| AID1665580 | Antitumor activity against human HT-29 cells xenografted in nude BALB/c mouse assessed as reduction in tumor volume at 40 mg/kg, ip dosed every day for 21 days | | | |
| AID1665556 | Antiproliferative activity against human HT-29 cells by MTT assay | | | |
| AID1665603 | Induction of autophagy in human HT-29 cells assessed as reduction in p62 protein level at 2.5 uM incubated for 72 hrs by Western blot analysis | | | |
| AID254795 | Inhibitory concentration against GSTP1-1 over-expressed in MCF7wt cells | 2005 | Journal of medicinal chemistry, Oct-20, Volume: 48, Issue:21
| Selective inhibition of MCF-7(piGST) breast tumors using glutathione transferase-derived 2-methylene-cycloalkenones. |
| AID305797 | Cytotoxicity against human H460 cells by MTT assay | 2007 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 17, Issue:2
| Analogues of 2-crotonyloxymethyl-(4R,5R,6R)-4,5,6-trihydroxycyclohex-2-enone (COTC) with anti-tumor properties. |
| AID1665593 | Induction of apoptosis in human HT-29 cells assessed as increase in Bax protein level at 2.5 uM incubated for 72 hrs by Western blot analysis | | | |
| AID1665595 | Induction of apoptosis in human HT-29 cells assessed as reduction in Bcl2 protein level at 2.5 uM incubated for 72 hrs by Western blot analysis | | | |
| AID305796 | Cytotoxicity against human A549 cells by MTT assay | 2007 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 17, Issue:2
| Analogues of 2-crotonyloxymethyl-(4R,5R,6R)-4,5,6-trihydroxycyclohex-2-enone (COTC) with anti-tumor properties. |
| AID84292 | Tested for cytotoxicity against HT-29 (MDR)cells | 2003 | Journal of medicinal chemistry, Jan-02, Volume: 46, Issue:1
| Molecular basis of the antitumor activities of 2-crotonyloxymethyl-2-cycloalkenones. |
| AID1665599 | Induction of apoptosis in human HT-29 cells assessed as increase in cleaved caspase-3 protein level at 2.5 uM incubated for 72 hrs by Western blot analysis | | | |
| AID255162 | Ratio between MCF7wt to MCF-7piGST cells overexpressing in GSTP1-1 | 2005 | Journal of medicinal chemistry, Oct-20, Volume: 48, Issue:21
| Selective inhibition of MCF-7(piGST) breast tumors using glutathione transferase-derived 2-methylene-cycloalkenones. |
| AID1665557 | Antiproliferative activity against human HepG2 cells by MTT assay | | | |
| AID309932 | Cytotoxicity against human H460 cells assessed as surviving cells after 4 days by MTT assay | 2007 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 17, Issue:21
| Arene cis-dihydrodiols: useful precursors for the preparation of analogues of the anti-tumour agent, 2-crotonyloxymethyl-(4R,5R,6R)-4,5,6-trihydroxycyclohex-2-enone (COTC). |
| AID1665558 | Antiproliferative activity against rat 9L-2 cells by MTT assay | | | |
| AID84293 | Tested for cytotoxicity against HT-29 (wt)cells | 2003 | Journal of medicinal chemistry, Jan-02, Volume: 46, Issue:1
| Molecular basis of the antitumor activities of 2-crotonyloxymethyl-2-cycloalkenones. |
| AID1665598 | Induction of apoptosis in human HT-29 cells assessed as increase in cleaved PARP protein level at 2.5 uM incubated for 72 hrs by Western blot analysis | | | |
| AID1665602 | Induction of autophagy in human HT-29 cells assessed as increase in Beclin-1 protein level at 2.5 uM incubated for 72 hrs by Western blot analysis | | | |
| AID40726 | Tested in vitro growth inhibition against B16 melanotic melanoma cells | 2003 | Journal of medicinal chemistry, Jan-02, Volume: 46, Issue:1
| Molecular basis of the antitumor activities of 2-crotonyloxymethyl-2-cycloalkenones. |
| AID1665584 | Induction of apoptosis in human HT-29 cells at 2.5 uM incubated for 72 hrs by FITC-AnnexinV/PI staining based flow cytometry relative to control | | | |
| AID309931 | Cytotoxicity against human A549 cells assessed as surviving cells after 4 days by MTT assay | 2007 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 17, Issue:21
| Arene cis-dihydrodiols: useful precursors for the preparation of analogues of the anti-tumour agent, 2-crotonyloxymethyl-(4R,5R,6R)-4,5,6-trihydroxycyclohex-2-enone (COTC). |
| AID254811 | Inhibitory concentration against GSTP1-1 over-expressed in MCF-7piGST cells | 2005 | Journal of medicinal chemistry, Oct-20, Volume: 48, Issue:21
| Selective inhibition of MCF-7(piGST) breast tumors using glutathione transferase-derived 2-methylene-cycloalkenones. |
| AID1665559 | Cytotoxicity against human CCD-841 cells by MTT assay | | | |
| AID1665601 | Induction of autophagy in human HT-29 cells assessed as increase in LC3-II protein level at 2.5 uM incubated for 72 hrs by Western blot analysis | | | |
| AID1665582 | Antitumor activity against human HT-29 cells xenografted in nude BALB/c mouse assessed as tumor weight level at 40 mg/kg, ip dosed every day for 21 days (Rvb = 1.49 +/- 0.27 g) | | | |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |