Compounds > thiazinamium
Page last updated: 2024-12-05

thiazinamium

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

thiazinamium: was heading 1975-94 (see under PROMETHAZINE 1980-90); METHYLPROMETHAZINE was see THIAZINAMIUM 1980-94; use PROMETHAZINE to search THIAZINAMIUM 1975-94; a quaternary ammonium phenothiazine, usually as the methyl sulfate, that has both histamine 1 and acetylcholine blocking actions [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID6016
CHEMBL ID2111135
CHEBI ID135268
SCHEMBL ID4425937
MeSH IDM0224695

Synonyms (20)

Synonym
thiazinamium
trimethyl-(1-methyl-2-phenothiazin-10-yl-ethyl)ammonium
n,n,n-trimethyl-n-[1-methyl-2-(10-phenothiazinyl)ethyl]-ammonium
CHEBI:135268
thiazinam
trimethyl(1-phenothiazin-10-ylpropan-2-yl)azanium
unii-666w2p28n2
trimethyl(1-methyl-2-phenothiazin-10-ylethyl)ammonium
2338-21-8
666w2p28n2 ,
10h-phenothiazine-10-ethanaminium, n,n,n,alpha-tetramethyl-,
trimethyl(1-methyl-2-phenothiazin-10-ylethyl)-ammonium
einecs 219-051-7
thiazinamium [who-dd]
10h-phenothiazine-10-ethanaminium, n,n,n,.alpha.-tetramethyl-
SCHEMBL4425937
CHEMBL2111135
DB13420
Q7783885
DTXSID001021633

Research Excerpts

Dosage Studied

ExcerptRelevanceReference
" Because there is a lack of chromatographic data available for its determination, the objective of the present investigation was to develop a sensitive and rapid HPLC method for the quantitative estimation of thiazinamium methylsulphate in a pharmaceutical dosage form, applicable to routine analysis."( A validated HPLC method for the determination of thiazinamium methylsulphate in pharmaceutical preparations.
Baeyens, WR; Kiekens, F; Remon, JP; Smet, E; Van der Weken, G; Vervaet, C, 2000)		0.75
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
phenothiazines
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Pathways (1)

PathwayProteinsCompounds
Thiazinamium H1-Antihistamine Action87

Research

Studies (11)

TimeframeStudies, This Drug (%)All Drugs %
pre-199010 (90.91)18.7374
1990's0 (0.00)18.2507
2000's1 (9.09)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 19.27

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index19.27 (24.57)
Research Supply Index2.64 (2.92)
Research Growth Index4.27 (4.65)
Search Engine Demand Index15.26 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (19.27)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other13 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
isoproterenol
Isoproterenol: Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on the heart, bronchi, skeletal muscle, alimentary tract, etc. It is used mainly as bronchodilator and heart stimulant.. isoprenaline : A secondary amino compound that is noradrenaline in which one of the hydrogens attached to the nitrogen is replaced by an isopropyl group. A sympathomimetic acting almost exclusively on beta-adrenergic receptors, it is used (mainly as the hydrochloride salt) as a bronghodilator and heart stimulant for the management of a variety of cardiac disorders.		1.9410catechols;
secondary alcohol;
secondary amino compound		beta-adrenergic agonist;
bronchodilator agent;
cardiotonic drug;
sympathomimetic agent
promethazine
Promethazine: A phenothiazine derivative with histamine H1-blocking, antimuscarinic, and sedative properties. It is used as an antiallergic, in pruritus, for motion sickness and sedation, and also in animals.. promethazine : A tertiary amine that is a substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropan-2-amine moiety.		3.72110phenothiazines;
tertiary amine		anti-allergic agent;
anticoronaviral agent;
antiemetic;
antipruritic drug;
H1-receptor antagonist;
local anaesthetic;
sedative
phenothiazine
10H-phenothiazine : The 10H-tautomer of phenothiazine.		8.4380phenothiazineferroptosis inhibitor;
plant metabolite;
radical scavenger
diethazine
diethazine: phenothiazine derivative anti-Parkinson agent with anticholinergic and antihistaminic actions; is effective against Parkinson tremor; minor descriptor (75-86); on-line & INDEX MEDICUS search PHENOTHIAZINES (75-86); RN given refers to cpd without isomeric designation		6.9310phenothiazines
ConditionIndicatedRelationship StrengthStudiesTrials
Koch's Disease
[description not available]		01.9310
Pulmonary Consumption
[description not available]		02.8440
Tuberculosis
Any of the infectious diseases of man and other animals caused by species of MYCOBACTERIUM TUBERCULOSIS.		01.9310
Tuberculosis, Pulmonary
MYCOBACTERIUM infections of the lung.		02.8440
Constriction, Pathological
[description not available]		01.9310
Constriction, Pathologic
The condition of an anatomical structure's being constricted beyond normal dimensions.		01.9310
Asthma, Bronchial
[description not available]		01.9310
Asthma
A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).		06.9310
Gastroduodenal Ulcer
[description not available]		01.9310
Peptic Ulcer
Ulcer that occurs in the regions of the GASTROINTESTINAL TRACT which come into contact with GASTRIC JUICE containing PEPSIN and GASTRIC ACID. It occurs when there are defects in the MUCOSA barrier. The common forms of peptic ulcers are associated with HELICOBACTER PYLORI and the consumption of nonsteroidal anti-inflammatory drugs (NSAIDS).		06.9310
Dermatitis, Contact, Phototoxic
[description not available]		01.9310
Bronchitis
Inflammation of the large airways in the lung including any part of the BRONCHI, from the PRIMARY BRONCHI to the TERTIARY BRONCHI.		01.9410
Anoxemia
[description not available]		01.9310
Hypoxia
Sub-optimal OXYGEN levels in the ambient air of living organisms.		01.9310