Compounds > chlotazol
Page last updated: 2024-12-06

chlotazol

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

chlotazol: for treatment of rheumatoid arthritis; condensation product of chloral hydrate & 2-aminothiazole [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID37113
SCHEMBL ID11525031
MeSH IDM0105411

Synonyms (28)

Synonym
khlotazol
nsc261134
35317-79-4
nsc-261134
trichloromethyl-(thiazoylamino(2))-methanol
ethanol, 2,2,2-trichloro-1-(2-thiazolylamino)-
2,2,2-trichlor-1-(2-thiazolylamino)-aethanol [german]
ethanol, 1-(2-thiazolylamino)-2,2,2-trichloro-
nsc 261134
chlotazole
2,2,2-trichloro-1-(2-thiazolylamino)ethanol
brn 0152089
clotazol
STK324580
2,2,2-trichloro-1-(1,3-thiazol-2-ylamino)ethanol
AKOS002324596
SCHEMBL11525031
82190-87-2
atizol
chlotazol
chlothazol
2,2,2-trichlor-1-(2-thiazolylamino)-aethanol
4-27-00-04586 (beilstein handbook reference)
AKOS016327075
Q4498280
CS-0364883
2,2,2-trichloro-1-(thiazol-2-ylamino)ethan-1-ol
DTXSID601031763
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (4)

TimeframeStudies, This Drug (%)All Drugs %
pre-19902 (50.00)18.7374
1990's2 (50.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.25

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.25 (24.57)
Research Supply Index2.20 (2.92)
Research Growth Index4.45 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.25)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other8 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
chloral hydrate
[no description available]		2.8840aldehyde hydrate;
ethanediol;
organochlorine compound		general anaesthetic;
mouse metabolite;
sedative;
xenobiotic
dimercaprol
Dimercaprol: An anti-gas warfare agent that is effective against Lewisite (dichloro(2-chlorovinyl)arsine) and formerly known as British Anti-Lewisite or BAL. It acts as a chelating agent and is used in the treatment of arsenic, gold, and other heavy metal poisoning.. dimercaprol : A dithiol that is propane-1,2-dithiol in which one of the methyl hydrogens is replaced by a hydroxy group. a chelating agent originally developed during World War II as an experimental antidote against the arsenic-based poison gas Lewisite, it has been used clinically since 1949 for the treatment of poisoning by arsenic, mercury and gold. It can also be used for treatment of poisoning by antimony, bismuth and possibly thallium, and (with sodium calcium edetate) in cases of acute leaad poisoning. Administration is by (painful) intramuscular injection of a suspension of dimercaprol in peanut oil, typically every 4 hours for 2-10 days depending on the toxicity. In the past, dimercaprol was also used for the treatment of Wilson's disease, a severely debilitating genetic disorder in which the body tends to retain copper, with resultant liver and brain injury.		1.9610dithiol;
primary alcohol		chelator
thiazoles
[no description available]		2.88401,3-thiazoles;
mancude organic heteromonocyclic parent;
monocyclic heteroarene
unithiol
Unithiol: A chelating agent used as an antidote to heavy metal poisoning.		6.9610
dinoprost
Dinoprost: A naturally occurring prostaglandin that has oxytocic, luteolytic, and abortifacient activities. Due to its vasocontractile properties, the compound has a variety of other biological actions.. prostaglandin F2alpha : A prostaglandins Falpha that is prosta-5,13-dien-1-oic acid substituted by hydroxy groups at positions 9, 11 and 15. It is a naturally occurring prostaglandin used to induce labor.		1.9610monocarboxylic acid;
prostaglandins Falpha		human metabolite;
mouse metabolite
ConditionIndicatedRelationship StrengthStudiesTrials
Rheumatoid Arthritis
[description not available]		06.9610
Arthritis, Rheumatoid
A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Etiology is unknown, but autoimmune mechanisms have been implicated.		01.9610
Chronic Illness
[description not available]		02.3820
Lymphocytopenia
[description not available]		01.9710
Bronchitis
Inflammation of the large airways in the lung including any part of the BRONCHI, from the PRIMARY BRONCHI to the TERTIARY BRONCHI.		02.3820
Chronic Disease
Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care (Dictionary of Health Services Management, 2d ed). For epidemiological studies chronic disease often includes HEART DISEASES; STROKE; CANCER; and diabetes (DIABETES MELLITUS, TYPE 2).		02.3820
Lymphopenia
Reduction in the number of lymphocytes.		01.9710
Recrudescence
[description not available]		02.3720
Experimental Lung Inflammation
Inflammation of any part, segment or lobe, of the lung parenchyma.		01.9710
Pneumonia
Infection of the lung often accompanied by inflammation.		06.9710
Convalescence
The period of recovery following an illness.		01.9610
Erysipelas
An acute infection of the skin caused by species of STREPTOCOCCUS. This disease most frequently affects infants, young children, and the elderly. Characteristics include pink-to-red lesions that spread rapidly and are warm to the touch. The commonest site of involvement is the face.		01.9610