2,2',4,6,6'-pentachlorobiphenyl profile

2,2',4,6,6'-pentachlorobiphenyl, also known as PCB 153, is a highly chlorinated polychlorinated biphenyl (PCB) congener. It is a persistent organic pollutant (POP) and a known environmental contaminant. PCB 153 is often used as a marker for total PCB contamination in environmental samples. It is a non-flammable, colorless, viscous liquid with a melting point of 60-62 degrees Celsius. PCBs are synthesized through the reaction of chlorine with biphenyl in the presence of a catalyst, typically a Lewis acid. This congener is particularly persistent in the environment and accumulates in the food chain, especially in fatty tissues of animals. It is classified as a probable human carcinogen by the International Agency for Research on Cancer (IARC). PCB 153 has been linked to various adverse health effects in humans and animals, including endocrine disruption, immune system suppression, reproductive problems, developmental toxicity, and cancer. Its presence in the environment is a major concern, as it can bioaccumulate in organisms and pose a threat to human and ecosystem health. The persistence, bioaccumulation, and toxic effects of PCB 153 make it a primary target for environmental monitoring and remediation efforts.'

ID Source	ID
PubMed CID	91662
SCHEMBL ID	4452879
MeSH ID	M0375116

Synonym
1,1'-biphenyl, 2,2',4,6,6'-pentachloro-
2,2',4,6,6'-pentachloro-1,1'-biphenyl
pcb 104
2,2',4,6,6'-pentachlorobiphenyl
2,4,6,2',6'-pentachlorobiphenyl
1,3,5-trichloro-2-(2,6-dichlorophenyl)benzene
56558-16-8
unii-z4yyf101n3
z4yyf101n3 ,
SCHEMBL4452879
MTCPZNVSDFCBBE-UHFFFAOYSA-N
DTXSID0074184 ,
1,1'-biphenyl, 2,2',4,6,6'-pentachloro-; 2,2',4,6,6'-pentachloro-1,1'-biphenyl; 2,2',4,6,6'-pentachlorobiphenyl; 2,4,6,2',6'-pentachlorobiphenyl; pcb 104; 2,2',4,6,6'-pentacb
pcb no. 104
Q27294999
CS-0453782
dtxcid4042090

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	8 (80.00)	29.6817
2010's	2 (20.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	1 (10.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	9 (90.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Trials	Classes	Roles
thiazoles [no description available]	2	1	0	1,3-thiazoles; mancude organic heteromonocyclic parent; monocyclic heteroarene
nitroblue tetrazolium Nitroblue Tetrazolium: Colorless to yellow dye that is reducible to blue or black formazan crystals by certain cells; formerly used to distinguish between nonbacterial and bacterial diseases, the latter causing neutrophils to reduce the dye; used to confirm diagnosis of chronic granulomatous disease.	2.05	1	0	organic cation
2,4,5,2',4',5'-hexachlorobiphenyl [no description available]	3.46	1	1	hexachlorobiphenyl
3,4,5,3',4'-pentachlorobiphenyl 3,3',4,4',5-pentachlorobiphenyl : A pentachlorobiphenyl in which the chlorines are located at the 3, 4, 5, 3', and 4' positions.	2.03	1	0	pentachlorobiphenyl; trichlorobenzene
thiazolyl blue thiazolyl blue: RN & II refers to bromide. 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide : The bromide salt of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium.	2	1	0	organic bromide salt	colorimetric reagent; dye
nadp [no description available]	2.05	1	0
dinoprostone prostaglandin E2 : Prostaglandin F2alpha in which the hydroxy group at position 9 has been oxidised to the corresponding ketone. Prostaglandin E2 is the most common and most biologically potent of mammalian prostaglandins.	2.02	1	0	prostaglandins E	human metabolite; mouse metabolite; oxytocic
trypan blue Trypan Blue: A diazo-naphthalene sulfonate that is widely used as a stain.. trypan blue : An organosulfonate salt that is the tetrasodium salt of 3,3'-[(3,3'-dimethylbiphenyl-4,4'-diyl)didiazene-2,1-diyl]bis(5-amino-4-hydroxynaphthalene-2,7-disulfonic acid).	2	1	0

Condition	Relationship Strength	Studies
Endometrioma An enlarged area of ENDOMETRIOSIS that resembles a tumor. It is usually found in the OVARY. When it is filled with old blood, it is known as a chocolate cyst.	2.17	1
Endometriosis A condition in which functional endometrial tissue is present outside the UTERUS. It is often confined to the PELVIS involving the OVARY, the ligaments, cul-de-sac, and the uterovesical peritoneum.	2.17	1
Innate Inflammatory Response [description not available]	2.01	1
Inflammation A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.	2.01	1
Polyploid [description not available]	2.02	1
Breast Cancer [description not available]	2.43	2
Metastase [description not available]	2.43	2
Invasiveness, Neoplasm [description not available]	2.02	1
Breast Neoplasms Tumors or cancer of the human BREAST.	2.43	2
Neoplasm Metastasis The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.	2.43	2
Hepatocellular Carcinoma [description not available]	2	1
Cancer of Liver [description not available]	2	1
Carcinoma, Hepatocellular A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.	2	1
Liver Neoplasms Tumors or cancer of the LIVER.	2	1

2,2',4,6,6'-pentachlorobiphenyl

Cross-References

Synonyms (17)

Research

Studies (10)

Market Indicators

Research Demand Index: 12.63

Study Types