Compounds > azocyclotin
Page last updated: 2024-11-06

azocyclotin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Azocyclotin is an organotin fungicide that was widely used in agriculture to control a variety of pests, including mites, aphids, and other insects. It is a white, crystalline solid that is soluble in organic solvents. Azocyclotin is synthesized by reacting cyclohexylisocyanate with tin tetrachloride in the presence of a catalyst. It acts by interfering with the nervous system of insects, leading to paralysis and death. Azocyclotin has been shown to have a number of adverse effects on the environment, including toxicity to aquatic organisms, birds, and mammals. It can also persist in the environment for long periods of time, leading to bioaccumulation in food chains. Due to its environmental impact, azocyclotin has been banned in many countries. However, it is still used in some parts of the world, and its potential effects on human health are still under investigation.'

azocyclotin: has inhibitory effects on X. laevis metamorphosis. [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

azocyclotin : A member of the class of triazoles that is 1,2,4-triazole substituted at position 1 by a tricyclohexylstannyl group. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID91634
CHEBI ID2959
SCHEMBL ID73254

Synonyms (35)

Synonym
AC-12492
azocyclotin
41083-11-8
NCGC00166174-01
CHEBI:2959 ,
tricyclohexyl(1h-1,2,4-triazol-1-yl)tin
tri(cyclohexyl)-1h-1,2,4-triazol-1-yltin
1-(tricyclohexylstannyl)-1h-1,2,4-triazole
peropal
(1h-1,2,4-triazolyl)tricyclohexylstannane
(1h-1,2,4-triazol-1-yl)tricyclohexylstannane
stannane, (1h-1,2,4-triazol-1-yl)tricyclohexyl-
hsdb 6559
tri(cyklohexyl)-1h-1,2,4-triazol-1-ylstannium [czech]
bay bue 1452
azocyclotin [bsi:iso]
brn 0621636
einecs 255-209-1
tricyclohexyl(1,2,4-triazol-1-yl)stannane
v4yrq367ke ,
tri(cyklohexyl)-1h-1,2,4-triazol-1-ylstannium
unii-v4yrq367ke
1h-1,2,4-triazole, 1-(tricyclohexylstannyl)-
AKOS015903255
azocyclotin [iso]
azocyclotin [hsdb]
SCHEMBL73254
DTXSID2058091
ONHBDDJJTDTLIR-UHFFFAOYSA-N
clermait
tricyclotin
azocyclotin, pestanal(r), analytical standard
Q410926
1,2-diaza-4-azanidacyclopenta-2,5-diene;tricyclohexylstannanylium
1-(tricyclohexylstannyl)-1h-1,2,4-triazole,

Research Excerpts

Bioavailability

ExcerptReferenceRelevance
" Azocyclotin also induced change in the expression of 17β-hsd3, suggesting increased bioavailability of 11-ketotestosterone (11-KT) in the blood."( Effects of azocyclotin on gene transcription and steroid metabolome of hypothalamic-pituitary-gonad axis, and their consequences on reproduction in zebrafish (Danio rerio).
Cao, CY; Gui, WJ; Ma, YN; Wang, QW; Zhu, GN, 2016)		1.73
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (2)

ClassDescription
organotin acaricide
triazolesAn azole in which the five-membered heterocyclic aromatic skeleton contains three N atoms and two C atoms.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (5)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
phosphopantetheinyl transferaseBacillus subtilisPotency56.23410.141337.9142100.0000AID1490
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)Homo sapiens (human)Potency28.18380.016525.307841.3999AID602332
vitamin D3 receptor isoform VDRAHomo sapiens (human)Potency50.11870.354828.065989.1251AID504847
nuclear receptor ROR-gamma isoform 1Mus musculus (house mouse)Potency28.93420.00798.23321,122.0200AID2546; AID2551
DNA polymerase kappa isoform 1Homo sapiens (human)Potency23.77810.031622.3146100.0000AID588579
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's4 (80.00)24.3611
2020's1 (20.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 32.49

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index32.49 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.59 (4.65)
Search Engine Demand Index41.22 (26.88)
Search Engine Supply Index2.32 (0.95)

This Compound (32.49)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
triiodothyronine
Triiodothyronine: A T3 thyroid hormone normally synthesized and secreted by the thyroid gland in much smaller quantities than thyroxine (T4). Most T3 is derived from peripheral monodeiodination of T4 at the 5' position of the outer ring of the iodothyronine nucleus. The hormone finally delivered and used by the tissues is mainly T3.. 3,3',5-triiodo-L-thyronine : An iodothyronine compound having iodo substituents at the 3-, 3'- and 5-positions. Although some is produced in the thyroid, most of the 3,3',5-triiodo-L-thyronine in the body is generated by mono-deiodination of L-thyroxine in the peripheral tissues. Its metabolic activity is about 3 to 5 times that of L-thyroxine. The sodium salt is used in the treatment of hypothyroidism.		2.21102-halophenol;
amino acid zwitterion;
iodophenol;
iodothyronine		human metabolite;
mouse metabolite;
thyroid hormone
11-ketotestosterone
11-ketotestosterone: RN given refers to cpd without isomeric designation. 11-oxotestosterone : A 3-oxo Delta(4)-steroid that is testosterone carrying an additional oxo substituent at position 11.		2.131011-oxo steroid;
17beta-hydroxy steroid;
3-oxo-Delta(4) steroid;
androstanoid		androgen;
human metabolite;
marine xenobiotic metabolite
triphenyltin hydroxide
fentin hydroxide : An organotin compound that is triphenylstannane in which the hydrogen attached to tin is replaced by a hydroxy group. A fungicide used to control a variety of infections including blight on potatoes, leaf spot on sugar beet and alternaria blight on carrots.		2.2110
vendex
Torque: The rotational force about an axis that is equal to the product of a force times the distance from the axis where the force is applied.		2.2110organotin acaricide
ConditionIndicatedRelationship StrengthStudiesTrials