Compounds > alstonisine
Page last updated: 2024-11-12

alstonisine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

alstonisine: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID14191522
CHEMBL ID592449
SCHEMBL ID21832078
MeSH IDM0445134

Synonyms (5)

Synonym
CHEMBL592449
alstonisine
alstonal
SCHEMBL21832078
(1s,2r,7r,9s,10s)-6-acetyl-1'-methylspiro[4-oxa-12-azatricyclo[7.2.1.02,7]dodec-5-ene-10,3'-indole]-2'-one
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (4)

Assay IDTitleYearJournalArticle
AID462410Inhibition of alpha-D-[U-14C]glucopyranoside uptake at human SGLT2 expressed in african green monkey COS1 cells at 50 uM after 30 mins by liquid scintillation counting2010Bioorganic & medicinal chemistry, Mar-15, Volume: 18, Issue:6
Alstiphyllanines E-H, picraline and ajmaline-type alkaloids from Alstonia macrophylla inhibiting sodium glucose cotransporter.
AID735342Cytotoxicity against human KB cells by resazurin assay2013Journal of natural products, Apr-26, Volume: 76, Issue:4
Alstoniaphyllines A-C, unusual nitrogenous derivatives from the bark of Alstonia macrophylla.
AID462409Inhibition of alpha-D-[U-14C]glucopyranoside uptake at human SGLT1 expressed in african green monkey COS1 cells at 50 uM after 30 mins by liquid scintillation counting2010Bioorganic & medicinal chemistry, Mar-15, Volume: 18, Issue:6
Alstiphyllanines E-H, picraline and ajmaline-type alkaloids from Alstonia macrophylla inhibiting sodium glucose cotransporter.
AID735343Antimalarial activity against multidrug-resistant Plasmodium falciparum K1 by [3H]-hypoxanthine incorporation assay2013Journal of natural products, Apr-26, Volume: 76, Issue:4
Alstoniaphyllines A-C, unusual nitrogenous derivatives from the bark of Alstonia macrophylla.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (7)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (28.57)29.6817
2010's4 (57.14)24.3611
2020's1 (14.29)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.54

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.54 (24.57)
Research Supply Index2.08 (2.92)
Research Growth Index4.62 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.54)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (14.29%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (85.71%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
ellipticine
ellipticine : A organic heterotetracyclic compound that is pyrido[4,3-b]carbazole carrying two methyl substituents at positions 5 and 11.		2.0810indole alkaloid;
organic heterotetracyclic compound;
organonitrogen heterocyclic compound;
polycyclic heteroarene		antineoplastic agent;
plant metabolite
phlorhizin
[no description available]		2.0510aryl beta-D-glucoside;
dihydrochalcones;
monosaccharide derivative		antioxidant;
plant metabolite
2-oxindole
2-oxindole: RN given refers to parent cpd; structure. indolin-2-one : An indolinone carrying an oxo group at position 2.		2.0810gamma-lactam;
indolinone
alstonerine
alstonerine: from Alstonia; structure in first source		2.4720
macroline
macroline: structure in first source		2.0810
sarpagine
sarpagine: structure in first source. sarpagine : An indole alkaloid that is sarpagan bearing hydroxy groups at positions 10 and 17.		2.0810indole alkaloid;
phenols;
primary alcohol;
secondary amino compound;
tertiary amino compound
picrinine
picrinine: structure in first source. picrinine : A natural product with formula C20H22N2O3 that is the member of the akuammiline family of alkaloids, first isolated in 1965 from the leaves of Alstonia scholaris.		2.0510alkaloid ester;
indole alkaloid;
methyl ester;
organic heteropentacyclic compound;
polycyclic ether		analgesic;
anti-asthmatic agent;
anti-inflammatory agent;
antitussive;
plant metabolite
ConditionIndicatedRelationship StrengthStudiesTrials