quinone binding
Definition
Target type: molecularfunction
Binding to a quinone, any member of a class of diketones derivable from aromatic compounds by conversion of two CH groups into CO groups with any necessary rearrangement of double bonds. [ISBN:0198506732]
Quinone binding is a molecular function involving the interaction of a protein with a quinone molecule. Quinones are organic compounds with a cyclic diketone structure, characterized by their ability to participate in redox reactions, transferring electrons and acting as electron carriers. Quinones play diverse roles in biological systems, including cellular respiration, photosynthesis, and detoxification.
Proteins that exhibit quinone binding often contain specific amino acid residues that interact with the quinone molecule through hydrogen bonding, hydrophobic interactions, and electrostatic interactions. This interaction can lead to conformational changes in the protein, influencing its activity and function.
Quinone binding can be involved in various molecular mechanisms, including:
* **Electron transfer:** Quinones act as electron carriers, facilitating the transfer of electrons in metabolic pathways such as the electron transport chain in mitochondria and photosynthesis.
* **Redox regulation:** Quinone binding can regulate the activity of proteins by modulating their redox state, impacting their catalytic activity or their interactions with other molecules.
* **Substrate binding:** Quinones can serve as substrates for enzymes that catalyze reactions involving their oxidation or reduction.
* **Signal transduction:** Quinone binding can initiate signaling pathways by triggering conformational changes in proteins, leading to downstream signaling events.
Specific examples of proteins that exhibit quinone binding include:
* **Cytochrome c oxidase:** This enzyme in the electron transport chain binds to ubiquinone (coenzyme Q), facilitating electron transfer from cytochrome c to molecular oxygen.
* **NADH dehydrogenase:** This enzyme in the electron transport chain binds to ubiquinone, facilitating electron transfer from NADH to ubiquinone.
* **Photosystem II:** This protein complex in photosynthesis binds to plastoquinone, facilitating electron transfer from water to plastoquinone.
In summary, quinone binding is a crucial molecular function involved in various cellular processes, including electron transfer, redox regulation, substrate binding, and signal transduction. The interaction of proteins with quinone molecules plays a vital role in maintaining cellular homeostasis and enabling essential biological functions.'
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Proteins (9)
| Protein | Definition | Taxonomy |
|---|---|---|
| Vitamin K epoxide reductase complex subunit 1 | [no definition available] | Bos taurus (cattle) |
| Sulfide:quinone oxidoreductase, mitochondrial | A sulfide:quinone oxidoreductase, mitochondrial that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y6N5] | Homo sapiens (human) |
| Vitamin K epoxide reductase complex subunit 1 | A vitamin K epoxide reductase complex subunit 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9BQB6] | Homo sapiens (human) |
| Vitamin K epoxide reductase complex subunit 1-like protein 1 | A vitamin K epoxide reductase complex subunit 1-like protein 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8N0U8] | Homo sapiens (human) |
| Membrane primary amine oxidase | A membrane primary amine oxidase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q16853] | Homo sapiens (human) |
| Amiloride-sensitive amine oxidase [copper-containing] | An amiloride-sensitive amine oxidase [copper-containing] that is encoded in the genome of human. [PRO:DNx, UniProtKB:P19801] | Homo sapiens (human) |
| NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial | An NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial that is encoded in the genome of human. [PRO:DNx] | Homo sapiens (human) |
| NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial | An NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial that is encoded in the genome of human. [PRO:DNx] | Homo sapiens (human) |
| Retina-specific copper amine oxidase | A retina-specific copper amine oxidase that is encoded in the genome of human. [PRO:DNx, UniProtKB:O75106] | Homo sapiens (human) |
Compounds (22)
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| phenethylamine | 2-phenylethylamine : A phenylethylamine having the phenyl substituent at the 2-position. phenethylamine: RN given refers to parent cpd; structure in Merck Index, 9th ed, #7016 | alkaloid; aralkylamine; phenylethylamine | Escherichia coli metabolite; human metabolite; mouse metabolite |
| diminazene | diminazene : A triazene derivative that is triazene in which each of the terminal nitrogens is substituted by a 4-carbamimidoylphenyl group. Diminazene: An effective trypanocidal agent. | carboxamidine; triazene derivative | antiparasitic agent; trypanocidal drug |
| carmofur | organohalogen compound; pyrimidines | ||
| phenelzine | Phenelzine: One of the MONOAMINE OXIDASE INHIBITORS used to treat DEPRESSION; PHOBIC DISORDERS; and PANIC. | primary amine | |
| pentamidine | pentamidine : A diether consisting of pentane-1,5-diol in which both hydroxyl hydrogens have been replaced by 4-amidinophenyl groups. A trypanocidal drug that is used for treatment of cutaneous leishmaniasis and Chagas disease. Pentamidine: Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of PNEUMOCYSTIS pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects. | aromatic ether; carboxamidine; diether | anti-inflammatory agent; antifungal agent; calmodulin antagonist; chemokine receptor 5 antagonist; EC 2.3.1.48 (histone acetyltransferase) inhibitor; NMDA receptor antagonist; S100 calcium-binding protein B inhibitor; trypanocidal drug; xenobiotic |
| rolipram | pyrrolidin-2-ones | antidepressant; EC 3.1.4.* (phosphoric diester hydrolase) inhibitor | |
| benzimidazole | 1H-benzimidazole : The 1H-tautomer of benzimidazole. | benzimidazole; polycyclic heteroarene | |
| benzylamine | aminotoluene : Any member of the class of toluenes carrying one or more amino groups. | aralkylamine; primary amine | allergen; EC 3.5.5.1 (nitrilase) inhibitor; plant metabolite |
| 2-aminobenzothiazole | benzothiazoles | ||
| 2-aminobenzimidazole | 2-aminobenzimidazole : A member of the class of benzimidazoles that is benzimidazole in which the hydrogen at position 2 is replaced by an amino group. 2-aminobenzimidazole: metabolite of benomyl; RN given refers to parent cpd | benzimidazoles | marine xenobiotic metabolite |
| phenylguanidine | phenylguanidine: RN given refers to parent cpd | ||
| 3-phenylpropylamine | 3-phenylpropylamine : A phenylalkylamine that is benzene in which one of the hydrogens is substituted by a 3-aminopropyl group. | benzenes; phenylalkylamine; primary amino compound | |
| maleic hydrazide | Maleic Hydrazide: 1,2-Dihydro-3,6-pyridazinedione. A herbicide and plant growth regulator; also used to control suckering of tobacco. Its residue in food and tobacco is highly toxic, causing CNS disturbances and liver damage. | pyridazinone | |
| 4-fluorobenzylamine | |||
| 2-amino-1-methylbenzimidazole | 2-amino-1-methylbenzimidazole: structure in first source | benzimidazoles | |
| 4-phenylbutylamine | 4-phenylbutylamine : A phenylalkylamine that is benzene in which one of the hydrogens is substituted by a 4-aminobutyl group. 4-phenylbutylamine: used as a drug partition into lipid bilayers in a cubic liquid-crystalline phase | benzenes; phenylalkylamine; primary amino compound | |
| aurapten | aurapten: RN refers to (E)-isomer; structure given in first source auraptene : A member of the class of coumarins that is umbelliferone in which the phenolic hydrogen has been replaced by a geranyl group. Ii is isolated from several edible fruits and vegetables and exhibits a variety of therapeutic properties. | coumarins; monoterpenoid | antihypertensive agent; antineoplastic agent; antioxidant; apoptosis inducer; dopaminergic agent; EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor; gamma-secretase modulator; gastrointestinal drug; hepatoprotective agent; matrix metalloproteinase inhibitor; neuroprotective agent; plant metabolite; PPARalpha agonist; vulnerary |
| vitamin k1 oxide | vitamin K1 oxide: RN given refers to parent cpd; see also record for 2,3-epoxymenaquinone | ||
| mofegiline | |||
| marmin | marmin: structure in first source; RN given for (R-(E))-isomer | ||
| warfarin | 4-hydroxy-3-(3-oxo-1-phenylbutyl)-1-benzopyran-2-one : A member of the class of coumarins that is 4-hydroxycoumarin which is substituted at position 3 by a 1-phenyl-3-oxo-1-butyl group. warfarin : A racemate comprising equal amounts of (R)- and (S)-warfarin. Extensively used as both an anticoagulant drug and as a pesticide against rats and mice. Warfarin: An anticoagulant that acts by inhibiting the synthesis of vitamin K-dependent coagulation factors. Warfarin is indicated for the prophylaxis and/or treatment of venous thrombosis and its extension, pulmonary embolism, and atrial fibrillation with embolization. It is also used as an adjunct in the prophylaxis of systemic embolism after myocardial infarction. Warfarin is also used as a rodenticide. | benzenes; hydroxycoumarin; methyl ketone | |
| zaprinast | zaprinast: anaphylaxis inhibitor; structure | triazolopyrimidines |