Compounds > cs 8958
Page last updated: 2024-11-11

cs 8958

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Description

CS 8958: prodrug of R-125489; 2- and 3-acylated isomers are in rapid equilibrium in aqueous solution; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID10412535
MeSH IDM0543370
PubMed CID9847629
CHEMBL ID467058
CHEBI ID134741
SCHEMBL ID11024932
MeSH IDM0543370

Synonyms (37)

Synonym
cs 8958
cs8958
(4s,5r,6r)-5-acetamido-4-guanidino-6-((1r,2r)-2-hydroxy-1-methoxy-3-(octanoyloxy)propyl)-5,6-dihydro-4h-pyran-2-carboxylic acid
S900005430 ,
(2r,4s)-4-carbamimidamido-3-acetamido-2-((1r,2r)-2-hydroxy-1-methoxy-3-(octanoyloxy)propyl)-3,4-dihydro-2h-pyran-6-carboxylic acid
(2r,4s)-3-acetamido-4-(diaminomethylideneamino)-2-[(1r,2r)-2-hydroxy-1-methoxy-3-octanoyloxypropyl]-3,4-dihydro-2h-pyran-6-carboxylic acid
r-118958
CHEBI:134741
cs-8958
laninamivir octanoate
5-(acetylamino)-4-[(aminoiminomethyl)amino]-2,6-anhydro-3,4,5-trideoxy-7-o-methyl-d-glycero-d-galacto-non-2-enonic acid 9-octanoate
CHEMBL467058
laninamivir octanoic acid ester
5-acetamido-2,6-anhydro-4-carbamimidamido-3,4,5-trideoxy-7-o-methyl-9-o-octanoyl-d-glycero-d-galacto-non-2-enonic acid
e026v904rl ,
unii-e026v904rl
203120-46-1
laninamivir octanoate, (+)-
(2r,3r,4s)-3-acetamido-4-guanidino-2-((1r,2r)-2-hydroxy-1-methoxy-3-(octanoyloxy)propyl)-3,4-dihydro-2h-pyran-6-carboxylic acid
laninamivir octanoate [who-dd]
laninamivir octanoic acid ester [mi]
SCHEMBL11024932
bdbm50483194
J-013205
C21598
(2r,3r,4s)-3-acetamido-4-(diaminomethylideneamino)-2-[(1r,2r)-2-hydroxy-1-methoxy-3-octanoyloxypropyl]-3,4-dihydro-2h-pyran-6-carboxylic acid
DB11888
5-(acetylamino)-2,6-anhydro-4-carbamimidamido-3,4,5-trideoxy-7-o-methyl-9-o-octanoyl-d-glycero-d-galacto-non-2-enonic
(4s,5r,6r)-5-acetamido-4-guanidino-6-[(1r,2r)- 2-hydroxy-1-methoxy-3-(octanoyloxy)propyl]-5,6-dihydro-4h-pyran-2-carboxylic acid
Q27276692
EX-A4621
MS-28745
HY-14818A
DTXSID001314719
CS-0077113
(2r,3r,4s)-4-carbamimidamido-3-acetamido-2-[(1r,2r)-2-hydroxy-1-methoxy-3-(octanoyloxy)propyl]-3,4-dihydro-2h-pyran-6-carboxylic acid
AC-36539

Research Excerpts

Pharmacokinetics

ExcerptReferenceRelevance
" CS-8958 disappeared from plasma with a half-life of about 2 hours, although laninamivir was slowly eliminated from the body, lasting for even up to 144 hours after administration with a half-life of about 3 days."( Clinical pharmacokinetics of laninamivir, a novel long-acting neuraminidase inhibitor, after single and multiple inhaled doses of its prodrug, CS-8958, in healthy male volunteers.
Ishizuka, H; Okabe, H; Yoshiba, S; Yoshihara, K, 2010)		0.36
" After intratracheal administration of CS-8958, plasma R-125489 concentration was slowly eliminated, and its half-life (14."( Pharmacokinetics and disposition of CS-8958, a long-acting prodrug of the novel neuraminidase inhibitor laninamivir in rats.
Hoshi, M; Kobayashi, N; Koyama, K; Murai, T; Nakai, N; Okazaki, O; Takahashi, M; Takakusa, H; Yamamura, N, 2010)		0.36
" The area under the concentration-time curve extrapolated to infinity (AUC(0-inf)), maximum concentration (C(max)), and time to C(max) of CS-8958 did not change with the degree of renal impairment, whereas the half-life (t(1/2)) of CS-8958 increased with increasing renal insufficiency."( Assessment of the effects of renal impairment on the pharmacokinetic profile of laninamivir, a novel neuraminidase inhibitor, after a single inhaled dose of its Prodrug, CS-8958.
Ishizuka, H; Okabe, H; Yoshiba, S; Yoshihara, K, 2011)		0.37

Dosage Studied

ExcerptRelevanceReference
" The clinical and laboratory parameters and plasma and urinary concentrations of CS-8958 and laninamivir for 144 hours post dosing were measured."( Clinical pharmacokinetics of laninamivir, a novel long-acting neuraminidase inhibitor, after single and multiple inhaled doses of its prodrug, CS-8958, in healthy male volunteers.
Ishizuka, H; Okabe, H; Yoshiba, S; Yoshihara, K, 2010)		0.36
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
fatty acid esterA carboxylic ester in which the carboxylic acid component can be any fatty acid.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (1)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Neuraminidase Influenza A virus (A/Wilson-Smith/1933(H1N1))IC50 (µMol)0.42810.00000.503510.0000AID542945; AID542946; AID542947; AID542948; AID542949; AID542950; AID542951; AID542952; AID542953; AID542954; AID542955; AID542956; AID542957; AID542958; AID542959; AID542960; AID542961; AID542962; AID542963; AID542964; AID542965; AID542966; AID542967; AID542968; AID542969; AID542970; AID542971; AID542995; AID542996; AID542997; AID542998; AID542999; AID543000; AID543001; AID543002
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (126)

Assay IDTitleYearJournalArticle
AID542945Inhibition of Influenza A virus (A/Puerto Rico/8/1934(H1N1)) neuraminidase after 30 mins by fluorescence analysis2009Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1
CS-8958, a prodrug of the new neuraminidase inhibitor R-125489, shows long-acting anti-influenza virus activity.
AID573451Prodrug conversion in BALB/cAnNCrlCrlj mouse lung S9 fraction assessed as compound conversion to R-125489 at 10 uM relative to untreated control2009Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11
CS-8958, a prodrug of the novel neuraminidase inhibitor R-125489, demonstrates a favorable long-retention profile in the mouse respiratory tract.
AID542981Inhibition of Influenza B virus (B/Aichi/3/2006(Victoria)) neuraminidase after 30 mins by fluorescence analysis2009Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1
CS-8958, a prodrug of the new neuraminidase inhibitor R-125489, shows long-acting anti-influenza virus activity.
AID1212164Aqueous solubility of the compound2013Drug metabolism and disposition: the biological fate of chemicals, Jan, Volume: 41, Issue:1
Pharmacokinetic mechanism involved in the prolonged high retention of laninamivir in mouse respiratory tissues after intranasal administration of its prodrug laninamivir octanoate.
AID524864Antimicrobial activity against Influenza A virus (A/Puerto Rico/8/34(H1N1)) infected in BALB/c mouse assessed as reduction in viral titer in lung at 0.24 mg/kg, itn administered 11 hrs post infection measured after 59 hrs post infection2010Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3
Laninamivir prodrug CS-8958, a long-acting neuraminidase inhibitor, shows superior anti-influenza virus activity after a single administration.
AID524834Antimicrobial activity against Influenza A virus (A/Puerto Rico/8/34(H1N1)) infected in BALB/c mouse assessed as increase in mouse survival at 0.18 mg/kg, itn administered for 7 days before infection2010Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3
Laninamivir prodrug CS-8958, a long-acting neuraminidase inhibitor, shows superior anti-influenza virus activity after a single administration.
AID542976Inhibition of Influenza B virus (B/Yamagata/15/2002(Victoria)) neuraminidase after 30 mins by fluorescence analysis2009Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1
CS-8958, a prodrug of the new neuraminidase inhibitor R-125489, shows long-acting anti-influenza virus activity.
AID1212160Prodrug activation in primary cultured BALB/c mouse airway epithelial cells assessed as formation of laninamivir measured at 60 mins by LC-MS/MS analysis2013Drug metabolism and disposition: the biological fate of chemicals, Jan, Volume: 41, Issue:1
Pharmacokinetic mechanism involved in the prolonged high retention of laninamivir in mouse respiratory tissues after intranasal administration of its prodrug laninamivir octanoate.
AID524835Antimicrobial activity against Influenza A virus (A/Puerto Rico/8/34(H1N1)) infected in BALB/c mouse assessed as increase in mouse survival at 0.37 mg/kg, itn administered for 7 days before infection2010Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3
Laninamivir prodrug CS-8958, a long-acting neuraminidase inhibitor, shows superior anti-influenza virus activity after a single administration.
AID542954Inhibition of Influenza A virus (A/Aichi/169/2005(H1N1)) neuraminidase after 30 mins by fluorescence analysis2009Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1
CS-8958, a prodrug of the new neuraminidase inhibitor R-125489, shows long-acting anti-influenza virus activity.
AID525073Antimicrobial activity against H274Y mutant oseltamivir-resistant influenza A virus (A/Yokohama/67/2006 (H1N1)) clone 11 infected in BALB/c mouse assessed as reduction in viral titer in lung at 0.080 mg/kg, itn administered 13 hrs post infection measured 2010Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3
Laninamivir prodrug CS-8958, a long-acting neuraminidase inhibitor, shows superior anti-influenza virus activity after a single administration.
AID1212187AUClast in BALB/cAnNCrlCrlj mouse epithelial lining fluid at 0.5 umol/kg administered intranasally2013Drug metabolism and disposition: the biological fate of chemicals, Jan, Volume: 41, Issue:1
Pharmacokinetic mechanism involved in the prolonged high retention of laninamivir in mouse respiratory tissues after intranasal administration of its prodrug laninamivir octanoate.
AID1212161Prodrug activation in primary cultured BALB/c mouse airway epithelial cells assessed as formation of laninamivir measured at 50 uM measured at 24 hrs by LC-MS/MS analysis2013Drug metabolism and disposition: the biological fate of chemicals, Jan, Volume: 41, Issue:1
Pharmacokinetic mechanism involved in the prolonged high retention of laninamivir in mouse respiratory tissues after intranasal administration of its prodrug laninamivir octanoate.
AID1212194Drug uptake in BALB/cAnNCrlCrlj mouse epithelial lining fluid at 0.5 umol/kg administered intranasally measured at 4 hrs by LC-MS/MS analysis2013Drug metabolism and disposition: the biological fate of chemicals, Jan, Volume: 41, Issue:1
Pharmacokinetic mechanism involved in the prolonged high retention of laninamivir in mouse respiratory tissues after intranasal administration of its prodrug laninamivir octanoate.
AID524856Antimicrobial activity against Influenza B virus (B/Malaysia/2506/2004) infected itn dosed Mustela putorius furo assessed as nasal viral titer treated after 4 hrs post infection measured after 3 days2010Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3
Laninamivir prodrug CS-8958, a long-acting neuraminidase inhibitor, shows superior anti-influenza virus activity after a single administration.
AID525060Antimicrobial activity against oseltamivir-sensitive influenza A virus (A/Yokohama/67/2006 (H1N1)) clone 1 infected in BALB/c mouse assessed as reduction in viral titer in lung at 0.080 mg/kg, itn administered 13 hrs post infection measured after 37 hrs p2010Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3
Laninamivir prodrug CS-8958, a long-acting neuraminidase inhibitor, shows superior anti-influenza virus activity after a single administration.
AID542993Inhibition of Influenza B virus (B/Yamagata/1/2005(Yamagata)) neuraminidase after 30 mins by fluorescence analysis2009Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1
CS-8958, a prodrug of the new neuraminidase inhibitor R-125489, shows long-acting anti-influenza virus activity.
AID542995Inhibition of Influenza A virus (A/R(duck/Mongolia/54/01-duck/Mongolia/47/01)(H5H1)) neuraminidase after 30 mins by fluorescence analysis2009Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1
CS-8958, a prodrug of the new neuraminidase inhibitor R-125489, shows long-acting anti-influenza virus activity.
AID525071Antimicrobial activity against H274Y mutant oseltamivir-resistant influenza A virus (A/Yokohama/67/2006 (H1N1)) clone 11 infected in BALB/c mouse assessed as reduction in viral titer in lung at 0.080 mg/kg, itn administered 13 hrs post infection measured 2010Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3
Laninamivir prodrug CS-8958, a long-acting neuraminidase inhibitor, shows superior anti-influenza virus activity after a single administration.
AID524846Antimicrobial activity against Influenza B virus (B/Hong Kong/05/1972)infected in BALB/c mouse assessed as increase in mouse survival at 0.076 mg/kg, itn administered for 7 days before infection2010Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3
Laninamivir prodrug CS-8958, a long-acting neuraminidase inhibitor, shows superior anti-influenza virus activity after a single administration.
AID542963Inhibition of Influenza A virus (A/Hiroshima/52/2005(H3N2)) neuraminidase after 30 mins by fluorescence analysis2009Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1
CS-8958, a prodrug of the new neuraminidase inhibitor R-125489, shows long-acting anti-influenza virus activity.
AID524851Antimicrobial activity against Influenza A virus (A/Puerto Rico/8/34(H1N1)) infected in BALB/c mouse assessed as reduction in viral titer in lung at 0.027 mg/kg, itn after 11 hrs post infection2010Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3
Laninamivir prodrug CS-8958, a long-acting neuraminidase inhibitor, shows superior anti-influenza virus activity after a single administration.
AID543001Inhibition of Influenza A virus (A/duck/Ukraine/1/1963(H3N8)) neuraminidase after 30 mins by fluorescence analysis2009Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1
CS-8958, a prodrug of the new neuraminidase inhibitor R-125489, shows long-acting anti-influenza virus activity.
AID542952Inhibition of Influenza A virus (A/Aichi/193/2004(H1N1)) neuraminidase after 30 mins by fluorescence analysis2009Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1
CS-8958, a prodrug of the new neuraminidase inhibitor R-125489, shows long-acting anti-influenza virus activity.
AID543002Inhibition of Influenza A virus (A/duck/Memphis/546/1974(H11N9)) neuraminidase after 30 mins by fluorescence analysis2009Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1
CS-8958, a prodrug of the new neuraminidase inhibitor R-125489, shows long-acting anti-influenza virus activity.
AID1212180Tmax in BALB/cAnNCrlCrlj mouse plasma at 0.5 umol/kg administered intranasally2013Drug metabolism and disposition: the biological fate of chemicals, Jan, Volume: 41, Issue:1
Pharmacokinetic mechanism involved in the prolonged high retention of laninamivir in mouse respiratory tissues after intranasal administration of its prodrug laninamivir octanoate.
AID542950Inhibition of Influenza A virus (A/Yamagata/57/2002(H1N1)) neuraminidase after 30 mins by fluorescence analysis2009Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1
CS-8958, a prodrug of the new neuraminidase inhibitor R-125489, shows long-acting anti-influenza virus activity.
AID542967Inhibition of Influenza A virus (A/Yamagata/2/2002(H3N2)) neuraminidase after 30 mins by fluorescence analysis2009Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1
CS-8958, a prodrug of the new neuraminidase inhibitor R-125489, shows long-acting anti-influenza virus activity.
AID573453Prodrug conversion in BALB/cAnNCrlCrlj mouse lung S9 fraction assessed as compound conversion to R-125489 at 10 uM in presence of esterase inhibitor eserine administered 10 mins before compound addition relative to untreated control2009Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11
CS-8958, a prodrug of the novel neuraminidase inhibitor R-125489, demonstrates a favorable long-retention profile in the mouse respiratory tract.
AID542986Inhibition of Influenza B virus (B/Shizuoka/58/2004(Yamagata)) neuraminidase after 30 mins by fluorescence analysis2009Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1
CS-8958, a prodrug of the new neuraminidase inhibitor R-125489, shows long-acting anti-influenza virus activity.
AID1872672Elimination half life in INH dosed mouse lungs2022European journal of medicinal chemistry, Mar-15, Volume: 232Influenza-existing drugs and treatment prospects.
AID542979Inhibition of Influenza B virus (B/Yamagata/145/2003(Victoria)) neuraminidase after 30 mins by fluorescence analysis2009Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1
CS-8958, a prodrug of the new neuraminidase inhibitor R-125489, shows long-acting anti-influenza virus activity.
AID573449Prodrug conversion in BALB/cAnNCrlCrlj mouse trachea assessed as compound conversion to R-125489 at 10 uM relative to untreated control2009Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11
CS-8958, a prodrug of the novel neuraminidase inhibitor R-125489, demonstrates a favorable long-retention profile in the mouse respiratory tract.
AID542956Inhibition of Influenza A virus (A/Singapore/1/1957(H2N2)) neuraminidase after 30 mins by fluorescence analysis2009Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1
CS-8958, a prodrug of the new neuraminidase inhibitor R-125489, shows long-acting anti-influenza virus activity.
AID542990Inhibition of Influenza B virus (B/Saitama/01/2005(Yamagata)) neuraminidase after 30 mins by fluorescence analysis2009Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1
CS-8958, a prodrug of the new neuraminidase inhibitor R-125489, shows long-acting anti-influenza virus activity.
AID1212191AUClast in BALB/cAnNCrlCrlj mouse plasma at 0.5 umol/kg administered intranasally2013Drug metabolism and disposition: the biological fate of chemicals, Jan, Volume: 41, Issue:1
Pharmacokinetic mechanism involved in the prolonged high retention of laninamivir in mouse respiratory tissues after intranasal administration of its prodrug laninamivir octanoate.
AID542998Inhibition of Influenza A virus (A/duck/Alberta/60/1976(H12N5)) neuraminidase after 30 mins by fluorescence analysis2009Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1
CS-8958, a prodrug of the new neuraminidase inhibitor R-125489, shows long-acting anti-influenza virus activity.
AID542955Inhibition of Influenza A virus (A/Yamagata/83/2006(H1N1)) neuraminidase after 30 mins by fluorescence analysis2009Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1
CS-8958, a prodrug of the new neuraminidase inhibitor R-125489, shows long-acting anti-influenza virus activity.
AID573455Prodrug conversion in BALB/cAnNCrlCrlj mouse lung S9 fraction assessed as compound conversion to R-125489 at 10 uM in presence of esterase inhibitor DTNB administered 10 mins before compound addition relative to untreated control2009Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11
CS-8958, a prodrug of the novel neuraminidase inhibitor R-125489, demonstrates a favorable long-retention profile in the mouse respiratory tract.
AID1212163Lipophilicity, log D of the compound at pH 7.42013Drug metabolism and disposition: the biological fate of chemicals, Jan, Volume: 41, Issue:1
Pharmacokinetic mechanism involved in the prolonged high retention of laninamivir in mouse respiratory tissues after intranasal administration of its prodrug laninamivir octanoate.
AID542997Inhibition of Influenza A virus (A/turkey/Ontario/6,118/1968(H8N4)) neuraminidase after 30 mins by fluorescence analysis2009Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1
CS-8958, a prodrug of the new neuraminidase inhibitor R-125489, shows long-acting anti-influenza virus activity.
AID525076Antimicrobial activity against Influenza A virus (A/Puerto Rico/8/34(H1N1)) infected in BALB/c mouse assessed as increase in mouse survival at 0.17 mg/kg, itn for 4 days post infection2010Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3
Laninamivir prodrug CS-8958, a long-acting neuraminidase inhibitor, shows superior anti-influenza virus activity after a single administration.
AID573450Prodrug conversion in BALB/cAnNCrlCrlj mouse trachea assessed as compound conversion to R-125489 at 10 uM in presence of esterase inhibitor DFP administered 10 mins before compound addition relative to untreated control2009Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11
CS-8958, a prodrug of the novel neuraminidase inhibitor R-125489, demonstrates a favorable long-retention profile in the mouse respiratory tract.
AID525081Antimicrobial activity against Influenza A virus (A/Puerto Rico/8/34(H1N1)) infected in BALB/c mouse assessed as increase in mouse survival at 0.017 mg/kg, itn administered 11 hrs post infection for 5 days before infection measured on day 202010Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3
Laninamivir prodrug CS-8958, a long-acting neuraminidase inhibitor, shows superior anti-influenza virus activity after a single administration.
AID573452Prodrug conversion in BALB/cAnNCrlCrlj mouse lung S9 fraction assessed as compound conversion to R-125489 at 10 uM in presence of esterase inhibitor DFP administered 10 mins before compound addition relative to untreated control2009Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11
CS-8958, a prodrug of the novel neuraminidase inhibitor R-125489, demonstrates a favorable long-retention profile in the mouse respiratory tract.
AID1212182Elimination half life in BALB/cAnNCrlCrlj mouse epithelial lining fluid at 0.5 umol/kg administered intranasally2013Drug metabolism and disposition: the biological fate of chemicals, Jan, Volume: 41, Issue:1
Pharmacokinetic mechanism involved in the prolonged high retention of laninamivir in mouse respiratory tissues after intranasal administration of its prodrug laninamivir octanoate.
AID524833Antimicrobial activity against Influenza A virus (A/Puerto Rico/8/34(H1N1)) infected in BALB/c mouse assessed as increase in mouse survival at 0.095 mg/kg, itn administered for 7 days before infection2010Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3
Laninamivir prodrug CS-8958, a long-acting neuraminidase inhibitor, shows superior anti-influenza virus activity after a single administration.
AID542949Inhibition of Influenza A virus (A/Yamagata/3/2002(H1N1)) neuraminidase after 30 mins by fluorescence analysis2009Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1
CS-8958, a prodrug of the new neuraminidase inhibitor R-125489, shows long-acting anti-influenza virus activity.
AID542983Inhibition of Influenza B virus (B/Mie/1/1993(Yamagata)) neuraminidase after 30 mins by fluorescence analysis2009Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1
CS-8958, a prodrug of the new neuraminidase inhibitor R-125489, shows long-acting anti-influenza virus activity.
AID542992Inhibition of Influenza B virus (B/Tokushima/1/2005(Yamagata)) neuraminidase after 30 mins by fluorescence analysis2009Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1
CS-8958, a prodrug of the new neuraminidase inhibitor R-125489, shows long-acting anti-influenza virus activity.
AID542951Inhibition of Influenza A virus (A/Saitama/78/2003(H1N1)) neuraminidase after 30 mins by fluorescence analysis2009Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1
CS-8958, a prodrug of the new neuraminidase inhibitor R-125489, shows long-acting anti-influenza virus activity.
AID1212169Cmax in BALB/cAnNCrlCrlj mouse epithelial lining fluid at 0.5 umol/kg administered intranasally2013Drug metabolism and disposition: the biological fate of chemicals, Jan, Volume: 41, Issue:1
Pharmacokinetic mechanism involved in the prolonged high retention of laninamivir in mouse respiratory tissues after intranasal administration of its prodrug laninamivir octanoate.
AID1212171Cmax in BALB/cAnNCrlCrlj mouse lung at 0.5 umol/kg administered intranasally2013Drug metabolism and disposition: the biological fate of chemicals, Jan, Volume: 41, Issue:1
Pharmacokinetic mechanism involved in the prolonged high retention of laninamivir in mouse respiratory tissues after intranasal administration of its prodrug laninamivir octanoate.
AID524850Antimicrobial activity against Influenza A virus (A/Puerto Rico/8/34(H1N1)) infected in BALB/c mouse assessed as increase in mouse survival at 0.017 mg/kg, itn administered 11 hrs post infection for 5 days before infection2010Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3
Laninamivir prodrug CS-8958, a long-acting neuraminidase inhibitor, shows superior anti-influenza virus activity after a single administration.
AID524863Antimicrobial activity against Influenza A virus (A/Puerto Rico/8/34(H1N1)) infected in BALB/c mouse assessed as reduction in viral titer in lung at 0.24 mg/kg, itn administered 11 hrs post infection measured after 35 hrs post infection2010Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3
Laninamivir prodrug CS-8958, a long-acting neuraminidase inhibitor, shows superior anti-influenza virus activity after a single administration.
AID1212183Elimination half life in BALB/cAnNCrlCrlj mouse lung at 0.5 umol/kg administered intranasally2013Drug metabolism and disposition: the biological fate of chemicals, Jan, Volume: 41, Issue:1
Pharmacokinetic mechanism involved in the prolonged high retention of laninamivir in mouse respiratory tissues after intranasal administration of its prodrug laninamivir octanoate.
AID542996Inhibition of Influenza A virus (A/duck/Hokkaido/84/2002(H5N3)) neuraminidase after 30 mins by fluorescence analysis2009Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1
CS-8958, a prodrug of the new neuraminidase inhibitor R-125489, shows long-acting anti-influenza virus activity.
AID542969Inhibition of Influenza A virus (A/Osaka/56/2004(H3N2)) neuraminidase after 30 mins by fluorescence analysis2009Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1
CS-8958, a prodrug of the new neuraminidase inhibitor R-125489, shows long-acting anti-influenza virus activity.
AID542946Inhibition of Influenza A virus (A/Yamagata/32/1989(H1N1)) neuraminidase after 30 mins by fluorescence analysis2009Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1
CS-8958, a prodrug of the new neuraminidase inhibitor R-125489, shows long-acting anti-influenza virus activity.
AID573456Prodrug conversion in BALB/cAnNCrlCrlj mouse lung S9 fraction assessed as compound conversion to R-125489 at 10 uM in presence of esterase inhibitor EDTA administered 10 mins before compound addition relative to untreated control2009Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11
CS-8958, a prodrug of the novel neuraminidase inhibitor R-125489, demonstrates a favorable long-retention profile in the mouse respiratory tract.
AID525077Antimicrobial activity against Influenza A virus (A/Puerto Rico/8/34(H1N1)) infected in BALB/c mouse assessed as increase in mouse survival at 0.17 mg/kg, itn for 1 day post infection2010Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3
Laninamivir prodrug CS-8958, a long-acting neuraminidase inhibitor, shows superior anti-influenza virus activity after a single administration.
AID524847Antimicrobial activity against Influenza B virus (B/Hong Kong/05/1972) infected in BALB/c mouse assessed as increase in mouse survival at 0.23 mg/kg, itn administered for 7 days before infection2010Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3
Laninamivir prodrug CS-8958, a long-acting neuraminidase inhibitor, shows superior anti-influenza virus activity after a single administration.
AID542961Inhibition of Influenza A virus (A/California/07/2004(H3N2)) neuraminidase after 30 mins by fluorescence analysis2009Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1
CS-8958, a prodrug of the new neuraminidase inhibitor R-125489, shows long-acting anti-influenza virus activity.
AID1212176Tmax in BALB/cAnNCrlCrlj mouse epithelial lining fluid at 0.5 umol/kg administered intranasally2013Drug metabolism and disposition: the biological fate of chemicals, Jan, Volume: 41, Issue:1
Pharmacokinetic mechanism involved in the prolonged high retention of laninamivir in mouse respiratory tissues after intranasal administration of its prodrug laninamivir octanoate.
AID1212185Elimination half life in BALB/cAnNCrlCrlj mouse plasma at 0.5 umol/kg administered intranasally2013Drug metabolism and disposition: the biological fate of chemicals, Jan, Volume: 41, Issue:1
Pharmacokinetic mechanism involved in the prolonged high retention of laninamivir in mouse respiratory tissues after intranasal administration of its prodrug laninamivir octanoate.
AID542999Inhibition of Influenza A virus (A/duck/England/1/1956(H11N6)) neuraminidase after 30 mins by fluorescence analysis2009Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1
CS-8958, a prodrug of the new neuraminidase inhibitor R-125489, shows long-acting anti-influenza virus activity.
AID525062Antimicrobial activity against oseltamivir-sensitive influenza A virus (A/Yokohama/67/2006 (H1N1)) clone 1 infected in BALB/c mouse assessed as reduction in viral titer in lung at 0.080 mg/kg, itn administered post 13 hrs infection measured after 85 hrs p2010Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3
Laninamivir prodrug CS-8958, a long-acting neuraminidase inhibitor, shows superior anti-influenza virus activity after a single administration.
AID542959Inhibition of Influenza A virus (A/Wyoming/03/2003(H3N2)) neuraminidase after 30 mins by fluorescence analysis2009Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1
CS-8958, a prodrug of the new neuraminidase inhibitor R-125489, shows long-acting anti-influenza virus activity.
AID542987Inhibition of Influenza B virus (B/Yamagata/85/2004(Yamagata)) neuraminidase after 30 mins by fluorescence analysis2009Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1
CS-8958, a prodrug of the new neuraminidase inhibitor R-125489, shows long-acting anti-influenza virus activity.
AID573441Half life in BALB/cAnNCrlCrlj mouse lung at 0.5 umol/kg administered as [14C]labeled compound intranasally as single dose2009Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11
CS-8958, a prodrug of the novel neuraminidase inhibitor R-125489, demonstrates a favorable long-retention profile in the mouse respiratory tract.
AID542985Inhibition of Influenza B virus (B/Shiga/31/2002(Yamagata)) neuraminidase after 30 mins by fluorescence analysis2009Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1
CS-8958, a prodrug of the new neuraminidase inhibitor R-125489, shows long-acting anti-influenza virus activity.
AID542994Inhibition of Influenza B virus (B/Yamagata/113/2005(Yamagata)) neuraminidase after 30 mins by fluorescence analysis2009Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1
CS-8958, a prodrug of the new neuraminidase inhibitor R-125489, shows long-acting anti-influenza virus activity.
AID542968Inhibition of Influenza A virus (A/Saitama/80/2003(H3N2)) neuraminidase after 30 mins by fluorescence analysis2009Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1
CS-8958, a prodrug of the new neuraminidase inhibitor R-125489, shows long-acting anti-influenza virus activity.
AID524865Antimicrobial activity against Influenza A virus (A/Puerto Rico/8/34(H1N1)) infected in BALB/c mouse assessed as reduction in viral titer in lung at 0.24 mg/kg, itn administered 11 hrs post infection measured after 83 hrs post infection2010Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3
Laninamivir prodrug CS-8958, a long-acting neuraminidase inhibitor, shows superior anti-influenza virus activity after a single administration.
AID573277Cmax in BALB/cAnNCrlCrlj mouse lung assessed as compound concentration per gram of tissue at 0.5 umol/kg administered as [14C]labeled compound intranasally as single dose2009Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11
CS-8958, a prodrug of the novel neuraminidase inhibitor R-125489, demonstrates a favorable long-retention profile in the mouse respiratory tract.
AID1212189AUClast in BALB/cAnNCrlCrlj mouse lung at 0.5 umol/kg administered intranasally2013Drug metabolism and disposition: the biological fate of chemicals, Jan, Volume: 41, Issue:1
Pharmacokinetic mechanism involved in the prolonged high retention of laninamivir in mouse respiratory tissues after intranasal administration of its prodrug laninamivir octanoate.
AID525072Antimicrobial activity against H274Y mutant oseltamivir-resistant influenza A virus (A/Yokohama/67/2006 (H1N1)) clone 11 infected in BALB/c mouse assessed as reduction in viral titer in lung at 0.080 mg/kg, itn administered 13 hrs post infection measured 2010Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3
Laninamivir prodrug CS-8958, a long-acting neuraminidase inhibitor, shows superior anti-influenza virus activity after a single administration.
AID524842Antimicrobial activity against Influenza A virus (A/Puerto Rico/8/34(H1N1)) infected in BALB/c mouse assessed as increase in mouse survival at 0.76 mg/kg, itn administered for 7 days before infection2010Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3
Laninamivir prodrug CS-8958, a long-acting neuraminidase inhibitor, shows superior anti-influenza virus activity after a single administration.
AID542948Inhibition of Influenza A virus (A/Shiga/1/2002(H1N1)) neuraminidase after 30 mins by fluorescence analysis2009Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1
CS-8958, a prodrug of the new neuraminidase inhibitor R-125489, shows long-acting anti-influenza virus activity.
AID352049Antiviral activity against Influenza A virus (A/Puerto Rico/8/34(H1N1)) infected mouse assessed as mouse survival at 0.3 umol/kg dosed intranasally 4 hrs before and 4 hrs, 17 hrs after viral infection measured 20 days post infection2009Bioorganic & medicinal chemistry letters, Jun-01, Volume: 19, Issue:11
Synthesis and in vivo influenza virus-inhibitory effect of ester prodrug of 4-guanidino-7-O-methyl-Neu5Ac2en.
AID1872671Tmax in INH dosed mouse lungs2022European journal of medicinal chemistry, Mar-15, Volume: 232Influenza-existing drugs and treatment prospects.
AID542989Inhibition of Influenza B virus (B/Aichi/186/2005(Yamagata)) neuraminidase after 30 mins by fluorescence analysis2009Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1
CS-8958, a prodrug of the new neuraminidase inhibitor R-125489, shows long-acting anti-influenza virus activity.
AID542965Inhibition of Influenza A virus (A/Shiga/5/2002(H3N2)) neuraminidase after 30 mins by fluorescence analysis2009Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1
CS-8958, a prodrug of the new neuraminidase inhibitor R-125489, shows long-acting anti-influenza virus activity.
AID524841Antimicrobial activity against Influenza A virus (A/Puerto Rico/8/34(H1N1)) infected in BALB/c mouse assessed as increase in mouse survival at 0.25 mg/kg, itn administered for 7 days before infection2010Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3
Laninamivir prodrug CS-8958, a long-acting neuraminidase inhibitor, shows superior anti-influenza virus activity after a single administration.
AID542962Inhibition of Influenza A virus (A/New York/55/2004(H3N2)) neuraminidase after 30 mins by fluorescence analysis2009Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1
CS-8958, a prodrug of the new neuraminidase inhibitor R-125489, shows long-acting anti-influenza virus activity.
AID543000Inhibition of Influenza A virus (A/seal/Massachusetts/1/1980(H7N7)) neuraminidase after 30 mins by fluorescence analysis2009Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1
CS-8958, a prodrug of the new neuraminidase inhibitor R-125489, shows long-acting anti-influenza virus activity.
AID525078Antimicrobial activity against Influenza A virus (A/Puerto Rico/8/34(H1N1)) infected in BALB/c mouse assessed as increase in mouse survival at 0.17 mg/kg, itn for 12 hrs post infection2010Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3
Laninamivir prodrug CS-8958, a long-acting neuraminidase inhibitor, shows superior anti-influenza virus activity after a single administration.
AID542975Inhibition of Influenza B virus (B/Shiga/17/2002(Victoria)) neuraminidase after 30 mins by fluorescence analysis2009Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1
CS-8958, a prodrug of the new neuraminidase inhibitor R-125489, shows long-acting anti-influenza virus activity.
AID1212208Prodrug activation in primary cultured BALB/c mouse airway epithelial cells assessed as formation of laninamivir at 50 uM measured up to 60 to 90 mins by LC-MS/MS analysis2013Drug metabolism and disposition: the biological fate of chemicals, Jan, Volume: 41, Issue:1
Pharmacokinetic mechanism involved in the prolonged high retention of laninamivir in mouse respiratory tissues after intranasal administration of its prodrug laninamivir octanoate.
AID524855Antimicrobial activity against Influenza B virus (B/Malaysia/2506/2004) infected itn dosed Mustela putorius furo assessed as nasal viral titer treated after 4 hrs post infection measured after 2 days2010Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3
Laninamivir prodrug CS-8958, a long-acting neuraminidase inhibitor, shows superior anti-influenza virus activity after a single administration.
AID542947Inhibition of Influenza A virus (A/New Caledonia/20/1999(H1N1)) neuraminidase after 30 mins by fluorescence analysis2009Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1
CS-8958, a prodrug of the new neuraminidase inhibitor R-125489, shows long-acting anti-influenza virus activity.
AID573278Tmax in BALB/cAnNCrlCrlj mouse lung at 0.5 umol/kg administered as [14C]labeled compound intranasally as single dose2009Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11
CS-8958, a prodrug of the novel neuraminidase inhibitor R-125489, demonstrates a favorable long-retention profile in the mouse respiratory tract.
AID1212174Cmax in BALB/cAnNCrlCrlj mouse plasma at 0.5 umol/kg administered intranasally2013Drug metabolism and disposition: the biological fate of chemicals, Jan, Volume: 41, Issue:1
Pharmacokinetic mechanism involved in the prolonged high retention of laninamivir in mouse respiratory tissues after intranasal administration of its prodrug laninamivir octanoate.
AID524854Antimicrobial activity against Influenza B virus (B/Malaysia/2506/2004) infected itn dosed Mustela putorius furo assessed as nasal viral titer treated after 4 hrs post infection measured after 1 day2010Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3
Laninamivir prodrug CS-8958, a long-acting neuraminidase inhibitor, shows superior anti-influenza virus activity after a single administration.
AID542958Inhibition of Influenza A virus (A/Kitakyushu/159/1993(H3N2)) neuraminidase after 30 mins by fluorescence analysis2009Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1
CS-8958, a prodrug of the new neuraminidase inhibitor R-125489, shows long-acting anti-influenza virus activity.
AID542953Inhibition of Influenza A virus (A/Okinawa/42/2004(H1N1)) neuraminidase after 30 mins by fluorescence analysis2009Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1
CS-8958, a prodrug of the new neuraminidase inhibitor R-125489, shows long-acting anti-influenza virus activity.
AID542988Inhibition of Influenza B virus (B/Yamagata/87/2004(Yamagata)) neuraminidase after 30 mins by fluorescence analysis2009Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1
CS-8958, a prodrug of the new neuraminidase inhibitor R-125489, shows long-acting anti-influenza virus activity.
AID524836Antimicrobial activity against Influenza A virus (A/Puerto Rico/8/34(H1N1)) infected in BALB/c mouse assessed as increase in mouse survival at 0.71 mg/kg, itn administered for 7 days before infection2010Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3
Laninamivir prodrug CS-8958, a long-acting neuraminidase inhibitor, shows superior anti-influenza virus activity after a single administration.
AID542980Inhibition of Influenza B virus (B/Yamagata/398/2003(Victoria)) neuraminidase after 30 mins by fluorescence analysis2009Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1
CS-8958, a prodrug of the new neuraminidase inhibitor R-125489, shows long-acting anti-influenza virus activity.
AID525074Antimicrobial activity against Influenza A virus (A/Puerto Rico/8/34(H1N1)) infected in BALB/c mouse assessed as reduction in viral titer in lung at 0.080 mg/kg, itn after 11 hrs post infection2010Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3
Laninamivir prodrug CS-8958, a long-acting neuraminidase inhibitor, shows superior anti-influenza virus activity after a single administration.
AID542984Inhibition of Influenza B virus (B/Shanghai/361/2002(Yamagata)) neuraminidase after 30 mins by fluorescence analysis2009Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1
CS-8958, a prodrug of the new neuraminidase inhibitor R-125489, shows long-acting anti-influenza virus activity.
AID543196Antiviral activity against Influenza A virus (A/Puerto Rico/8/1934(H1N1)) infected in mouse infection model at 0.3 umol/kg, itn administered 4 hrs pre-infection and at 4 hrs and 17 hrs post-infection up to 20 days2009Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1
CS-8958, a prodrug of the new neuraminidase inhibitor R-125489, shows long-acting anti-influenza virus activity.
AID542977Inhibition of Influenza B virus (B/Akita/9/2003(Victoria)) neuraminidase after 30 mins by fluorescence analysis2009Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1
CS-8958, a prodrug of the new neuraminidase inhibitor R-125489, shows long-acting anti-influenza virus activity.
AID542974Inhibition of Influenza B virus (B/Ohio/01/2005(Victoria)) neuraminidase after 30 mins by fluorescence analysis2009Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1
CS-8958, a prodrug of the new neuraminidase inhibitor R-125489, shows long-acting anti-influenza virus activity.
AID352048Antiviral activity against Influenza A virus (A/Puerto Rico/8/34(H1N1)) infected mouse assessed as mouse survival at 0.3 umol/kg dosed intranasally 4 hrs before and 4 hrs, 17 hrs after viral infection measured 8 days post infection2009Bioorganic & medicinal chemistry letters, Jun-01, Volume: 19, Issue:11
Synthesis and in vivo influenza virus-inhibitory effect of ester prodrug of 4-guanidino-7-O-methyl-Neu5Ac2en.
AID542960Inhibition of Influenza A virus (A/Wellington/1/2004(H3N2)) neuraminidase after 30 mins by fluorescence analysis2009Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1
CS-8958, a prodrug of the new neuraminidase inhibitor R-125489, shows long-acting anti-influenza virus activity.
AID525075Antimicrobial activity against Influenza A virus (A/Puerto Rico/8/34(H1N1)) infected in BALB/c mouse assessed as increase in mouse survival at 0.17 mg/kg, itn for 7 days post infection2010Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3
Laninamivir prodrug CS-8958, a long-acting neuraminidase inhibitor, shows superior anti-influenza virus activity after a single administration.
AID543197Antiviral activity against Influenza A virus (A/Puerto Rico/8/1934(H1N1)) infected in mouse infection model at 95 ug/kg, itn administered 4 hrs pre-infection and at 4 hrs and 17 hrs post-infection up to 20 days2009Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1
CS-8958, a prodrug of the new neuraminidase inhibitor R-125489, shows long-acting anti-influenza virus activity.
AID542991Inhibition of Influenza B virus (B/Sapporo/29/2005(Yamagata)) neuraminidase after 30 mins by fluorescence analysis2009Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1
CS-8958, a prodrug of the new neuraminidase inhibitor R-125489, shows long-acting anti-influenza virus activity.
AID542966Inhibition of Influenza A virus (A/Yamagata/1/2002(H3N2)) neuraminidase after 30 mins by fluorescence analysis2009Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1
CS-8958, a prodrug of the new neuraminidase inhibitor R-125489, shows long-acting anti-influenza virus activity.
AID573457Prodrug conversion in BALB/cAnNCrlCrlj mouse lung S9 fraction assessed as compound conversion to R-125489 at 10 uM in presence of esterase inhibitor PCMB administered 10 mins before compound addition relative to untreated control2009Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11
CS-8958, a prodrug of the novel neuraminidase inhibitor R-125489, demonstrates a favorable long-retention profile in the mouse respiratory tract.
AID524848Antimicrobial activity against Influenza B virus (B/Hong Kong/05/1972) infected in BALB/c mouse assessed as increase in mouse survival at 0.71 mg/kg, itn administered for 7 days before infection2010Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3
Laninamivir prodrug CS-8958, a long-acting neuraminidase inhibitor, shows superior anti-influenza virus activity after a single administration.
AID542964Inhibition of Influenza A virus (A/Wisconsin/67/2005(H3N2)) neuraminidase after 30 mins by fluorescence analysis2009Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1
CS-8958, a prodrug of the new neuraminidase inhibitor R-125489, shows long-acting anti-influenza virus activity.
AID542971Inhibition of Influenza A virus (A/Saitama/07/2006(H3N2)) neuraminidase after 30 mins by fluorescence analysis2009Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1
CS-8958, a prodrug of the new neuraminidase inhibitor R-125489, shows long-acting anti-influenza virus activity.
AID1212178Tmax in BALB/cAnNCrlCrlj mouse lung at 0.5 umol/kg administered intranasally2013Drug metabolism and disposition: the biological fate of chemicals, Jan, Volume: 41, Issue:1
Pharmacokinetic mechanism involved in the prolonged high retention of laninamivir in mouse respiratory tissues after intranasal administration of its prodrug laninamivir octanoate.
AID542970Inhibition of Influenza A virus (A/Tokushima/1/2005(H3N2)) neuraminidase after 30 mins by fluorescence analysis2009Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1
CS-8958, a prodrug of the new neuraminidase inhibitor R-125489, shows long-acting anti-influenza virus activity.
AID542978Inhibition of Influenza B virus (B/Tokushima/1/2003(Victoria)) neuraminidase after 30 mins by fluorescence analysis2009Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1
CS-8958, a prodrug of the new neuraminidase inhibitor R-125489, shows long-acting anti-influenza virus activity.
AID542972Inhibition of Influenza B virus (B/Brisbane/32/2002(Victoria) neuraminidase after 30 mins by fluorescence analysis2009Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1
CS-8958, a prodrug of the new neuraminidase inhibitor R-125489, shows long-acting anti-influenza virus activity.
AID542982Inhibition of Influenza B virus (B/Saitama/01/2006(Victoria)) neuraminidase after 30 mins by fluorescence analysis2009Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1
CS-8958, a prodrug of the new neuraminidase inhibitor R-125489, shows long-acting anti-influenza virus activity.
AID573454Prodrug conversion in BALB/cAnNCrlCrlj mouse lung S9 fraction assessed as compound conversion to R-125489 at 10 uM in presence of esterase inhibitor BNPP administered 10 mins before compound addition relative to untreated control2009Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11
CS-8958, a prodrug of the novel neuraminidase inhibitor R-125489, demonstrates a favorable long-retention profile in the mouse respiratory tract.
AID542957Inhibition of Influenza A virus (A/Aichi/2/1968(H3N2)) neuraminidase after 30 mins by fluorescence analysis2009Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1
CS-8958, a prodrug of the new neuraminidase inhibitor R-125489, shows long-acting anti-influenza virus activity.
AID1212207Drug uptake in primary cultured BALB/c mouse airway epithelial cells at 50 uM measured up to 90 mins by LC-MS/MS analysis2013Drug metabolism and disposition: the biological fate of chemicals, Jan, Volume: 41, Issue:1
Pharmacokinetic mechanism involved in the prolonged high retention of laninamivir in mouse respiratory tissues after intranasal administration of its prodrug laninamivir octanoate.
AID525084Antimicrobial activity against Influenza B virus (B/Hong Kong/05/1972) infected in BALB/c mouse assessed as increase in mouse survival at 0.23 mg/kg, itn administered for 7 days before infection measured at day 202010Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3
Laninamivir prodrug CS-8958, a long-acting neuraminidase inhibitor, shows superior anti-influenza virus activity after a single administration.
AID542973Inhibition of Influenza B virus (B/Malaysia/2506/2004(Victoria)) neuraminidase after 30 mins by fluorescence analysis2009Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1
CS-8958, a prodrug of the new neuraminidase inhibitor R-125489, shows long-acting anti-influenza virus activity.
AID525061Antimicrobial activity against oseltamivir-sensitive influenza A virus (A/Yokohama/67/2006 (H1N1)) clone 1 infected in BALB/c mouse assessed as reduction in viral titer in lung at 0.080 mg/kg, itn administered 13 hrs post infection measured after 61 hrs p2010Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3
Laninamivir prodrug CS-8958, a long-acting neuraminidase inhibitor, shows superior anti-influenza virus activity after a single administration.
AID524840Antimicrobial activity against Influenza A virus (A/Puerto Rico/8/34(H1N1)) infected in BALB/c mouse assessed as increase in mouse survival at 0.085 mg/kg, itn administered for 7 days before infection2010Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3
Laninamivir prodrug CS-8958, a long-acting neuraminidase inhibitor, shows superior anti-influenza virus activity after a single administration.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (15)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (20.00)29.6817
2010's11 (73.33)24.3611
2020's1 (6.67)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 17.88

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index17.88 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.65 (4.65)
Search Engine Demand Index10.37 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (17.88)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials3 (27.27%)5.53%
Trials0 (0.00%)5.53%
Reviews1 (9.09%)6.00%
Reviews1 (16.67%)6.00%
Case Studies0 (0.00%)4.05%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Observational0 (0.00%)0.25%
Other7 (63.64%)84.16%
Other5 (83.33%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
zanamivir
Zanamivir: A guanido-neuraminic acid that is used to inhibit NEURAMINIDASE.		7.25113guanidinesantiviral agent;
EC 3.2.1.18 (exo-alpha-sialidase) inhibitor
oseltamivir
Oseltamivir: An acetamido cyclohexene that is a structural homolog of SIALIC ACID and inhibits NEURAMINIDASE.. oseltamivir : A cyclohexenecarboxylate ester that is the ethyl ester of oseltamivir acid. An antiviral prodrug (it is hydrolysed to the active free carboxylic acid in the liver), it is used to slow the spread of influenza.		5.4641acetamides;
amino acid ester;
cyclohexenecarboxylate ester;
primary amino compound		antiviral drug;
EC 3.2.1.18 (exo-alpha-sialidase) inhibitor;
environmental contaminant;
prodrug;
xenobiotic
laninamivir
laninamivir: an antiviral agent		6.6182acetamides
zanamivir
Zanamivir: A guanido-neuraminic acid that is used to inhibit NEURAMINIDASE.		2.7430guanidinesantiviral agent;
EC 3.2.1.18 (exo-alpha-sialidase) inhibitor
oseltamivir
Oseltamivir: An acetamido cyclohexene that is a structural homolog of SIALIC ACID and inhibits NEURAMINIDASE.. oseltamivir : A cyclohexenecarboxylate ester that is the ethyl ester of oseltamivir acid. An antiviral prodrug (it is hydrolysed to the active free carboxylic acid in the liver), it is used to slow the spread of influenza.		2.0510acetamides;
amino acid ester;
cyclohexenecarboxylate ester;
primary amino compound		antiviral drug;
EC 3.2.1.18 (exo-alpha-sialidase) inhibitor;
environmental contaminant;
prodrug;
xenobiotic
tamiflu
[no description available]		2.0510phosphate salt
quercetin 5,7,3',4'-tetramethyl ether
quercetin 5,7,3',4'-tetramethyl ether : A tetramethoxyflavone that is the 5,7,3',4'-tetramethy-derivative of quercetin.		3.5110flavonols;
tetramethoxyflavone		plant metabolite
favipiravir
favipiravir : A member of the class of pyrazines that is pyrazine substituted by aminocarbonyl, hydroxy and fluoro groups at positions 2, 3 and 6, respectively. It is an anti-viral agent that inhibits RNA-dependent RNA polymerase of several RNA viruses and is approved for the treatment of influenza in Japan.		3.5110hydroxypyrazine;
organofluorine compound;
primary carboxamide		anticoronaviral agent;
antiviral drug;
EC 2.7.7.48 (RNA-directed RNA polymerase) inhibitor
laninamivir
laninamivir: an antiviral agent		3.1550acetamides
ConditionIndicatedRelationship StrengthStudiesTrials
Grippe
[description not available]		06.161
Influenza, Human
An acute viral infection in humans involving the respiratory tract. It is marked by inflammation of the NASAL MUCOSA; the PHARYNX; and conjunctiva, and by headache and severe, often generalized, myalgia.		18.161
Disease Models, Animal
Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.		03.8940
Infections, Orthomyxoviridae
[description not available]		02.7530
Orthomyxoviridae Infections
Virus diseases caused by the ORTHOMYXOVIRIDAE.		02.7530
Kidney Failure
A severe irreversible decline in the ability of kidneys to remove wastes, concentrate URINE, and maintain ELECTROLYTE BALANCE; BLOOD PRESSURE; and CALCIUM metabolism.		03.4511
Renal Insufficiency
Conditions in which the KIDNEYS perform below the normal level in the ability to remove wastes, concentrate URINE, and maintain ELECTROLYTE BALANCE; BLOOD PRESSURE; and CALCIUM metabolism. Renal insufficiency can be classified by the degree of kidney damage (as measured by the level of PROTEINURIA) and reduction in GLOMERULAR FILTRATION RATE.		03.4511