [description not available]	2.05	1
Cancer of Liver [description not available]	2.05	1
Carcinoma, Hepatocellular A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.	2.05	1
Liver Neoplasms Tumors or cancer of the LIVER.	2.05	1

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