Target type: molecularfunction
Catalysis of the reaction: 5-alpha-cholest-7-en-3-beta-ol = 5-alpha-cholest-8-en-3-beta-ol. [RHEA:15281]
Cholestenol delta-isomerase activity is a type of enzymatic activity that catalyzes the isomerization of cholestenol, a cholesterol precursor, into 7-dehydrocholesterol. This reaction involves the conversion of the double bond in the B ring of cholestenol from the 5,6 position to the 7,8 position.
This enzyme plays a crucial role in the biosynthesis of vitamin D. Specifically, it catalyzes the penultimate step in the conversion of 7-dehydrocholesterol into previtamin D3. Upon exposure to ultraviolet B (UVB) radiation, 7-dehydrocholesterol undergoes photoisomerization to form previtamin D3. Previtamin D3 then undergoes a series of thermal rearrangements to form vitamin D3 (cholecalciferol), which is the biologically active form of vitamin D.
Cholestenol delta-isomerase activity is found in various tissues, including the skin, liver, and intestines, and is essential for maintaining adequate levels of vitamin D in the body. Vitamin D is vital for calcium absorption, bone health, and immune function. Deficiency in vitamin D can lead to various health issues, including rickets in children and osteomalacia in adults.'
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| Protein | Definition | Taxonomy |
|---|---|---|
| Emopamil-binding protein-like | An emopamil-binding protein-like that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9BY08] | Homo sapiens (human) |
| 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase | A 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15125] | Homo sapiens (human) |
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| amiodarone | amiodarone : A member of the class of 1-benzofurans that is 1-benzofuran substituted by a butyl group at position 2 and a 4-[2-(diethylamino)ethoxy]-3,5-diiodobenzoyl group at position 3. It is a cardiovascular drug used for the treatment of cardiac dysrhythmias. Amiodarone: An antianginal and class III antiarrhythmic drug. It increases the duration of ventricular and atrial muscle action by inhibiting POTASSIUM CHANNELS and VOLTAGE-GATED SODIUM CHANNELS. There is a resulting decrease in heart rate and in vascular resistance. | 1-benzofurans; aromatic ketone; organoiodine compound; tertiary amino compound | cardiovascular drug |
| buflomedil | buflomedil: RN given refers to parent cpd; synonym LL 1656 refers to HCl; structure | aromatic ketone | |
| haloperidol | haloperidol : A compound composed of a central piperidine structure with hydroxy and p-chlorophenyl substituents at position 4 and an N-linked p-fluorobutyrophenone moiety. Haloperidol: A phenyl-piperidinyl-butyrophenone that is used primarily to treat SCHIZOPHRENIA and other PSYCHOSES. It is also used in schizoaffective disorder, DELUSIONAL DISORDERS, ballism, and TOURETTE SYNDROME (a drug of choice) and occasionally as adjunctive therapy in INTELLECTUAL DISABILITY and the chorea of HUNTINGTON DISEASE. It is a potent antiemetic and is used in the treatment of intractable HICCUPS. (From AMA Drug Evaluations Annual, 1994, p279) | aromatic ketone; hydroxypiperidine; monochlorobenzenes; organofluorine compound; tertiary alcohol | antidyskinesia agent; antiemetic; dopaminergic antagonist; first generation antipsychotic; serotonergic antagonist |
| nafoxidine | Nafoxidine: An estrogen antagonist that has been used in the treatment of breast cancer. | benzenes; naphthalenes; ring assembly | |
| raloxifene | raloxifene : A member of the class of 1-benzothiophenes that is 1-benzothiophene in which the hydrogens at positions 2, 3, and 6 have been replaced by p-hydroxyphenyl, p-[2-(piperidin-1-yl)ethoxy]benzoyl, and hydroxy groups, respectively. | 1-benzothiophenes; aromatic ketone; N-oxyethylpiperidine; phenols | bone density conservation agent; estrogen antagonist; estrogen receptor modulator |
| trifluoperazine | N-alkylpiperazine; N-methylpiperazine; organofluorine compound; phenothiazines | antiemetic; calmodulin antagonist; dopaminergic antagonist; EC 1.8.1.12 (trypanothione-disulfide reductase) inhibitor; EC 5.3.3.5 (cholestenol Delta-isomerase) inhibitor; phenothiazine antipsychotic drug | |
| trifluperidol | Trifluperidol: A butyrophenone with general properties similar to those of HALOPERIDOL. It is used in the treatment of PSYCHOSES including MANIA and SCHIZOPHRENIA. (From Martindale, The Extra Pharmacopoeia, 30th ed, p621) | aromatic ketone | |
| corticosterone | 11beta-hydroxy steroid; 20-oxo steroid; 21-hydroxy steroid; 3-oxo-Delta(4) steroid; C21-steroid; glucocorticoid; primary alpha-hydroxy ketone | human metabolite; mouse metabolite | |
| triparanol | Triparanol: Antilipemic agent with high ophthalmic toxicity. According to Merck Index, 11th ed, the compound was withdrawn from the market in 1962 because of its association with the formation of irreversible cataracts. | stilbenoid | anticoronaviral agent |
| 1,3-ditolylguanidine | 1,3-ditolylguanidine: structure given in first source; a selective ligand for the sigma binding sites in the brain | toluenes | |
| opipramol | Opipramol: A tricyclic antidepressant with actions similar to AMITRIPTYLINE. | dibenzoazepine | |
| jervine | jervine: teratogen from Veratrum grandiflorum; RN given refers to parent cpd(3beta,23beta)-isomer; structure | piperidines | |
| naftifine | naftifine : A tertiary amine in which the nitrogen is substituted by methyl, alpha-naphthylmethyl, and (1E)-cinnamyl groups. It is used (usually as its hydrochloride salt) for the treatment of fungal skin infections. naftifine: allylamine der; RN given refers to unlabeled parent cpd | allylamine antifungal drug; naphthalenes; tertiary amine | EC 1.14.13.132 (squalene monooxygenase) inhibitor; sterol biosynthesis inhibitor |
| carbizocaine | |||
| fenpropimorph | alkylbenzene | ||
| chrysamine g | chrysamine G: structure given in first source; RN refers to disodium salt | ||
| preclamol | |||
| enclomiphene | Enclomiphene: The trans or (E)-isomer of clomiphene. | ||
| zuclomiphene | Zuclomiphene: The cis or (Z)-isomer of clomiphene. | stilbenoid | |
| terbinafine | acetylenic compound; allylamine antifungal drug; enyne; naphthalenes; tertiary amine | EC 1.14.13.132 (squalene monooxygenase) inhibitor; P450 inhibitor; sterol biosynthesis inhibitor | |
| tamoxifen | stilbenoid; tertiary amino compound | angiogenesis inhibitor; antineoplastic agent; bone density conservation agent; EC 1.2.3.1 (aldehyde oxidase) inhibitor; EC 2.7.11.13 (protein kinase C) inhibitor; estrogen antagonist; estrogen receptor antagonist; estrogen receptor modulator | |
| bm 15766 | BM 15766: 7-dehydrocholesterol reductase antagonist | ||
| ne 100 | |||
| sa 4503 |