biotinate : Conjugate base of biotin arising from deprotonation of the carboxy group. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]
| ID Source | ID |
|---|---|
| PubMed CID | 6560210 |
| CHEBI ID | 57586 |
| Synonym |
|---|
| 2C1Q |
| biotinate |
| biotinate anion |
| CHEBI:57586 |
| 5-[(3as,4s,6ar)-2-oxohexahydro-1h-thieno[3,4-d]imidazol-4-yl]pentanoate |
| 5-[(3as,4s,6ar)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoate |
| 3EFR |
| 3RDO |
| 2JGS |
| 2ZSC |
| 3EW2 |
| 2UYW |
| 4DVE |
| Q27124798 |
| Role | Description |
|---|---|
| human metabolite | Any mammalian metabolite produced during a metabolic reaction in humans (Homo sapiens). |
| Saccharomyces cerevisiae metabolite | Any fungal metabolite produced during a metabolic reaction in Baker's yeast (Saccharomyces cerevisiae). |
| cofactor | An organic molecule or ion (usually a metal ion) that is required by an enzyme for its activity. It may be attached either loosely (coenzyme) or tightly (prosthetic group). |
| [role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Class | Description |
|---|---|
| monocarboxylic acid anion | A carboxylic acid anion formed when the carboxy group of a monocarboxylic acid is deprotonated. |
| vitamin B7 | Any member of a group of vitamers that belong to the chemical structural class called biotins that exhibit biological activity against vitamin B7 deficiency. Vitamin B7 deficiency is very rare in individuals who take a normal balanced diet. Foods rich in biotin are egg yolk, liver, cereals, vegetables (spinach, mushrooms) and rice. Symptoms associated with vitamin B7 deficiency include thinning hair, scaly skin rashes around eyes, nose and mouth, and brittle nails. The vitamers include biotin and its ionized and salt forms. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Chain A, Circular Permutant Of Avidin | Gallus gallus (chicken) | Kd | 0.2400 | 0.2400 | 0.2400 | 0.2400 | AID977611 |
| Chain B, Circular Permutant Of Avidin | Gallus gallus (chicken) | Kd | 0.2400 | 0.2400 | 0.2400 | 0.2400 | AID977611 |
| Chain A, Xenavidin | Xenopus tropicalis (tropical clawed frog) | Kd | 0.0000 | 0.0000 | 0.0000 | 0.0000 | AID977611 |
| Chain A, Tamavidin2 | Pleurotus cornucopiae (cornucopia mushroom) | Kd | 0.0870 | 0.0870 | 0.0870 | 0.0870 | AID977611 |
| Chain B, Tamavidin2 | Pleurotus cornucopiae (cornucopia mushroom) | Kd | 0.0870 | 0.0870 | 0.0870 | 0.0870 | AID977611 |
| Chain A, Biotin [acetyl-CoA-carboxylase] ligase | Aquifex aeolicus | Kd | 8.3000 | 4.6000 | 6.4500 | 8.3000 | AID977611 |
| Chain A, Biotin [acetyl-CoA-carboxylase] ligase | Aquifex aeolicus | Kd | 8.3000 | 4.6000 | 6.4500 | 8.3000 | AID977611 |
| Chain A, rhizavidin | Rhizobium etli CFN 42 | Kd | 0.2150 | 0.2150 | 0.2150 | 0.2150 | AID977611 |
| Chain A, Streptavidin | Streptomyces avidinii | Kd | 0.0001 | 0.0001 | 0.0001 | 0.0001 | AID977611 |
| Chain A, Streptavidin | Streptomyces avidinii | Kd | 0.0001 | 0.0001 | 0.0001 | 0.0001 | AID977611 |
| Chain A, Biotin transporter BioY | Lactococcus cremoris subsp. cremoris MG1363 | Kd | 0.0003 | 0.0003 | 0.0003 | 0.0003 | AID977611 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID977611 | Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB | 2009 | Journal of molecular biology, Mar-20, Volume: 387, Issue:1 | Structural and functional studies of the biotin protein ligase from Aquifex aeolicus reveal a critical role for a conserved residue in target specificity. |
| AID977611 | Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB | 2009 | BMC structural biology, Sep-29, Volume: 9 | Structural and functional characteristics of xenavidin, the first frog avidin from Xenopus tropicalis. |
| AID977611 | Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB | 2012 | Proceedings of the National Academy of Sciences of the United States of America, Aug-28, Volume: 109, Issue:35 | Structural divergence of paralogous S components from ECF-type ABC transporters. |
| AID977611 | Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB | 2008 | Chembiochem : a European journal of chemical biology, May-05, Volume: 9, Issue:7 | Rational modification of ligand-binding preference of avidin by circular permutation and mutagenesis. |
| AID977611 | Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB | 2011 | Protein science : a publication of the Protein Society, Jul, Volume: 20, Issue:7 | Evolved streptavidin mutants reveal key role of loop residue in high-affinity binding. |
| AID977611 | Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB | 2009 | Journal of molecular biology, Feb-20, Volume: 386, Issue:2 | Crystal structure of rhizavidin: insights into the enigmatic high-affinity interaction of an innate biotin-binding protein dimer. |
| AID977611 | Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB | 2009 | The FEBS journal, Mar, Volume: 276, Issue:5 | Tamavidins--novel avidin-like biotin-binding proteins from the Tamogitake mushroom. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (71.43) | 29.6817 |
| 2010's | 2 (28.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| This Compound (32.94) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 7 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||