Compounds > desacetylcinobufagin
Page last updated: 2024-11-12

desacetylcinobufagin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

desacetylcinobufagin: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID11877495
CHEMBL ID465893
MeSH IDM0586526

Synonyms (9)

Synonym
desacetylcinobufagin
3-beta,16-beta-dihydroxy-14,15-beta-epoxy-5-beta-bufa-20,22-dienolide
CHEMBL465893
CS-3699
HY-N0881
mfcd01740865
5-[(1r,2s,4r,5r,6r,7r,10s,11s,14s,16r)-5,14-dihydroxy-7,11-dimethyl-3-oxapentacyclo[8.8.0.02,4.02,7.011,16]octadecan-6-yl]pyran-2-one
MS-26814
5-[(1r,2s,4r,5r,6r,7r,10s,11s,14s,16r)-5,14-dihydroxy-7,11-dimethyl-3-oxapentacyclo[8.8.0.0,.0,.0,octadecan-6-yl]-2h-pyran-2-one
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (6)

Assay IDTitleYearJournalArticle
AID155910Inhibitory activity against the primary liver carcinoma (PLC) cell line PLC/PRF/52002Journal of medicinal chemistry, Dec-05, Volume: 45, Issue:25
QSAR evaluation of the Ch'an Su and related bufadienolides against the colchicine-resistant primary liver carcinoma cell line PLC/PRF/5(1).
AID357630Cytotoxicity against mouse MH60 cells after 72 hrs by MTT assay2001Journal of natural products, Sep, Volume: 64, Issue:9
Isolation and structure of five new cancer cell growth inhibitory bufadienolides from the Chinese traditional drug Ch'an Su.
AID357628Cytotoxicity against human KB cells after 72 hrs by MTT assay2001Journal of natural products, Sep, Volume: 64, Issue:9
Isolation and structure of five new cancer cell growth inhibitory bufadienolides from the Chinese traditional drug Ch'an Su.
AID1221925Retention time in Sprague-Dawley rat liver microsomes treated with 100 uM cinobufagin at 37 degC after 30 mins by UFLC-DAD-ESI-MS analysis2011Drug metabolism and disposition: the biological fate of chemicals, Apr, Volume: 39, Issue:4
Comparative metabolism of cinobufagin in liver microsomes from mouse, rat, dog, minipig, monkey, and human.
AID357629Cytotoxicity against human HL60 cells after 72 hrs by MTT assay2001Journal of natural products, Sep, Volume: 64, Issue:9
Isolation and structure of five new cancer cell growth inhibitory bufadienolides from the Chinese traditional drug Ch'an Su.
AID155909Inhibitory activity against colchicine resistant parent primary liver carcinoma (PLC) cell line PLC/PRF/52002Journal of medicinal chemistry, Dec-05, Volume: 45, Issue:25
QSAR evaluation of the Ch'an Su and related bufadienolides against the colchicine-resistant primary liver carcinoma cell line PLC/PRF/5(1).
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (33.33)29.6817
2010's4 (66.67)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.79

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.79 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.73 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.79)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
periplogenin
periplogenin: structure		2.0110
hellebrigenin
hellebrigenin: structure		2.0110
cinobufotalin
cinobufotalin: RN given refers to (3beta,5beta,15beta,16beta)-isomer; RN for cpd without isomeric designation not avail 4/90		2.7130
Gamabufogenin
gamabufotalin: antiangiogenic, main active compound isolated from Chinese medicine Chansu; structure in first source		2.4120steroid lactone
telocinobufagin
telocinobufagin: structure		2.4120steroid lactone
digitoxigenin
Digitoxigenin: 3 beta,14-Dihydroxy-5 beta-card-20(22)enolide. A cardenolide which is the aglycon of digitoxin. Synonyms: Cerberigenin; Echujetin; Evonogenin; Thevetigenin.. digitoxigenin : A 5beta-cardenolide that is 5beta-cardanolide with hydroxy substituents at the 3beta- and 14beta-positions and double bond unsaturation at C(20)-C(22).		2.011014beta-hydroxy steroid;
3beta-hydroxy steroid
bufogenin
bufogenin: respiratory stimulant; from toad; structure. bufogenin : A steroid lactone of Chan su (toad venom), a Chinese medicine obtained from the skin venom gland of toads. A specific Na/K-ATPase protein inhibitor, it is used as a cardiotonic and central nervous system (CNS) respiratory agent, an analgesic and anesthetic, and as a remedy for ulcers.		2.4120epoxy steroid;
steroid lactone		EC 3.6.3.9 (Na(+)/K(+)-transporting ATPase) inhibitor
bufalin
bufalin: cardiotonic; powerful anesthetic & one of the active constituents of the Chinese drug ch'an su(senso); in Japan prepared from skin of Bufo bufo garfarizans; RN given refers to (3beta,5beta)-isomer. bufalin : A 14beta-hydroxy steroid that is bufan-20,22-dienolide having hydroxy substituents at the 5beta- and 14beta-positions. It has been isolated from the skin of the toad Bufo bufo.		2.412014beta-hydroxy steroid;
3beta-hydroxy steroid		animal metabolite;
anti-inflammatory agent;
antineoplastic agent;
cardiotonic drug
cinobufagin
cinobufagin: isolated from Chinese medicinal preparation ch'an su; derived from toad venom		2.7130steroid lactone
bufotalin
bufotalin: from toads; structure		2.4120steroid lactone
ConditionIndicatedRelationship StrengthStudiesTrials
Granulocytic Leukemia
[description not available]		0210
Cancer of Nasopharynx
[description not available]		0210
Leukemia, Myeloid
Form of leukemia characterized by an uncontrolled proliferation of the myeloid lineage and their precursors (MYELOID PROGENITOR CELLS) in the bone marrow and other sites.		0210
Nasopharyngeal Neoplasms
Tumors or cancer of the NASOPHARYNX.		0210
Cancer of Liver
[description not available]		02.0110
Liver Neoplasms
Tumors or cancer of the LIVER.		02.0110