Compounds > excisanin a
Page last updated: 2024-09-26

excisanin a

Description

excisanin A: isolated from leaves and stems of Radbosia serra (Maxim) Hara; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID11772488
CHEMBL ID480677
MeSH IDM0136869

Synonyms (6)

Synonym
excisanin a
CHEMBL480677
(1r,2r,4r,8s,9r,10s,12s,13r,16r)-2,8,12,16-tetrahydroxy-5,5,9-trimethyl-14-methylidenetetracyclo[11.2.1.01,10.04,9]hexadecan-15-one
AKOS040761723
HY-136699
CS-0133355

Bioassays (6)

Assay IDTitleYearJournalArticle
AID422509Cytotoxicity against human PC3 cells after 48 hrs by WST-8 assay2009Journal of natural products, Jan, Volume: 72, Issue:1
ent-Kaurane diterpenoids from Isodon scoparius.
AID400230Cytotoxicity against mouse P388 cells2004Journal of natural products, Mar, Volume: 67, Issue:3
Excisanin H, a novel cytotoxic 14,20-epoxy-ent-kaurene diterpenoid, and three new ent-kaurene diterpenoids from Rabdosia excisa.
AID422506Cytotoxicity against human NB4 cells after 48 hrs by WST-8 assay2009Journal of natural products, Jan, Volume: 72, Issue:1
ent-Kaurane diterpenoids from Isodon scoparius.
AID422508Cytotoxicity against human SH-SY5Y cells after 48 hrs by WST-8 assay2009Journal of natural products, Jan, Volume: 72, Issue:1
ent-Kaurane diterpenoids from Isodon scoparius.
AID422507Cytotoxicity against human A549 cells after 48 hrs by WST-8 assay2009Journal of natural products, Jan, Volume: 72, Issue:1
ent-Kaurane diterpenoids from Isodon scoparius.
AID422510Cytotoxicity against human MCF7 cells after 48 hrs by WST-8 assay2009Journal of natural products, Jan, Volume: 72, Issue:1
ent-Kaurane diterpenoids from Isodon scoparius.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (7)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (14.29)18.7374
1990's0 (0.00)18.2507
2000's4 (57.14)29.6817
2010's2 (28.57)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other7 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceDescriptionRelationhip StrengthStudiesTrialsClassesRoles
kamebakaurin[no description available]medium20
paclitaxel[no description available]medium10taxane diterpenoid;
tetracyclic diterpenoid		antineoplastic agent;
human metabolite;
metabolite;
microtubule-stabilising agent
etoposide[no description available]medium20beta-D-glucoside;
furonaphthodioxole;
organic heterotetracyclic compound		antineoplastic agent;
DNA synthesis inhibitor
pyrazolanthrone[no description available]medium10anthrapyrazole;
aromatic ketone;
cyclic ketone		antineoplastic agent;
c-Jun N-terminal kinase inhibitor;
geroprotector
ConditionIndicatedRelationship StrengthStudiesTrials
Breast Cancer0low20
Breast Carcinoma0low20
Breast Neoplasms0low20
Breast Tumors0low20
Cancer of Breast0low20
Cancer of Liver0low10
Cancer of the Breast0low20
Cancer of the Liver0low10
Cancer, Hepatocellular0low10
Carcinoma, Hepatocellular0low10
Hepatic Cancer0low10
Hepatic Neoplasms0low10
Hepatocellular Cancer0low10
Hepatocellular Carcinoma0low10
Hepatoma0low10
Human Mammary Carcinoma0low20
Invasiveness, Neoplasm0low10
Leukemia P3880low10
Liver Cancer0low10
Liver Cancer, Adult0low10
Liver Cell Carcinoma0low10
Liver Cell Carcinoma, Adult0low10
Liver Neoplasms0low10
Malignant Neoplasm of Breast0low20
Malignant Tumor of Breast0low20
Mammary Cancer0low20
Mammary Carcinoma, Human0low20
Mammary Neoplasm, Human0low20
Mammary Neoplasms, Human0low20
Neoplasm Invasion0low10
Neoplasm Invasiveness0low10
Neoplasms, Breast0low20
Neoplasms, Hepatic0low10
Neoplasms, Liver0low10
P388D(1) Leukemia0low10
Tumors, Breast0low20