Compounds > butolame
Page last updated: 2024-11-08

butolame

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

butolame: modified ESTRADIOL with amino-alcohol side chain at the C17 position; has anticoagulant & estrogenic effects; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID197608
MeSH IDM0221475

Synonyms (10)

Synonym
butolame
(8r,9s,13s,14s,17s)-17-(4-hydroxybutylamino)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-ol
unii-4upr2b5sg4
4upr2b5sg4 ,
17beta-(4'-hydroxy-1'-butylamino)-1,3,5(10)-estratriene-3-ol
150748-23-5
buolame
DTXSID80934056
estra-1,3,5(10)-trien-3-ol, 17-[(4-hydroxybutyl)amino]-, (17beta)-
(17beta)-17-[(4-hydroxybutyl)amino]estra-1,3,5(10)-trien-3-ol

Research Excerpts

Dosage Studied

ExcerptRelevanceReference
" Dose-response curves were performed using immature CD1 mice and Wistar rats."( Estrogenic effects of 17 beta-aminoestrogens assessed in uteri of rats and mice.
Avila, ME; Franco, Y; Jaimez, R; Lemini, C, 2005)		0.33
" Dose-response curves were performed in rats by single subcutaneous (s."( Effects of 17beta-aminoestrogens on the sexual behavior of female rats.
Canchola, E; Lemini, C, 2009)		0.35
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (14)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (7.14)18.2507
2000's8 (57.14)29.6817
2010's4 (28.57)24.3611
2020's1 (7.14)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.14

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.14 (24.57)
Research Supply Index2.71 (2.92)
Research Growth Index4.84 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.14)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other14 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
prolame
prolame: a derivative of natural estrogenic steroid with a 17-beta-amino-alcohol side chain, 3-hydroxypropylamine; exhibits estrogenic and anti-coagulation effects		3.75100
tamoxifen
[no description available]		2.0810stilbenoid;
tertiary amino compound		angiogenesis inhibitor;
antineoplastic agent;
bone density conservation agent;
EC 1.2.3.1 (aldehyde oxidase) inhibitor;
EC 2.7.11.13 (protein kinase C) inhibitor;
estrogen antagonist;
estrogen receptor antagonist;
estrogen receptor modulator
pentolame
pentolame: 17-beta-amino-estrogen with anticoagulant & estrogenic effects; structure given in first source		4.06140
ConditionIndicatedRelationship StrengthStudiesTrials
Breast Cancer
[description not available]		02.6320
Breast Neoplasms
Tumors or cancer of the human BREAST.		02.6320
Anxiety Neuroses
[description not available]		02.1310
Depression, Endogenous
[description not available]		02.1310
Disease Models, Animal
Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.		02.5120
Anxiety Disorders
Persistent and disabling ANXIETY.		02.1310
Depressive Disorder
An affective disorder manifested by either a dysphoric mood or loss of interest or pleasure in usual activities. The mood disturbance is prominent and relatively persistent.		02.1310
Birth Weight
The mass or quantity of heaviness of an individual at BIRTH. It is expressed by units of pounds or kilograms.		02.0110
Body Weight
The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.		02.0110