Compounds > cinmethacin
Page last updated: 2024-12-11

cinmethacin

Cross-References

ID SourceID
PubMed CID6433761
CHEMBL ID2104135
CHEBI ID135478
SCHEMBL ID25139
SCHEMBL ID25138
MeSH IDM0062012

Synonyms (39)

Synonym
5-methoxy-2-methyl-1-(1-oxo-3-phenyl-2-propenyl)-1h-indole-3-acetic acid
cinmetacina [inn-spanish]
1h-indole-3-acetic acid, 5-methoxy-2-methyl-1-(1-oxo-3-phenyl-2-propenyl)-
cinmetacinum [inn-latin]
cinmetacin
cinmetacin [inn]
einecs 243-555-6
cinmetacine [inn-french]
indolacin
1-cinnamoyl-5-methoxy-2-methylindole-3-acetic acid
cindomet
1-cinnamoyl-2-methyl-5-methoxy-3-indolylacetic acid
indole-3-acetic acid, 1-cinnamoyl-5-methoxy-2-methyl-
cinmethacin
CHEBI:135478
2-[5-methoxy-2-methyl-1-[(e)-3-phenylprop-2-enoyl]indol-3-yl]acetic acid
CHEMBL2104135
3zli4719j9 ,
unii-3zli4719j9
881743-37-9
1h-indole-3-acetic acid, 5-methoxy-2-methyl-1((2e)-1-oxo-3-phenyl-2-propen-1-yl)
cinmetacine
1-cinnamoyl-5-methoxy-2-methyl-3-indolylessigsaeure
cinmetacinum
cinmetacina
s 1290
20168-99-4
tvx 1764
cinmetacin [mart.]
cinmetacin [who-dd]
cinmetacin [mi]
1h-indole-3-acetic acid, 5-methoxy-2-methyl-1-((2e)-1-oxo-3-phenyl-2-propen-1-yl)-
SCHEMBL25139
SCHEMBL25138
(2-amino-2-iminoethyl)phenylmethylcarbamicacid ester,monohydrochloride
Q27258257
DTXSID00864922
5-methoxy-2-methyl-1-[(2e)-1-oxo-3-phenyl-2-propen-1-yl]-1h-indole-3-acetic acid
1h-indole-3-acetic acid, 5-methoxy-2-methyl-1-(1-oxo-3-phenyl-2-propen-1-yl)-

Research Excerpts

Pharmacokinetics

ExcerptReferenceRelevance
" Following administration, the Cmax was reached at the 2nd h in 7 out of 8 subjects with an average value of 18."( Plasma pharmacokinetics of cinmetacin following oral administration in healthy volunteers.
Acerbi, D; Danesi, R; Del Tacca, M; Ducci, M, 1988)		0.27
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
indole-3-acetic acidsAn indol-3-yl carboxylic acid in which the carboxylic acid specified is acetic acid.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19903 (60.00)18.7374
1990's2 (40.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials2 (40.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other3 (60.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
indomethacin
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.. indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.		1.9610aromatic ether;
indole-3-acetic acids;
monochlorobenzenes;
N-acylindole		analgesic;
drug metabolite;
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
environmental contaminant;
gout suppressant;
non-steroidal anti-inflammatory drug;
xenobiotic metabolite;
xenobiotic
dinoprostone
prostaglandin E2 : Prostaglandin F2alpha in which the hydroxy group at position 9 has been oxidised to the corresponding ketone. Prostaglandin E2 is the most common and most biologically potent of mammalian prostaglandins.		1.9810prostaglandins Ehuman metabolite;
mouse metabolite;
oxytocic
ConditionIndicatedRelationship StrengthStudiesTrials
Polyarthritis
[description not available]		03.3411
Arthritis
Acute or chronic inflammation of JOINTS.		03.3411
Periodontitis, Acute Nonsuppurative
[description not available]		01.9810
Periapical Periodontitis
Inflammation of the PERIAPICAL TISSUE. It includes general, unspecified, or acute nonsuppurative inflammation. Chronic nonsuppurative inflammation is PERIAPICAL GRANULOMA. Suppurative inflammation is PERIAPICAL ABSCESS.		01.9810
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