Compounds > schisanhenol b
Page last updated: 2024-12-07

schisanhenol b

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Description

schisanhenol B: isolated from kernels of Schisandra rubriflora; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID128150
CHEMBL ID463499
MeSH IDM0140703

Synonyms (22)

Synonym
benzo[3',4']cycloocta[1',2':4,5]benzo[1,2-d][1,3]dioxol-1-ol, 5,6,7,8-tetrahydro-2,3,13-trimethoxy-6,7-dimethyl-, (6r,7s)-
(+/-)-gomisin m1
schisanhenol b
CHEMBL463499 ,
(+)-schisanhenol b
benzo(3,4)cycloocta(1,2-f)(1,3)benzodioxol-1-ol, 5,6,7,8-tetrahydro-2,3,13-trimethoxy-6,7-dimethyl-, stereoisomer
102681-52-7
benzo(3,4)cycloocta(1,2-f)(1,3)benzodioxol-1-ol, 5,6,7,8-tetrahydro-2,3,13-trimethoxy-6,7-dimethyl-, (6r,7s,13ar)-rel-
gomisin m
c0678jed3a ,
gomisin m1, (+/-)-
unii-c0678jed3a
schisanhenol-b
DTXSID70145452
benzo(3,4)cycloocta(1,2-f)(1,3)benzodioxol-1-ol, 5,6,7,8-tetrahydro-2, 3,13-trimethoxy-6,7-dimethyl-
1350802-13-9
(6r,7s,13ar)-5,6,7,8-tetrahydro-2,3,13-trimethoxy-6,7-dimethylbenzo[3,4]cycloocta[1,2-f][1,3]benzodioxol-1-ol
Q27275004
(9r,10s)-4,5,19-trimethoxy-9,10-dimethyl-15,17-dioxatetracyclo[10.7.0.02,7.014,18]nonadeca-1(19),2,4,6,12,14(18)-hexaen-3-ol
D85023
AKOS040760817
bdbm50582612
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (1)

Activation Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
RISC-loading complex subunit TARBP2Homo sapiens (human)Kd7.42500.09404.98138.0600AID1817266; AID1884723
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (14)

Processvia Protein(s)Taxonomy
regulation of translationRISC-loading complex subunit TARBP2Homo sapiens (human)
negative regulation of protein kinase activityRISC-loading complex subunit TARBP2Homo sapiens (human)
siRNA processingRISC-loading complex subunit TARBP2Homo sapiens (human)
pre-miRNA processingRISC-loading complex subunit TARBP2Homo sapiens (human)
miRNA processingRISC-loading complex subunit TARBP2Homo sapiens (human)
negative regulation of cytoplasmic pattern recognition receptor signaling pathwayRISC-loading complex subunit TARBP2Homo sapiens (human)
positive regulation of viral genome replicationRISC-loading complex subunit TARBP2Homo sapiens (human)
regulation of viral transcriptionRISC-loading complex subunit TARBP2Homo sapiens (human)
negative regulation of defense response to virus by hostRISC-loading complex subunit TARBP2Homo sapiens (human)
regulation of siRNA processingRISC-loading complex subunit TARBP2Homo sapiens (human)
RISC complex assemblyRISC-loading complex subunit TARBP2Homo sapiens (human)
global gene silencing by mRNA cleavageRISC-loading complex subunit TARBP2Homo sapiens (human)
regulation of miRNA processingRISC-loading complex subunit TARBP2Homo sapiens (human)
regulation of regulatory ncRNA processingRISC-loading complex subunit TARBP2Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (10)

Processvia Protein(s)Taxonomy
pre-miRNA bindingRISC-loading complex subunit TARBP2Homo sapiens (human)
double-stranded RNA bindingRISC-loading complex subunit TARBP2Homo sapiens (human)
protein bindingRISC-loading complex subunit TARBP2Homo sapiens (human)
enzyme bindingRISC-loading complex subunit TARBP2Homo sapiens (human)
siRNA bindingRISC-loading complex subunit TARBP2Homo sapiens (human)
miRNA bindingRISC-loading complex subunit TARBP2Homo sapiens (human)
pre-mRNA bindingRISC-loading complex subunit TARBP2Homo sapiens (human)
identical protein bindingRISC-loading complex subunit TARBP2Homo sapiens (human)
protein homodimerization activityRISC-loading complex subunit TARBP2Homo sapiens (human)
pre-miRNA bindingRISC-loading complex subunit TARBP2Homo sapiens (human)
protein sequestering activityRISC-loading complex subunit TARBP2Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (8)

Processvia Protein(s)Taxonomy
nucleoplasmRISC-loading complex subunit TARBP2Homo sapiens (human)
cytoplasmRISC-loading complex subunit TARBP2Homo sapiens (human)
cytosolRISC-loading complex subunit TARBP2Homo sapiens (human)
nuclear bodyRISC-loading complex subunit TARBP2Homo sapiens (human)
perinuclear region of cytoplasmRISC-loading complex subunit TARBP2Homo sapiens (human)
RISC-loading complexRISC-loading complex subunit TARBP2Homo sapiens (human)
RISC complexRISC-loading complex subunit TARBP2Homo sapiens (human)
nucleusRISC-loading complex subunit TARBP2Homo sapiens (human)
cytoplasmRISC-loading complex subunit TARBP2Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (89)

Assay IDTitleYearJournalArticle
AID1817247Effect on human SK-HEP1 cells assessed as increase in miR-497-5p level by qRT-PCR analysis2021Journal of medicinal chemistry, 06-10, Volume: 64, Issue:11
Identification of a Novel TAR RNA-Binding Protein 2 Modulator with Potential Therapeutic Activity against Hepatocellular Carcinoma.
AID1817235Inhibition of epithelial-mesenchymal transition in human SK-HEP1 cells assessed as change in E-cadherin expression at 10 to 50 uM incubated for 24 hrs by Western blot analysis2021Journal of medicinal chemistry, 06-10, Volume: 64, Issue:11
Identification of a Novel TAR RNA-Binding Protein 2 Modulator with Potential Therapeutic Activity against Hepatocellular Carcinoma.
AID1817227Inhibition of colony formation in human HeLa cells at 30 uM incubated for 14 days by crystal violet staining based assay2021Journal of medicinal chemistry, 06-10, Volume: 64, Issue:11
Identification of a Novel TAR RNA-Binding Protein 2 Modulator with Potential Therapeutic Activity against Hepatocellular Carcinoma.
AID1817240Antitumor activity in human MHCC97 cells xenografted in SCID mouse assessed as suppression of tumor growth at 40 mg/kg, ip administered once every 3 day for 30 days by bioluminescence analysis2021Journal of medicinal chemistry, 06-10, Volume: 64, Issue:11
Identification of a Novel TAR RNA-Binding Protein 2 Modulator with Potential Therapeutic Activity against Hepatocellular Carcinoma.
AID1817228Inhibition of colony formation in human MDA-MB-231 cells at 30 uM incubated for 14 days by crystal violet staining based assay2021Journal of medicinal chemistry, 06-10, Volume: 64, Issue:11
Identification of a Novel TAR RNA-Binding Protein 2 Modulator with Potential Therapeutic Activity against Hepatocellular Carcinoma.
AID1817257Inhibition of STAT3 phosphorylation in human SK-HEP1 cells at 30 uM by Western blot analysis2021Journal of medicinal chemistry, 06-10, Volume: 64, Issue:11
Identification of a Novel TAR RNA-Binding Protein 2 Modulator with Potential Therapeutic Activity against Hepatocellular Carcinoma.
AID1817288Effect on TRBP protein expression in human SK-HEP1 cells at 30 uM after 24 hrs by immunoblot analysis2021Journal of medicinal chemistry, 06-10, Volume: 64, Issue:11
Identification of a Novel TAR RNA-Binding Protein 2 Modulator with Potential Therapeutic Activity against Hepatocellular Carcinoma.
AID1817261Downregulation of UBE2S expression in mouse liver at 40 mg/kg measured after 30 days by immunohistochemical staining analysis2021Journal of medicinal chemistry, 06-10, Volume: 64, Issue:11
Identification of a Novel TAR RNA-Binding Protein 2 Modulator with Potential Therapeutic Activity against Hepatocellular Carcinoma.
AID1817236Inhibition of epithelial-mesenchymal transition in human SK-HEP1 cells assessed as change in N-cadherin expression at 10 to 50 uM incubated for 24 hrs by Western blot analysis2021Journal of medicinal chemistry, 06-10, Volume: 64, Issue:11
Identification of a Novel TAR RNA-Binding Protein 2 Modulator with Potential Therapeutic Activity against Hepatocellular Carcinoma.
AID1817223Inhibition of colony formation in human HCT-116 cells at 30 uM incubated for 14 days by crystal violet staining based assay2021Journal of medicinal chemistry, 06-10, Volume: 64, Issue:11
Identification of a Novel TAR RNA-Binding Protein 2 Modulator with Potential Therapeutic Activity against Hepatocellular Carcinoma.
AID1817248Effect on human SK-HEP1 cells assessed as increase in miR-146a-5p level by qRT-PCR analysis2021Journal of medicinal chemistry, 06-10, Volume: 64, Issue:11
Identification of a Novel TAR RNA-Binding Protein 2 Modulator with Potential Therapeutic Activity against Hepatocellular Carcinoma.
AID1817260Downregulation of CDC20 expression in mouse liver at 40 mg/kg measured after 30 days by immunohistochemical staining analysis2021Journal of medicinal chemistry, 06-10, Volume: 64, Issue:11
Identification of a Novel TAR RNA-Binding Protein 2 Modulator with Potential Therapeutic Activity against Hepatocellular Carcinoma.
AID1817216Antiproliferative activity against human HepG2 cells incubated for 24 hrs by alamar blue assay2021Journal of medicinal chemistry, 06-10, Volume: 64, Issue:11
Identification of a Novel TAR RNA-Binding Protein 2 Modulator with Potential Therapeutic Activity against Hepatocellular Carcinoma.
AID1817213Antiproliferative activity against human SK-HEP1 cells assessed as decrease in miR-30a-5p level at 20 uM by qRT-PCR analysis2021Journal of medicinal chemistry, 06-10, Volume: 64, Issue:11
Identification of a Novel TAR RNA-Binding Protein 2 Modulator with Potential Therapeutic Activity against Hepatocellular Carcinoma.
AID1817231Induction of apoptosis in human SK-HEP1 cells at 30 uM incubated for 24 hrs by Annexin V-FITC/PI staining based flow cytometry2021Journal of medicinal chemistry, 06-10, Volume: 64, Issue:11
Identification of a Novel TAR RNA-Binding Protein 2 Modulator with Potential Therapeutic Activity against Hepatocellular Carcinoma.
AID1817220Antiproliferative activity against human HCT-116 cells incubated for 24 hrs by alamar blue assay2021Journal of medicinal chemistry, 06-10, Volume: 64, Issue:11
Identification of a Novel TAR RNA-Binding Protein 2 Modulator with Potential Therapeutic Activity against Hepatocellular Carcinoma.
AID1817229Induction of cell cycle arrest in human SK-HEP1 cells assessed as G2 phase accumulation at 20 uM incubated for 24 hrs by propidium iodide staining based flow cytometry analysis (Rvb = 24.12%)2021Journal of medicinal chemistry, 06-10, Volume: 64, Issue:11
Identification of a Novel TAR RNA-Binding Protein 2 Modulator with Potential Therapeutic Activity against Hepatocellular Carcinoma.
AID1817286Effect on Dicer protein expression in human SK-HEP1 cells at 30 uM after 24 hrs by immunoblot analysis2021Journal of medicinal chemistry, 06-10, Volume: 64, Issue:11
Identification of a Novel TAR RNA-Binding Protein 2 Modulator with Potential Therapeutic Activity against Hepatocellular Carcinoma.
AID1817278Antiproliferative activity against human MHCC97 cells at 25 uM incubated for 24 hrs by alamar blue assay2021Journal of medicinal chemistry, 06-10, Volume: 64, Issue:11
Identification of a Novel TAR RNA-Binding Protein 2 Modulator with Potential Therapeutic Activity against Hepatocellular Carcinoma.
AID1817282Antiproliferative activity against human MDA-MB-231 cells at 25 uM incubated for 24 hrs by alamar blue assay2021Journal of medicinal chemistry, 06-10, Volume: 64, Issue:11
Identification of a Novel TAR RNA-Binding Protein 2 Modulator with Potential Therapeutic Activity against Hepatocellular Carcinoma.
AID1817214Antiproliferative activity against human SK-HEP1 cells incubated for 24 hrs by alamar blue assay2021Journal of medicinal chemistry, 06-10, Volume: 64, Issue:11
Identification of a Novel TAR RNA-Binding Protein 2 Modulator with Potential Therapeutic Activity against Hepatocellular Carcinoma.
AID1817208Antiproliferative activity against human SK-HEP1 cells assessed as increase in miR-106b-5p level at 20 uM by qRT-PCR analysis2021Journal of medicinal chemistry, 06-10, Volume: 64, Issue:11
Identification of a Novel TAR RNA-Binding Protein 2 Modulator with Potential Therapeutic Activity against Hepatocellular Carcinoma.
AID1817258Inhibition of IkappaB phosphorylation in human SK-HEP1 cells at 30 uM by Western blot analysis2021Journal of medicinal chemistry, 06-10, Volume: 64, Issue:11
Identification of a Novel TAR RNA-Binding Protein 2 Modulator with Potential Therapeutic Activity against Hepatocellular Carcinoma.
AID1817279Antiproliferative activity against human HepG2 cells at 25 uM incubated for 24 hrs by alamar blue assay2021Journal of medicinal chemistry, 06-10, Volume: 64, Issue:11
Identification of a Novel TAR RNA-Binding Protein 2 Modulator with Potential Therapeutic Activity against Hepatocellular Carcinoma.
AID1817243Toxicity in SCID mouse xenografted with human MHCC97 cells assessed as increase in body weight at 40 mg/kg, ip administered once every 3 day for 30 days2021Journal of medicinal chemistry, 06-10, Volume: 64, Issue:11
Identification of a Novel TAR RNA-Binding Protein 2 Modulator with Potential Therapeutic Activity against Hepatocellular Carcinoma.
AID1817262Binding affinity to TRBP in human SK-HEP1 cells assessed as decrease in thermal stability at 50 uM incubated for 30 mins by cellular thermal shift assay2021Journal of medicinal chemistry, 06-10, Volume: 64, Issue:11
Identification of a Novel TAR RNA-Binding Protein 2 Modulator with Potential Therapeutic Activity against Hepatocellular Carcinoma.
AID379883Antiviral activity against HIV1 3B in H9 cells after 4 days by p24-antigen ELISA2006Journal of natural products, Dec, Volume: 69, Issue:12
Rubrisandrins A and B, lignans and related anti-HIV compounds from Schisandra rubriflora.
AID1817281Antiproliferative activity against human HeLa cells at 25 uM incubated for 24 hrs by alamar blue assay2021Journal of medicinal chemistry, 06-10, Volume: 64, Issue:11
Identification of a Novel TAR RNA-Binding Protein 2 Modulator with Potential Therapeutic Activity against Hepatocellular Carcinoma.
AID1817245Antitumor activity in human MHCC97 cells xenografted in SCID mouse assessed as reduction in infiltration of inflammatory cells in left outer lobe of liver at 40 mg/kg, ip administered once every 3 days measured after 30 days by H and E staining based immu2021Journal of medicinal chemistry, 06-10, Volume: 64, Issue:11
Identification of a Novel TAR RNA-Binding Protein 2 Modulator with Potential Therapeutic Activity against Hepatocellular Carcinoma.
AID1817250Effect on human SK-HEP1 cells assessed as decrease in miR-224-5p level at 10 to 50 uM by qRT-PCR analysis2021Journal of medicinal chemistry, 06-10, Volume: 64, Issue:11
Identification of a Novel TAR RNA-Binding Protein 2 Modulator with Potential Therapeutic Activity against Hepatocellular Carcinoma.
AID1817215Antiproliferative activity against human MHCC97 cells incubated for 24 hrs by alamar blue assay2021Journal of medicinal chemistry, 06-10, Volume: 64, Issue:11
Identification of a Novel TAR RNA-Binding Protein 2 Modulator with Potential Therapeutic Activity against Hepatocellular Carcinoma.
AID1817207Antiproliferative activity against human HeLa cells assessed as increase in miR-21 biogenesis level measured after 24 hrs by luciferase assay2021Journal of medicinal chemistry, 06-10, Volume: 64, Issue:11
Identification of a Novel TAR RNA-Binding Protein 2 Modulator with Potential Therapeutic Activity against Hepatocellular Carcinoma.
AID1884723Binding affinity to human recombinant TRBP by SPR assay2022Journal of medicinal chemistry, 08-25, Volume: 65, Issue:16
Discovery of a Novel Small-Molecule Inhibitor Disrupting TRBP-Dicer Interaction against Hepatocellular Carcinoma via the Modulation of microRNA Biogenesis.
AID1817273Antiproliferative activity against human SK-HEP1 cells assessed as increase in miR-214-5p level at 20 uM by qRT-PCR analysis2021Journal of medicinal chemistry, 06-10, Volume: 64, Issue:11
Identification of a Novel TAR RNA-Binding Protein 2 Modulator with Potential Therapeutic Activity against Hepatocellular Carcinoma.
AID1817212Antiproliferative activity against human SK-HEP1 cells assessed as decrease in miR135a-5p level at 20 uM by qRT-PCR analysis2021Journal of medicinal chemistry, 06-10, Volume: 64, Issue:11
Identification of a Novel TAR RNA-Binding Protein 2 Modulator with Potential Therapeutic Activity against Hepatocellular Carcinoma.
AID1817246Antitumor activity in human MHCC97 cells xenografted in SCID mouse assessed as reduction in infiltration of inflammatory cells in left middle lobe of liver at 40 mg/kg, ip measured after 30 days by H and E staining based immunohistochemical analysis2021Journal of medicinal chemistry, 06-10, Volume: 64, Issue:11
Identification of a Novel TAR RNA-Binding Protein 2 Modulator with Potential Therapeutic Activity against Hepatocellular Carcinoma.
AID1817232Inhibition of cell migration in human SK-HEP1 cells at 30 uM incubated for 12 hrs by crystal violet staining based transwell assay2021Journal of medicinal chemistry, 06-10, Volume: 64, Issue:11
Identification of a Novel TAR RNA-Binding Protein 2 Modulator with Potential Therapeutic Activity against Hepatocellular Carcinoma.
AID1817237Inhibition of epithelial-mesenchymal transition in human SK-HEP1 cells assessed as change in vimentin expression at 10 to 50 uM incubated for 24 hrs by Western blot analysis2021Journal of medicinal chemistry, 06-10, Volume: 64, Issue:11
Identification of a Novel TAR RNA-Binding Protein 2 Modulator with Potential Therapeutic Activity against Hepatocellular Carcinoma.
AID751134Cytotoxicity against human NB4 cells after 3 days by MTT assay2013Journal of natural products, Jun-28, Volume: 76, Issue:6
Bioactive dibenzocyclooctadiene lignans from the stems of Schisandra neglecta.
AID1817272Antiproliferative activity against human SK-HEP1 cells assessed as increase in miR-122-5p level at 20 uM by qRT-PCR analysis2021Journal of medicinal chemistry, 06-10, Volume: 64, Issue:11
Identification of a Novel TAR RNA-Binding Protein 2 Modulator with Potential Therapeutic Activity against Hepatocellular Carcinoma.
AID1817230Induction of cell cycle arrest in human SK-HEP1 cells assessed as S phase accumulation at 20 uM incubated for 24 hrs by propidium iodide staining based flow cytometry analysis (Rvb = 26.72%)2021Journal of medicinal chemistry, 06-10, Volume: 64, Issue:11
Identification of a Novel TAR RNA-Binding Protein 2 Modulator with Potential Therapeutic Activity against Hepatocellular Carcinoma.
AID1817284Antitumor activity against human MHCC97 cells xenografted in SCID mouse assessed as decrease in tumor size at 20 mg/kg, ip administered once every 3 days and measured after 10 days2021Journal of medicinal chemistry, 06-10, Volume: 64, Issue:11
Identification of a Novel TAR RNA-Binding Protein 2 Modulator with Potential Therapeutic Activity against Hepatocellular Carcinoma.
AID1817233Inhibition of cell migration in human MHCC97H cells at 30 uM incubated for 12 hrs by crystal violet staining based transwell assay2021Journal of medicinal chemistry, 06-10, Volume: 64, Issue:11
Identification of a Novel TAR RNA-Binding Protein 2 Modulator with Potential Therapeutic Activity against Hepatocellular Carcinoma.
AID1817217Antiproliferative activity against human Huh-7 cells incubated for 24 hrs by alamar blue assay2021Journal of medicinal chemistry, 06-10, Volume: 64, Issue:11
Identification of a Novel TAR RNA-Binding Protein 2 Modulator with Potential Therapeutic Activity against Hepatocellular Carcinoma.
AID1817241Antimetastatic activity against human MHCC97 cells xenografted in SCID mouse assessed as decrease in liver metastasis at 20 mg/kg, ip administered once every 3 days and measured after 10 days2021Journal of medicinal chemistry, 06-10, Volume: 64, Issue:11
Identification of a Novel TAR RNA-Binding Protein 2 Modulator with Potential Therapeutic Activity against Hepatocellular Carcinoma.
AID1817225Inhibition of colony formation in human MHCC97H cells at 30 uM incubated for 14 days by crystal violet staining based assay2021Journal of medicinal chemistry, 06-10, Volume: 64, Issue:11
Identification of a Novel TAR RNA-Binding Protein 2 Modulator with Potential Therapeutic Activity against Hepatocellular Carcinoma.
AID1817276Antiproliferative activity against human SK-HEP1 cells assessed as increase in miR-222-5p level at 20 uM by qRT-PCR analysis2021Journal of medicinal chemistry, 06-10, Volume: 64, Issue:11
Identification of a Novel TAR RNA-Binding Protein 2 Modulator with Potential Therapeutic Activity against Hepatocellular Carcinoma.
AID1817263Antiproliferative activity against human SK-HEP1 cells knockdown TRBP at 20 uM measured by crystal violet dye based colony formation assay2021Journal of medicinal chemistry, 06-10, Volume: 64, Issue:11
Identification of a Novel TAR RNA-Binding Protein 2 Modulator with Potential Therapeutic Activity against Hepatocellular Carcinoma.
AID1817252Inhibition of p65 phosphorylation in human SK-HEP1 cells at 30 uM by Western blot analysis2021Journal of medicinal chemistry, 06-10, Volume: 64, Issue:11
Identification of a Novel TAR RNA-Binding Protein 2 Modulator with Potential Therapeutic Activity against Hepatocellular Carcinoma.
AID379884Cytotoxicity against human H9 cells after 4 days2006Journal of natural products, Dec, Volume: 69, Issue:12
Rubrisandrins A and B, lignans and related anti-HIV compounds from Schisandra rubriflora.
AID1817277Antiproliferative activity against human SK-HEP1 cells assessed as increase in miR-10a-5p level at 20 uM by qRT-PCR analysis2021Journal of medicinal chemistry, 06-10, Volume: 64, Issue:11
Identification of a Novel TAR RNA-Binding Protein 2 Modulator with Potential Therapeutic Activity against Hepatocellular Carcinoma.
AID1817259Downregulation of TPX2 expression in mouse liver at 40 mg/kg measured after 30 days by immunohistochemical staining analysis2021Journal of medicinal chemistry, 06-10, Volume: 64, Issue:11
Identification of a Novel TAR RNA-Binding Protein 2 Modulator with Potential Therapeutic Activity against Hepatocellular Carcinoma.
AID1817264Inhibition of cell migration in human SK-HEP1 cells overexpressing TRBP at 20 uM measured after 12 hrs using crystal violet staining inverted microscope based transwell assay2021Journal of medicinal chemistry, 06-10, Volume: 64, Issue:11
Identification of a Novel TAR RNA-Binding Protein 2 Modulator with Potential Therapeutic Activity against Hepatocellular Carcinoma.
AID1817287Effect on AGO2 protein expression in human SK-HEP1 cells at 30 uM after 24 hrs by immunoblot analysis2021Journal of medicinal chemistry, 06-10, Volume: 64, Issue:11
Identification of a Novel TAR RNA-Binding Protein 2 Modulator with Potential Therapeutic Activity against Hepatocellular Carcinoma.
AID1817255Inhibition of p38 phosphorylation in human SK-HEP1 cells at 30 uM by Western blot analysis2021Journal of medicinal chemistry, 06-10, Volume: 64, Issue:11
Identification of a Novel TAR RNA-Binding Protein 2 Modulator with Potential Therapeutic Activity against Hepatocellular Carcinoma.
AID1817224Inhibition of colony formation in human HepG2 cells at 30 uM incubated for 14 days by crystal violet staining based assay2021Journal of medicinal chemistry, 06-10, Volume: 64, Issue:11
Identification of a Novel TAR RNA-Binding Protein 2 Modulator with Potential Therapeutic Activity against Hepatocellular Carcinoma.
AID1817211Antiproliferative activity against human SK-HEP1 cells assessed as increase in miR-22-5p level at 20 uM by qRT-PCR analysis2021Journal of medicinal chemistry, 06-10, Volume: 64, Issue:11
Identification of a Novel TAR RNA-Binding Protein 2 Modulator with Potential Therapeutic Activity against Hepatocellular Carcinoma.
AID1817204Induction of cell cycle arrest in human SK-HEP1 cells assessed as G1 phase accumulation at 20 uM incubated for 24 hrs by propidium iodide staining based flow cytometry analysis (Rvb = 48.61%)2021Journal of medicinal chemistry, 06-10, Volume: 64, Issue:11
Identification of a Novel TAR RNA-Binding Protein 2 Modulator with Potential Therapeutic Activity against Hepatocellular Carcinoma.
AID1817285Antitumor activity against human MHCC97 cells xenografted in SCID mouse assessed as decrease in tumor size at 40 mg/kg, ip administered once every 3 days and measured after 10 days2021Journal of medicinal chemistry, 06-10, Volume: 64, Issue:11
Identification of a Novel TAR RNA-Binding Protein 2 Modulator with Potential Therapeutic Activity against Hepatocellular Carcinoma.
AID751132Cytotoxicity against human SH-SY5Y cells after 3 days by MTT assay2013Journal of natural products, Jun-28, Volume: 76, Issue:6
Bioactive dibenzocyclooctadiene lignans from the stems of Schisandra neglecta.
AID1817206Antiproliferative activity against human SK-HEP1 cells overexpressing TRBP at 20 uM measured by crystal violet dye based colony formation assay2021Journal of medicinal chemistry, 06-10, Volume: 64, Issue:11
Identification of a Novel TAR RNA-Binding Protein 2 Modulator with Potential Therapeutic Activity against Hepatocellular Carcinoma.
AID1817275Antiproliferative activity against human SK-HEP1 cells assessed as increase in miR-452-5p level at 20 uM by qRT-PCR analysis2021Journal of medicinal chemistry, 06-10, Volume: 64, Issue:11
Identification of a Novel TAR RNA-Binding Protein 2 Modulator with Potential Therapeutic Activity against Hepatocellular Carcinoma.
AID1817251Inhibition of MEK phosphorylation in human SK-HEP1 cells at 30 uM by Western blot analysis2021Journal of medicinal chemistry, 06-10, Volume: 64, Issue:11
Identification of a Novel TAR RNA-Binding Protein 2 Modulator with Potential Therapeutic Activity against Hepatocellular Carcinoma.
AID1817222Inhibition of colony formation in human SK-HEP1 cells at 10 to 50 uM incubated for 14 days by crystal violet staining based assay2021Journal of medicinal chemistry, 06-10, Volume: 64, Issue:11
Identification of a Novel TAR RNA-Binding Protein 2 Modulator with Potential Therapeutic Activity against Hepatocellular Carcinoma.
AID1817234Inhibition of cell invasion in human SK-HEP1 cells at 30 uM incubated for 12 hrs by crystal violet staining based transwell assay2021Journal of medicinal chemistry, 06-10, Volume: 64, Issue:11
Identification of a Novel TAR RNA-Binding Protein 2 Modulator with Potential Therapeutic Activity against Hepatocellular Carcinoma.
AID1817269Binding affinity to TRBP (unknown origin) at 30 uM incubated for 2 hrs by pull down assay2021Journal of medicinal chemistry, 06-10, Volume: 64, Issue:11
Identification of a Novel TAR RNA-Binding Protein 2 Modulator with Potential Therapeutic Activity against Hepatocellular Carcinoma.
AID1817209Antiproliferative activity against human SK-HEP1 cells assessed as increase in miR-21-5p level at 20 uM by qRT-PCR analysis2021Journal of medicinal chemistry, 06-10, Volume: 64, Issue:11
Identification of a Novel TAR RNA-Binding Protein 2 Modulator with Potential Therapeutic Activity against Hepatocellular Carcinoma.
AID1817226Inhibition of colony formation in human Huh-7 cells at 30 uM incubated for 14 days by crystal violet staining based assay2021Journal of medicinal chemistry, 06-10, Volume: 64, Issue:11
Identification of a Novel TAR RNA-Binding Protein 2 Modulator with Potential Therapeutic Activity against Hepatocellular Carcinoma.
AID1817210Antiproliferative activity against human SK-HEP1 cells assessed as increase in miR-26a-5p level at 20 uM by qRT-PCR analysis2021Journal of medicinal chemistry, 06-10, Volume: 64, Issue:11
Identification of a Novel TAR RNA-Binding Protein 2 Modulator with Potential Therapeutic Activity against Hepatocellular Carcinoma.
AID751130Cytotoxicity against human PC3 cells after 3 days by MTT assay2013Journal of natural products, Jun-28, Volume: 76, Issue:6
Bioactive dibenzocyclooctadiene lignans from the stems of Schisandra neglecta.
AID379885Therapeutic index, ratio of IC50 for human H9 cells to EC50 for HIV1 3B2006Journal of natural products, Dec, Volume: 69, Issue:12
Rubrisandrins A and B, lignans and related anti-HIV compounds from Schisandra rubriflora.
AID1817238Inhibition of epithelial-mesenchymal transition in human SK-HEP1 cells assessed as change in beta-catenin expression at 10 to 50 uM incubated for 24 hrs by Western blot analysis2021Journal of medicinal chemistry, 06-10, Volume: 64, Issue:11
Identification of a Novel TAR RNA-Binding Protein 2 Modulator with Potential Therapeutic Activity against Hepatocellular Carcinoma.
AID1817205Downregulation of KIF14 expression in mouse liver at 40 mg/kg measured after 30 days by immunohistochemical staining analysis2021Journal of medicinal chemistry, 06-10, Volume: 64, Issue:11
Identification of a Novel TAR RNA-Binding Protein 2 Modulator with Potential Therapeutic Activity against Hepatocellular Carcinoma.
AID1817242Antimetastatic activity against human MHCC97 cells xenografted in SCID mouse assessed as decrease in liver metastasis at 40 mg/kg, ip administered once every 3 days and measured after 10 days2021Journal of medicinal chemistry, 06-10, Volume: 64, Issue:11
Identification of a Novel TAR RNA-Binding Protein 2 Modulator with Potential Therapeutic Activity against Hepatocellular Carcinoma.
AID1817249Effect on human SK-HEP1 cells assessed as decrease in miR-10b-5p level at 10 to 50 uM by qRT-PCR analysis2021Journal of medicinal chemistry, 06-10, Volume: 64, Issue:11
Identification of a Novel TAR RNA-Binding Protein 2 Modulator with Potential Therapeutic Activity against Hepatocellular Carcinoma.
AID1817219Antiproliferative activity against human MDA-MB-231 cells incubated for 24 hrs by alamar blue assay2021Journal of medicinal chemistry, 06-10, Volume: 64, Issue:11
Identification of a Novel TAR RNA-Binding Protein 2 Modulator with Potential Therapeutic Activity against Hepatocellular Carcinoma.
AID751129Cytotoxicity against human MCF7 cells after 3 days by MTT assay2013Journal of natural products, Jun-28, Volume: 76, Issue:6
Bioactive dibenzocyclooctadiene lignans from the stems of Schisandra neglecta.
AID751131Cytotoxicity against human A549 cells after 3 days by MTT assay2013Journal of natural products, Jun-28, Volume: 76, Issue:6
Bioactive dibenzocyclooctadiene lignans from the stems of Schisandra neglecta.
AID1817274Antiproliferative activity against human SK-HEP1 cells assessed as increase in miR-224-5p level at 20 uM by qRT-PCR analysis2021Journal of medicinal chemistry, 06-10, Volume: 64, Issue:11
Identification of a Novel TAR RNA-Binding Protein 2 Modulator with Potential Therapeutic Activity against Hepatocellular Carcinoma.
AID1817256Inhibition of STAT1 phosphorylation in human SK-HEP1 cells at 30 uM by Western blot analysis2021Journal of medicinal chemistry, 06-10, Volume: 64, Issue:11
Identification of a Novel TAR RNA-Binding Protein 2 Modulator with Potential Therapeutic Activity against Hepatocellular Carcinoma.
AID1817280Antiproliferative activity against human Huh-7 cells at 25 uM incubated for 24 hrs by alamar blue assay2021Journal of medicinal chemistry, 06-10, Volume: 64, Issue:11
Identification of a Novel TAR RNA-Binding Protein 2 Modulator with Potential Therapeutic Activity against Hepatocellular Carcinoma.
AID1817254Inhibition of ERK1/2 phosphorylation in human SK-HEP1 cells at 30 uM by Western blot analysis2021Journal of medicinal chemistry, 06-10, Volume: 64, Issue:11
Identification of a Novel TAR RNA-Binding Protein 2 Modulator with Potential Therapeutic Activity against Hepatocellular Carcinoma.
AID1817266Binding affinity to CM5 sensor chip immobilized recombinant full-length TRBP (unknown origin) assessed as dissociation constant by SPR analysis2021Journal of medicinal chemistry, 06-10, Volume: 64, Issue:11
Identification of a Novel TAR RNA-Binding Protein 2 Modulator with Potential Therapeutic Activity against Hepatocellular Carcinoma.
AID1817253Inhibition of AKT phosphorylation in human SK-HEP1 cells at 30 uM by Western blot analysis2021Journal of medicinal chemistry, 06-10, Volume: 64, Issue:11
Identification of a Novel TAR RNA-Binding Protein 2 Modulator with Potential Therapeutic Activity against Hepatocellular Carcinoma.
AID1817283Antiproliferative activity against human HCT-116 cells at 25 uM incubated for 24 hrs by alamar blue assay2021Journal of medicinal chemistry, 06-10, Volume: 64, Issue:11
Identification of a Novel TAR RNA-Binding Protein 2 Modulator with Potential Therapeutic Activity against Hepatocellular Carcinoma.
AID1817221Antiproliferative activity against human QSG7701 cells incubated for 24 hrs by alamar blue assay2021Journal of medicinal chemistry, 06-10, Volume: 64, Issue:11
Identification of a Novel TAR RNA-Binding Protein 2 Modulator with Potential Therapeutic Activity against Hepatocellular Carcinoma.
AID1817239Antitumor activity in human MHCC97 cells xenografted in SCID mouse assessed as suppression of tumor growth at 20 mg/kg, ip administered once every 3 day for 30 days by bioluminescence analysis2021Journal of medicinal chemistry, 06-10, Volume: 64, Issue:11
Identification of a Novel TAR RNA-Binding Protein 2 Modulator with Potential Therapeutic Activity against Hepatocellular Carcinoma.
AID1817218Antiproliferative activity against human HeLa cells incubated for 24 hrs by alamar blue assay2021Journal of medicinal chemistry, 06-10, Volume: 64, Issue:11
Identification of a Novel TAR RNA-Binding Protein 2 Modulator with Potential Therapeutic Activity against Hepatocellular Carcinoma.
AID1817265Inhibition of cell migration in human SK-HEP1 cells knockdown TRBP at 20 uM measured after 12 hrs using crystal violet staining inverted microscope based transwell assay2021Journal of medicinal chemistry, 06-10, Volume: 64, Issue:11
Identification of a Novel TAR RNA-Binding Protein 2 Modulator with Potential Therapeutic Activity against Hepatocellular Carcinoma.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (20.00)18.7374
1990's0 (0.00)18.2507
2000's1 (20.00)29.6817
2010's1 (20.00)24.3611
2020's2 (40.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 13.13

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index13.13 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.92 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (13.13)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
enoxacin
Enoxacin: A broad-spectrum 6-fluoronaphthyridinone antibacterial agent that is structurally related to NALIDIXIC ACID.. enoxacin : A 1,8-naphthyridine derivative that is 1,4-dihydro-1,8-naphthyridine with an ethyl group at the 1 position, a carboxy group at the 3-position, an oxo sustituent at the 4-position, a fluoro substituent at the 5-position and a piperazin-1-yl group at the 7 position. An antibacterial, it is used in the treatment of urinary-tract infections and gonorrhoea.		2.76201,8-naphthyridine derivative;
amino acid;
fluoroquinolone antibiotic;
monocarboxylic acid;
N-arylpiperazine;
quinolone antibiotic		antibacterial drug;
DNA synthesis inhibitor
zidovudine
Zidovudine: A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA during reverse transcription. It improves immunologic function, partially reverses the HIV-induced neurological dysfunction, and improves certain other clinical abnormalities associated with AIDS. Its principal toxic effect is dose-dependent suppression of bone marrow, resulting in anemia and leukopenia.. zidovudine : A pyrimidine 2',3'-dideoxyribonucleoside compound having a 3'-azido substituent and thymine as the nucleobase.		2.4620azide;
pyrimidine 2',3'-dideoxyribonucleoside		antimetabolite;
antiviral drug;
HIV-1 reverse transcriptase inhibitor
paclitaxel
Taxus: Genus of coniferous yew trees or shrubs, several species of which have medicinal uses. Notable is the Pacific yew, Taxus brevifolia, which is used to make the anti-neoplastic drug taxol (PACLITAXEL).		2.0810taxane diterpenoid;
tetracyclic diterpenoid		antineoplastic agent;
human metabolite;
metabolite;
microtubule-stabilising agent
rubschisandrin
rubschisandrin: isolated from kernels of Schisandra rubriflora; structure given in first source		1.9610tannin
sorafenib
[no description available]		2.3110(trifluoromethyl)benzenes;
aromatic ether;
monochlorobenzenes;
phenylureas;
pyridinecarboxamide		angiogenesis inhibitor;
anticoronaviral agent;
antineoplastic agent;
EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor;
ferroptosis inducer;
tyrosine kinase inhibitor
lignans
Lignans: A class of dibenzylbutane derivatives which occurs in higher plants and in fluids (bile, serum, urine, etc.) in man and other animals. These compounds, which have a potential anti-cancer role, can be synthesized in vitro by human fecal flora. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)		1.9610
schizandrin
[no description available]		2.0310
gomisin j
gomisin J: a lignan from Schizandra fruits		2.0310
schisantherin b
schisantherin B: lignan isolated from fruit of Schisandra sphenanthera; RN given refers to schisanterin B and gomisin B		2.0310tannin
ConditionIndicatedRelationship StrengthStudiesTrials
Hepatocellular Carcinoma
[description not available]		02.7620
Cancer of Liver
[description not available]		02.7620
Carcinoma, Hepatocellular
A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.		02.7620
Liver Neoplasms
Tumors or cancer of the LIVER.		02.7620