Page last updated: 2024-12-06

2'-deoxyxanthosine

2'-deoxyxanthosine is a synthetic nucleoside analog that has shown promising antiviral activity against various viruses, including herpes simplex virus (HSV), cytomegalovirus (CMV), and Epstein-Barr virus (EBV). It is a modified form of the naturally occurring nucleoside xanthosine, where the 2'-hydroxyl group on the ribose sugar has been removed. This modification enhances its antiviral activity by inhibiting viral DNA polymerase, an enzyme essential for viral replication. The synthesis of 2'-deoxyxanthosine typically involves chemical modification of xanthosine using a variety of methods, such as using a protecting group strategy or a one-pot reaction. 2'-deoxyxanthosine is being investigated for its potential as a therapeutic agent for viral infections, particularly for those resistant to conventional antiviral drugs. Its unique chemical structure and antiviral activity make it a promising candidate for further research and development.'

Cross-References

ID SourceID
PubMed CID65372
SCHEMBL ID855722
MeSH IDM0208755

Synonyms (10)

Synonym
9-[(2r,4s,5r)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3h-purine-2,6-dione
xanthosine, 2'-deoxy-
29049-22-7
2'-deoxyxanthosine
SCHEMBL855722
mfcd18643182
DTXSID40183285
desoxyxanthosin
9-((2r,4s,5r)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9h-purine-2,6-diol
9-[(2r,4s,5r)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-9h-purine-2,6-diol
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
purines 2'-deoxy-D-ribonucleoside
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (12)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's4 (33.33)18.2507
2000's8 (66.67)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.97

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index11.97 (24.57)
Research Supply Index2.56 (2.92)
Research Growth Index4.54 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (11.97)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other12 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
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