Page last updated: 2024-12-07

4,4',6-trimethylangelicin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

4,4',6-trimethylangelicin: new monofunctional furocoumarin; potential agent for photochemotherapy of psoriasis; capable of photoreacting with DNA to a large extent forming only monoadducts; produces singlet oxygen to an insignificant extent; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID107731
CHEMBL ID173365
CHEBI ID82543
SCHEMBL ID17174622
MeSH IDM0123355

Synonyms (24)

Synonym
4,6,9-trimethyl-2h-furo[2,3-h]chromen-2-one
4,6,4'-trimethylangelicin
4,6,9-trimethyl-2h-furo(2,3-h)-1-benzopyran-2-one
4-hydroxy-beta,3,7-trimethyl-5-benzofuranacrylic acid delta-lactone
4,4',6-trimethylangelicin
4,6,9-trimethyl-2h-furo(2,3-h)(1)benzopyran-2-one plus ultraviolet a radiation
4,4',6-trimethylangelicin plus ultraviolet a radiation
brn 4467945
ccris 4277
4,4,6-trimethylangelicin
2h-furo(2,3-h)-1-benzopyran-2-one, 4,6,9-trimethyl-
2h-furo(2,3-h)(1)benzopyran-2-one, 4,6,9-trimethyl, plus ultraviolet a radiation
90370-29-9
CHEMBL173365
chebi:82543 ,
4,6,9-trimethylfuro[2,3-h]chromen-2-one
C19538
unii-t2myr3390l
t2myr3390l ,
AKOS025119188
SCHEMBL17174622
DTXSID20238106
Q27156054
BB 0266510

Research Excerpts

Bioavailability

ExcerptReferenceRelevance
" In contrast with in vitro experiments, photobinding of CPZ to epidermal DNA/RNA was not found in vivo; apparently the bioavailability in the nucleus is very low."( Photobinding of 8-methoxypsoralen, 4,6,4'-trimethylangelicin and chlorpromazine to Wistar rat epidermal biomacromolecules in vivo.
Beijersbergen van Henegouwen, GM; Caffieri, S; Dall'Acqua, F; Persons, CC; Schoonderwoerd, SA, 1991
)
0.28
" In this current study, cellular bioavailability of 8-MOP, TMA and CPZ was investigated in vitro, using low doses of UVA relevant for the clinical setting of ECP."( Phototoxicity, distribution and kinetics of association of UVA-activated chlorpromazine, 8-methoxypsoralen, and 4,6,4'-trimethylangelicin in Jurkat cells.
Dobrucki, J; Rajwa, B; Sarna, T; Skrzeczyńska-Moncznik, J; van Henegouwen, GB; Wolnicka-Głubisz, A, 2005
)
0.33
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
furanocoumarinAny furochromene that consists of a furan ring fused with a coumarin. The fusion may occur in different ways in give several isomers.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (59)

Assay IDTitleYearJournalArticle
AID54115Compound was evaluated for the binding parameter by determining the number of nucleotides occluded by a bound angelicin (n)1984Journal of medicinal chemistry, Aug, Volume: 27, Issue:8
6-Methylangelicins: a new series of potential photochemotherapeutic agents for the treatment of psoriasis.
AID1357671Genotoxicity in Salmonella typhimurium TA100 assessed as revertant colonies at 1 uL/plate in presence of Sprague-Dawley rat S9 metabolic activation after 72 hrs by Ames test (Rvb = 1 No_unit)2018European journal of medicinal chemistry, May-10, Volume: 151Design, synthesis and biological evaluation of novel trimethylangelicin analogues targeting nuclear factor kB (NF-kB).
AID1357658Genotoxicity in Salmonella typhimurium TA98 assessed as revertant colonies at 10 uL/plate in absence of Sprague-Dawley rat S9 metabolic activation after 72 hrs by Ames test (Rvb = 1 No_unit)2018European journal of medicinal chemistry, May-10, Volume: 151Design, synthesis and biological evaluation of novel trimethylangelicin analogues targeting nuclear factor kB (NF-kB).
AID16264Percentage of clearance of psoriatic lesions by 8-methoxypsoralen (8-MOP) for comparison at dose of 10 J/cm e2 ultraviolet-A radiation1984Journal of medicinal chemistry, Aug, Volume: 27, Issue:8
6-Methylangelicins: a new series of potential photochemotherapeutic agents for the treatment of psoriasis.
AID89071Erythema induction by 8-methoxypsoralen (8-MOP) for comparison at dose of 4 J/cm e2 ultraviolet-A radiation in female patient; +++=very strong1984Journal of medicinal chemistry, Aug, Volume: 27, Issue:8
6-Methylangelicins: a new series of potential photochemotherapeutic agents for the treatment of psoriasis.
AID619965Inhibition of NF-KB p50 subunit/DNA interaction after 20 mins by EMSA2011European journal of medicinal chemistry, Oct, Volume: 46, Issue:10
Development of a novel furocoumarin derivative inhibiting NF-κB dependent biological functions: design, synthesis and biological effects.
AID88890Number of treatments at dose of 10 J/cm e2 ultraviolet-A radiation1984Journal of medicinal chemistry, Aug, Volume: 27, Issue:8
6-Methylangelicins: a new series of potential photochemotherapeutic agents for the treatment of psoriasis.
AID88892Number of treatments at dose of 6 J/cm e2 ultraviolet-A radiation1984Journal of medicinal chemistry, Aug, Volume: 27, Issue:8
6-Methylangelicins: a new series of potential photochemotherapeutic agents for the treatment of psoriasis.
AID89080Erythema induction by the compound at dose of 8 J/cm e2 ultraviolet-A radiation in female patient; - = absent1984Journal of medicinal chemistry, Aug, Volume: 27, Issue:8
6-Methylangelicins: a new series of potential photochemotherapeutic agents for the treatment of psoriasis.
AID1357654Induction of damage in salmon testes DNA at 100 uM in presence of 2.5 to 7.5 J/cm2 UVA irradiation by ethidium bromide dye-based agarose gel electrophoresis analysis2018European journal of medicinal chemistry, May-10, Volume: 151Design, synthesis and biological evaluation of novel trimethylangelicin analogues targeting nuclear factor kB (NF-kB).
AID90073Pigmentation capacity of 8-methoxypsoralen (8-MOP) for comparison at dose of 6 J/cm e2 ultraviolet-A radiation in female patient; + = moderate1984Journal of medicinal chemistry, Aug, Volume: 27, Issue:8
6-Methylangelicins: a new series of potential photochemotherapeutic agents for the treatment of psoriasis.
AID90078Pigmentation capacity at dose of 10 J/cm e2 ultraviolet-A radiation in female patient; ++=strong1984Journal of medicinal chemistry, Aug, Volume: 27, Issue:8
6-Methylangelicins: a new series of potential photochemotherapeutic agents for the treatment of psoriasis.
AID88893Number of treatments at dose of 8 J/cm e2 ultraviolet-A radiation1984Journal of medicinal chemistry, Aug, Volume: 27, Issue:8
6-Methylangelicins: a new series of potential photochemotherapeutic agents for the treatment of psoriasis.
AID16271Percentage of clearance of psoriatic lesions by the compound at dose of 8 J/cm e2 ultraviolet-A radiation1984Journal of medicinal chemistry, Aug, Volume: 27, Issue:8
6-Methylangelicins: a new series of potential photochemotherapeutic agents for the treatment of psoriasis.
AID1357674Genotoxicity in Salmonella typhimurium TA100 assessed as revertant colonies at 50 uL/plate in presence of Sprague-Dawley rat S9 metabolic activation after 72 hrs by Ames test (Rvb = 1 No_unit)2018European journal of medicinal chemistry, May-10, Volume: 151Design, synthesis and biological evaluation of novel trimethylangelicin analogues targeting nuclear factor kB (NF-kB).
AID89078Erythema induction by the compound at dose of 4 J/cm e2 ultraviolet-A radiation in female patient; - = absent1984Journal of medicinal chemistry, Aug, Volume: 27, Issue:8
6-Methylangelicins: a new series of potential photochemotherapeutic agents for the treatment of psoriasis.
AID90079Pigmentation capacity at dose of 6 J/cm e2 ultraviolet-A radiation in female patient; + = moderate1984Journal of medicinal chemistry, Aug, Volume: 27, Issue:8
6-Methylangelicins: a new series of potential photochemotherapeutic agents for the treatment of psoriasis.
AID89070Erythema induction by 8-methoxypsoralen (8-MOP) for comparison at dose of 10 J/cm e2 ultraviolet-A radiation in female patient; +++=very strong1984Journal of medicinal chemistry, Aug, Volume: 27, Issue:8
6-Methylangelicins: a new series of potential photochemotherapeutic agents for the treatment of psoriasis.
AID89073Erythema induction by 8-methoxypsoralen (8-MOP) for comparison at dose of 6 J/cm e2 ultraviolet-A radiation in female patient; +++ = very strong1984Journal of medicinal chemistry, Aug, Volume: 27, Issue:8
6-Methylangelicins: a new series of potential photochemotherapeutic agents for the treatment of psoriasis.
AID1357668Genotoxicity in Salmonella typhimurium TA100 assessed as revertant colonies at 10 uL/plate in absence of Sprague-Dawley rat S9 metabolic activation after 72 hrs by Ames test (Rvb = 1 No_unit)2018European journal of medicinal chemistry, May-10, Volume: 151Design, synthesis and biological evaluation of novel trimethylangelicin analogues targeting nuclear factor kB (NF-kB).
AID16270Percentage of clearance of psoriatic lesions by the compound at dose of 6 J/cm e2 ultraviolet-A radiation1984Journal of medicinal chemistry, Aug, Volume: 27, Issue:8
6-Methylangelicins: a new series of potential photochemotherapeutic agents for the treatment of psoriasis.
AID1357669Genotoxicity in Salmonella typhimurium TA100 assessed as revertant colonies at 50 uL/plate in absence of Sprague-Dawley rat S9 metabolic activation after 72 hrs by Ames test (Rvb = 1 No_unit)2018European journal of medicinal chemistry, May-10, Volume: 151Design, synthesis and biological evaluation of novel trimethylangelicin analogues targeting nuclear factor kB (NF-kB).
AID1357665Genotoxicity in Salmonella typhimurium TA98 assessed as revertant colonies at 100 uL/plate in presence of Sprague-Dawley rat S9 metabolic activation after 72 hrs by Ames test (Rvb = 1 No_unit)2018European journal of medicinal chemistry, May-10, Volume: 151Design, synthesis and biological evaluation of novel trimethylangelicin analogues targeting nuclear factor kB (NF-kB).
AID1357667Genotoxicity in Salmonella typhimurium TA100 assessed as revertant colonies at 5 uL/plate in absence of Sprague-Dawley rat S9 metabolic activation after 72 hrs by Ames test (Rvb = 1 No_unit)2018European journal of medicinal chemistry, May-10, Volume: 151Design, synthesis and biological evaluation of novel trimethylangelicin analogues targeting nuclear factor kB (NF-kB).
AID90083Pigmentation capacity at dose of 9 J/cm e2 ultraviolet-A radiation in female patient; +=moderate1984Journal of medicinal chemistry, Aug, Volume: 27, Issue:8
6-Methylangelicins: a new series of potential photochemotherapeutic agents for the treatment of psoriasis.
AID89072Erythema induction by 8-methoxypsoralen (8-MOP) for comparison at dose of 6 J/cm e2 ultraviolet-A radiation in female patient; ++ = strong1984Journal of medicinal chemistry, Aug, Volume: 27, Issue:8
6-Methylangelicins: a new series of potential photochemotherapeutic agents for the treatment of psoriasis.
AID16268Percentage of clearance of psoriatic lesions by the compound at dose of 10 J/cm e2 ultraviolet-A radiation1984Journal of medicinal chemistry, Aug, Volume: 27, Issue:8
6-Methylangelicins: a new series of potential photochemotherapeutic agents for the treatment of psoriasis.
AID91202Number of treatments at dose of 6 J/cm e2 ultraviolet-A radiation1984Journal of medicinal chemistry, Aug, Volume: 27, Issue:8
6-Methylangelicins: a new series of potential photochemotherapeutic agents for the treatment of psoriasis.
AID1357663Genotoxicity in Salmonella typhimurium TA98 assessed as revertant colonies at 10 uL/plate in presence of Sprague-Dawley rat S9 metabolic activation after 72 hrs by Ames test (Rvb = 1 No_unit)2018European journal of medicinal chemistry, May-10, Volume: 151Design, synthesis and biological evaluation of novel trimethylangelicin analogues targeting nuclear factor kB (NF-kB).
AID16265Percentage of clearance of psoriatic lesions by 8-methoxypsoralen (8-MOP) for comparison at dose of 6 J/cm e2 ultraviolet-A radiation1984Journal of medicinal chemistry, Aug, Volume: 27, Issue:8
6-Methylangelicins: a new series of potential photochemotherapeutic agents for the treatment of psoriasis.
AID16266Percentage of clearance of psoriatic lesions by 8-methoxypsoralen (8-MOP) for comparison at dose of 8 J/cm e2 ultraviolet-A radiation1984Journal of medicinal chemistry, Aug, Volume: 27, Issue:8
6-Methylangelicins: a new series of potential photochemotherapeutic agents for the treatment of psoriasis.
AID90071Pigmentation capacity of 8-methoxypsoralen (8-MOP) for comparison at dose of 10 J/cm e2 ultraviolet-A radiation in female patient; +=moderate1984Journal of medicinal chemistry, Aug, Volume: 27, Issue:8
6-Methylangelicins: a new series of potential photochemotherapeutic agents for the treatment of psoriasis.
AID1357660Genotoxicity in Salmonella typhimurium TA98 assessed as revertant colonies at 100 uL/plate in absence of Sprague-Dawley rat S9 metabolic activation after 72 hrs by Ames test (Rvb = 1 No_unit)2018European journal of medicinal chemistry, May-10, Volume: 151Design, synthesis and biological evaluation of novel trimethylangelicin analogues targeting nuclear factor kB (NF-kB).
AID89074Erythema induction by 8-methoxypsoralen (8-MOP) for comparison at dose of 8 J/cm e2 ultraviolet-A radiation in female patient, +=moderate1984Journal of medicinal chemistry, Aug, Volume: 27, Issue:8
6-Methylangelicins: a new series of potential photochemotherapeutic agents for the treatment of psoriasis.
AID89077Erythema induction by the compound at dose of 10 J/cm e2 ultraviolet-A radiation in female patient; - = absent1984Journal of medicinal chemistry, Aug, Volume: 27, Issue:8
6-Methylangelicins: a new series of potential photochemotherapeutic agents for the treatment of psoriasis.
AID90074Pigmentation capacity of 8-methoxypsoralen (8-MOP) for comparison at dose of 6 J/cm e2 ultraviolet-A radiation in female patient; ++ = strong1984Journal of medicinal chemistry, Aug, Volume: 27, Issue:8
6-Methylangelicins: a new series of potential photochemotherapeutic agents for the treatment of psoriasis.
AID54807Compound was evaluated for the binding parameter by determining rate constant1984Journal of medicinal chemistry, Aug, Volume: 27, Issue:8
6-Methylangelicins: a new series of potential photochemotherapeutic agents for the treatment of psoriasis.
AID54116Compound was evaluated for the frequency of the binding site that is the number of molecules bound to every nucleotide (1/n)1984Journal of medicinal chemistry, Aug, Volume: 27, Issue:8
6-Methylangelicins: a new series of potential photochemotherapeutic agents for the treatment of psoriasis.
AID1357656Genotoxicity in Salmonella typhimurium TA98 assessed as revertant colonies at 5 uL/plate in absence of Sprague-Dawley rat S9 metabolic activation after 72 hrs by Ames test (Rvb = 1 No_unit)2018European journal of medicinal chemistry, May-10, Volume: 151Design, synthesis and biological evaluation of novel trimethylangelicin analogues targeting nuclear factor kB (NF-kB).
AID16269Percentage of clearance of psoriatic lesions by the compound at dose of 4 J/cm e2 ultraviolet-A radiation1984Journal of medicinal chemistry, Aug, Volume: 27, Issue:8
6-Methylangelicins: a new series of potential photochemotherapeutic agents for the treatment of psoriasis.
AID1357662Genotoxicity in Salmonella typhimurium TA98 assessed as revertant colonies at 5 uL/plate in presence of Sprague-Dawley rat S9 metabolic activation after 72 hrs by Ames test (Rvb = 1 No_unit)2018European journal of medicinal chemistry, May-10, Volume: 151Design, synthesis and biological evaluation of novel trimethylangelicin analogues targeting nuclear factor kB (NF-kB).
AID1357670Genotoxicity in Salmonella typhimurium TA100 assessed as revertant colonies at 100 uL/plate in absence of Sprague-Dawley rat S9 metabolic activation after 72 hrs by Ames test (Rvb = 1 No_unit)2018European journal of medicinal chemistry, May-10, Volume: 151Design, synthesis and biological evaluation of novel trimethylangelicin analogues targeting nuclear factor kB (NF-kB).
AID1357659Genotoxicity in Salmonella typhimurium TA98 assessed as revertant colonies at 50 uL/plate in absence of Sprague-Dawley rat S9 metabolic activation after 72 hrs by Ames test (Rvb = 1 No_unit)2018European journal of medicinal chemistry, May-10, Volume: 151Design, synthesis and biological evaluation of novel trimethylangelicin analogues targeting nuclear factor kB (NF-kB).
AID88891Number of treatments at dose of 4 J/cm e2 ultraviolet-A radiation (female patient)1984Journal of medicinal chemistry, Aug, Volume: 27, Issue:8
6-Methylangelicins: a new series of potential photochemotherapeutic agents for the treatment of psoriasis.
AID130473Compound was evaluated for 50% inhibition of DNA synthesis in Ehrlich ascites tumor cells by irradiation (365 nM) at 1.9 x 10e -5M incubated with [3H]thymidine at 37 degree C (p 0.05)1984Journal of medicinal chemistry, Aug, Volume: 27, Issue:8
6-Methylangelicins: a new series of potential photochemotherapeutic agents for the treatment of psoriasis.
AID90072Pigmentation capacity of 8-methoxypsoralen (8-MOP) for comparison at dose of 4 J/cm e2 ultraviolet-A radiation in female patient; - = absent1984Journal of medicinal chemistry, Aug, Volume: 27, Issue:8
6-Methylangelicins: a new series of potential photochemotherapeutic agents for the treatment of psoriasis.
AID1357701Inhibition of NF-kappaB (unknown origin) assessed as decrease in NF-kappaB/DNA interaction at 12.5 to 100 uM using 32P-labeled target NF-kappaB double-stranded oligonucleotide after 30 mins by EMSA2018European journal of medicinal chemistry, May-10, Volume: 151Design, synthesis and biological evaluation of novel trimethylangelicin analogues targeting nuclear factor kB (NF-kB).
AID1357666Genotoxicity in Salmonella typhimurium TA100 assessed as revertant colonies at 1 uL/plate in absence of Sprague-Dawley rat S9 metabolic activation after 72 hrs by Ames test (Rvb = 1 No_unit)2018European journal of medicinal chemistry, May-10, Volume: 151Design, synthesis and biological evaluation of novel trimethylangelicin analogues targeting nuclear factor kB (NF-kB).
AID1357657Genotoxicity in Salmonella typhimurium TA98 assessed as revertant colonies at 1 uL/plate in absence of Sprague-Dawley rat S9 metabolic activation after 72 hrs by Ames test (Rvb = 1 No_unit)2018European journal of medicinal chemistry, May-10, Volume: 151Design, synthesis and biological evaluation of novel trimethylangelicin analogues targeting nuclear factor kB (NF-kB).
AID1357672Genotoxicity in Salmonella typhimurium TA100 assessed as revertant colonies at 5 uL/plate in presence of Sprague-Dawley rat S9 metabolic activation after 72 hrs by Ames test (Rvb = 1 No_unit)2018European journal of medicinal chemistry, May-10, Volume: 151Design, synthesis and biological evaluation of novel trimethylangelicin analogues targeting nuclear factor kB (NF-kB).
AID1357675Genotoxicity in Salmonella typhimurium TA100 assessed as revertant colonies at 100 uL/plate in presence of Sprague-Dawley rat S9 metabolic activation after 72 hrs by Ames test (Rvb = 1 No_unit)2018European journal of medicinal chemistry, May-10, Volume: 151Design, synthesis and biological evaluation of novel trimethylangelicin analogues targeting nuclear factor kB (NF-kB).
AID89079Erythema induction by the compound at dose of 6 J/cm e2 ultraviolet-A radiation in female patient; - = absent1984Journal of medicinal chemistry, Aug, Volume: 27, Issue:8
6-Methylangelicins: a new series of potential photochemotherapeutic agents for the treatment of psoriasis.
AID1357673Genotoxicity in Salmonella typhimurium TA100 assessed as revertant colonies at 10 uL/plate in presence of Sprague-Dawley rat S9 metabolic activation after 72 hrs by Ames test (Rvb = 1 No_unit)2018European journal of medicinal chemistry, May-10, Volume: 151Design, synthesis and biological evaluation of novel trimethylangelicin analogues targeting nuclear factor kB (NF-kB).
AID54459Compound was evaluated for the association constant to an isolated site of DNA1984Journal of medicinal chemistry, Aug, Volume: 27, Issue:8
6-Methylangelicins: a new series of potential photochemotherapeutic agents for the treatment of psoriasis.
AID1357661Genotoxicity in Salmonella typhimurium TA98 assessed as revertant colonies at 1 uL/plate in presence of Sprague-Dawley rat S9 metabolic activation after 72 hrs by Ames test (Rvb = 1 No_unit)2018European journal of medicinal chemistry, May-10, Volume: 151Design, synthesis and biological evaluation of novel trimethylangelicin analogues targeting nuclear factor kB (NF-kB).
AID90080Pigmentation capacity at dose of 8 J/cm e2 ultraviolet-A radiation in female patient; +++=very strong1984Journal of medicinal chemistry, Aug, Volume: 27, Issue:8
6-Methylangelicins: a new series of potential photochemotherapeutic agents for the treatment of psoriasis.
AID90075Pigmentation capacity of 8-methoxypsoralen (8-MOP) for comparison at dose of 8 J/cm e2 ultraviolet-A radiation in female patient; +=moderate1984Journal of medicinal chemistry, Aug, Volume: 27, Issue:8
6-Methylangelicins: a new series of potential photochemotherapeutic agents for the treatment of psoriasis.
AID1357664Genotoxicity in Salmonella typhimurium TA98 assessed as revertant colonies at 50 uL/plate in presence of Sprague-Dawley rat S9 metabolic activation after 72 hrs by Ames test (Rvb = 1 No_unit)2018European journal of medicinal chemistry, May-10, Volume: 151Design, synthesis and biological evaluation of novel trimethylangelicin analogues targeting nuclear factor kB (NF-kB).
AID1357702Induction of damage in salmon testes DNA at 100 uM in absence of 2.5 to 7.5 J/cm2 UVA irradiation by ethidium bromide dye-based agarose gel electrophoresis analysis2018European journal of medicinal chemistry, May-10, Volume: 151Design, synthesis and biological evaluation of novel trimethylangelicin analogues targeting nuclear factor kB (NF-kB).
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (44)

TimeframeStudies, This Drug (%)All Drugs %
pre-19908 (18.18)18.7374
1990's21 (47.73)18.2507
2000's5 (11.36)29.6817
2010's9 (20.45)24.3611
2020's1 (2.27)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 10.95

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index10.95 (24.57)
Research Supply Index3.81 (2.92)
Research Growth Index4.76 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (10.95)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (2.27%)6.00%
Case Studies2 (4.55%)4.05%
Observational0 (0.00%)0.25%
Other41 (93.18%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]