Compounds > prolame
Page last updated: 2024-12-07

prolame

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

prolame: a derivative of natural estrogenic steroid with a 17-beta-amino-alcohol side chain, 3-hydroxypropylamine; exhibits estrogenic and anti-coagulation effects [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID127441
MeSH IDM0138001

Synonyms (11)

Synonym
prolame
99876-41-2
(8r,9s,13s,14s,17s)-17-(3-hydroxypropylamino)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-ol
unii-o0un4kn1ev
estra-1,3,5(10)-trien-3-ol, 17-((3-hydroxypropyl)amino)-, (17beta)-
o0un4kn1ev ,
n-(3-hydroxy-1,3,5(10)-estratrien-17-yl)-3-hydroxypropylamine
17beta-(3-hydroxy-1-propylamino)-1,3,5(10)-estratrien-3-ol
DTXSID40912431
(17.beta.)-17-((3-hydroxypropyl)amino)estra-1,3,5(10)-trien-3-ol
estra-1,3,5(10)-trien-3-ol, 17-((3-hydroxypropyl)amino)-, (17.beta.)-

Research Excerpts

Overview

Prolame is a synthetic steroid with estrogenic and antidepressant-like effects that may produce fewer adverse effects.

ExcerptReferenceRelevance
"Prolame is a synthetic steroid with estrogenic and antidepressant-like effects that may produce fewer adverse effects."( Effects of post-ovariectomy time frame and age on the antidepressant-like actions of estradiol and prolame in female rats.
Chavira, R; Hernández-Hernández, OT; Herrera-Pérez, JJ; Lemini, C; Martínez-Mota, L, 2022)		1.66

Treatment

ExcerptReferenceRelevance
"The prolame treatment significantly reduced spatial-memory impairment and decreased lipid peroxidation, reactive oxygen species, and reactive gliosis."( Neuroprotective effect of the aminoestrogen prolame against impairment of learning and memory skills in rats injected with amyloid-β-25-35 into the hippocampus.
Díaz, A; Fernandez-G, JM; Guevara, J; Hernandez, M; Limón, D; Montaño, LF; Pérez-Severiano, F; Rendón-Huerta, EP; Torres-Martínez, AC, 2012)		1.12

Dosage Studied

ExcerptRelevanceReference
" Dose-response curves were performed using immature CD1 mice and Wistar rats."( Estrogenic effects of 17 beta-aminoestrogens assessed in uteri of rats and mice.
Avila, ME; Franco, Y; Jaimez, R; Lemini, C, 2005)		0.33
" Dose-response curves were performed in rats by single subcutaneous (s."( Effects of 17beta-aminoestrogens on the sexual behavior of female rats.
Canchola, E; Lemini, C, 2009)		0.35
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (21)

TimeframeStudies, This Drug (%)All Drugs %
pre-19902 (9.52)18.7374
1990's4 (19.05)18.2507
2000's6 (28.57)29.6817
2010's8 (38.10)24.3611
2020's1 (4.76)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 28.93

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index28.93 (24.57)
Research Supply Index3.09 (2.92)
Research Growth Index4.83 (4.65)
Search Engine Demand Index34.37 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (28.93)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other21 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
estrone
Hydroxyestrones: Estrone derivatives substituted with one or more hydroxyl groups in any position. They are important metabolites of estrone and other estrogens.		6.971017-oxo steroid;
3-hydroxy steroid;
phenolic steroid;
phenols		antineoplastic agent;
bone density conservation agent;
estrogen;
human metabolite;
mouse metabolite
adenosine diphosphate
Adenosine Diphosphate: Adenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.		1.9710adenosine 5'-phosphate;
purine ribonucleoside 5'-diphosphate		fundamental metabolite;
human metabolite
butolame
butolame: modified ESTRADIOL with amino-alcohol side chain at the C17 position; has anticoagulant & estrogenic effects; structure given in first source		3.75100
tamoxifen
[no description available]		2.0810stilbenoid;
tertiary amino compound		angiogenesis inhibitor;
antineoplastic agent;
bone density conservation agent;
EC 1.2.3.1 (aldehyde oxidase) inhibitor;
EC 2.7.11.13 (protein kinase C) inhibitor;
estrogen antagonist;
estrogen receptor antagonist;
estrogen receptor modulator
pentolame
pentolame: 17-beta-amino-estrogen with anticoagulant & estrogenic effects; structure given in first source		3.75100
ConditionIndicatedRelationship StrengthStudiesTrials
No-Reflow Phenomenon
Markedly reduced or absent REPERFUSION in an infarct zone following the removal of an obstruction or constriction of an artery.		02.1110
Disease Models, Animal
Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.		03.1950
Cardiovascular Stroke
[description not available]		02.1110
Injury, Myocardial Reperfusion
[description not available]		02.1110
Myocardial Infarction
NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).		02.1110
Anxiety Neuroses
[description not available]		02.1310
Depression, Endogenous
[description not available]		02.1310
Anxiety Disorders
Persistent and disabling ANXIETY.		02.1310
Depressive Disorder
An affective disorder manifested by either a dysphoric mood or loss of interest or pleasure in usual activities. The mood disturbance is prominent and relatively persistent.		02.1310
Breast Cancer
[description not available]		02.1510
Breast Neoplasms
Tumors or cancer of the human BREAST.		02.1510
Academic Disorder, Developmental
[description not available]		02.4820
Age-Related Memory Disorders
[description not available]		02.4820
Anxiety
Feelings or emotions of dread, apprehension, and impending disaster but not disabling as with ANXIETY DISORDERS.		07.0710
Learning Disabilities
Conditions characterized by a significant discrepancy between an individual's perceived level of intellect and their ability to acquire new language and other cognitive skills. These may result from organic or psychological conditions. Relatively common subtypes include DYSLEXIA, DYSCALCULIA, and DYSGRAPHIA.		02.4820
Memory Disorders
Disturbances in registering an impression, in the retention of an acquired impression, or in the recall of an impression. Memory impairments are associated with DEMENTIA; CRANIOCEREBRAL TRAUMA; ENCEPHALITIS; ALCOHOLISM (see also ALCOHOL AMNESTIC DISORDER); SCHIZOPHRENIA; and other conditions.		02.4820
Acute Confusional Senile Dementia
[description not available]		02.0710
Alzheimer Disease
A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)		02.0710