Compounds > 11-beta-chloromethyl-estradiol
Page last updated: 2024-11-06

11-beta-chloromethyl-estradiol

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID SourceID
PubMed CID67088
CHEMBL ID175602
CHEBI ID34142
SCHEMBL ID8746070
MeSH IDM0116929

Synonyms (19)

Synonym
11beta-chloromethylestradiol
org 4333
71794-60-0
(8s,9r,11s,13s,14s,17s)-11-(chloromethyl)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol
CHEMBL175602
chebi:34142 ,
unii-brp4dw4see
brp4dw4see ,
estra-1,3,5(10)-triene-3,17-diol, 11-(chloromethyl)-, (11beta,17beta)-
org-4333
11-beta-chloromethyl-estradiol
SCHEMBL8746070
11beta-chloromethylestra-1,3,5(10)-trien-3,17beta-diol
DTXSID40992450
Q27115844
estra-1,3,5(10)-triene-3,17-diol, 11-(chloromethyl)-, (11.beta.,17.beta.)-
11.beta.-cme2
11.beta.-chloromethylestradiol
(11.beta.,17.beta.)-11-(chloromethyl)estra-1,3,5(10)-triene-3,17-diol
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
3-hydroxy steroidAny hydroxy steroid carrying a hydroxy group at position 3.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (2)

Assay IDTitleYearJournalArticle
AID69391Binding affinity against estrogen receptor was determined by using [3H]estradiol as radioligand in competitive radiometric binding assay1998Bioorganic & medicinal chemistry letters, Nov-17, Volume: 8, Issue:22
Ligands for the estrogen receptor, containing cyclopentadienyltricarbonylrhenium units.
AID69390Binding affinity against estrogen receptor was determined by using [3H]estradiol as radioligand in competitive radiometric binding assay1998Bioorganic & medicinal chemistry letters, Nov-17, Volume: 8, Issue:22
Ligands for the estrogen receptor, containing cyclopentadienyltricarbonylrhenium units.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19904 (66.67)18.7374
1990's1 (16.67)18.2507
2000's1 (16.67)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.12

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.12 (24.57)
Research Supply Index2.08 (2.92)
Research Growth Index4.20 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.12)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other7 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
hexestrol
[no description available]		1.9910stilbenoid
estriol
hormonin: estrogen replacement; each tablet contains 600 ug micronized 17beta-estradiol, 270 ug estriol and 1.4 mg estrone. chlorapatite : A phosphate mineral with the formula Ca5(PO4)3Cl.		2.021016alpha-hydroxy steroid;
17beta-hydroxy steroid;
3-hydroxy steroid		estrogen;
human metabolite;
human xenobiotic metabolite;
mouse metabolite
estrone
Hydroxyestrones: Estrone derivatives substituted with one or more hydroxyl groups in any position. They are important metabolites of estrone and other estrogens.		2.021017-oxo steroid;
3-hydroxy steroid;
phenolic steroid;
phenols		antineoplastic agent;
bone density conservation agent;
estrogen;
human metabolite;
mouse metabolite
dimethylformamide
Dimethylformamide: A formamide in which the amino hydrogens are replaced by methyl groups.. N,N-dimethylformamide : A member of the class of formamides that is formamide in which the amino hydrogens are replaced by methyl groups.		1.9710formamides;
volatile organic compound		geroprotector;
hepatotoxic agent;
polar aprotic solvent
promegestone
Promegestone: A synthetic progestin which is useful for the study of progestin distribution and progestin tissue receptors, as it is not bound by transcortin and binds to progesterone receptors with a higher association constant than progesterone.. promegestone : A progestin consisting of 17beta-propionylestra-4,9-dien-3-one substituted at position 17 by a methyl group.		1.961020-oxo steroid;
3-oxo-Delta(4) steroid		antineoplastic agent;
progesterone receptor agonist;
progestin
ketononestrol aziridine
ketononestrol aziridine: estrogenic affinity label for the estrogen receptor; structure given in first source		1.9710
3-(2-iodoacetamido)-2,2,5,5-tetramethyl-1-pyrrolidinyloxyl
3-(2-iodoacetamido)-2,2,5,5-tetramethyl-1-pyrrolidinyloxyl: structure given in first source		2.0210aminoxyls;
organoiodine compound;
pyrrolidinecarboxamide
cysteine
Cysteine: A thiol-containing non-essential amino acid that is oxidized to form CYSTINE.. L-cysteinium : The L-enantiomer of cysteinium.. cysteine : A sulfur-containing amino acid that is propanoic acid with an amino group at position 2 and a sulfanyl group at position 3.		2.0210cysteiniumfundamental metabolite
ConditionIndicatedRelationship StrengthStudiesTrials
Breast Cancer
[description not available]		02.3720
Breast Neoplasms
Tumors or cancer of the human BREAST.		02.3720