desacetylcinobufagin and Leukemia--Myeloid

desacetylcinobufagin has been researched along with Leukemia--Myeloid* in 1 studies

Other Studies

1 other study(ies) available for desacetylcinobufagin and Leukemia--Myeloid

Article	Year
Isolation and structure of five new cancer cell growth inhibitory bufadienolides from the Chinese traditional drug Ch'an Su. Journal of natural products, 2001, Volume: 64, Issue:9 Five new bufadienolides, 3beta-formyloxyresibufogenin (1), 19-oxobufalin (2), 19-oxodesacetylcinobufagin (3), 6alpha-hydroxycinobufagin (4), and 1beta-hydroxybufalin (5), have been isolated together with the previously known bufadienolides 6-20 from the Chinese traditional drug "Ch'an Su". The structures were elucidated employing spectroscopic methods. Bufadienolides 1-5 provided significant inhibitory activity against the KB and HL-60 cancer cell lines. In addition, bufadienolide 1 was found active against the MH-60 cancer cell line. Topics: Animals; Antineoplastic Agents; Bufanolides; Bufonidae; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; HL-60 Cells; Humans; KB Cells; Leukemia, Myeloid; Magnetic Resonance Spectroscopy; Medicine, Chinese Traditional; Mice; Molecular Conformation; Molecular Structure; Nasopharyngeal Neoplasms; Skin; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet; Tumor Cells, Cultured	2001

Article

Year

Isolation and structure of five new cancer cell growth inhibitory bufadienolides from the Chinese traditional drug Ch'an Su.

Journal of natural products, 2001, Volume: 64, Issue:9

Five new bufadienolides, 3beta-formyloxyresibufogenin (1), 19-oxobufalin (2), 19-oxodesacetylcinobufagin (3), 6alpha-hydroxycinobufagin (4), and 1beta-hydroxybufalin (5), have been isolated together with the previously known bufadienolides 6-20 from the Chinese traditional drug "Ch'an Su". The structures were elucidated employing spectroscopic methods. Bufadienolides 1-5 provided significant inhibitory activity against the KB and HL-60 cancer cell lines. In addition, bufadienolide 1 was found active against the MH-60 cancer cell line.

Topics: Animals; Antineoplastic Agents; Bufanolides; Bufonidae; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; HL-60 Cells; Humans; KB Cells; Leukemia, Myeloid; Magnetic Resonance Spectroscopy; Medicine, Chinese Traditional; Mice; Molecular Conformation; Molecular Structure; Nasopharyngeal Neoplasms; Skin; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet; Tumor Cells, Cultured

2001