Compounds > 4,4'-dimethylangelicin
Page last updated: 2024-12-06

4,4'-dimethylangelicin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

4,4'-dimethylangelicin: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID62767
CHEMBL ID172673
CHEBI ID82452
MeSH IDM0115006

Synonyms (18)

Synonym
2h-furo(2,3-h)(1)benzopyran-2-one, 4,9-dimethyl-, plus ultraviolet a radiation
4,4'-dimethylisopsoralen plus ultraviolet a radiation
4,4'-dimethylangelicin plus ultraviolet a radiation
brn 0196616
4,4'-dimethylangelicin
4,4'-dimethylisopsoralen
4,9-dimethyl-2h-furo(2,3-h)-1-benzopyran-2-one plus ultraviolet a radiation
chebi:82452 ,
CHEMBL172673
22975-76-4
C19404
aab2uya0sr ,
2h-furo(2,3-h)-1-benzopyran-2-one, 4,9-dimethyl-
unii-aab2uya0sr
DTXSID80177522
Q27155950
4,9-dimethyl-2h-furo(2,3-h)-1-benzopyran-2-one
4,4'-dimethylangelicin plus ultraviolet a radiation [iarc]
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
furanocoumarinAny furochromene that consists of a furan ring fused with a coumarin. The fusion may occur in different ways in give several isomers.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (12)

Assay IDTitleYearJournalArticle
AID54251Association constant to an isolated site calf thymus DNA1983Journal of medicinal chemistry, Jun, Volume: 26, Issue:6
4'-Methylangelicins: new potential agents for the photochemotherapy of psoriasis.
AID234711In vivo inhibition of epidermal DNA synthesis in mouse after topical application relative to that of 8-MOP1983Journal of medicinal chemistry, Jun, Volume: 26, Issue:6
4'-Methylangelicins: new potential agents for the photochemotherapy of psoriasis.
AID234405In vivo inhibition of epidermal DNA synthesis in mouse after oral administration relativ to that of 8-MOP1983Journal of medicinal chemistry, Jun, Volume: 26, Issue:6
4'-Methylangelicins: new potential agents for the photochemotherapy of psoriasis.
AID224105In vivo inhibition of epidermal DNA synthesis in mouse after topical application1983Journal of medicinal chemistry, Jun, Volume: 26, Issue:6
4'-Methylangelicins: new potential agents for the photochemotherapy of psoriasis.
AID226322Number of nucleotides occluded by a bound furocoumarin molecule1983Journal of medicinal chemistry, Jun, Volume: 26, Issue:6
4'-Methylangelicins: new potential agents for the photochemotherapy of psoriasis.
AID20131Rate constant of the photoreaction between compound and DNA.1983Journal of medicinal chemistry, Jun, Volume: 26, Issue:6
4'-Methylangelicins: new potential agents for the photochemotherapy of psoriasis.
AID467954Antiproliferative activity against mouse EAC cells assessed as ratio of ID50 of compound to ID50 of 8-methoxypsoralen2009European journal of medicinal chemistry, Nov, Volume: 44, Issue:11
Scoring function for DNA-drug docking of anticancer and antiparasitic compounds based on spectral moments of 2D lattice graphs for molecular dynamics trajectories.
AID21528Solubility in water was determined1983Journal of medicinal chemistry, Jun, Volume: 26, Issue:6
4'-Methylangelicins: new potential agents for the photochemotherapy of psoriasis.
AID21235Partition coefficient between octanol and water1983Journal of medicinal chemistry, Jun, Volume: 26, Issue:6
4'-Methylangelicins: new potential agents for the photochemotherapy of psoriasis.
AID224104In vivo inhibition of epidermal DNA synthesis in mouse after oral administration1983Journal of medicinal chemistry, Jun, Volume: 26, Issue:6
4'-Methylangelicins: new potential agents for the photochemotherapy of psoriasis.
AID1324224Induction of melanin synthesis in mouse B16F10 cells at 50 uM after 48 hrs by spectrophotometric analysis relative to control2016Bioorganic & medicinal chemistry, 11-15, Volume: 24, Issue:22
Synthesis and biological evaluation of furocoumarin derivatives on melanin synthesis in murine B16 cells for the treatment of vitiligo.
AID227032Frequency of binding sites i.e., number of ligands bound per nucleotide1983Journal of medicinal chemistry, Jun, Volume: 26, Issue:6
4'-Methylangelicins: new potential agents for the photochemotherapy of psoriasis.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19902 (33.33)18.7374
1990's1 (16.67)18.2507
2000's2 (33.33)29.6817
2010's1 (16.67)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.52

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.52 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.46 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.52)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
5-methoxypsoralen
5-Methoxypsoralen: A linear furanocoumarin that has phototoxic and anti-inflammatory properties, with effects similar to METHOXSALEN. It is used in PUVA THERAPY for the treatment of PSORIASIS.. 5-methoxypsoralen : A 5-methoxyfurocoumarin that is psoralen substituted by a methoxy group at position 5.		2.42205-methoxyfurocoumarin;
organic heterotricyclic compound;
psoralens		hepatoprotective agent;
plant metabolite
methoxsalen
Methoxsalen: A naturally occurring furocoumarin compound found in several species of plants, including Psoralea corylifolia. It is a photoactive substance that forms DNA ADDUCTS in the presence of ultraviolet A irradiation.. methoxsalen : A member of the class of psoralens that is 7H-furo[3,2-g]chromen-7-one in which the 9 position is substituted by a methoxy group. It is a constituent of the fruits of Ammi majus. Like other psoralens, trioxsalen causes photosensitization of the skin. It is administered topically or orally in conjunction with UV-A for phototherapy treatment of vitiligo and severe psoriasis.		2.9240aromatic ether;
psoralens		antineoplastic agent;
cross-linking reagent;
dermatologic drug;
photosensitizing agent;
plant metabolite
trioxsalen
Trioxsalen: Pigmenting photosensitizing agent obtained from several plants, mainly Psoralea corylifolia. It is administered either topically or orally in conjunction with ultraviolet light in the treatment of vitiligo.. lactone : Any cyclic carboxylic ester containing a 1-oxacycloalkan-2-one structure, or an analogue having unsaturation or heteroatoms replacing one or more carbon atoms of the ring.. antipsoriatic : A drug used to treat psoriasis.. trioxsalen : 7H-Furo[3,2-g]chromen-7-one in which positions 2, 5, and 9 are substituted by methyl groups. Like other psoralens, trioxsalen causes photosensitization of the skin. It is administered orally in conjunction with UV-A for phototherapy treatment of vitiligo. After photoactivation it creates interstrand cross-links in DNA, inhibiting DNA synthesis and cell division, and can lead to cell injury; recovery from the cell injury may be followed by increased melanisation of the epidermis.		2.4420psoralensdermatologic drug;
photosensitizing agent
ficusin
Ficusin: A naturally occurring furocoumarin, found in PSORALEA. After photoactivation with UV radiation, it binds DNA via single and double-stranded cross-linking.. psoralen : The simplest member of the class of psoralens that is 7H-furo[3,2-g]chromene having a keto group at position 7. It has been found in plants like Psoralea corylifolia and Ficus salicifolia.		2.4820psoralensplant metabolite
angelicin
angelicin: used as tranquillizer; sedative; or anticonvulsant; structure		2.9140furanocoumarin
4,5'-dimethylangelicin
[no description available]		2.420furanocoumarin
5-methylangelicin
[no description available]		2.3720furanocoumarin
4-methylangelicin
[no description available]		2.730
4,4',6-trimethylangelicin
4,4',6-trimethylangelicin: new monofunctional furocoumarin; potential agent for photochemotherapy of psoriasis; capable of photoreacting with DNA to a large extent forming only monoadducts; produces singlet oxygen to an insignificant extent; structure given in first source		1.9610furanocoumarin
4,4',5'-trimethylazapsoralen
4,4',5'-trimethylazapsoralen: structure given in first source		2.0510
ConditionIndicatedRelationship StrengthStudiesTrials
Palmoplantaris Pustulosis
[description not available]		02.6630
Psoriasis
A common genetically determined, chronic, inflammatory skin disease characterized by rounded erythematous, dry, scaling patches. The lesions have a predilection for nails, scalp, genitalia, extensor surfaces, and the lumbosacral region. Accelerated epidermopoiesis is considered to be the fundamental pathologic feature in psoriasis.		02.6630
Vitiligo
A disorder consisting of areas of macular depigmentation, commonly on extensor aspects of extremities, on the face or neck, and in skin folds. Age of onset is often in young adulthood and the condition tends to progress gradually with lesions enlarging and extending until a quiescent state is reached.		02.1310